Michael Lanz

Klinikum Bremen-Ost, Bremen, Bremen, Germany

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Publications (13)30.82 Total impact

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    ABSTRACT: Question of the study The aim of the study was to examine subjective sleep perception not only in patients with insomnia but also in other sleep disorders. Subjects and methods A total of 159 patients with insomnia, sleep-related movement disorders (SMD), hypersomnia, and parasomnia underwent full cardiorespiratory polysomnography with videometry during two consecutive nights. In addition, patients filled in sleep logs assessing subjective sleep parameters as well as several questionnaires including the Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), and Center for Epidemiologic Studies-Depression scale (CES-D). Results For the second night, not only subjective sleep efficiency, total sleep time (TST), and sleep latency but also objective TST and efficiency significantly differed across diagnostic groups. Comparison between subjective and objective TST, efficiency and latency revealed insomnia patients to significantly underestimate their sleep efficiency and TST, while overestimating their sleep latency. Subjective and objective sleep efficiency as well as sleep latencies differed significantly in the SMD group. Parasomnia and hypersomnia patients only showed significant differences in sleep latencies. PSQI scores significantly differed across patient groups. Conclusion The PSQI is useful as a screening instrument for distinguishing between diagnostic categories of sleep disorders. Not only insomnia patients significantly misinterpreted sleep parameters, but patients with SMD, hypersomnia, and parasomnia also displayed significant misinterpretation of at least one sleep parameter.
    Somnologie - Schlafforschung und Schlafmedizin 01/2010; 14(4):253-259.
  • Movement Disorders 06/2009; 24(10):1549-50. · 5.63 Impact Factor
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    ABSTRACT: We combined diffusion tensor imaging (DTI) measures of the corpus callosum (CC) and the superior longitudinal fascicle (SLF) with calculation of brain atrophy in 53 patients with relapsing-remitting multiple sclerosis (MS) and 15 healthy controls, to analyze their interrelation and their correlation with disease duration and clinical impairment. The lateral ventricle volume in MS patients was increased; the fractional anisotropy in the CC was decreased as was the fiber volume. Perpendicular (in the literature also referred to as radial) diffusivity (ped), which reflects the diffusion perpendicular to the long axis of the axons within the fiber bundle, was increased in the SLF and the posterior CC, but contrary to our predictions, parallel (also called axial) diffusivity (pad) that refers to the amount of diffusion in the direction of the axon was increased, too. Brain atrophy and DTI-derived parameters were highly intercorrelated and both correlated with disease duration. Discriminant analysis showed that DTI-derived atrophy measures are superior to brain atrophy measures in classifying patients and controls. In light of our results, animal studies focusing on demyelination and axonal loss are reinterpreted.
    Journal of neuroimaging: official journal of the American Society of Neuroimaging 06/2009; 20(4):334-44. · 3.36 Impact Factor
  • Clinical Neurophysiology - CLIN NEUROPHYSIOL. 01/2009; 120(1).
  • Sleep Medicine 06/2008; 9(4):455-6. · 3.49 Impact Factor
  • Klinische Neurophysiologie - KLIN NEUROPHYSIOL. 01/2008; 39(01).
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    ABSTRACT: Multiple sclerosis (MS) is a common neurological disease in the Western hemisphere that leads to neurological dysfunctions and frequently from its onset to cognitive impairment, which together predict quality of life. Recent pathological and imaging studies have focused on brain atrophy representing axonal injury and loss as being crucial for developing disability and neuropsychological impairment. Brain atrophy has therefore been proposed to be a tool for monitoring disease progress. Here, we review the possible origins of brain atrophy and its correlation with cognitive impairment in MS.
    Journal of Neurology 06/2007; 254 Suppl 2:II43-8. · 3.58 Impact Factor
  • Michael Lanz, Svenja Happe
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    ABSTRACT: The restless legs syndrome (RLS) is a frequently occurring neurological disease that is often associated with sleep disorders and reduced quality of life. The cause of RLS still has not been clearly established; however, the dopaminergic and opioid systems and iron metabolism appear to have major roles in the disease. The therapy of choice is treatment with dopaminergic drugs. In addition, opiates and anticonvulsants such as gabapentin are used. The most important side effect of dopaminergic therapy is augmentation. If therapy-related augmentation occurs while taking levodopa, the medication should be changed to dopamine agonists. If augmentation occurs while taking dopamine agonists, opiates or gabapentin should be taken instead.
    MMW Fortschritte der Medizin 06/2007; 149 Suppl 2:42-4.
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    ABSTRACT: Cognitive disorders are common in MS patients without any generally recommended treatment. Recent brain imaging studies show considerable neuroplasticity for cognitive tasks in MS patients, but also brain atrophy already early in the disease progression. We explored the benefits of a home-based cognitive training program for memory and working memory functions in relapsing-remitting MS patients controlling for whole brain and central brain atrophy as covariates. Using a single-blinded controlled study design, 42 patients were randomised into a treatment group and a control group. Home based computer training focusing on memory and working memory was started at least 4 weeks after the discontinuation of methylprednisolone treatment and lasted for 6 weeks. Two weeks later the patients were re-investigated for their clinical and cognitive performance. We assessed also quality of life (QoL), depression and fatigue using self-rating scales. Training had no effect on the neurological status and on QoL or fatigue. However, the treatment group showed better verbal learning, long-delay verbal memory performance, and working memory performance. The impact of treatment on long-delay verbal memory performance was independent from the extent of brain atrophy, whereas for the other findings brain atrophy played a significant role. An intensive home-based cognitive training program is suitable to improve the cognitive performance of MS patients. The impact of brain atrophy on rehabilitation outcome may differ for cognitive functions.
    Restorative neurology and neuroscience 02/2007; 25(1):33-43. · 2.93 Impact Factor
  • Aktuelle Neurologie - AKTUEL NEUROL. 01/2006; 33(5):284-286.
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    ABSTRACT: Chronic alcohol abuse leads to cognitive deficits. The authors investigated whether a systematic increase of interference in a 2-back working memory paradigm would lead to cognitive deficits in alcoholic participants and compared their performance in such a task with that in an alternate-response task. Twenty-four nonamnesic and nondemented alcohol abuse (AA) patients and 12 patients with Korsakoff's syndrome (KS) were compared with a control group. AA patients were impaired in the alternate-response task but not in working memory interference resolution. KS patients performed worse than the AA patients and the controls in both tasks. The neurotoxic side effects of alcohol therefore lead to a specific deficit in alternating between response rules but not in working memory, independently of whether the working memory task involves interference resolution or not.
    Neuropsychology 05/2004; 18(2):203-11. · 3.58 Impact Factor
  • Neurology 11/2003; 61(8):1152-3. · 8.25 Impact Factor
  • Aktuelle Neurologie - AKTUEL NEUROL. 01/2003; 30(3):118-126.