Cesur Gümüş

Cumhuriyet University, Megalopolis, Sivas, Turkey

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Publications (22)21.86 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Hearing loss (HL) is common in patients with chronic renal failure (CRF), but its cause is controversial. The aim of this study was to determine the effect of CRF on the bone density of the otic capsule using densitometric measurements with MDCT and to evaluate the relationship between changes in the otic capsule density and HL in patients with CRF. The study included 34 patients with nonsyndromic CRF undergoing hemodialysis and 35 healthy control subjects. A CT was obtained, for a variety of reasons, in control subjects who did not have CRF or HL, but patients with trauma and infection were excluded. Control subjects were chosen on the basis of a normal CT and pure tone audiometry findings. Densitometric measurements were made using CT in the region anterior to the oval window and anterior to the internal auditory canal. These measurements were compared between patients and control subjects. Pure tone audiometry was performed to detect HL. The average levels of parathyroid hormone in the previous 6 months and the duration of hemodialysis in patients were documented. The association between the levels of parathyroid hormone, the duration of hemodialysis, and the region-of-interest density values in the patient groups were evaluated using the Pearson correlation coefficient. HL was found in 40 of 68 ears (58.8%) in the patient group. A significant difference in the otic capsule density was found between the ears with and without HL. There was a strong negative correlation between the parathyroid hormone level and the densitometric measurement of the otic capsule. There is osseous remodeling of the otic capsule in CRF with loss of bone density, and this is associated with HL in CRF.
    American Journal of Roentgenology 02/2013; 200(2):396-9. · 2.90 Impact Factor
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    ABSTRACT: Objective: Sivas is the leading region with regard to the intensity of environmental asbestos exposure in our country. Clinical observations suggest pulmonary and/or pleural involvements to various degrees, due to this exposure. However, although most common asbestosis formations were found in the southern and south-eastern parts of Sivas, the incidence of mesothelioma is lower in this region compared to northern and north-western parts. The objectives of this study were to examine the cause of this situation by means of mineralogical, clinical and radiological data and to investigate both the prevalence of asbestosis-related diseases and the frequency of malignancy based on verbal autopsy findings in residents of these two regions. Material and Methods: The individuals born in two villages situated each in two different study regions and lived at least 20 years in those villages, who were accessible and aged 20 years or older and who agreed to participate in the study were enrolled. The mineralogical compositions of inorganic samples taken from habitats in the towns were determined by the X-ray diffraction (XRD) method. Physical examination and posteroanterior chest X-ray were done following thorough medical history including age, gender, occupation, asbestos exposure, family history, and respiratory symptoms. The X-rays were evaluated according to the 2000 Classification of the International Labor Organization. Results: Mineralogical examinations showed that tremolite asbestos was not detected in our region and the samples contained chrysotile asbestos at similar intensity. The study included 96 participants. Verbal autopsy investigation revealed cancer in the family history of 49 (50.5%) subjects. Dyspnea was the most common symptom, being present in 32 (33%) patients. Twenty-nine (30%) cases had at least one physical examination finding. In terms of parenchymal, pleural and additional pathologies, there was no significant difference between chest radiographs of patients who lived in two villages. Small parenchymal opacities consistent with asbestosis and pleural pathology were found in 25 (25.8%) and 24 (24.7%) cases, respectively. Of the 96 subjects with chest x-rays, 37 (38.1%) had parenchymal 1/0 and above densities compatible with pneumoconiosis. Pleural pathology was detected in 24.7% and additional pathologies were detected in 69.1% of the cases. Conclusion: This study revealed that there was chrysotile (serpentine) asbestos exposure instead of tremolite in our region and in the vast majority of the population over 20 years of age, there was significant clinical and radiological influences.
    Turkiye Klinikleri Journal of Medical Sciences 01/2013; 33(3):613-620. · 0.10 Impact Factor
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    ABSTRACT: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and is responsible for 8-10% of patients with end-stage renal failure. The major extrarenal complications of ADPKD are cardiovascular abnormalities. Interrupted aortic arch (IAA) is a lethal congenital cardiac abnormality seen with a frequency of 3/1000000 births and is defined as a segment of the arcus aorta being atresic. In the literature, there are no any reports showing that polycystic kidney disease and interrupted aortic arch occur together. In this study, we present a rare case in which the patient has polycystic kidney disease and IAA together and discuss whether IAA is a complication of ADPKD.
    Case Reports in Medicine 01/2013; 2013:404710.
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    ABSTRACT: Background: A narrow internal auditory canal (IAC) is significantly associated with congenital sensorineural hearing loss. It would therefore seem likely that any patient with an IAC measured radiographically to be under the normal range represents an abnormality and probable IAC stenosis. If narrow IAC is diagnosed with routine magnetic resonance imaging (MRI), then the cochlear nerve may be evaluated with special MRI studies. However, there is no consensus in the literature on the normal measurements of the IAC or on what parameters should be used to determine narrow IAC using MRI. In this study, we aimed to assess the normative size of IAC in normal-hearing ears and to determine whether canal size varies with age and gender using MRI. Material and methods: A retrospective review was undertaken from 2010 to 2012. A total of 7572 normal-hearing ears of 3786 patients were assessed, who had MRI due to various reasons except hearing loss. Patients under 20 years old and over 60 years old were excluded, and the subjects were divided into 4 groups at 10-year intervals. All subjects were divided by gender also. Anteroposterior (AP) and craniocaudal (CC) measurements were obtained in the middle of the IAC on axial and coronal images of 1.5-T MRI. Results: The mean age was 42 years (range 20-60 years). The mean IAC diameters were 5.93 mm with a standard deviation of 0.25 mm (max 6.99 mm, min 4.73 mm) on AP measurements and were 5.70 mm with a standard deviation of 0.26 mm (max 6.82 mm, min 4.71 mm) on CC measurements. There were no differences in the IAC diameters between males and females or with age groups. Conclusions: These measurements should provide a normative reference for comparison in radiographic assessment of any patient with suspected IAC stenosis. This measurement can help the diagnosis of narrow IAC. To our knowledge, this is the first study using MRI with a large group of patients in the literature.
    Folia morphologica 11/2012; 71(4):217-20. · 0.47 Impact Factor
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    ABSTRACT: The aim of this study was to evaluate the distribution and absorption of local anesthetic solutions in inferior alveolar nerve block using magnetic resonance imaging. Forty healthy volunteers were divided into 4 groups and injected with 1.5 mL for inferior alveolar nerve block and 0.3 mL for lingual nerve block. The solutions used for the different groups were 2% lidocaine, 2% lidocaine with 0.125 mg/mL epinephrine, 4% articaine with 0.006 mg/mL epinephrine, and 4% articaine with 0.012 mg/mL epinephrine. All subjects had axial T2-weighted and fat-suppressed images at 0, 60, and 120 minutes after injection. The localization, area, and intensity (signal characteristics) of the solutions were analyzed and onset and duration times of the anesthesia were recorded. There were no significant differences between groups with regard to the intensity and area of the solutions at 0, 60, and 120 minutes after injection, but differences were found within each group. No between-group differences were found on magnetic resonance imaging in the distribution and absorption of lidocaine with or without epinephrine and articaine with 0.006 and 0.012 mg/mL epinephrine. All solutions were noticeably absorbed at 120 minutes after injection.
    Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons 07/2011; 69(11):2722-30. · 1.58 Impact Factor
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    ABSTRACT: The aim of this experimental study was to evaluate the effects of systemically applied zoledronic acid on bone regeneration in response to expansion of the sagittal suture and relapse in rats. Thirty-six male Wistar rats were divided into 3 groups. In the first and second groups, saline solution was given subcutaneously after expansion, and the retention periods lasted 14 and 7 days, respectively. In the third group, 0.1 mg of zoledronic acid was diluted with saline solution and given subcutaneously after expansion; the retention period lasted for 7 days. Expansion and relapse amounts were measured by using computed tomography. After the retention period, 6 rats from each group were killed for histologic and immunohistochemical assessments. The other 6 rats from each group were used for observation of the relapse. The histologic evaluation showed that, in groups 1 and 2, the numbers of osteoblasts were less than observed in group 3. When scores of staining intensity were compared, immunoreactivities were statistically significantly increased in group 3 compared with groups 2 and 1. Statistically significant differences were found when the relapse percentages were compared between the groups (P <0.05). The smallest relapse occurred in group 3. Zoledronic acid has positive effects on bone formation in the sagittal suture in response to expansion and decreases the relapse ratio after expansion in rats.
    American journal of orthodontics and dentofacial orthopedics: official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 07/2011; 140(1):e31-41. · 1.33 Impact Factor
  • Firat Oztürk, Hasan Babacan, Cesur Gümüs
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    ABSTRACT: The aim of this study was to investigate the effects of systemically applied zoledronic acid (ZA) on osteoblastic bone formation and relapse in the rat sagittal suture after expansion. Eighteen 12-week-old male Wistar rats were divided into three groups. In groups 1 and 2, a saline solution was given subcutaneously after expansion and the retention period lasted for 14 and 7 days, respectively. In group 3, 0.1 mg of ZA was diluted with saline and given subcutaneously after expansion: the retention period lasted for 7 days. Computed tomography (CT) measurements were obtained at the start of the study (T1), after expansion (T2), after the retention period (T3), and after the follow-up period (T4). The amount of expansion and relapse and the density of the newly formed bone in the expansion area were measured. The mean bone density values in hounsfield unit (HU) of the newly formed bone were recorded using MX View Workstation. Data were analysed using the Kruskal-Wallis, Friedman, Wilcoxon, and Mann-Whitney U-tests. The results showed that there were significant differences between the groups in the density of newly formed bone after the retention period (P < 0.05). Statistically significant differences were observed when the relapse percentages were compared between the groups (P < 0.05). ZA stimulated bone formation and decreased the relapse ratio after expansion in the rat sagittal suture.
    The European Journal of Orthodontics 03/2011; 34(2):141-6. · 1.08 Impact Factor
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    ABSTRACT: Primary hydatid disease of the pancreas is very rare. We report the case of a 7-year-old girl who presented with abdominal pain and an epigastric mass. The Casoni and indirect hemagglutination test for hydatid disease were negative. A diagnosis of a pancreatic pseudocyst was established by ultrasonography (US) and computed tomography scan before surgery. Ultrasound guided percutaneous drainage was planned as treatment. During the procedure, the cyst was perforated and as germinative membrane was seen by US, we arranged surgery. Hydatid disease should be considered in the differential diagnosis of all cystic masses in the pancreas, even if Casoni and indirect hemagglutination tests negative, especially in geographic regions like Turkey, where the disease is endemic.
    Turkiye parazitolojii dergisi / Turkiye Parazitoloji Dernegi = Acta parasitologica Turcica / Turkish Society for Parasitology 01/2011; 35(1):50-2.
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    ABSTRACT: Bronchobiliary fistula (BBF), which often presents itself with yellow sputum, is an abnormal communication between the bronchial system and biliary tree. BBF is a serious complication of hydatid cyst of the liver. It is a complication associated with a high mortality rate and requires a well-planned management strategy. We reported a case of BBF which occurred after surgery for hepatic hydatid cyst and was diagnosed by magnetic resonance cholangiography.
    Cumhuriyet Tıp Dergisi. 01/2011; 33:361-364.
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    ABSTRACT: The aim of this study was to evaluate the presence of probable diffused local anesthetic solution at and anesthesia of palatal tissues after buccal injection of 4% articaine hydrochloride (HCl) with 1:100,000 epinephrine or 1:200,000 epinephrine at the premolar and molar region. Thirty volunteers received maxillary buccal injections of 4% articaine HCl with 1:100,000 epinephrine or 1:200,000 epinephrine bilaterally to the first premolar or first molar. Magnetic resonance images were obtained before and 5 minutes after local anesthetic injections, and a visual evaluation was done to determine the presence of local anesthetic solution at palatal tissues. Anesthesia of palatal tissues after buccal injection was assessed by needle-prick stimulation pain with a visual analog scale (VAS). The Kruskal-Wallis test was used for comparison of the VAS values. The visual evaluation of the magnetic resonance images did not show any signal change as an indicator of the presence of local anesthetic solution at the palatal region. Most of the volunteers described moderate or severe pain with needle-prick stimulation. The mean VAS score for needle-prick stimulation was 86.33 +/- 39.45 mm (1:100,000 epinephrine) and 87.0 +/- 36.28 mm (1:200,000 epinephrine) in the first premolar region and 57.20 +/- 46.69 mm (1:100,000 epinephrine) and 75.53 +/- 49.78 mm (1:200,000 epinephrine) in the molar region (P > .05). We could not establish the presence of anesthesia or 4% articaine HCl at the palatal tissues after buccal injection. Maxillary tooth removal without palatal injection requires further objective investigations.
    Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons 03/2010; 68(5):1032-7. · 1.58 Impact Factor
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    ABSTRACT: In this study, oxaprozin, a long-acting nonsteroidal anti-inflammatory drug, and naproxen sodium were compared in terms of their effects on edema, pain, and trismus after surgery for impacted mandibular third molars. Thirty healthy patients with bilaterally impacted mandibular third molars were included in this randomized, cross-over, double-blind, placebo-controlled study. Patients were assigned randomly to 1 of 3 surgery groups and received postoperatively 1,200 mg oxaprozin, 550 mg naproxen sodium, or a placebo. Postoperative edema was measured with ultrasonography performed before and after surgery. Trismus was measured by comparison of preoperative and postoperative maximum interincisal mouth opening measurements by caliper. Pain was assessed by a visual analog scale (VAS) and by recording the number of rescue analgesic pills taken. After removal of impacted third molars, the patients administered oxaprozin and naproxen showed superior results over those given placebo in terms of pain parameters (P < .05), but these treatments had no statistically significant effect on facial swelling. Comparing the oxaprozin and naproxen groups, there were no differences in the mouth opening measurements, but naproxen showed a statistically superior effect over the placebo (P < .05). Although not statistically significant, oxaprozin showed a more pronounced effect in reducing trismus than did the placebo (P = .07). Administration of either oxaprozin or naproxen sodium during the postoperative period is effective and has similar effects in reducing pain but questionable benefit for the management of trismus. However, neither agent has clinical benefit in terms of reducing edema.
    Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons 03/2010; 68(5):1018-24. · 1.58 Impact Factor
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    ABSTRACT: A preventable occupational disease, pneumoconiosis that is often widespread on to a very kind of quartz, carbon and metal dust exposed work place.The data for the prevalence of pneumoconiosis and respiratory findings among dental laboratory technician is insufficient. The aim of this study is to determine the prevalence of pneumoconiosis and respiratory findings among dental laboratory technicians, working in province of Sivas. For this reason all the dental technicians (except 2, totally 36) participated in the study. A questionnaire which contains demographic characteristics, work conditions and symptoms were applied to all participants. Also spirometric measurements and chest x-rays were performed. The x-rays of dental technicians were evaluated by a radiologist and a chest disease specialist according to the ILO-2000 classification of pneumoconiosis. Almost half of the all participants have dyspnea and phlegm expectoration. The prevalence of pneumoconiosis was 5 (13.8%) among 36 dental technicians. There were no statistically significant differences between two groups with regard to respiratory symptoms. Values of lung function parameters of the dental technician group were not significantly different from those of control group except FEV(1). In conclusion, dental laboratory technicians are at significant risks for occupational respiratory diseases so the primary prevention rules are essential for these work places.
    Tuberkuloz ve toraks 01/2010; 58(2):135-41.
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    ABSTRACT: Mass-like lesions and anatomical variations sometimes create challenges for diagnosis in both clinical and radiology practice. We present a "pseudomass" originating from the right abdominal wall in a 75-year-old patient with invasive ductal carcinoma of the breast. Age-related structural changes in the abdominal wall, as well as anatomical variations, should be kept in mind in order to establish the correct radiological diagnosis and to avoid unnecessary procedures.
    The British journal of radiology 02/2009; 82(973):e1-2. · 2.11 Impact Factor
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    ABSTRACT: The aim of this study was to evaluate the effects of local and systemic simvastatin application on distraction osteogenesis. Eighteen New Zealand white rabbits underwent unilateral mandibular distraction osteogenesis. After 7 days of neutral fixation, 0.4 mm twice per day, distraction was performed for 10 days. Simvastatin was applied locally during the osteotomy phase with a gelatin sponge carrier and systemically during the distraction osteogenesis period by oral gavage. All animals were killed at the end of the consolidation period of 14 days. The distracted mandibles were harvested and evaluated by plain radiography, by peripheral quantitative computed tomography, and with histomorphometry. Radiographic evaluation with peripheral quantitative computed tomography showed that the area of the regenerate increased by 9.6% in the local simvastatin group and by 19.3% in the systemic simvastatin group as compared with the control group. In both experimental groups the density of the regenerate increased by 6.7% as compared with the control group. Statistical evaluation of radiographic data showed that all of these changes were not significant. Histomorphometric evaluation determined that there was no statistical difference among groups with regard to the ratios of bone tissue volume to fibrous tissue volume and bone tissue volume to marrow tissue volume. The results of this study suggest that simvastatin's effect on enhancing distraction regenerate is limited with the applied doses and methods.
    Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons 12/2008; 66(11):2233-8. · 1.58 Impact Factor
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    ABSTRACT: Popliteal artery entrapment syndrome (PAES) is a disorder of the young age group characterized by ischemia of the lower extremities due to an abnormal association between the popliteal artery and adjacent musculotendinous structures. Several underlying anatomical abnormalities causing this syndrome are described and classified. In this study, we present an unusual case of PAES along with multidetector computed tomographic angiography findings.
    Annals of Vascular Surgery 02/2008; 22(1):130-3. · 0.99 Impact Factor
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    ABSTRACT: To demonstrate the detailed imaging characteristics of early tuberculous meningitis (TBM) and changes over time on standard gadolinium-enhanced, T1-weighted magnetic resonance imaging (MRI) images. Contrast-enhanced, T1-weighted, spin-echo MRI images of 26 patients with early TBM were evaluated retrospectively. Meningeal enhancement characteristics were categorized according to distribution and pattern as diffuse, focal, linear, nodular, and mixed. We found that 35% of patients had diffuse meningeal enhancement and 65% of cases had focal meningeal enhancement. There was a predilection for focal meningeal enhancement in basal pial areas, the interpeduncular fossa being the most common. In six patients with diffuse meningeal enhancement admitted to hospital relatively early after the onset of symptoms, the type of meningeal enhancement later changed to the focal form. Reactive diffuse meningeal enhancement occurs in the early period of TBM on contrast medium-enhanced T1-weighted MR images, but later becomes limited to basal areas.
    Clinical Radiology 01/2008; 62(12):1206-15. · 1.82 Impact Factor
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    ABSTRACT: El síndrome de atrapamiento de la arteria poplítea (SAAP) es una entidad que afecta a individuos jóvenes y se caracteriza por isquemia de las extremidades inferiores debida a una asociación anormal entre la arteria poplítea y las estructuras musculotendinosas adyacentes. Se describen y clasifican las diversas anomalías anatómicas subyacentes como causa de este síndrome. En este artículo, presentamos un caso insólito de SAAP, junto con los hallazgos de la angiotomografía computerizada mediante multidetector.
    Anales de Cirugía Vascular. 01/2008; 22(1).
  • Annales De Chirurgie Vasculaire. 01/2008; 22(1):138-141.
  • Clinical Radiology 10/2007; 62(9):907-13. · 1.82 Impact Factor
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    ABSTRACT: Osteoinductive characteristics of bone grafts are important for enhancing osseous healing at grafted defect sites. The cholesterol-lowering drug simvastatin has been shown to stimulate bone formation by increasing the gene expression of bone morphogenetic protein-2 and vascular endothelial growth factor. The purpose of this study was to determine the effect of local simvastatin application on bone defect healing and compare the amount of new bone produced by simvastatin gelatin sponge graft with that produced by a gelatin sponge graft and with natural healing. Twenty-one bone defects at 3 mm diameter were created in the angulus mandible region of Wistar albino rats. In the experimental group, nine defects were grafted with simvastatin dissolved in water mixed with a gelatin sponge. In the control groups, eight defects were grafted with water mixed with a gelatin sponge alone (active control) and six were left empty (passive control). Animals were killed on day 14 and the defects were prepared for radiologic and histologic assessment. Density of the regenerate was evaluated by peripheral quantitative computed tomography. The density of the experimental group was 240% more than the passive control group and 190% more than the active control group (P < 0.01). Histologic examination also showed more new bone formation in the experimental group than control groups. In conclusion, the simvastatin gelatin sponge enhanced bone defect healing in the mandible of rats.
    Journal of Craniofacial Surgery 05/2007; 18(3):546-50. · 0.69 Impact Factor

Publication Stats

60 Citations
21.86 Total Impact Points

Institutions

  • 2006–2013
    • Cumhuriyet University
      • Faculty of Medicine
      Megalopolis, Sivas, Turkey
  • 2010
    • University of Gaziantep
      • Department of Oral and Maxillofacial Surgery
      Ayıntap, Gaziantep, Turkey
  • 2008
    • Erciyes Üniversitesi
      • Department of Oral and Maxillofacial Surgery
      Kayseri, Kayseri, Turkey