Laurent Schmitt

Publications (36)94.14 Total impact

• Source

  Available from: Eric Bui

  Article: Childhood trauma, personality disorders symptoms and current major depressive disorder in Togo.

  Kossi B Kounou, Eric Bui, Kolou S Dassa, Devon Hinton, Laura Fischer, Gnansa Djassoa, Philippe Birmes, Laurent Schmitt
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  ABSTRACT: PURPOSE: Childhood trauma (CT) has been found to be associated with major depressive disorder (MDD) and personality disorders (PD) in adulthood in Western countries, but little is known about the relationship between CT, PD and MDD in sub-Saharan Africa. The present study aims to examine: (1) the frequency of the CT, (2) the association between CT, PD symptoms and MDD and (3) the mediating role of PD between CT and MDD in Togo. METHODS: One hundred and eighty-one participants (91 individuals with current MDD and 90 healthy controls without psychiatric history) completed the 28-item CT Questionnaire (CTQ) and the Personality Diagnostic Questionnaire (PDQ-4+). RESULTS: Participants in the MDD group reported more frequently emotional, sexual and physical abuse and emotional and physical neglect than controls (p < 0.001). There was a significant positive correlation between the total abuse and the PDQ-4 + score (r = 0.48, p < 0.01) in the total sample. Emotional and sexual abuses were associated with current MDD and the number of PD criteria endorsed. Furthermore, PD symptoms mediated partially the relationship between CT and current MDD. CONCLUSIONS: Our results suggest an association between CT and current MDD in French-speaking sub-Saharan Africa, and that this relationship may be explained by PD symptoms. Prospective studies to confirm these results are warranted.
  Social Psychiatry 12/2012; · 2.05 Impact Factor
• Article: Peritraumatic distress predicts acute posttraumatic stress disorder symptoms after a first stroke.

  Clara Letamendia, Nicole J Leblanc, Jérémie Pariente, Naomi M Simon, Charmaine L Thomas, Henri Chabrol, François Chollet, Nicolas Raposo, Laurent Schmitt, Philippe Birmes, Eric Bui
  General hospital psychiatry 04/2012; 34(5):e11-3. · 2.67 Impact Factor
• Article: Children’s Enduring PTSD Symptoms are Related to Their Family’s Adaptability and Cohesion

  Philippe Birmes, Jean-Philippe Raynaud, Laetitia Daubisse, Alain Brunet, Christophe Arbus, Rémy Klein, Lionel Cailhol, Charlotte Allenou, Franck Hazane, Hélène Grandjean, Laurent Schmitt
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  ABSTRACT: This study compared, 18–24months after an industrial disaster, in two groups of children (those with clinically relevant PTSD symptoms versus those with low PTSD symptoms), the child’s perception of family cohesion and adaptability, the child’s experience of the explosion, and parental characteristics. Enmeshed family cohesion or rigid family adaptability were more frequently found in children with low PTSD symptoms. PTSD symptoms in the mother, living in a family of 3 or more children, and being female were significantly associated with PTSD symptoms in the children. The assessment of traumatized children should include assessment of family’s adaptability and cohesion.
  Community Mental Health Journal 04/2012; 45(4):290-299. · 1.03 Impact Factor
• Article: Body Piercings and Posttraumatic Stress Disorder Symptoms in Young Adults.

  Eric Bui, Rachel Rodgers, Naomi M Simon, Louis Jehel, Christina A Metcalf, Philippe Birmes, Laurent Schmitt
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  ABSTRACT: Body piercing, which is prevalent in young adults, has been suggested to be associated with features usually related to posttraumatic stress disorder (PTSD) such as high-risk behaviours and psychopathological symptoms and might be motivated by a wish to deal with prior traumatic experiences. However, to date, no research has investigated the relationship between this practice and PTSD symptoms. The present research aims to investigate the possible relationship between body piercing and PTSD symptoms in French-speaking young adults. According to our results, having two or more body piercings was associated with a twofold increased risk for scoring above the cut-off score for PTSD on the PTSD checklist. Our findings suggest that two or more body piercings might serve as an identifiable marker for PTSD symptoms and may have important implications for clinical screening. Copyright © 2012 John Wiley & Sons, Ltd.
  Stress and Health 04/2012; · 1.23 Impact Factor
• Article: Personality differences between drug injectors and non-injectors among substance-dependent patients in substitution treatment.

  Julie Saint-Lèbes, Rachel Rodgers, Philippe Birmes, Laurent Schmitt
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  ABSTRACT: Understanding personality differences between injectors and non-injectors in substitution treatment may provide new insights to help improve treatment programs. The aim of this study was to compare drug injectors and non-injectors in terms of personality disorders and dimensions. Forty participants recruited from substance abuse treatment centers (23 injectors and 17 non-injectors) completed the self-report Personality Diagnostic Questionnaire 4th version and Temperament and Character Inventory. Mann-Whitney U tests were used to compare means of personality disorder traits, temperament, and character differences between injectors and non-injectors. The mean (SD) age of the sample (72.5% male) was 36.5 (8.7) years. Injectors reported more borderline personality disorders and increased global personality disturbance (p < .05). Similarly, Anticipatory worry, Shyness, and Fatigability facet scores were higher among injectors (p < .01). Attachment, Purposeful, and Congruent second nature facet scores were higher among non-injectors (p < .01). According to the route of drug administration, drug dependents differed in terms of personality disorders and dimensions. These results may have implications for the implementation of treatment programs. New research in this area may contribute to the understanding and prevention of intravenous drug use.
  The American Journal of Drug and Alcohol Abuse 03/2012; 38(2):135-9. · 1.55 Impact Factor
• Article: Ineffective normobaric LHTL: room confinement or inappropriate training intensity?

  Laurent Schmitt, Grégoire P Millet
  Journal of Applied Physiology 02/2012; 112(3):527; author reply 528. · 3.75 Impact Factor
• Source

  Available from: Eric Bui

  Article: Peritraumatic reactions and posttraumatic stress disorder symptoms after psychiatric admission.

  Agnès Ladois-Do Pilar Rei, Eric Bui, Benjamin Bousquet, Naomi M Simon, Julie Rieu, Laurent Schmitt, Julien Billard, Rachel Rodgers, Philippe Birmes
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  ABSTRACT: The present study aimed to explore exposure to stressful events during a psychiatric admission and the predictive power of peritraumatic distress and dissociation in the development of posttraumatic stress disorder (PTSD) symptoms after exposure to such events. Psychiatric inpatients (N = 239) were asked to report exposure to stressful events during their admission within 48 hours of being admitted. Individuals reporting at least one stressful event during admission (n = 70, 29%) were assessed for peritraumatic dissociation and distress in relation to this event and, 5 weeks later, were reassessed for PTSD symptoms. Eight participants (12.3%) scored above the cutoff for probable PTSD. Multiple regression analyses revealed that peritraumatic distress was a significant predictor of 5-week PTSD symptoms. Our findings suggest that individuals experiencing increased peritraumatic distress in relation to a stressful event experienced during a psychiatric admission might be at risk of PTSD symptoms and might benefit from increased attention.
  The Journal of nervous and mental disease 01/2012; 200(1):88-90. · 1.77 Impact Factor
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  Available from: Eric Bui

  Article: An Overview of the Symptoms and Typical Disorders Associated with Alice in Wonderland Syndrome

  Francois Montastruc, Noah Schwarz, Laurent Schmitt, Eric Bui
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  ABSTRACT: The Alice in Wonderland syndrome refers to a set of symptoms characterized by perceptual distortions, such as visual distortions (i.e., metamorphopsia), body image and time distortions. The Alice in Wonderland syndrome has been described consistently over the past five decades in various cultural settings. Migraine headaches and epilepsy were the etiologies first described and most frequently reported in the literature; however, infectious, neurological, toxic and psychiatric causes have also been reported. Although little is known regarding the specific pathophysiological pathways, dysfunctions of the NMDA neurotransmission and inflammations, as well as edemas of cerebral regions close to the visual pathways may be implicated.
  Neuropsychiatry 01/2012; 2(4):281-289.
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  Available from: Eric Bui

  Article: The importance of drug-drug interactions as a cause of adverse drug reactions: a pharmacovigilance study of serotoninergic reuptake inhibitors in France.

  Francois Montastruc, Agnès Sommet, Emmanuelle Bondon-Guitton, Geneviève Durrieu, Eric Bui, Haleh Bagheri, Maryse Lapeyre-Mestre, Laurent Schmitt, Jean-Louis Montastruc
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  ABSTRACT: To quantify the importance of drug-drug interactions (DDIs) in the occurrence of adverse drug reactions (ADRs) reported with serotoninergic reuptake inhibitors in a pharmacovigilance database. All spontaneous reports of ADRs registered in 2008 by the Midi-Pyrénées PharmacoVigilance Centre that contained mention of one of the serotoninergic reuptake inhibitor (SRI) antidepressants marketed in France were reviewed. DDIs were identified according to the French National Drug Formulary (Vidal) and the interaction supplement of the French independent drug bulletin La Revue Prescrire. ADRs explained by DDIs were characterised. Among the 2,101 spontaneous reports recorded, 177 involved at least one SRI antidepressant. Among the 156 ADRs with at least one theoretical DDI, 41% (95% confidence interval 34-49%) could be explained by a DDI. The most frequent antidepressant involved in DDIs was escitalopram, followed by fluoxetine and citalopram. Among the 65 ADRs related to DDIs, 37 (52.9%) were "serious", mainly bleedings, confusion and falls, hyponatremia and serotoninergic syndromes. The most frequent drug interactions occurred with psychotropics (antipsychotics, benzodiazepines, among others), followed by antithrombotic agents (antagonists of vitamin K, antiplatelets), diuretics and angiotensin II antagonists. The group with ADRs related to DDIs was older than the group with ADRs not related to DDIs. ADRs were threefold more "serious" in the case of DDIs. Around 40% of ADRs reported with SRIs were related to DDIs. Most of these occurred after association with psychotropics, antithrombotics, or diuretics, especially in the elderly.
  European Journal of Clinical Pharmacology 11/2011; 68(5):767-75. · 2.85 Impact Factor
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  Available from: Eric Bui

  Article: Effects of a psychiatric label on medical residents' attitudes.

  Audrey Neauport, Rachel F Rodgers, Naomi M Simon, Philippe J Birmes, Laurent Schmitt, Eric Bui
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  ABSTRACT: Few data are available on the effects of a psychiatric label on medical residents' attitudes towards an individual. To investigate the effect of a psychiatric label on the attitudes of medical residents towards an individual. Medical residents were randomly assigned to one of two vignettes describing the same apparently healthy person, differing only in the presence of a psychiatric label for one of them. Participants (N = 322) reported their attitudes towards the described individual and their willingness to treat this person. Residents allocated to the psychiatric-diagnostic label group reported being less at ease with becoming the individual's nextdoor neighbour, working in the same place, sharing a house, having him look after their children, having a member of their family date him, having their finances run by the individual, less willing to become friends with the described individual and more uneasy having to examine him the next time he visits the emergency room. Implementing effective programmes to combat stigma in the curriculum of medical residents appears to be needed.
  International Journal of Social Psychiatry 06/2011; 58(5):485-7. · 1.15 Impact Factor
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  Available from: Thomas Wagner

  Article: Iodine-123 fluoropropyl-carbomethoxy-3-β-(4-iodophenyltropane) single-photon emission computed tomography findings before and after electroconvulsive therapy in major depressive disorder with Parkinsonism.

  Eric Bui, Julien Delrieu, Thomas Wagner, Julie Rieu, Etienne Véry, Clara Letamendia, Pierre Payoux, Laurent Schmitt
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  ABSTRACT: To date, only a few cases of improvement of Parkinsonism in depressed patients treated with electroconvulsive therapy (ECT) have been reported. However, no functional imaging data are available to support this finding. To describe the first observation of increase in dopamine transporter uptake after ECT. Iodine-123 fluoropropyl-carbomethoxy-3-β-(4-iodophenyltropane) single-photon emission computed tomographic imaging was conducted in a 77-year-old depressed patient displaying symptoms of Parkinson disease (PD) before and after a series of 12 bilateral ECTs. The patient displayed improvement in PD symptoms and increase in dopamine transporter uptake after ECT. Our observation suggests that the PD symptoms and decrease in striatal uptake appearing in the context of a depressive episode might warrant further attention, as they might be reversible.
  The journal of ECT 06/2011; 27(4):331-3. · 1.19 Impact Factor
• Article: Prescribed drugs and violence: a case/noncase study in the French PharmacoVigilance Database.

  Nadège Rouve, Haleh Bagheri, Norbert Telmon, Atul Pathak, Nicolas Franchitto, Laurent Schmitt, Daniel Rougé, Maryse Lapeyre-Mestre, Jean-Louis Montastruc
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  ABSTRACT: Our aim was to identify prescribed drugs associated with violent behaviours using the French PharmacoVigilance Database (FPVD). All reports of adverse drug reactions (ADR) recorded in the FPVD between 1 January 1985 and 31 July 2008 and including the terms aggressiveness or violence were selected. We compared proportion of exposure to different drugs between cases (reports with violence) and noncases (other reports in the database). Among 537 cases, 56 were included (48 men, mean age 46 years). Misuse was observed in ten cases (18%). In 25 cases (44.6%), a previous psychiatric history was documented. Main drugs involved were nervous system (63.6%) followed by respiratory (7.8%), alimentary tract and metabolism (7.8%), dermatological (5.2%) and anti-infective (5.2%) agents. Case/noncase analysis found an association with dopaminergic agonists (pergolide, pramipexole, bromocriptine, piribedil), benzodiazepines (alprazolam, bromazepam) and serotoninergic antidepressants (taken as a whole), but not antipsychotics or antiepileptics. Association was also found with varenicline, isotretinoin, interferon alpha-2b, rimonabant, benfluorex, topiramate and antiviral drugs (ribavirin, efavirenz). Dopaminergic agonists, benzodiazepines and serotoninergic antidepressants are the main pharmacological classes able to induce aggressive behaviour. This study also emphasises the putative role of other drugs less known to be involved in such ADR.
  European Journal of Clinical Pharmacology 06/2011; 67(11):1189-98. · 2.85 Impact Factor
• Article: Buprenorphine versus methadone in pregnant opioid-dependent women: a prospective multicenter study.

  Isabelle Lacroix, Alain Berrebi, Daniel Garipuy, Laurent Schmitt, Yamina Hammou, Catherine Chaumerliac, Maryse Lapeyre-Mestre, Jean-Louis Montastruc, Christine Damase-Michel
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  ABSTRACT: In order to investigate the effects of exposure to buprenorphine compared with methadone during pregnancy, a prospective multicenter study was conducted in collaboration with maternity hospitals, maintenance therapy centers, and general practitioners involved in addiction care. Ninety pregnant women exposed to buprenorphine and 45 to metadone were selected for the study. During pregnancy, some women were exposed to illicit agents: cannabis (42% in the buprenorphine group vs. 58% in the methadone-treated group), heroin (17% vs. 44%), or cocaine (3% vs. 11%). Pregnancies ended in 85 vs. 40 live births, one vs. two stillbirths, two vs. one spontaneous abortion, two vs. one voluntary termination, and one vs. one medical termination in the buprenorphine and the methadone groups, respectively. Newborns had a birth weight of 2,892 ± 506 g (buprenorphine) vs. 2,731 ± 634 g (methadone) and a body length of 47.6 ± 2.5 cm vs. 47.1 ± 3 cm. 18.8% vs. 10% of newborns were delivered before 37 weeks of amenorrhea. Neonatal withdrawal syndrome occurred more frequently in the methadone group (62.5% vs. 41.2, p = 0.03). After adjustment for heroin exposure in late pregnancy, rates of neonatal withdrawal were no longer different between the methadone and buprenorphine groups. Twenty-one babies (84%) in the methadone group and 20 (57%) in the buprenorphine group (p = 0.03) required opiate treatment. We did not observe more frequent malformations or cases of withdrawal syndrome in the buprenorphine group than in the methadone-treated group. Buprenorphine appears to be as safe as the currently approved substitute methadone considered to date as the reference treatment for pregnant opioid-dependent women.
  European Journal of Clinical Pharmacology 05/2011; 67(10):1053-9. · 2.85 Impact Factor
• Source

  Available from: Henri Chabrol

  Article: Is Anakin Skywalker suffering from borderline personality disorder?

  Eric Bui, Rachel Rodgers, Henri Chabrol, Philippe Birmes, Laurent Schmitt
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  ABSTRACT: Anakin Skywalker, one of the main characters in the "Star Wars" films, meets the criteria for borderline personality disorder (BPD). This finding is interesting for it may partly explain the commercial success of these movies among adolescents and be useful in educating the general public and medical students about BPD symptoms.
  Psychiatry Research 01/2011; 185(1-2):299. · 2.52 Impact Factor
• Article: Efficacy of ultrabrief cognitive and behavioural therapy performed by psychiatric residents on depressed inpatients.

  Julie Rieu, Eric Bui, Virginie Rouch, Karine Faure, Philippe Birmes, Laurent Schmitt
  Psychotherapy and Psychosomatics 01/2011; 80(6):374-6. · 6.28 Impact Factor
• Article: Peritraumatic distress predicts posttraumatic stress symptoms in older people.

  Eric Bui, Séverine Joubert, Aude Manetti, Cécile Camassel, Sandrine Charpentier, Régis Ribereau-Gayon, Laurent Schmitt, Bruno Aouizerate, Alain Brunet, Philippe Birmes, Christophe Arbus
  International Journal of Geriatric Psychiatry 12/2010; 25(12):1306-7. · 2.42 Impact Factor
• Article: Course of posttraumatic stress symptoms over the 5 years following an industrial disaster: a structural equation modeling study.

  Eric Bui, Laurent Tremblay, Alain Brunet, Rachel Rodgers, Louis Jehel, Etienne Véry, Laurent Schmitt, Stéphane Vautier, Philippe Birmes
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  ABSTRACT: The present study examined individual latent changes in posttraumatic stress disorder (PTSD) symptoms over a 60-month period after an industrial disaster. Participants were recruited from survivors of a factory explosion. Participants were assessed retrospectively for peritraumatic reactions and acute stress symptoms. Posttraumatic stress disorder symptoms were then assessed at 6, 15, and 60 months. Using structural equation modeling, the authors tested 3 hypotheses of individual latent change: stability of PTSD symptoms between 6, 15, and 60 months; change between 6 and 15 months; and change between 15 and 60 months. Only one model provided a good fit suggesting that PTSD symptoms evolved between 6 and 15 months after trauma exposure and remained stable at the individual level thereafter.
  Journal of Traumatic Stress 12/2010; 23(6):759-66. · 2.72 Impact Factor
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  Available from: Eric Bui

  Article: Psychotraumatology in antiquity

  Philippe J. Birmes, Eric Bui, Rémy Klein, Julien Billard, Laurent Schmitt, Charlotte Allenou, Nicolas Job, Christophe Arbus
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  ABSTRACT: From antiquity onwards, chroniclers have reported cases of agitation or stupor sometimes associated with terrifying nightmares. Responses during the impact of a traumatic experience have attracted attention: terror, confusion and disorganized behaviour during the fire of Rome; the numbness of Patroclus, and loss of bowel and bladder control among warriors. The same applies to the most obvious post-traumatic responses: the recurrent and intrusive distressing recollections of Gilgamesh, the dreams of battle in De Natura Rerum and the dissociative episodes concerning Marius. Although symptoms of re-experience are perfectly described, the long-term dissociative symptoms and their somatic components are also the object of unequivocal anecdotes. The scientific reading of the historical studies of a clinical and seemingly isolated fact contributes towards the establishment of modern psychotraumatology. Copyright © 2009 John Wiley & Sons, Ltd.
  Stress and Health 01/2010; 26(1):21 - 31. · 1.23 Impact Factor
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  Available from: Eric Bui

  Article: Alice in wonderland syndrome in major depressive disorder.

  Eric Bui, Aurelien Chatagner, Laurent Schmitt
  The Journal of neuropsychiatry and clinical neurosciences 01/2010; 22(3):352j.e16-352.e16. · 2.34 Impact Factor
• Article: Effects of depressive symptoms, anxiety and alexithymia on physical functioning 6 months after percutaneous transluminal coronary angioplasty.

  Eric Bui, Lionel Cailhol, Jacques Puel, Philippe Birmes, Laurent Schmitt
  Psychotherapy and Psychosomatics 11/2009; 79(1):59-60. · 6.28 Impact Factor