-
Ying-hui Liu,
Jian-meng Liu,
Lan Liu,
Rui Ma,
Rong-wei Ye,
Song Li,
Hua Chen,
Ming-jun Xue,
Ling-chun Cheng, Li-Min Wu,
Yu-Juan Pan,
Hao Chen,
Zhu Li
[show abstract]
[hide abstract]
ABSTRACT: To examine the relationship between prepregnancy body mass index (BMI) and the risk of pregnancy-induced hypertension (PIH) in Chinese population.
Data were collected in 6 counties/cities covered by Perinatal Health Care Surveillance System which was part of the Sino-American cooperative project on neural tube defects prevention established in 1992. The study population consisted of 83 159 women who attended premarital or preconception medical physical examination and delivered single live births with at least 20 gestational weeks from 1995 to 2000 in Jiaxing area. The Chi-square test was employed to test the difference in the rates of PIH among groups with different BMI. Multivariate logistic regression was conducted to examine the association between prepregnancy BMI and the risk of PIH.
The rate of PIH was 11.01% (9153/83 159; 95% CI: 10.79% - 11.22%). The rate of PIH among women with BMI < 18.5 kg/m(2), 18.5 - 22.9 kg/m(2), 23.0 - 24.9 kg/m(2), and > or = 25.0 kg/m(2) were 9.08% (1405/15 472; 95% CI: 8.63% - 9.54%), 10.82% (6389/59 054; 95% CI: 10.57% - 11.07%), 14.63% (943/6444; 95% CI: 13.78% - 15.52%), and 19.00% (416/2189; 95% CI: 17.38% - 20.71%), respectively, the difference was significant (chi(trend)(2) = 261.028, P = 0.000). Taking those with BMI 18.5 - 22.9 kg/m(2) as reference, the unadjusted RR for PIH was 0.82 (95% CI: 0.77 - 0.87) among women with BMI < 18.5 kg/m(2), 1.41 (95% CI: 1.31 - 1.52) among women with BMI 23.0 - 24.9 kg/m(2), and 1.93 (95% CI: 1.73 - 2.16) among women with BMI > or = 25.0 kg/m(2). After controlling for area, maternal age at delivery, educational level, occupation, parity, times of prenatal visit as well as the individual or family history of chronic hypertension, the estimated RR were 0.85 (95% CI: 0.80 - 0.90), 1.37 (95% CI: 1.27 - 1.47) and 1.88 (95% CI: 1.68 - 2.10), respectively.
High prepregnancy BMI could increase the risk of PIH.
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 04/2009; 43(4):299-304.
-
Ying-hui Liu,
Jian-meng Liu,
Wei-hong Liu,
Rui Ma,
Rong-wei Ye,
Huan Chen,
Ming-jun Xue,
Ling-chun Cheng, Li-min Wu,
Yu-juan Pan,
Hao Chen,
Ai-guo Ren,
Song Li,
Zhu Li
[show abstract]
[hide abstract]
ABSTRACT: To assess the relationship between pre-pregnancy body mass index (BMI), weight gain during pregnancy, and the risk of neonatal asphyxia.
Data was collected in 6 countiedeities covered by Peri-natal Health Care Surveillance System which was part of a Sino-American cooperative project on neural tube defects prevention established in 1992. The study population consisted of 83,030 women who attended premarital/preconception medical physical examination program and had delivered single live birth with at least 20 gestational weeks from 1995 to 2000 in Jiaxing area, Zhejiang province.
from the Chi-square test were employed to test the differences in the rates of neonatal asphyxia between groups with different BMI and other characteristics. Multivariate logistic regression method was conducted to examine the association between pre-pregnancy BMI, gestational weight gain, and the risk of asphyxia. Results The average rate of neonatal asphyxia was 11.3% (95% CI: 11.1%-11.6%). The rates of neonatal asphyxia among women with BMI < 18.5 kg/m2, 18.5-22.9 kg/m2, 23.0-24.9 kg/m2, and > or = 25.0 kg/m2 were 11.0% (95% CI: 10.5%-11.5%), 11.3% (95% CI: 11.1%- 11.6%), 11.8% (95% CI: 11.0%-12.6%), and 12.9% (95% CI: 11.6%-14.4%) respectively. The rates of neonatal asphyxia were 12.4% among women with weight gain < 0.3 kg/wk, higher than women with higher weight gain. After adjusting for residential area, maternal age, educational level, occupation, parity, times of prenatal visit, high-risk experiences during pregnancy, high-risk experiences at time of delivery, gestational week and birth weight, the estimated ORs were 1.03 (95% CI: 0.97-1.09), 1.06 (95% CI: 0.96-1.16) and 1.14 (95% CI: 1.00-1.31), respectively. These ORs became 1.02 (95% CI: 0.95-1.09), 1.01 (95% CI:0.90-1.13) and 1.08 (95% CI: 0.92-1.28) after further adjusting the variable "gestational weight gain". The estimated ORs for neonatal asphyxia were 1.06 (95% CI: 1.01-1.12) for women with weight gain at 0.3-kg/wk and 1.09 (95% CI: 1.02-1.20) for women with weight gain <0.3 kg/wk when compared to those with weight gain > or = 0.5 kg/wk.
Lower weight gain seemed to have the effect of increasing the risk of neonatal asphyxia.
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 08/2008; 29(7):661-7.
-
Rui Ma,
Jian-Meng Liu,
Song Li,
Rong-Wwei Ye,
Hua Chen,
Ming-Jun Xue,
Tai-Mei Wang,
Ling-Chun Cheng,
Jun-Chi Zheng, Li-Min Wu,
Yu-Juan Pan,
Hao Chen,
Zhu Li
[show abstract]
[hide abstract]
ABSTRACT: To describe the epidemiological characters of pregnancy-induced hypertension (PIH) in Jiaxing areas of Zhejiang province of China between 1995 and 2000.
We analyzed the perinatal health surveillance data that was collected as part of the Sino-American cooperative project on neural tube defects prevention established in 1992. The study population consisted of 136 070 pregnant women with at least 20 weeks of gestational age. National diagnostic criteria were used to identify the cases which were divided into three subgroups: mild, moderate and severe.
15 127 cases were identified and the overall incidence rate of PIH was 11.1% (95% CI : 11.0% - 11.3%). Among all the cases, mild, moderate and severe PIH were accounted for 71.4%, 22.3% and 6.3%, respectively. The proportions of PIH cases that occurred in the second trimester, third trimester and during delivery appeared to be 4.2%, 34.4% and 61.4%, respectively. There was a significant fall in the trend of PIH occurrence every year, which dropped from 10.7% in 1995 to 8.6% in 2000 by 19.6%. More risk of PIH seemed to be related to those mothers living in the urban areas with age under 20 or above 35, being peasants and having little educational, having had multiple gestations, conceiving in spring/summer or delivering in winter or spring etc. Compared with the results of national survey in 1988, the incidence rate of PIH was higher by 18.1%, while the proportion of severe PIH was much lower by 68.8%. Although the incidence rates of PIH in urban and rural areas were somehow similar, the proportion of severe PIH in rural areas was much higher than that in urban areas.
Overall incidence rate and distribution of PIH were reported. Compared with the results in 1988, incidence rate of PIH was much higher, particularly for mild cases.
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 01/2006; 26(12):960-3.
-
Li-Jun Pei,
Ai-Guo Ren,
Hui-Ping Zhu,
Ling Hao,
Wen-Rui Zhao,
Zhu Li,
Guang-Wang Hou,
Bo-Lan Zhang,
Yan-Ying Jiang, Li-Min Wu,
Yu-Juan Pan,
Meng-Lan Zhang
[show abstract]
[hide abstract]
ABSTRACT: To describe the distribution of reduced folate carrier gene (RFC1)genotype and allele frequency between southern and northern, female and male Chinese population.
RFC1 (A80G) genotype was detected, using polymerase chain reaction-restriction fragment length polymorphism (RFLP-PCR) on 720 blood spot DNA from the normal subjects.
The frequencies of the northern population with AA, GG and GA genotypes were 22.28%, 31.09% and 46.63%, and the frequencies of the southern population were 18.56%, 22.75% and 58.68%, respectively. Findings showed that there were significant differences between southerners and northerners in RFC1 (A80G) genotype (P < 0.01). There was no significant difference between G allele frequency of the northern (52.10%) and southern population (54.40%). The frequencies of male with RFC1 (A80G) AA, GG and GA genotype were 24.88%, 25.85% and 49.27%, and among female were 18.83%, 27.77% and 53.40%, respectively. There were no significant differences between male and female in RFC1 genotype (P > 0.05), or between G allele frequency in female (50.49%) and that in male (54.47%).
The distribution of RFC1 genotype seemed to be consistent with neural tube defects (NTDs) while its prevalence among the northerners was higher than that of southerners, with female having a higher NTDs prevalence. This study provided genetic epidemiological data for etiological hypothesis between RFC1 and diseases relative to folate metabolism.
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 06/2004; 25(6):499-502.
-
[show abstract]
[hide abstract]
ABSTRACT: In order to understand molecular basis of heterosis, mRNA differential display was used to analyze the differences in gene expression between seeds of 18 reciprocal hybrids and their 6 parents at 6th day after pollination. The relationship between gene expression patterns and heterosis was determined. Only bands that can be repeated in duplicate PCR were used for analysis so as to reduce false positive bands. Among the total of 2,025 bands displayed, 1,386 bands (68.43%) were reproducible. Eight patterns (fifteen kinds) of gene expression were observed, which include: (1) bands occurring in only one parent (two kinds); (2) bands observed in both hybrids and one parent (two kinds); (3) bands detected in parents and one hybrid (two kinds); (4) bands displayed in only one hybrid (two kinds); (5) bands revealed in one hybrid and its corresponding female (two kinds) or male (two kinds) parent; (6) bands visualized in only both hybrids (one kind); (7) bands occurring in only parents (one kind); (8) bands observed in parents and both hybrids (one kind). Our results indicate that differences of gene expression between hybrids and their parents are very obvious. The percentages of bands observed in only both hybrids and in only both parents are lower. The analysis shows that bands observed in parents and both hybrids are not correlated with all nine agronomic traits, which indicates differentially expressed genes are mainly responsible for the observed heterosis. At least one pattern of differential gene expression is significantly correlated with nine agronomic traits. Silenced bands in hybrid (which include bands occurring in only one parent, bands detected in both parents and one hybrid and bands in only parents) and bands present in one hybrid and its corresponding female or male parent are likely to play important roles in heterosis. These results suggest that early seed development could be closely related to heterosis.
Acta Genetica Sinica 04/2003; 30(3):260-6.
