Gian Peppino Ledda

Università degli studi di Cagliari, Cagliari, Sardinia, Italy

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Publications (13)14.29 Total impact

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    ABSTRACT: A case of pleomorphic rhabdomyosarcoma of the larynx is presented, which is extremely rare in a laryngeal site. The symptomatology and macroscopic aspect of the neoplasm can simulate the presence of other neoplastic variants of the larynx, and, for this reason, histological examination must be associated with immunohistochemistry for correct diagnosis and treatment.
    Acta otorhinolaryngologica Italica: organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale 02/2010; 30(1):52-7. · 0.79 Impact Factor
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    ABSTRACT: We report the prevalence of thyroarytenoid (TA) muscle invasion in 109 consecutive patients with T1 glottic carcinoma submitted to endoscopic laser cordectomy between February 1997 and January 2006, in order to evaluate if routine resection of the TA is necessary. A total of 109 patients staged as T1 underwent endoscopic treatment with carbon dioxide laser (CO(2)), 36 cases were treated with type I or II cordectomies, and 73 patients underwent type III, IV or V cordectomies, with resection of all or part of the TA. Over a total of 109 patients, 6 (5.5%) cases staged as pT1 showed TA invasion. The endoscopic treatment of T1 glottic cancer should be as conservative as possible in terms of TA resection, since muscle invasion is rare. In many cases, type III and IV cordectomies can be regarded as excessive treatment. Muscle invasion found histologically after type II cordectomy can be managed by further excision.
    Archives of Oto-Rhino-Laryngology 04/2009; 266(11):1787-91. · 1.29 Impact Factor
  • Gian Peppino Ledda, Roberto Puxeddu
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    ABSTRACT: To define the oncologic efficacy of transoral endoscopic CO2 laser surgery in early glottic carcinoma. A retrospective study of 103 patients with glottic carcinoma (14 Tis, 68 pT1a, 14 pT1b, and 7 pT2) treated from October 1993 to June 2001. Surgical treatment included endoscopic CO2 laser cordectomies according to the classification of the European Laryngological Society. According to the Kaplan-Meier method, the probability of remaining free of local recurrence 5 years after primary surgery alone was 100% for the Tis, 96.05% for the T1, and 100% for the T2. Local control at 5 years after exclusive CO2 laser salvage surgery was 98.03%. The probability of remaining free of local recurrence 5 years after any type of salvage surgery was 100%. Laryngeal preservation was achieved in 100% of the cases. According to the present series, endoscopic CO2 laser surgery is an effective treatment for early glottic cancer. C-4.
    Otolaryngology Head and Neck Surgery 07/2006; 134(6):911-5. · 1.73 Impact Factor
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    ABSTRACT: To analyze vocal outcome after endoscopic CO2 laser treatment of early glottic carcinoma by perceptive and objective assessment. Retrospective study. Retrospective analysis of 141 consecutive patients undergoing surgery for previously untreated early glottic carcinoma between October 1993 and July 2003. Five types of laser cordectomies as classified by the European Laryngological Society classification were performed. Comparison of voice results between the different types of cordectomies as well as with a control group was performed. There was no significant difference in the vocal parameters between subepithelial and subligamental cordectomies and controls (P > .05). There was, however, a significant difference between the groups of transmuscular, total, and extended cordectomies and controls (P < .05). Good oncologic results and vocal outcomes with no difference between controls and subepithelial and subligamental cordectomies support the use of CO2 laser endoscopic surgery as the first line of treatment for early glottic cancer.
    The Laryngoscope 06/2006; 116(6):1007-11. · 1.98 Impact Factor
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    ABSTRACT: Background: Nasall obularc apillaryh emangiom(aL CH) is a benignl esiono f unknowne tiologyt hat must bei ncludedi n thed ifferential diagnosiso f aascularle sionsB. asedo n a largec ohorto f LCH patients,w e retrospectiaealyn alyzedth ec linicalp resentationh, istologicaal ntl radiologicafli ndings, and the treatments tratery. Methods: Clinical recordso f 40 patientsa ffectedb y LCH, treatedi n a l}-year perioda t two unioersityh ospitalsw, erer etsiewedD, ata concernings ymptomsp, ossiblee tiologícfa ctors,e ndoscopfiicn dings, imngings tudies,a nd treatmentw erec ollected. Results: Preaiousn asalt raumaa nd pregnancyw erei dentifieda s possiblec ausesin six (15%)a nd two (Sok)p atients,r espectioelyT. he mains ymptomsw ereu nilaterael pistaxis(9 5%)a ndn asalo bstruction(3 5%).L esionsra ngedin sizeft om L to 8 cm and mainlyi nuolaed then asasl eptum( 45%)a nd then asaal estibul(e1 7.5%)I.n thef our (10%)p atientsw ith a largel esionr,a diologicaela aluatiown ash etpful not only in assessintgh ee xtentb, ut alsoi n suggestintgh ep ossiblnea tureo f thel esionA. ll patientsu nderwenet ndoscopriec sectiounn der local( 72.5%)o r genera(l 27.5%)a nesthesiAat. meanfo llow-upt imeo f 53 monthsn, o recurrenchen sb eeno bseraed. Conclusion: To the besto f our knowledget,h is is the largests erieso f patientsu sithn asalL CH. Whent he massi s considerablien size, differentiatiofnr om otherh yperaascularizeleds ionsm ay bei ntriguing. l)nder thesec ircumstancesin, formationo btainedw ith imagingm ay sometimessu ggesat correctd iagnosistt tithoutr esortingt o biopsy.E ndoscopiscu rgeryi s the treatmento f choicee oenfo r largel esionst,h at do not requirep reoperatiaeem bolizatio
    American Journal of Rhinology and Allergy 01/2006; 20(4):480-484.
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    ABSTRACT: Nasal lobular capillary hemangioma (LCH) is a benign lesion of unknown etiology that must be included in the differential diagnosis of vascular lesions. Based on a large cohort of LCH patients, we retrospectively analyzed the clinical presentation, histological and radiological findings, and the treatment strategy. Clinical records of 40 patients affected by LCH, treated in a 20-year period at two university hospitals, were reviewed. Data concerning symptoms, possible etiologic factors, endoscopic findings, imaging studies, and treatment were collected. Previous nasal trauma and pregnancy were identified as possible causes in six (15%) and two (5%) patients, respectively. The main symptoms were unilateral epistaxis (95%) and nasal obstruction (35%). Lesions ranged in size from 1 to 8 cm and mainly involved the nasal septum (45%) and the nasal vestibule (17.5%). In the four (10%) patients with a large lesion, radiological evaluation was helpful not only in assessing the extent, but also in suggesting the possible nature of the lesion. All patients underwent endoscopic resection under local (72.5%) or general (27.5%) anesthesia. At mean follow-up time of 53 months, no recurrence has been observed. To the best of our knowledge, this is the largest series of patients with nasal LCH. When the mass is considerable in size, differentiation from other hypervascularized lesions may be intriguing. Under these circumstances, information obtained with imaging may sometimes suggest a correct diagnosis without resorting to biopsy. Endoscopic surgery is the treatment of choice even for large lesions, that do not require preoperative embolization.
    American Journal of Rhinology 01/2006; 20(4):480-4. · 1.36 Impact Factor
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    ABSTRACT: A total of 20 stapedotomy and 24 stapedectomy cases were retrospectively reviewed to establish the causes of failure, and to evaluate hearing results after revision surgery. Our series included 23 male and 21 female patients. Mean age at revision time was 42 years, and the mean interval from primary surgery and revision stapes surgery was 27 months. The retrospective review of our data, revealed that the most common cause for revision surgery was a displaced prosthesis (47.7%). After revision surgery, the mean post-operative air-bone gap was 14.78 dB. A mean post-operative air-bone gap within 10 dB occurred in 24 patients (54.5%), in 14 patients (31.5%) this was between 11 and 20 dB, in 5 patients (11.5%) between 21 and 30 dB, and in one patient (2.5%) > 30 dB. There were no "dead ears" in this series. Our results compare to other reported series, and confirm that after revision stape surgery, an air-bone gap closure within 10 dB is difficult to obtain. In the present series, the use of the total ossicular replacement prosthesis resulted in the poorest functional hearing results.
    Acta otorhinolaryngologica Italica: organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale 12/2005; 25(6):347-52. · 0.79 Impact Factor
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    ABSTRACT: The aim of the study was to asses the anatomic and functional results and quality of life of a cohort of patients submitted to immediate reconstruction with the iliac osteomusculocutaneous free flap following composite resection for carcinoma of the oral cavity. Twelve patients affected by squamous cell carcinoma of the oral cavity were submitted to a single surgical procedure that included a segmental mandibulectomy in a composite resection, followed by primary reconstruction using a vascularized bone-containing free flap of the iliac crest. Reconstruction failed in one patient. Functional results as well as quality of life of 10/12 patients were evaluated using the Performance Status Scale and Functional Assessment Cancer Therapy General Scale questionnaires, appropriately modified for the pathology. The results were compared with those obtained in a group of five patients who underwent composite resection for oral carcinoma without mandibular reconstruction. Patients submitted to reconstruction noted a greater physical well being (score 22/78% vs. 16/53%; max. 28/100%), socio-family relationships (score 23/81% vs. 18/64%; max. 28/100%), emotional (score 18/90% vs. 14/70%; max. 20/100%) and general functional well-being (score 24/86% vs. 14/50%; max. 28/100%). Better recovery in functional mastication and swallowing was also observed (score 17/70% vs. 9/37%; max. 24/100%). A follow-up of longer than 6 months showed minimal donor site morbidity.
    Archiv für Klinische und Experimentelle Ohren- Nasen- und Kehlkopfheilkunde 05/2004; 261(4):202-7. · 1.46 Impact Factor
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    ABSTRACT: Recurrent glottic carcinoma after radiotherapy (RT) may be managed by open neck or endoscopic surgery. The impact of endoscopic treatment with CO(2) laser for recurrent glottic carcinoma after RT is reported. We present the oncologic and vocal outcomes of a retrospective study based on a series of 16 patients with rT1 and rT2 glottic carcinoma who were endoscopically managed between February 1995 and December 1999 after RT failure. All patients were males with a mean age of 68.7 years (range, 50 to 87 years). Before RT, the lesions had been staged as T1 N0 in 11 patients and T2 N0 in 5, and after RT as rT1 N0 in 12 and rT2 N0 in 4. According to the European Laryngological Society classification, a total of 9 transmuscular, 3 total, and 4 extended cordectomies were performed. Mean follow-up was 45 months (range, 9 to 79 months). Endoscopic salvage surgery was successful in 14 patients. One of them developed a second recurrence and was definitively cured with an additional endoscopic procedure. Two of the 16 patients had recurrent disease after salvage laser surgery and died due to progression of disease. Ultimate local control with laser alone at 3 years was 87.1%, according to the Kaplan-Meier method. Laryngeal preservation was obtained in all survivors after endoscopic rescue surgery. Voice analysis showed a clear correlation between the amount of vocal cord tissue resected and decrease of the vocal outcome. The present series indicates that selected recurrences after primary RT for T1 and T2 glottic carcinoma are eligible for endoscopic salvage surgery with oncologic results comparable to those with open neck procedures but with a lower complication rate and a favorable functional outcome.
    Otolaryngology Head and Neck Surgery 02/2004; 130(1):84-8. · 1.73 Impact Factor
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    ABSTRACT: Aim of the study was to evaluate whether laser endoscopic microsurgery is a reliable and appropriate approach to treatment of laryngeal supraglottic cancer. A retrospective study was made of 12 patients (11 M/1 F; mean age 62.5 years) treated from December 1995 to October 2001 in the Department of Surgical Sciences and Organ Transplantations, Section of Otorhinolaryngology, University of Cagliari, Italy. Surgical steps and oncologic results are reported. These 12 patients with supraglottic cancer underwent transoral laser surgery (TNM classification: T1, 3 patients; T2, 9 patients; N-, 9 patients; N+, 3 patients; M-, 12 patients). On the basis of the different subsites removed, the following resections were performed: 1 limited excisional biopsy (false chord), 3 wide excisional biopsies (2 or 3 subsites), 2 simple epiglottectomies, 1 extended epiglottectomy, 3 horizontal supraglottic laryngectomies, and 2 horizontal supraglottic laryngectomies that were extended to the anterior commissure and to one arytenoid, respectively. Five patients underwent functional neck dissection, and one patient underwent post-operative radiotherapy at sites of tumour and lymph nodes. Temporary tracheotomy was carried out in 10 patients. Mean follow-up was 33.3 months. No local recurrences were noted. Local control was thus 100%. Aspiration was the main post-operative problem, but there were no cases of aspiration-associated pneumonia. Moreover, no patient needed laryngectomy or a permanent tracheotomy for aspiration. In conclusion, although our experience with supraglottic cancers treated by endoscopy is still too limited to confirm the definitive oncologic validity of this type of surgery, in our hands, it seems to be a reasonable tool in selected cases and a safe, time- and cost-effective alternative to traditional surgery or radiotherapy for selected supraglottic carcinomas.
    Acta otorhinolaryngologica Italica: organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale 01/2004; 23(6):459-66. · 0.79 Impact Factor
  • Roberto Puxeddu, Gian Peppino Ledda
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    ABSTRACT: Objectives: To define the oncologic efficacy of transoral endoscopic CO2 laser surgery in early glottic carcinoma.Methods: Retrospective study of 103 patients with well to undifferentiated glottic carcinoma (14 Tis, 68 pT1a, 14 pT1b, and 7 pT2 with impairment of vocal cord mobility) were treated from October 1993 to June 2001 at the Section of Otorhinolaryngology at the Department of Surgical Sciences and Organ Transplantations of Cagliari University, Italy. Mean follow-up was 3.9 years. Surgical treatment included endoscopic CO2 laser cordectomies from type I to type Vc, according to the classification proposed by the European Laryngological Society in 2000.Results: According to the Kaplan-Meier method, the probability of remaining free of local recurrence 3 years after primary surgery was 100% for the Tis group, 93.4% for the T1 group (SE 3.85%) and 100% for the T2 group. Local control at 3 years after exclusive CO2 laser salvage surgery was 94.95% (SE 3.54%). The probability of remaining free of local recurrence 3 years after any type of salvage surgery was 100% for all the classes. Laryngeal preservation was achieved in 100% of the cases. Anterior commissure spread resulted in a not statistically significant difference in local control (P = 0.6), between the group of patients without (96.54%; SE 2.43%) and with anterior commissure involvement (87.5%; SE 11.69%).Conclusions: According to our experience, endoscopic CO2 laser surgery is an efficacious treatment for early stage glottic cancer.
    Otolaryngology-head and Neck Surgery - OTOLARYNGOL HEAD NECK SURG. 01/2004; 131(2).
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    ABSTRACT: Among the different laryngeal neoplasms, glottic carcinoma is known to be one of the most suitable for functional management. Nevertheless, the best treatment for T1 and T2 glottic carcinoma, whether an open neck procedure, endoscopy or radiotherapy, with reference to recurrence, survival, and functional results, has long been debated. From February 1983 to September 1997, 83 patients with well to undifferentiated glottic carcinoma (48 pT1a, 14 pT1b, and 21 selected cases of pT2 with impairment of vocal cord mobility) were submitted to surgery at the Otorhinolaryngologic Section of the Department of Surgical Sciences and Organ Transplantations of Cagliari University. Surgical treatment included 30 laryngofissures with simple or enlarged cordectomy, 22 horizontal glottectomies and 31 endoscopic laser resections. A retrospective review of the records of the patients was performed in order to obtain a better understanding of the outcome of the three different surgical procedures in our institution. According to the Kaplan-Meier method, the probability of remaining free of local recurrence 3 years after primary surgery was 0.90 for the T1 group and 0.85 for the T2 group. The distribution of recurrences for cordectomy, glottectomy and CO2 laser at 3 years showed a cumulative probability of remaining free of disease after primary surgery of 0.86, 0.85 and 0.88. The probability of remaining free of local recurrence 3 years after salvage surgery was 0.96 for the T1 group and 0.95 for the T2 group. Analyzing the phenomena for type of surgical procedure, local control at 3 years after salvage surgery for cordectomy, glottectomy and exclusive CO2 laser was 0.93, 0.90 and 0.92, respectively. In the endoscopic group, local control rate after any type of salvage therapy modified the percentage at 3 years to 100%. Anterior commissure spread (AC1-AC2) resulted in a difference (not statistically significant) in local control between the group of patients without and with anterior commissure involvement. Laryngeal preservation was achieved in 93.7% (45/48) of patients who survived after salvage surgery following open neck procedures and in 100% of patients originally submitted to the endoscopic approach. In our experience, although open laryngeal procedures can be still considered a valid option in the treatment of T1 and selected cases of T2 glottic carcinoma, endoscopic laser excision offered an oncologically adequate alternative to the traditional techniques, with minimum discomfort for the patient and satisfactory preliminary functional results.
    Tumori 86(4):277-82. · 0.92 Impact Factor
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    ABSTRACT: The objectives of the study were (1) to evaluate glottic function following carbon dioxide laser-assisted phonosurgery of benign laryngeal disease, and (2) to assess postoperative glottic morphology and disease recurrence rates, using the study design of comparative prospective non-randomized case series of patients with benign glottic pathology treated by laser-assisted phonosurgery over 10years. 235 consecutive patients had pre- and postoperative data collected by objective laryngeal examination, videostroboscopy recording of vocal fold mucosal wave movement, electroacoustic voice analysis (statistical analysis: Wilcoxon test) and perceptual voice evaluation. Comparing pre- and postoperative functional results demonstrated a statistically significant improvement in all spectrographically analysed objective voice parameters (P<0.001). Postoperative morphological analysis confirmed three recurrences of granuloma and one of Reinke’s oedema. Carbon dioxide laser-assisted voice restoration for benign glottic disease is effective.
    Archiv für Klinische und Experimentelle Ohren- Nasen- und Kehlkopfheilkunde 267(1):87-93. · 1.46 Impact Factor