Robert W Ward

Publications (7)17.97 Total impact

• Article: Aryl sulphonyl amides as potent agonists of the growth hormone secretagogue (ghrelin) receptor.

  Jason Witherington, Lee Abberley, Benjamin R Bellenie, Rio Boatman, Katharine Collis, David K Dean, Alessandra Gaiba, N Paul King, Nicola Shuker, Jon G A Steadman, Andrew K Takle, Gareth Sanger, Sharon Butler, Fiona McKay, Alison Muir, Kim Winborn, Robert W Ward, Tom D Heightman
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  ABSTRACT: As part of an on-going lead optimisation effort, a cross screening exercise identified an aryl sulphonyl amide hit that was optimised to afford a highly potent series of ghrelin receptor agonists.
  Bioorganic & medicinal chemistry letters 01/2009; 19(3):684-7. · 2.65 Impact Factor
• Article: Pyridone derivatives as potent, orally bioavailable VLA-4 integrin antagonists.

  Jason Witherington, Emma L Blaney, Vincent Bordas, Richard L Elliott, Alessandra Gaiba, Neil Garton, Philip M Green, Antoinette Naylor, David G Smith, David J Spalding, Andrew K Takle, Robert W Ward
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  ABSTRACT: A series of pyridone-N-benzyl-propanoic acids have been optimised to afford potent orally bioavailable VLA-4 antagonists.
  Bioorganic & Medicinal Chemistry Letters 12/2006; 16(21):5538-41. · 2.55 Impact Factor
• Article: Pyridone derivatives as potent and selective VLA-4 integrin antagonists.

  Jason Witherington, Vincent Bordas, Alessandra Gaiba, Phil M Green, Antoinette Naylor, Nigel Parr, David G Smith, Andrew K Takle, Robert W Ward
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  ABSTRACT: A novel series of pyridone inhibitors has been identified through pharmacophore analysis, as potent antagonists of VLA-4.
  Bioorganic & Medicinal Chemistry Letters 05/2006; 16(8):2256-9. · 2.55 Impact Factor
• Article: 6-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).

  Jason Witherington, Vincent Bordas, Alessandra Gaiba, Neil S Garton, Antoinette Naylor, Anthony D Rawlings, Brian P Slingsby, David G Smith, Andrew K Takle, Robert W Ward
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  ABSTRACT: A novel series of 6-aryl-pyrazolo[3,4-b]pyridines has been identified that are potent inhibitors of glycogen synthase kinase-3 (GSK-3).
  Bioorganic & Medicinal Chemistry Letters 10/2003; 13(18):3055-7. · 2.55 Impact Factor
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  Article: 6-heteroaryl-pyrazolo[3,4-b]pyridines: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3).

  Jason Witherington, Vincent Bordas, Alessandra Gaiba, Antoinette Naylor, Anthony D Rawlings, Brian P Slingsby, David G Smith, Andrew K Takle, Robert W Ward
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  ABSTRACT: A series of 6-heteroaryl-pyrazolo[3,4-b]pyridines has been optimised to afford potent inhibitors of Glycogen Synthase Kinase-3 (GSK-3). These analogues display excellent selectivity over the closely related Cyclin Dependent Kinase-2 (CDK-2).
  Bioorganic & Medicinal Chemistry Letters 10/2003; 13(18):3059-62. · 2.55 Impact Factor
• Article: 5-aryl-pyrazolo[3,4-b]pyridazines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).

  Jason Witherington, Vincent Bordas, David Haigh, Deirdre M B Hickey, Robert J Ife, Anthony D Rawlings, Brian P Slingsby, David G Smith, Robert W Ward
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  ABSTRACT: Introduction of a nitrogen atom into the 6-position of a series of pyrazolo[3,4-b]pyridines led to a dramatic improvement in the potency of GSK-3 inhibition. Rationalisation of the binding mode suggested participation of a putative structural water molecule, which was subsequently confirmed by X-ray crystallography.
  Bioorganic & Medicinal Chemistry Letters 06/2003; 13(9):1581-4. · 2.55 Impact Factor
• Article: 5-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).

  Jason Witherington, Vincent Bordas, Stephen L Garland, Deirdre M B Hickey, Robert J Ife, John Liddle, Martin Saunders, David G Smith, Robert W Ward
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  ABSTRACT: A novel series of pyrazolo[3,4-b]pyridines has been identified that are potent inhibitors of glycogen synthase kinase-3 (GSK-3).
  Bioorganic & Medicinal Chemistry Letters 06/2003; 13(9):1577-80. · 2.55 Impact Factor