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ABSTRACT: Fifty-three autism patients ranging in age from 2 to 22 yr with a mean age of 9 yr were evaluated by MR imaging over a 3-yr study period. Sagittal, axial, and coronal spin-echo and short TI inversion recovery scans were performed on a 0.5 Tesla (Picker Inc., Cleveland, OH) system. Results were compared to 32 control patients age range 1 to 17 yr, mean 8.5 yr. MR scans were evaluated by three neuroradiologists. Measurements of midsagittal vermian height and AP diameter were performed. Subjective estimates were made of ventricular size, amygdala size, fourth ventricular size, and vermian shape. Results were correlated with clinical presentation, course, and lab analyses by a pediatric neurologist. MR findings did not present a single pattern capable of predicting the presence or severity of autism. The constellation of MR findings in this group of 53 patients was highly variable, thus we advise caution in the interpretation of MR images in autistic patients. Autism is a heterogeneous disease entity containing different clinical subgroups, which do not manifest similar radiologic pictures.
Magnetic Resonance Imaging 02/1990; 8(6):811-6. · 1.99 Impact Factor
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ABSTRACT: Twenty-three pediatric patients with white matter abnormalities on MR images were evaluated retrospectively to assess the contribution of MR compared with CT in diagnosing these conditions. In addition, the MR findings in major categories of white matter diseases were analyzed for sensitivity in detecting the presence of an abnormality. White matter disease categories included demyelinating disease (five cases), dysmyelinating disease (eight cases), developmental white matter abnormalities (four cases), and white matter abnormalities of unknown origin (idiopathic) (six cases), as seen on long TR images. We found that MR is not more sensitive than CT in detecting disease in the demyelinating or dysmyelinating categories, although it is more sensitive than CT in detecting the degree of disease present. In cases of developmental delay, MR is distinctly more useful than CT in demonstrating abnormalities of myelination. And in the idiopathic group, MR detected the presence of focal white matter abnormalities on long TR images in children with neurologic complaints and normal CT. MR may serve to redefine and broaden the spectrum of reported imaging abnormalities in pediatric patients.
American Journal of Roentgenology 09/1988; 151(2):359-65. · 2.78 Impact Factor
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ABSTRACT: A case report of an 11 years old boy with new onset of a seizure disorder is presented. A computed tomography scan demonstrated a noncalcified, nonenhancing focal region of abnormal cortex. A magnetic resonance imaging scan delineated both an isointense area of abnormally thickened gyri and linear areas of abnormal high signal intensity in the subjacent white matter. A review of the radiologic and pathologic literature suggests that this lesion represents the entity focal cortical dysplasia as described by Taylor, et al. This abnormality is part of a spectrum of disorders including hamartomas (of tuberous sclerosis), focal cortical dysplasia and heterotopias.
Journal of Computed Tomography 02/1988; 12(1):61-3.
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ABSTRACT: Appropriate spin-echo (SE) pulse sequence parameters generate magnetic resonance (MR) images with very high gray matter/white matter contrast in neonates and young infants. In these young patients, long SE sequences with a repetition time of 3,000-3,500 msec and multiple echoes with the longest echo time of 120-160 msec are employed to yield high-contrast images. A high-contrast MR image of a 1-month-old infant is presented.
Radiology 02/1987; 162(1 Pt 1):272-3. · 5.73 Impact Factor
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ABSTRACT: Three cases of giant cystic craniopharyngiomas with large areas of extension beyond the suprasellar area are presented. The magnetic resonance (MR) appearance in one case is described. These giant tumors had large, multilobulated cysts that comprised the bulk of the tumors. In one case, there was an unusual extension of the large tumor cyst into the lateral ventricle. In two cases, the tumors extended to the level of the foramen magnum. On CT, the cyst contents of these two tumors were hyperdense and became hypodense postoperatively. All three tumors harbored calcifications in the form of clumps in the suprasellar region and rim calcifications around the cysts. None of the tumors exhibited contrast enhancement. A literature review of the radiographic features of craniopharyngiomas is discussed.
Neuroradiology 02/1987; 29(5):468-73. · 2.82 Impact Factor
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ABSTRACT: Fast low-angle multiecho (FLAME) imaging uses partial flip angles of less than 90 degrees with 180 degrees radiofrequency refocusing pulses. The partial flip angle permits imaging with shorter repetition time (TR) values on the order of 750-1,000 ms for 30 degrees angles with image contrast characteristics identical to those obtained with conventional 90-180 degrees schemes and TRs on the order of 2,500 ms. The approximately threefold reduction in imaging time is accompanied by a decrease in signal-to-noise ratio. In many circumstances, however, this trade-off may produce entirely acceptable images of the CNS at a significant reduction in imaging time.
Journal of Computer Assisted Tomography 12(1):171-4. · 1.22 Impact Factor
