Osman Mermi

Firat University, Mezreh, Elazığ, Turkey

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Publications (9)24.28 Total impact

  • Murad Atmaca, Osman Mermi
    Journal of clinical psychopharmacology 08/2011; 31(4):550-1. · 5.09 Impact Factor
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    ABSTRACT: Although a number of magnetic resonance imaging (MRI) and genetic studies have been performed on obsessive-compulsive disorder (OCD), only limited studies in which genetic and neuroanatomical variables are evaluated concurrently have been performed. Therefore, the aim of our present study is (to understand) better understanding how genetic variation in the promoter region of the 5-HTT gene (5-HTTLPR) is associated with key brain structures in OCD, orbito-frontal cortex (OFC), thalamus and anterior cingulate. 5-HTT genotypes (SS, SL, LL) were determined for 40 patients with OCD and the same number of healthy controls. MRI-derived volumes of the OFC, thalamus, and anterior cingulate were determined by reliable tracing techniques. Volumetric measurements were made with T1-weighted coronal MRI images, with 1.5-mm-thick slices, at 1.5T, and were done blindly. In comparison with controls, OCD patients demonstrated volumes reduction in OFC, increased volumes of thalamus and total white matter volumes, but no difference in total brain volume, total gray matter volumes and anterior cingulate volumes. No significant difference was observed in allelic frequencies between the patients and controls. The stronger effects of 5-HTT polymorphism on brain morphology in OCD than those in controls were determined in the both OFC and thalamus. On the other hand, for the OCD patients, ANCOVA revealed a significant main effect of genotype for both the OFC and thalamus and a significant genotype-by-side interaction for the OFC, demonstrating that the short variants had a smaller right OFC than the long variants. In conclusion, we found a significant genotype-diagnosis interaction effects on key brain structures, with a stronger effects of 5-HTT polymorphism in OFC and thalamus of OCD patients, whereas no morphological changes related to the polymorphism were found in normal individuals.
    Journal of anxiety disorders 03/2011; 25(5):680-5. · 2.68 Impact Factor
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    ABSTRACT: The aim of the present study was to retrospectively identify sexual dysfunction changes in the patients under mirtazapine-augmented serotonin reuptake inhibito (SSRI) treatment. The study comprised medical records of 20 outpatients, under mirtazapine-augmented SSRI treatment for their major depressive disorder, who had been selected among the patients that had developed sexual dysfunction to previous treatment as monotherapy, with SSRI for at least six weeks. These drugs were maintained and mirtazapine were added (15-45 mg/day). There was a significant difference in scores between baseline and week 4 or week 8 on the both Hamilton Depression Rating and Arizona Sexual Experience Scale. According to Clinical Global Impression-Improvement, 68.4% of the patients were responders. The use of low-dose mirtazapine as an add-on treatment to SSRIs appears to be an effective and well-tolerated augmenttaion for sexual dysfunction caused by SSRIs.
    Psychiatry investigation 03/2011; 8(1):55-7. · 1.06 Impact Factor
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    ABSTRACT: There has been dearth of investigations concerning morphometric magnetic resonance imaging (MRI) study of regional brain volumes in body dysmorphic disorder (BDD). So we performed a volumetric MRI study in patients with BDD focusing on the in vivo neuroanatomy of thalamus, caudate nucleus, anterior cingulate cortex, and orbito-frontal cortex (OFC) concurrently. The whole brain, total gray and white matter volume, thalamus, caudate nucleus, anterior cingulate cortex, and OFC volumes were blindly measured in 12 unmedicated male BDD patients not having any comorbidity and 12 male control subjects matched for age, and gender. The mean OFC and anterior cingulate volumes were significantly smaller than those of healthy controls. The mean white matter volume was larger than that of controls. There was a trend toward increased thalamic volume in patients compared with that of control subjects. Length of illness was inversely correlated with OFC volumes in the patient group both on the left and right sides. These findings may be interpreted as further evidence for the inclusion of BDD among a group of obsessive-compulsive spectrum disorders. Future research is necessary to confirm these preliminary findings, to extend them, and to clarify their significance with respect to the etiology and pathophysiology of BDD.
    Journal of affective disorders 10/2009; 123(1-3):258-63. · 3.76 Impact Factor
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    ABSTRACT: Sertindole has been marketed and offered daily clinical practice only for 9 months in our country, so no data has been its QTc prolongation potential. In the present study, we performed a clinical trial to investigate the effects of sertindole on QTc in patients with schizophrenia. The study comprised 21 patients with schizophrenia. Sertindole was administered in the following dosing regime: treatment was initiated with 4 mg/day sertindole. From day 3 to day 6, the dose was increased to 8 mg/day, and up to day 9, it was raised to 12 mg/day. The protocol allowed up to dose of 20mg/day according to effectiveness and tolerability. QTc values were determined at beginning, months 3 and 6. In addition, Positive and Negative Syndrome Scale (PANSS) were scored concomitantly. At the beginning of 6-month period, the mean QTc interval of patients was 391.7+/-19.2 ms. At the end of this period, it was 402.8+/-23.8 ms. Although the mean QTc interval changing was significant throughout 6-month period, of the patients, at any evaluation point, only 1 female (451 ms) and 1 male (433 ms) had borderline prolongation at month 3 for both, without any exceeding the dangerous limits. In summary, our results suggest that sertindole is tolerable and despite dose-related QT prolongation, sertindole had not the proarrhythmic profile. Future studies with larger sample evaluating the effects of treatment are required.
    Neuroscience Letters 09/2008; 442(1):1-3. · 2.03 Impact Factor
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    ABSTRACT: Functional and structural neuroimaging studies have implicated the hippocampus-amygdala complex in the pathophysiology of obsessive-compulsive disorder (OCD), although no consensus has been established. These brain regions have not been investigated in refractory OCD patients. Volumes of the hippocampus, and amygdala were measured by magnetic resonance imaging (MRI) in a sample of 14 refractory OCD patients and 14 healthy comparison subjects. The mean left and right hippocampal and amygdala volumes of the patients were smaller than those of the healthy controls. OCD severity was not correlated with amygdala volumes but was related to the left hippocampus. Duration of illness was correlated with both hippocampus and left amygdala. Our findings suggest that hippocampus and amygdalar abnormalities can be considered in refractoriness to OCD.
    Progress in Neuro-Psychopharmacology and Biological Psychiatry 08/2008; 32(5):1283-6. · 3.55 Impact Factor
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    ABSTRACT: Rheumatoid arthritis (RA) mostly follows a painful, progressively disabling course, and individuals with RA experience more psychological distress than healthy individuals. The objective of the present study is to examine the prevalences of accompanying anxiety and depression in RA cases. The study included 82 RA cases and 41 age- and sex-matched healthy volunteers as the control group. Psychiatric examinations of all cases of the patient and control groups were performed according to DSM-IV criteria. Hamilton Anxiety Scale or Hamilton Depression Scale was applied to those who were found to have anxiety or depression. Total prevalence of anxiety, depression, and mixed anxiety-depressive disorder was found to be 70.8% (n=58) in the patient group and 7.3% (n=3) in the control group, and the difference was significant (p<0.001). Of the RA patients, 41.5% (n=34) was found to have depression, 13.4% (n=11) anxiety, and 15.9% (n=13) mixed anxiety-depressive disorder. The disease duration in patients with anxiety was shorter than the RA patient with depression (p<0.05). The disease duration was positively correlated with the degree of depression and negatively correlated with the degree of anxiety (r=0.341, p<0.05; r=-0.642, p<0.05, respectively). The results of our study suggest that prevalences of anxiety and mainly depression, increase in RA cases. When the clinical picture in RA cases becomes complicated with anxiety or depression, some problems at patients' adaptation and response to treatment may be possible. RA cases should be monitored for accompanying anxiety or depression during follow-up.
    Clinical Rheumatology 06/2007; 26(6):872-8. · 2.04 Impact Factor
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    ABSTRACT: P-wave dispersion (PWD) is defined as the difference between the maximum and the minimum P-wave (Pmax and Pmin, respectively) duration. Significant variation in cardiac atrial PWD has been correlated with changes in systemic autonomic tone such as during periods of anxiety. It is also known that the degree of PWD seen on 12-lead electrocardiogram (ECG) may be a predictor of susceptibility of the atrial myocardium to future atrial fibrillation (AF). Therefore, we firstly aimed to show an association between PWD and panic disorder, a state of high sympathetic tone. PWD was measured in 40 outpatients with panic disorder and in 40 physically and mentally healthy age- and gender-matched controls. In addition, the Panic Agoraphobia Scale (PAS) and the Hamilton Depression Rating Scale (HDRS) were scored concomitantly. Both Pmax and Pmin were significantly higher than those of healthy controls. PWD was significantly greater in the panic disorder group than in the controls. As expected, the mean score on PAS was significantly higher for the panic disorder group than for the controls and correlated significantly with PWD. Heart rate (measured as RR intervals in milliseconds on electrocardiogram) did not differ significantly between the groups. The findings of the present study suggest that the disorder may be associated with an increase in PWD. This association may result from prolonged anxiety and increase in sympathetic modulation, which are main characteristics of panic disorder.
    Psychosomatic Medicine 06/2007; 69(4):344-7. · 4.08 Impact Factor
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    ABSTRACT: ÖZET: Obsesif kompulsif bozuklukta 5-HT1DB geni ile anahtar beyin bölgeleri aras›ndaki iliflki Amaç: Obsesif kompulsif bozuklukta (OKB) nöroanatomik ve genetik deiflkenler aras›ndaki iliflkiyi inceleyen oldukça s›n›rl› say›da çal›flma bulunmaktad›r. Bu çal›flman›n amac›, 5-HT1 DB gen polimorfizminin OKB'li hastalarla sal›kl› kontrollerde beyin morfolojisi üzerine olan etkilerini incelemektir. Metod: Çal›flmada 44 hasta ve ayn› say›da kontrol denek deerlendirildi. Deneklerin talamus ve orbito-frontal korteks (OFC) bölgelerinin manyetik rezonans görüntülemesi gerçeklefltirildi. Ek olarak venöz kan örneklemlerinden 5-HT1B reseptor geni G861C polimorfizmi için genotipleme yap›ld›. Bulgular: Genotip ve tan› aras›ndaki iliflkinin çal›fl›lan beyin volümleriyle iliflkili olduunu gözlemledik. OFC bölgesinde 5-HT1 DB polimorfizminin beyin morfolojisi üzerindeki etkisi hasta grubunda, kontrollere göre anlaml› olarak daha belirgindi (P