A V Amelin

Publications (22)1.46 Total impact

• Article: [Diagnosis of primary of symptomatic forms of chronic daily headache].

  A V Amelin, Iu N Bogdanova, M I Koreshkina, E V Protsenko, A A Skoromets, S V Tarasova
  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 01/2011; 111(4):82-4. · 0.12 Impact Factor
• Article: [The contribution of professor E.L. Venderovich to the Russian neurology (130 anniversary of birthday)].

  A A Skoromets, V M Kazakov, A V Amelin, E R Barantsevich, S V Mozhaev, T A Skoromets, N V Shuleshova
  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 01/2011; 111(10 Pt 1):73-4. · 0.12 Impact Factor
• Article: [The contribution of professor A.I. Shvarev (1919-1985) to the Russian neurology].

  A A Skoromtes, A V Amelin, E R Barantsevich, V M Kazakov, V A Sorokoumov
  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 01/2011; 111(5):69-70. · 0.12 Impact Factor
• Article: [Contribution of professor M.P. Nikitin to Russian neurology].

  A A Skoromets, A V Amelin, E R Barantsevich, V M Kazakov
  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 01/2009; 109(11):89-93. · 0.12 Impact Factor
• Article: [The efficacy of different anticonvulsants in chronic daily headache].

  A V Amelin, S V Tarasova, A Iu Sokolov, B Ch Tumelevich, M I Miatleva, S M Endal'tseva, G N Tumanova
  [show abstract] [hide abstract]
  ABSTRACT: Efficacy of 4 medications--topiramate, valproate, gabapentine and carbamazepine--was studied in 180 patients: 84 with chronic migraine, 63 with chronic headache of tension and 33 with a combination of the above types of headache. Mean age of the patients was 40,4+/-11,7 (from 19 to 65 years), most patients were female (n=152). The treatment was conducted during 12 weeks with assessment of efficacy every 2 weeks and 4 weeks after the end of the treatment. The response was high for all anticonvulsants, with the highest efficacy in chronic migraine. Among antidepressants used topiramate proved to be most effective. The use of anticonvulsants allows the reduction of the dosage of analgetics as much as twice and the complete withdrawal of the latter in 20% of cases.
  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 02/2007; 107(1):16-20. · 0.12 Impact Factor
• Article: Responses of neurons in the spinal nucleus of the trigeminal nerve to electrical stimulation of the dura mater of the rat brain.

  S S Panteleev, A Yu Sokolov, D E Kartus, A V Amelin, Yu D Ignatov
  [show abstract] [hide abstract]
  ABSTRACT: The pathogenesis of migraine is based on the aseptic inflammation of dura mater tissues surrounding the large cranial vessels, such as the superior sagittal sinus. This inflammation develops in conditions of antidromic activation of sensory terminals of the trigeminal nerve and is accompanied by changes in the responses of neurons in the spinal nucleus of the trigeminal nerve to electrical stimulation of the superior sagittal sinus. However, the characteristics of the responses of these neurons to this stimulation have received virtually no study. Experiments on anesthetized rats were performed with recording of the responses of 387 neurons in the spinal nucleus of the trigeminal nerve to electrical stimulation of the superior sagittal sinus. The results showed that the responses of neurons to this stimulation was biphasic, consisting of a short initial phase with a latent period of 7-19 (11.4 +/- 0.17) msec, followed by a longer-lived discharge with a latent period of 20-50 (34.2 +/- 0.8) msec. It is suggested that the first phase reflects orthodromic activation of perivascular A(delta) and C fibers of the trigeminal nerve, while the second phase is associated with activation of meningeal C fibers with low conduction velocities and/or secondary activation of the perivascular sensory endings of the trigeminal nerve by algogenic and vasoactive substances released from them during antidromic activation. These changes seen in animal experiments may serve as an indicator of the efficacy of antimigraine agents.
  Neuroscience and Behavioral Physiology 07/2005; 35(5):555-9.
• Article: [Response of the spinal trigeminal nucleus neurons to electric stimulation of the rat dura mater].

  S S Panteleev, A Iu Sokolov, D E Kartus, A V Amelin, Iu D Ignatov
  [show abstract] [hide abstract]
  ABSTRACT: Aseptic inflammation of tissues surrounding large meningeal blood vessels, e.g. the superior sagittal sinus, underlies pathogenesis of migraine. This inflammation develops due to antidromic activation of sensory trigeminal nerve endings and is followed by changes in responses of the spinal nucleus of the trigeminal nerve neurons to electrical stimulation of the superior sagittal sinus. However, characteristics of these reactions are still unclear. In experiments ou urethane-anesthetized rats, responses of 387 neurons of the spinal nucleus of the trigeminal nerve to electrical stimulation of the superior sagittal sinus, were recorded. It was tial discharge with the latency 7 to 19 ms (11.4 +/- 0.17 ms) and a subsequent long-lasting discharge with the latency 20 to 50 ms (34.2 +/- 0.8 ms). It is presumed that the first phase reflects orthodromic activation of prevascular A delta and C-fibers of the trigeminal nerve while the second phase is connected with activation of meningeal C-fibers which have low conduction velocity, and/or with a secondary activation of perivascular sensory endings of trigeminal nerve by releasing algogenic and vasoactive substances. These changes could be used as an indicator of efficacy of some antimigraine substances in animal experiments.
  Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 02/2004; 90(1):3-10.
• Article: [Current views on migraine and anti-migraine preparations].

  Iu D Ignatov, A A Skoromets, A V Amelin
  [show abstract] [hide abstract]
  ABSTRACT: On the basis of comprehensive experimental and clinical research the authors defined a variety of migraine-related mechanisms and schemes of migraine-correction by drugs, which should be both of the vascular- and general-actions to ensure an effective medication.
  Vestnik Rossiĭskoĭ akademii meditsinskikh nauk / Rossiĭskaia akademiia meditsinskikh nauk 02/2003;
• Article: [Comparative efficacy of betaserc and cinnarizine of vertigo in patients with migraine].

  A V Amelin, A A Skoromets, M A Gonchar, B Ch Tumelevich, K A Nikitin
  [show abstract] [hide abstract]
  ABSTRACT: Headache and vertigo often emerge simultaneously. Fifty six (40%) out of 140 patients complaining of vertigo were studied. Emerging in the aura and/or in headache phases, vertigo was more frequently registered in patients suffered from migraine with aura (57%). Vertigo associated with migraine was diagnosed in 25% of the cases. The patients were randomized into 2 equal identical groups, one of which was treated by betaserc (16 mg, 3 times daily before meal) and the other one was given cinnarizine (25 mg, 3 times daily). Treatment duration was 12 weeks. Reduction of vertigo attacks frequency and headache by 50% and over, in comparison to the baseline period, was considered as beneficial. Fifty three (95%) patients completed the treatment course. Decrease of a risk for negative results and a frequency of positive effect of vertigo therapy were significantly higher in the group receiving betaserc. Reduction of monthly relapses by 50% and over was detected in 79% of the patients of betaserc group and in 52% of those of cinnarizine one. Migraine attacks monthly frequency was diminished by 43% and 64%, respectively. Therefore, betaserc is considered for using as vertigolytic medication and for migraine attacks prevention.
  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 02/2003; 103(5):43-8. · 0.12 Impact Factor
• Article: [Autonomic reactivity in children and adolescents with enuresis].

  L A Korenko, A A Skoromets, A V Amelin
  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 02/2002; 102(6):48-9. · 0.12 Impact Factor
• Article: [EEG mapping in patients with migraine].

  L A Korenko, A A Skoromets, A V Amelin
  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 02/2002; 102(6):46-7. · 0.12 Impact Factor
• Article: [The role of serotonin and serotonin receptors in the pathogenesis of migraine and in the mechanisms of action of anti-migraine drugs].

  A V Amelin, A A Skoromets, Iu D Ignatov
  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 02/2000; 100(7):55-8. · 0.12 Impact Factor
• Article: [A comparative efficiency of amitriptyline, fluoxetine and maprotiline in prevention of migraine in attack-free period].

  A V Amelin, A A Skoromets, L A Korenko, B Ch Tumelevich, M A Gonchar
  [show abstract] [hide abstract]
  ABSTRACT: To reduce frequency and severity of the attacks, migraine was treated preventively between the attacks. The most effective drugs were beta-blockers and antidepressants. In a single-blind study we estimated comparative efficiency of amitriptiline (inhibitor of noradrenaline and serotonin reuptake and 5-HT2-receptor antagonist) 12.5-25 mg/daily, fluoxetine (a selective serotonin reuptake inhibitor) 10-20 mg/daily, and maprotiline (a selective noradrenaline reuptake inhibitor) 10-25 mg/daily. The duration of the therapy of migraine between the attacks was 12 weeks. Each group included 20 patients. 46 patients completed the whole course of therapy: 14 patients received amitriptyline, 16 patients--fluoxetine, and 16 patients--maprotiline. Positive results of the treatment (a reduction of the frequency of the migraine attacks during a treatment by 50% as compared with the baseline period) were observed in 71% of the patients treated with amitriptyline, in 56% of the patients treated with fluoxetine, and in 38% of the patients treated with maprotiline. All the drugs were able to reduce both intensity and duration of a headache. Index of the Quality of Life in the patients with migraine was increased in the groups treated with either amitriptyline or fluoxetine, but not in a group treated with maprotiline. The results obtained agree with the notion about high efficiency of antidepressants given between migraine attacks. Amitriptyline and fluoxetine were more efficient in preventive therapy than maprotiline. These findings suggested indirectly, that the efficiency of antidepressants in treatment of migraine is explained by inhibition of serotonin reuptake and by 5-HT2-receptor antagonism, while influence on the inhibition of noradrenaline reuptake was not so significant.
  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 02/2000; 100(8):20-3. · 0.12 Impact Factor
• Article: [Differentiated therapy of migraine attack].

  A A Skoromets, A V Amelin, L A Korenko
  [show abstract] [hide abstract]
  ABSTRACT: 91 patients with migraine were examined in terms of quantitative evaluation of the severity of the attacks. Efficiencies of application of step-by-step or stratification ways of therapy were compared. Indications for the administration of the drugs for "specific" therapy of the attacks of migraine were determined.
  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 02/1999; 99(12):39. · 0.12 Impact Factor
• Article: [Effect of spreading cortical depression on the activity of sensory neurons from the trigeminal complex].

  V E Ivanov, A V Amelin
  Biulleten' eksperimental'noĭ biologii i meditsiny 01/1999; 126(12):640-2.
• Article: [The efficacy of Solpadeine in patients with primary forms of headache].

  A V Amelin, V A Sorokoumov
  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 02/1997; 97(9):56-7. · 0.12 Impact Factor
• Article: [The effect of tropoxin on the neurogenic and vasogenic inflammation of the dura mater vessels].

  A V Amelin, V E Ivanov, Iu D Ignatov, B Ch Tumelevich, A A Pushkarev, N I Usachev
  [show abstract] [hide abstract]
  ABSTRACT: Subchronic administration of tropoxin (in doses of 7.5 and 10 mg/kg) caused dose-dependent blocking of 131I-albumin plasma transudation from the dura mater vessels, induced by electrical stimulation of the trigeminal ganglion and intravenous infusion of the agonist of 5-HT2B/2C receptors metachlorophenylpiperazine. The antimigraine agent metisergid produced a similar effect. A single injection of metisergid and tropoxin did not block albumin transudation. A 3 mg/kg dose of mianserin prevented the blocking effect of tropoxin and metisergid on plasma exudation into the dura mater. It is suggested that the mechanism of the tropoxin antimigraine effect is realized through the presynaptic 5-HT1 receptors of afferent endings of the trigeminal nerve and the postsynaptic 5-HT2B/2C receptors of the dura mater vessels.
  Eksperimental'naia i klinicheskaia farmakologiia 62(4):14-7.
• Article: [Study of mechanisms of action of amitriptyline and acupuncture using nociceptive flexor reflex in patients with chronic forms of headache].

  A V Amelin, A A Zaĭtsev, V E Ivanov, Iu D Ignatov, L A Korenko, A A Skoromets
  [show abstract] [hide abstract]
  ABSTRACT: The nociceptive flexor reflex (NFR, R3) was tried for quantitative assessment of pain in patients with various forms of primary and secondary headaches. Amitriptyline and acupuncture elevated the threshold of R3-reflex emergence, though the threshold of subjective pain sensitivity increased only in response to amitriptyline. NFR is adequate for assessing anesthesia efficacy and investigating the mechanisms of action of analgesics in patients with headache.
  Anesteziologiia i reanimatologiia
• Article: [The effect of klofelin on the activity of the sensory neurons of the trigeminal complex induced by stimulation of the superior sagittal sinus].

  V E Ivanov, A V Amelin
  [show abstract] [hide abstract]
  ABSTRACT: In doses of 0.25 and 0.5 mg/kg clophelin inhibited the responses of the trigeminal complex sensory neurons to electrical stimulation of the superior sagittal sinus in conscious immobilized rats. Naloxon (0.1 mg/kg) and yohimbine (1 mg/kg) weakened whereas prazosin (1 mg/kg) did not affect the inhibiting effect of clophelin.
  Eksperimental'naia i klinicheskaia farmakologiia 62(3):15-7.
• Article: [The effect of clofelin on the transudation of plasma proteins into the dura mater induced by stimulation of the trigeminal ganglion].

  A V Amelin, V E Ivanov, N I Usachev, A A Pushkarev
  [show abstract] [hide abstract]
  ABSTRACT: Intravenous administration of clofelin blocks transudation of 131I-albumin into the dura mater of rats in electrical stimulation of the trigeminal ganglion. Preliminary injection of the alpha-adrenoblocker yohimbine and the antagonist of serotonin receptors 5-NT1 mianserin completely removes the blocking effect of clofelin. Naloxon and the alpha 1-adrenoblocker prazosin had no effect on the degree of expression of albumin transudation and the clophelin effect. The role of the adrenergic system, the presynaptic alpha 2-adrenoceptors in particular, in functioning of the trigeminovascular system and the development of neurogenic inflammation in the dura mater is discussed.
  Eksperimental'naia i klinicheskaia farmakologiia 62(2):12-5.