Young-Hoon Joo

Catholic University of Korea, Sŏul, Seoul, South Korea

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Publications (61)107.15 Total impact

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    ABSTRACT: Lymph node density (LND) is more useful than the TNM classification in predicting survival after surgery for many cancers. The purpose of this study was to clarify independent prognostic factors for hypopharyngeal squamous cell carcinoma (HPSCC) and broaden the staging system to improve its predictive value. The present study included 105 patients with HPSCC treated with hypophagectomy and neck dissection between 1993 and 2014. The median LND in patients with HPSCC was 0.060 (range 0.026-0.620). We found a significant difference in LND values between patients with and without recurrence (0.063 vs. 0.030, respectively; p = 0.001). The cutoff value of LND for recurrence was 0.055, with a sensitivity of 68% and specificity of 71%. Cervical lymph node metastasis, advanced pathologic T stage, lymphovascular invasion, LND ≥0.055, and extracapsular spread had significant adverse effects on 5-year overall and disease-specific survival in a univariate analysis. Multivariate analysis confirmed a significant association between 5-year overall survival and LND ≥0.055 [hazard ratio (HR) 2.19; 95% confidence interval (CI) 1.06-4.51; p = 0.035] and extracapsular spread (HR 2.47; 95% CI 1.09-5.61; p = 0.030). Furthermore, LND ≥0.055 (HR 2.30; 95% CI 1.07-4.93; p = 0.034) and extracapsular spread (HR 2.95; 95% CI 1.20-7.29; p = 0.019) were associated with 5-year, disease-specific survival. The median LND cutoff values ≥0.055 are associated with a greater risk of recurrence and survival in patients with HPSCC.
    Annals of Surgical Oncology 07/2015; DOI:10.1245/s10434-015-4726-6 · 3.94 Impact Factor
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    ABSTRACT: The current study investigated the prevalence of suicidal ideation and behavior in a representative sample of South Koreans with or without tinnitus. A cross-sectional study. Based on data from the 2010-2012 Korean National Health and Nutrition Examination Survey (KNHANES) PARTICIPANTS: The study included 17,446 Korean individuals. Participants provided demographic, socioeconomic, and behavioral information, as well as responses to questionnaires assessing the presence and severity of tinnitus, mental health status regarding stress, depression, and suicidal ideation and attempts. In the univariate analysis, the Rao-Scott chi-square test and logistic regression analysis were used to test the association between tinnitus and risk factors. Simple and multiple linear regression analyses were used to examine the association between tinnitus and mental status. A total of 20.9% and 1.2% of participants with tinnitus, and 12.2% and 0.6% of those without, reported suicidal ideation and attempts, respectively (p < 0.0001 and p = 0.001). Participants reporting suicide attempts showed a higher proportion of severe annoying (6.0%) and irritating (11.8%) tinnitus than those with suicidal ideation (1.4% and 10.2%, respectively). Risks for experiencing tinnitus were significantly associated with suicidal ideation and attempts after adjusting for confounding variables. The present study has important implications for enhanced screening and evaluation of mental health status and suicidal ideation/behavior among tinnitus patients. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    Clinical otolaryngology: official journal of ENT-UK; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery 07/2015; DOI:10.1111/coa.12500 · 2.27 Impact Factor
  • Young-Hoon Joo, Kyung-Do Han, Seong-Su Lee
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    ABSTRACT: This study aimed to investigate the relationship between obesity and chronic laryngitis in South Korea using data from the Korea National Health and Nutrition Examination Surveys (KNHANES) collected during 2008-2010. KNHANES was a cross-sectional survey of the civilian, non-institutionalized population of South Korea (n = 13,819). Obesity status was measured by using BMI and waist circumference. Among the population over 19 years of age, the prevalence of chronic laryngitis was 4.0 ± 0.4%. Chronic laryngitis was significantly associated with age, BMI, waist circumference, fat proportion, both systolic and diastolic blood pressure, fasting blood sugar, triglycerides, and high-density lipoprotein cholesterol in women. Old age and current smoking were significantly associated with chronic laryngitis in men. Obese women were at a higher risk for chronic laryngitis than women without obesity (odds ratio (OR) 2.022, 95% confidence interval (95% CI) 1.412-2.895) after further adjustment for confounders. Women with abdominal obesity were also at higher risk for chronic laryngitis (OR 1.475, 95% CI 1.024-2.126). Obese women in Korea have an elevated risk for developing chronic laryngitis. Further epidemiological and experimental studies are necessary to clarify the impact of obesity on this condition. © 2015 S. Karger GmbH, Freiburg.
    Obesity Facts 07/2015; 8(4):252-260. DOI:10.1159/000437004 · 1.71 Impact Factor
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    ABSTRACT: We investigated the relationship between olfactory dysfunction and depressive symptoms and suicidal ideation in South Korea by using data from the 2010-2011 Korea National Health and Nutrition Examination Surveys (KNHANES). Cross-sectional data of 11,972 adults who completed the KNHANES were analyzed. The prevalence of olfactory dysfunction was 5.0% among the population ≥ 19 years of age. Olfactory dysfunction was significantly associated with age, alcohol consumption, waist circumference, job, education level, and rhinitis. Depressed mood for two or more continuous weeks was reported by 19.2% of participants with olfactory dysfunction and 12.8% of participants without olfactory dysfunction (p = 0.0009). Suicidal ideation was reported by 20.5% of participants with olfactory dysfunction and 14.1% of participants without olfactory dysfunction (p < 0.0001). The participants with olfactory dysfunction were at higher risk for depressed mood than were participants without olfactory dysfunction (odds ratio [OR] 1.505 [95% confidence interval [CI], 1.106-2.048]) after adjusting for confounders. The participants with olfactory dysfunction were also at higher risk for suicidal ideation (OR 1.306 [95% CI, 1.027-1.662]). In the Korean population, olfactory dysfunction was associated with an increased risk for depressed mood and suicidal ideation. Further epidemiologic and experimental studies are necessary to clarify the impact of olfactory dysfunction on psychological diseases.
    American Journal of Rhinology and Allergy 07/2015; 29(4):268-72. DOI:10.2500/ajra.2015.29.4194 · 2.18 Impact Factor
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    ABSTRACT: The purpose of this study was to evaluate the utility of lymph node density for predicting the survival of patients with tonsillar cancer and positive neck nodes. We reviewed data for 64 patients diagnosed with tonsillar cancer with lymph node metastasis in a retrospective single center audit. Lymph node density (≥0.05), extracapsular spread (ECS), number of ECS (≥3), vascular invasion, perineural invasion, and N classification (N1/N2a vs N2b/N2c) were significant predictors of 5-year disease-free survival (DFS). Lymph node density (≥0.05), human papillomavirus (HPV) infection, and N classification (N1/N2a vs N2b/N2c) were significant predictors of 5-year overall survival (OS). In the multivariate analysis, categorical lymph node density remained a significant predictor of DFS (p = .025*; hazard ratio [HR] = 6.063) and no parameter was significantly predictive of OS. Lymph node density might be useful as an independent predictor of survival in patients with tonsillar cancer and positive lymph nodes. © 2015 Wiley Periodicals, Inc. Head Neck, 2015. © 2015 Wiley Periodicals, Inc.
    Head & Neck 06/2015; DOI:10.1002/hed.24074 · 3.01 Impact Factor
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    ABSTRACT: Globus symptoms are not uncommon after an uncomplicated thyroidectomy. However, their associated factors and etiology have not been investigated. We investigated the etiology and factors related to globus symptoms after thyroidectomy. The medical records of 289 patients who underwent thyroidectomy and completed a voice analysis, psychiatric screening, and voice-related questionnaires before and 1 month after the surgery were reviewed. Patients were excluded if they had globus symptoms before surgery or scored high on the psychiatric questionnaire. The selected patients were divided into two groups according to development of globus symptoms after surgery. Clinicopathological parameters and results of the voice analysis and voice-related questionnaires were compared between the two groups. A total of 157 patients were enrolled, and more than half (80/155, 51 %) showed development of globus symptoms 1 month after thyroidectomy. Female patients [hazard ratio (HR), 2.605; P = 0.010], patients who had central lymph node metastasis (HR, 3.533; P = 0.001), and patients who underwent central neck dissection (HR, 3.652; P = 0.014) had a higher probability of developing globus symptoms. Patients who developed globus symptoms scored higher on the voice-related questionnaire, and had a greater decrease in speaking fundamental frequency (P < 0.001). Globus symptoms developed after 1 month in more than half of patients who underwent thyroidectomy. Female sex and central lymph node metastasis and dissection increased the possibility of developing the symptoms.
    Archives of Oto-Rhino-Laryngology 06/2015; DOI:10.1007/s00405-015-3676-8 · 1.61 Impact Factor
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    ABSTRACT: The purpose of this study was to develop a CMCSCC-1 cell line for head and neck cancer research into new therapies for head and neck squamous cell carcinoma (SCC). The CMCSCC-1 cell line was isolated from a primary oral tongue tumor specimen of a female patient. Tumor cells were evaluated for biomarkers expression by Western blots, RT-PCR, FACs, and immunostaining. Cell proliferation in response to radiation was measured by the WST-8 assay. The characterization analyses revealed a typical epithelial morphology; a doubling time of approximately 24h, high tumorigenicity in immunodeficient mice, and upregulated biomarkers. CMCSCC-1 cells were negative for human papillomavirus (HPV) infection, but more sensitive to radiation compared with those FaDu cell line. CMCSCC-1, a novel oral tongue SCC cell line was established. It will help to in the elucidation of the molecular pathogenesis of HPV-negative, radiosensitive tumors. This article is protected by copyright. All rights reserved. © 2015 Wiley Periodicals, Inc.
    Head & Neck 03/2015; DOI:10.1002/hed.24037 · 3.01 Impact Factor
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    Young-Hoon Joo, Kyung-do Han, Kyung Ho Park
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    ABSTRACT: Hearing loss and tinnitus are global public health concerns. There have been some studies suggesting a relationship between hearing loss and tinnitus and impaired health-related quality of life (HRQoL), but there have been no large cross-sectional epidemiologic studies of a representative sample of the entire country population investigating this possible association. The aim of this study was to investigate the relationship between hearing loss and tinnitus and HRQoL in South Korea using data from the Korea National Health and Nutrition Examination Surveys during 2010-2012. Cross-sectional data of 11,266 adults who completed the Korea National Health and Nutrition Examination Surveys were analyzed. Subjects were divided into four groups as follows: normal hearing without tinnitus, normal hearing with tinnitus, hearing loss without tinnitus, and hearing loss with tinnitus. Among the population that was ≥19 years of age, the prevalence of unilateral hearing loss was 9.69% and that of tinnitus in the prior 12 months was 32.76%. The hearing loss with tinnitus group had the highest percentage of subjects who responded "some or extreme problems" in all five dimensions (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression) of HRQoL. After adjustment for age, gender, body mass index, smoking status, alcohol intake, regular exercise, house income, education level, diabetes, hypertension, and stress level, the HRQoL odds ratios (OR) were 1.47 (95% confidence interval [CI], 1.07-2.02) for mobility, 1.59 (95% CI, 1.07-2.37) for usual activity, and 1.84 (95% CI, 1.25-2.70) for anxiety/depression in the hearing loss with tinnitus group, compared with the normal hearing without tinnitus group. The ORs for the normal hearing with tinnitus group compared with the hearing loss without tinnitus group was increased in all five dimensions of HRQoL after adjustment for confounders. Hearing loss with tinnitus has a considerable impact on HRQoL in the Korean population. In our study, the hearing loss without tinnitus group showed better a HRQoL than the normal hearing with tinnitus group.
    PLoS ONE 01/2015; 10(6):e0131247. DOI:10.1371/journal.pone.0131247 · 3.53 Impact Factor
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    ABSTRACT: This study was performed to verify the efficacy and feasibility of primary closure for communication defects in the neck after transoral robotic surgery (TORS) for tonsillar cancer, and to verify the necessity of en bloc resection, which can create communication defects during TORS.
    Auris Nasus Larynx 09/2014; 42(1). DOI:10.1016/j.anl.2014.08.009 · 1.00 Impact Factor
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    ABSTRACT: Conclusion: Median 18F-FDG PET/CT maximum standardized uptake values (SUVmax) cut-off values of 7.9 or greater were associated with high-risk human papillomavirus (HPV) negativity in patients with hypopharyngeal squamous cell carcinoma (HPSCC). Furthermore, median 18F-FDG PET/CT SUVmax cut-off values of 7.9 or greater and high-risk HPV negativity were associated with adverse outcomes. Objectives: We studied the association and the potential prognostic significance of 18F-FDG PET/CT and high-risk HPV status in HPSCC. Methods: The medical records of 45 patients who underwent 18F-FDG PET/CT for HPSCC before surgery were reviewed. High-risk HPV in situ hybridization was performed to detect HPV infection. Results: The median SUVmax was 9.91 ± 4.91 (range 1.9–22.1) and the positive rate of high-risk HPV in situ hybridization was 11% (5 of 45). The SUVmax values of negativity for the high-risk HPV subtypes (10.47 ± 4.87) and positivity (5.48 ± 2.45) were found to be significantly different (p = 0.030). The SUVmax cut-off value for differentiating negativity for the high-risk HPV subtypes from positivity was 7.9, with a sensitivity of 65% and a specificity of 80%. The 5-year disease-specific survival rate (DSSR) in our cohort was 57%. Patients with an SUVmax value higher than 7.9 (p = 0.005) and high-risk HPV negativity (p = 0.047) had decreased 5-year DSSR.
    Acta Oto-Laryngologica 09/2014; 134(10). DOI:10.3109/00016489.2014.905701 · 0.99 Impact Factor
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    ABSTRACT: Background: To evaluate the long-term swallowing function in patients with vertical hemipharyngolaryngectomy (VHPL) for hypopharyngeal cancer. Methods: A retrospective review of 30 patients followed for more than 2 years with VHPL between 1998 and 2011 was performed. Results: Five patients (16.7%) experienced gastrostomy tube placement, 4 patients (13%) pharyngoesophageal stricture, and 13 patients (45%) aspiration pneumonia. There was a significant difference in the fraction of gastrostomy tube placement among type II VHPL (35.7%), type I VHPL (0%), and type III VHPL (0%) (p=0.014). Gastrostomy tube dependence was significantly associated with flap size (larger than 70 cm(2) ) (p=0.043) and aspiration pneumonia (p=0.009). A significant positive correlation was found between current smoker and aspiration pneumonia (p=0.030). Conclusion: Type II VHPL, large flap reconstruction, and aspiration pneumonia had predictable values for gastrostomy tube dependence. Smoking status correlated with aspiration pneumonia. Better counseling and vigilance concerning swallowing difficulties may be possible. Head Neck, 2014.
    Head & Neck 09/2014; DOI:10.1002/hed.23867 · 3.01 Impact Factor
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    ABSTRACT: Objectives The aim of this study was to determine the role of preepiglottic space (PES) invasion in lymph node metastasis and prognosis in patients undergoing supracricoid partial laryngectomy (SCPL) with cricohyoidopexy (CHP). Methods A retrospective review of 42 previously untreated patients with squamous cell carcinoma of the larynx that underwent surgery was performed. The mean age of the subjects was 61.3 years, and the male-to-female ratio was 38:4. Regarding their pathological stages, there were 3, 8, 22, and 9 cases of stage T1 to T4, respectively. Concerning the disease stage of the cervical lymph nodes, there were 30, 5, 6, and 1 cases with N0 to N3, respectively. Results The PES invasion rate was 23.8% (10/42). Significant correlations were found between PES invasion and cervical lymph node metastasis (P=0.002). Seven of the 10 patients (70.0%) with PES invasion had cervical lymph node metastasis, whereas only 5 of the 32 patients (15.6%) without any evidence of PES invasion had lymph node metastasis. There was also a significant correlation of PES invasion with age (P=0.002) and T stage (P=0.030). However, there was no significant relationship between gender, primary tumor site, anterior commissure invasion, subglottic extension, paraglottic space invasion and PES invasion. There was a 5-year disease-specific survival of 70%. PES invasion served as a statistically significant prognostic factor for disease-specific survival (P=0.004). Cervical nodal metastasis (P=0.003) and subglottic extension (P=0.01) were also statistically significant prognostic factors associated with disease-specific survival. Conclusion The PES invasion was significantly related to the cervical lymph node metastasis and prognosis in patients undergoing SCPL with CHP.
    Clinical and Experimental Otorhinolaryngology 09/2014; 7(3):205-9. DOI:10.3342/ceo.2014.7.3.205 · 0.84 Impact Factor
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    ABSTRACT: Background A new approach to modifying facelift incision was recently developed for robotic thyroid surgery that seemed to be advantageous over other existing approaches. In this study, we aimed to investigate the feasibility and safety of the facelift approach not only for robotic thyroid surgery, but also for endoscope-assisted thyroid surgery. Methods Endoscope-assisted facelift thyroid lobectomy was performed for 11 patients with papillary microcarcinoma. Results All 11 operations were successfully performed endoscopically. This approach through a modified facelift incision provided safe dissection of the laryngeal nerves and exposed an adequate working space. We identified and preserved all neighboring critical structures (parathyroid gland and superior and recurrent laryngeal nerves) during surgery. The operative duration for simple thyroid lobectomy with central lymph node dissection in 11 patients was 120-180 min (average duration: 140 min). Sensory change around the earlobe occurred in three patients and was recovered within 2 months after surgery in all patients. No patient displayed laryngeal nerve palsy or a low-pitched voice. Conclusions The facelift approach seems to provide a shorter and more direct route to the thyroid, requiring minimal dissection, and an adequate workspace not only for robotic surgery but also for endoscopic surgery. It is worthwhile to develop and refine the surgical techniques of endoscopic facelift thyroid surgery.
    Surgical Endoscopy 08/2014; 29(6). DOI:10.1007/s00464-014-3826-x · 3.31 Impact Factor
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    ABSTRACT: The purpose of this study was to establish normative data of laryngotracheal dimensions and shape and to evaluate differences associated with age and sex using three-dimensional (3D) imaging. A total of 120 patients (64 boys and 56 girls) were included. Subjects were divided into four groups: Group 1 (0-2 years), Group 2 (3-7 years), Group 3 (8-13 years), and Group 4 (14-20 years). Using 3D image processing software, the laryngeal volume (LV), tracheal volume (TV), anteroposterior diameter at the glottis, cross-sectional area (CSA) at the subglottis, and laryngeal angle (LA) of the thyroid laminae were measured. Parameters of laryngotracheal volume and size were positively correlated with age, whereas the LA was inversely correlated with age. The LV, TV, CSA-3 mm, and CSA-5 mm exhibited a growth spurt in Groups 2 and 3. The LA decreased at a faster rate in Group 1 (P = 0.012). In Groups 1 and 2, there were no differences between genders for each laryngotracheal segmentation or plane. However, gender differences in the TV of Group 3 were statistically significant (P = 0.030). In Group 4, gender differences of all airway parameters were evident. Volume and other dimensions of the laryngotracheal airway increase with age. There was a significant increase in the LV, TV, CSA-3 mm, and CSA-5 mm in Groups 2 and 3. The LA correlated negatively with age in the Group 1. Significant sex dimorphisms are evident in Group 4. Clin. Anat., 2013. © 2013 Wiley Periodicals, Inc.
    Clinical Anatomy 04/2014; 27(3). DOI:10.1002/ca.22290 · 1.16 Impact Factor
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    ABSTRACT: Abstract Conclusion: High-risk human papillomavirus (HPV) infection was significantly related to lymph node size in patients with single node metastasis of oral and oropharyngeal cancer. Objective: The purpose of this study was to examine the relationship between high-risk HPV infection and lymph node size in patients with single node metastasis of oral and oropharyngeal carcinoma. Methods: This study included 48 patients with oral and oropharyngeal carcinoma. Pathologic lymph node stages comprised 36 N1 and 12 N2a. Results: High-risk HPV in situ hybridization was positive in 29% of patients (14/48). Of those patients with high-risk HPV, there was a significant difference (p = 0.008) between oral (9.5%) and oropharyngeal (44.4%) cancers. Average lymph node diameter was 20.7 ± 12.6 mm (range 5-54 mm). We found a positive correlation between high-risk HPV status and lymph node size (p = 0.018). Mean lymph node diameter in high-risk HPV-positive cases was 27.3 ± 13.1 mm and 18.0 ± 11.5 mm in high-risk HPV-negative cases. Extracapsular spread (p = 0.030) and cystic nodal metastases (p = 0.019) were also significantly related to lymph node size. High-risk HPV negative status (p = 0.043), advanced tumor stage (p = 0.009), and extracapsular spread (p = 0.038) all had significant adverse effects on 5-year disease-specific survival.
    Acta oto-laryngologica 04/2014; 134(4):395-400. DOI:10.3109/00016489.2013.844364 · 0.99 Impact Factor
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    ABSTRACT: The ductal cyst of the hypopharynx is a very rare tumor. We report a case of hypopharyngeal ductal cyst in a 63-year-old man presenting with globus sensation. It was removed by a laryngomicrosurgical technique, using a microdissection electrode. Masses of the hypopharynx may not always be easily visible on routine examination of the hypopharynx with flexible fiberoptic laryngoscopes. Particularly in cases of benign tumors, the diagnosis may be delayed due to a prolonged history of mild and subtle symptoms. We missed the hypopharyngeal mass at the initial presentation, but could detect the mass in the pyriform sinus with a double contrast barium swallow study. We describe the diagnostic method to detect hypopharyngeal tumors and the treatment of benign hypopharyngeal masses.
    Clinical and Experimental Otorhinolaryngology 03/2014; 7(1):76-8. DOI:10.3342/ceo.2014.7.1.76 · 0.84 Impact Factor
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    ABSTRACT: BACKGROUND: To evaluate the association of (18) F-fluorodeoxyglucose-positron emission tomography ((18) F-FDG PET/CT) and high-risk human papillomavirus (HPV) status and to establish the histologic correlates in oropharyngeal cancer (OPSCC). METHOD: The medical records of 78 patients who underwent (18) F-FDG PET/CT for OPSCC before surgery were reviewed. RESULTS: The positive rate of high-risk HPV in situ hybridization was 36% (28 of 78). The maximum standardized uptake values (SUVmax ) of negativity for the high-risk HPV subtypes (10.29 ± 4.30) and positivity (6.69 ± 4.17) were found to be significantly different (p = .001). The SUVmax cutoff value for differentiating negativity for the high-risk HPV subtypes from positivity was 7.10, with the sensitivity of 78% and the specificity of 68%. A median SUVmax (using 7.10 as a cutoff) (p = .041) and high-risk HPV status (p = .040) were found to be associated with 5-year disease-specific survival (DSS). CONCLUSIONS: Median (18) F-FDG PET/CT SUVmax cutoff values 7.10 or greater are associated with a high-risk HPV negativity in OPSCC patients. © 2013 Wiley Periodicals, Inc. Head Neck, 2013.
    Head & Neck 03/2014; 36(3). DOI:10.1002/hed.23296 · 3.01 Impact Factor
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    ABSTRACT: The concept of natural orifice transluminal endoscopic surgery (NOTES) is an emerging experimental alternative to conventional surgery that eliminates skin incisions using an endoscope passed through a natural orifice (e.g., mouth, urethra, or anus). This study was designed to evaluate the feasibility and safety of thyroid resection via an entirely transoral tri-vestibular route using endoscopy, and to introduce NOTES to the head and neck area of medicine. We performed ten complete endoscopic thyroid lobectomies with central lymph node dissection via a tri-vestibular approach in fresh-frozen cadavers. A 5-mm endoscope with a deflectable tip was used to visualize the surgical field. Three cannulas were inserted through the midline and bilateral incision sites in the vestibule to position the instruments and endoscope. We refined and described the surgical technique in each step using video clips. We identified and preserved neighboring critical structures during surgery. We also confirmed that there were no obvious remnant thyroid tissues and no injury to the neighboring structures after exploration. The transoral tri-vestibular approach seems to provide a good view and surgical field for endoscopic thyroidectomy. However, the transoral approach for thyroidectomy remains experimental, and the detailed surgical technique should be refined via further clinical studies.
    Archives of Oto-Rhino-Laryngology 02/2014; 271(12). DOI:10.1007/s00405-014-2911-z · 1.61 Impact Factor
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    ABSTRACT: Although T stage is an important prognostic tool for oral tongue cancer, it fails to define the depth of invasion and true three-dimensional volume of primary tumors. The purpose of this paper is to determine the relations between tumor volume and lymph node metastasis and survival in early oral tongue cancer. Forty-seven patients with T1-2 tongue cancer were included. Tumor volumes were measured by the computerized segmentation of T2-weighted magnetic resonance imaging. The overall average tumor volume was 27.7 cm(3) (range, 1.4 to 60.1 cm(3)). A significant positive correlation was found between tumor volume and pathological T stage, depth of invasion, and cervical lymph node metastasis (P<0.001, P<0.001, and P=0.002, respectively). When the tumor volume exceeded 20 cm(3), the cervical metastasis rate increased to 69.2%. The overall 5-year disease specific survival rate was 80%. There was a statistically significant association between large tumor volume (≥20 cm(3)) and the 5-year disease-specific survival (P=0.046). Tumor volume larger than 20 cm(3) was associated with greater risk cervical lymph node metastasis and poor 5-year disease-specific survival rate in early oral tongue cancer patients.
    Clinical and Experimental Otorhinolaryngology 12/2013; 6(4):243-8. DOI:10.3342/ceo.2013.6.4.243 · 0.84 Impact Factor
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    ABSTRACT: BACKGROUND: The purpose of this study was to evaluate the use of fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT for the identification of extracapsular spread (ECS) with supporting histologic correlation in hypopharyngeal cancer. METHOD: We retrospectively reviewed the medical records of 57 patients who underwent FDG PET/CT for hypopharyngeal cancer. RESULTS: ECS was present in 79% dissected necks (45 of 57 patients) and in 64% dissected cervical levels (55 of 86). A significant difference in standardized uptake value maximum (SUVmax ) values was found between cervical lymph nodes with and without ECS (6.10 ± 3.51 vs 1.75 ± 1.46, respectively; p < .001). The cutoff value of SUVmax for differentiating with and without ECS was 2.65 with a sensitivity of 80% and a specificity of 74%. The presence of ECS and median SUVmax were found to have a significant adverse effect on 5-year disease-specific survival. CONCLUSION: Median FDG PET/CT SUVmax cutoff values of 2.65 or greater are associated with a greater risk of ECS in cervical lymph node metastasis from hypopharyngeal squamous cell carcinoma (SCC). © 2013 Wiley Periodicals, Inc. Head Neck, 2013.
    Head & Neck 12/2013; 35(12). DOI:10.1002/hed.23239 · 3.01 Impact Factor

Publication Stats

167 Citations
107.15 Total Impact Points

Institutions

  • 2009–2015
    • Catholic University of Korea
      • College of Medicine
      Sŏul, Seoul, South Korea
  • 2014
    • Inje University
      • College of Medicine
      Kŭmhae, Gyeongsangnam-do, South Korea
  • 2013
    • The Australian Society of Otolaryngology Head & Neck Surgery
      Evans Head, New South Wales, Australia