D Malheiro

Hospital de São João, Oporto, Porto, Portugal

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Publications (8)7.04 Total impact

  • Allergologia et Immunopathologia 01/2009; 37(1):50-1. · 1.23 Impact Factor
  • European Journal of Anaesthesiology 04/2007; 24(3):289-90. · 2.79 Impact Factor
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    ABSTRACT: Corticosteroids (CS) are widely used in the treatment of asthma, allergic disorders and other immunological diseases due to their anti-inflammatory and immunosuppressive properties. Physicians seldom suspect them of causing allergic reactions. However, more and more cases of hypersensitivity reactions to CS have been described. Reports of delayed allergic reactions to CS in patients with asthma or allergic rhinitis are scarce. We report the case of a 44-year-old woman with a history of mild persistent asthma and intermittent allergic rhinitis, treated with inhaled beclomethasone and salbutamol, who developed a delayed mucocutaneous and respiratory reaction after substitution of beclomethasone with budesonide. The interest of this case lies in the rarity of allergic reactions from inhaled CS in patients with asthma and/or rhinitis. These reactions therefore represent a diagnostic and therapeutic challenge.
    Allergologia et Immunopathologia 01/2005; 33(6):329-32. · 1.23 Impact Factor
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    ABSTRACT: Nimesulide is a cyclooxygenase (COX) inhibitor with a high degree of selectivity to COX-2. It is a widely used and well tolerated nonsteroidal antiinflammatory drug that also has analgesic and antipyretic properties. The most frequently reported side effects concern the gastrointestinal tract. Pruritus and skin rash are the most common cutaneous adverse reactions. There are only eight cases of fixed drug eruptions due to nimesulide, described in the literature. The authors report a case of a patient with a history of antihistamine hypersensitivity who developed a bullous form of pigmented fixed drug eruption after nimesulide ingestion. Patch tests performed on residual skin lesion were positive to nimesulide, confirming that this was the culprit drug. Fixed drug eruptions are common cutaneous drug reactions, often misdiagnosed. A detailed anamnesis and physical examination are the key to suspect this condition.
    Allergologia et Immunopathologia 01/2005; 33(5):285-7. · 1.23 Impact Factor
  • Allergy & Clinical Immunology International-journal of The World Allergy Organization - ALLERGY CLIN IMMUNOL INT. 01/2005; 17(02):48-52.
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    ABSTRACT: The asthma diagnosis is primarily based on clinical data, sometimes, however, objective measures are useful. We aimed to study the use of Exhaled Nitric Oxide (eNO) and spirometry before and after inhaled albuterol (PFT) in asthma screening of adult volunteers recruited through media announcements. Each individual also answered structured questionnaires including the LQ Test (ACAAI), a valid test for asthma screening and disease impact. Sixty one patients were analyzed, 38% were men, with mean(SD age of 46(16 years, nasal symptoms 79%; smokers 20%; LQ 10(5; eNO 34.6(41.3 ppb; FEV1 % predicted 102(16% e fev1/fvc 96(13%. The eNO measurement duration ranged between 2,3 and 11,6 minutes (median 4,8) and a total of 317 (165 valid) exhalations were performed (3-9 per individual; median -5).All ATS guideline measurement criteria were fulfilled for 48(79%) individuals for eNO and 39(64%) for PFT. When applying GINA PFT criteria for asthma diagnosis 45% of patients with LQ(13 were identified as asthmatics, and when using a cut-off of 20 ppb for eNO, 46% were identified. The use of eNO and PFT in asthma screening can be technically performed and useful, nevertheless are, at present, insufficient for diagnosis of asthma.
    Revista portuguesa de pneumologia 12/2003; 9(5 Suppl):47-8. · 0.56 Impact Factor
  • Journal of Allergy and Clinical Immunology - J ALLERG CLIN IMMUNOL. 01/2003; 111(1).
  • Journal of Allergy and Clinical Immunology - J ALLERG CLIN IMMUNOL. 01/2003; 111(1).