-
[show abstract]
[hide abstract]
ABSTRACT: In this paper the physiological role of NO and isoforms of NOS in the gastrointestinal tract and the involvement of NO in pathological processes of digestive tract as well as the perspective of therapeutic use of NO-donating drugs and selective inhibitors of phosphodiesterase in the treatment of gastric diseases were presented.
Mini Reviews in Medicinal Chemistry 01/2009; 8(14):1549-60. · 2.53 Impact Factor
-
J Juszczyk,
B Bolewska,
J Flieger,
K Swietek, B Adamek,
M Biskupska-Karasińska,
A P Dziambor,
A Boroń-Kaczmarska,
M Wawrzynowicz-Syczewska,
J Cianciara, [......],
Z Gonciarz,
W Mazur,
M Machniak,
W Kryczka,
D Zarebska-Michaluk,
H Trocha,
K Witczak-Malinowska,
E Lakomy,
J Kuydowicz,
A Niwicka-Michałowska
[show abstract]
[hide abstract]
ABSTRACT: Interferon alpha (INF) is routine treatment in patients with chronic hepatitis C. Many controlled investigations were evaluated to establish the optimal schedule of treatment with sustained virological and biochemical response. Recently, multicentre meta-analyses suggest that combination therapy (INF + Ribavirin) was more effective than treatment with interferon alone. The aim of this study was to compare the efficacy of four schedules of antiviral treatment in 445 patients with chronic hepatitis C. Combination therapy (INF + Ribavirin) given for 6 mo. and monotherapy (INF) for 18 mo. were more effective than interferon alone given for 6 mo. Treatment with INF alone for 6 mo. was demonstrated to be insufficient.
Polski merkuriusz lekarski: organ Polskiego Towarzystwa Lekarskiego 11/2001; 11(64):340-3.
-
[show abstract]
[hide abstract]
ABSTRACT: The frequency of Pneumocystis carinii occurrence in BAL of 38 HIV-infected patients was determined with three different method. BAL sediments were stained with Giemsa method, silvered according to Gomori-Grocott method and studied with indirect immunofluorescence assay. Using Giemsa method staining Pneumocystis carinii was diagnosed in 81.6% of patients, in Gomori-Grocott method--in 31.6% of patients, but results of indirect immunofluorescence assay were positive only in 23.,7%. In our study staining BAL sediments with Giemsa method allowed to detect Pneumocystis carinii in the highest percentage of examined patients.
Wiadomości parazytologiczne 02/2001; 47(3):543-8.
-
[show abstract]
[hide abstract]
ABSTRACT: The evaluation of TNF-alpha and CRP in cerebrospinal fluid (CSF) concentrations determining in the differential diagnosis of infectious meningitis was shown. The highest concentrations of these parameters were detected in the group of patients with bacterial meningitis. The findings correlated with the severity of clinical course of bacterial meningitis and with the routine determined laboratory data of CSF. Usefulness of examination CSF for TNF-alpha and CRP in differential diagnosis of meningitis was underlined, especially in cases, where routine parameters of CSF are not conclusive.
Polski merkuriusz lekarski: organ Polskiego Towarzystwa Lekarskiego 07/1997; 2(12):359-62.
-
[show abstract]
[hide abstract]
ABSTRACT: Among 267 patients with central nervous system infections, 43 patients (16.1%) suffered from purulent bacterial meningitis. An etiological agent was established in 15 cases (34.9%): Str. pneumoniae--9 cases, N. meningitidis--4 cases and Staph. aureus--2 cases. Most patients had severe course of the disease; lethality was 18.6%, the recovery with subsequent sequelae was noted in 11.6% cases, and 69.8% cases fully recovered. In two patients brain abscess and intracranial empyema, and persistent cerebral ischaemia were found, one of these patients died. Frequent use of antibiotics before hospitalization reduces the possibility of establishing the etiological agent. Bacterial infections of the central nervous system are still danger diseases producing high lethality and subsequent neurological sequelae.
Przegla̧d epidemiologiczny 02/1997; 51(3):297-302.
-
[show abstract]
[hide abstract]
ABSTRACT: On the basis of our own material and the literature review the analysis of 10 cases of botulism is presented. A mild course of the disease was observed in 40%, a medium-severe course in 30% and a severe course also in 30% of patients. Fatal courses were not recorded. All patients were discharged from the Clinic in the good state of health. Etiopathogenesis, symptomatology and treatment of botulism is discussed. Attention is paid to new diagnostic method.
Przegla̧d epidemiologiczny 02/1993; 47(3):285-8.
-
[show abstract]
[hide abstract]
ABSTRACT: In the central nervous system (CNS) infections a substantial role play inflammatory cytokines, especially TNF-alpha. They are implicated to initiate the local response leading to cerebral damage during meningitis. The purpose of this study was estimation of the diagnostic value of determining TNF-alpha concentrations in the CSF in the course of neuroinfections. Analyses were performed in 15 patients with purulent, bacterial meningitis (group A) and in 15 patients with lymphocytic meningitis (group B). CSF's concentrations of TNF-alpha were measured by the ELISA method (Genzyme Diagnostic, Cambridge, USA), on the day of admission and on the fourteenth day of treatment. In group A mean TNF-alpha concentration in CSF on admission was 285.73 pg/ml and in group B 4.07 pg/ml. On the fourteenth day of treatment mean TNF-alpha concentrations were 1.14 pg/ml and 0 pg/ml, respectively. The highest CSF TNF-alpha levels were observed in the most severely ill patients (group A). In several cases in this group there were positive correlations between TNF-alpha concentration and CSF white blood cell counts and protein concentration. Correlation of high levels of TNF-alpha with the severity of clinical course was observed in group B as well. Examination of CSF for TNF-alpha concentration could be useful in the differential diagnosis of CNS inflammations. TNF-alpha concentrations in CSF correlate with the severity of clinical course of meningitis and could have a prognostic value.
Neurologia i neurochirurgia polska 32(3):533-42. · 0.43 Impact Factor
