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Journal of obstetrics and gynaecology: the journal of the Institute of Obstetrics and Gynaecology 10/2011; 31(7):664. · 0.43 Impact Factor
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ABSTRACT: Summary Transferrin levels were determined in the seminal plasma of 185 men classified according to diagnosis of infertility and also on the basis of normal or abnormal semen analysis. There was a wide overlap between concentrations of seminal plasma transferrin between normal controls and infertile patients in the various diagnostic groups. Mean seminal plasma transferrin levels in men with oligo-asthenozoospermia and azoospermia were lower than those in men with normal semen. There was a positive correlation between seminal plasma transferrin concentration and sperm density, and between seminal plasma transferrin level and sperm motility. A weak negative correlation was found between transferrin and fructose concentrations in the seminal plasma. Seminal plasma transferrin is not a useful marker for Sertoli cell or seminiferous tubular dysfunction. The estimation of this protein in the seminal plasma is not of diagnostic value in male infertility.
07/2009; 11(3):211-214.
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ABSTRACT: Uterine fibroids represent a rare cause of acute urinary retention (AUR) and most cases have been reported in pregnant women.
We report the case of a non-pregnant woman who presented with AUR due to a uterine fibroid.
When evaluating patients who present with severe oliguria or anuria, it is important to rule out urinary tract obstruction. Early identification of reversible causes of acute oliguria and institution of appropriate therapy are crucial to prevent the development of protracted acute renal failure. Close collaboration between gynaecologists, urologists and radiological services is required to promptly diagnose and treat uterine fibroid-associated AUR, a rare but reversible cause of acute renal failure.
Clinical and experimental obstetrics & gynecology 02/2009; 36(1):62-3. · 0.43 Impact Factor
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Journal of obstetrics and gynaecology: the journal of the Institute of Obstetrics and Gynaecology 06/2008; 28(4):441-3. · 0.43 Impact Factor
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ABSTRACT: We report a case of diamniotic, dichorionic pregnancy presented at 24 weeks with premature rupture of the first amnionic sac. Seven days later, premature labour and delivery of the first twin took place, with unfortunate outcome. The second twin was left in utero. The management included combination of tocolytics, antibiotics and cervical cerclage. Caesarean section was performed 48 days later, at 32 weeks and we delivered a live male infant, successfully.
Hippokratia 02/2007; 11(1):44-6. · 0.52 Impact Factor
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ABSTRACT: During the third stage of labour there are a lot of causes of significant hemorrhage. The commonest causes of acute hemorrhage are the uterine atony, the retained placenta, the lower tract lacerations, uterine rupture, placenta accreta, hereditary coagulopathy. Also, there could be significant bleeding, during caesarian section, usually at the time of removal of the placenta in cases of low lying placenta or placenta previa. A lot of times we have to confront serious hemorrhages in gynecological procedures like hysterectomies in cases of cervical, uterine or ovarian cancers. In order to deal with these problems successfully, general and specific measures are being taken. In cases of atonic uterus when all the other methods are unsuccessful we have to proceed to ligation of the internal iliac artery or even hysterectomy. Material-Methods: We have tried to use the hemostatic type I collagen in obstetrical and gynecological cases in order to control the bleeding. We have used the collagen type I totally in 8 cases. Five of them were cases of atonic uterus after normal delivery or caesarian section and three of them were gynecological cases of uterine fibroids and ovarian cancer. RESULTS: By placing the collagen type I over the bleeding surfaces we have realized that in a very short period of time, there has been satisfactory control of the bleeding and immediate clinical improvement of the patient. In four out of five obstetrical cases that we have used the type I collagen, we have managed to avoid the hysterectomy.
Hippokratia 01/2006; 10(4):182-4. · 0.52 Impact Factor
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ABSTRACT: The empty follicle syndrome (EFS) is characterized by the lack of retrieved oocytes from follicles after ovulation induction and apparently normal follicular development for in vitro fertilization, despite repeated aspiration and flushing. The underlying mechanism of the EFS remains hypothetical. Some Authors have suggested that it is related to the "cause" leading to female infertility, whereas others have pointed to the alternative suggestion that it might reflect dysfunctional folliculogenesis, with early oocyte atresia and apparently normal hormonal response. Moreover, some Authors believe that the EFS does not exist, and that the oocyte retrieval failure is a pharmacological fault. The risk of recurrence is higher as the age of the patients increases. The EFS cannot be predicted by the pattern of ovarian response to stimulation either sonographically or hormonally. Consequently, the diagnosis of EFS is retrospective. Whatever the underlying cause of an EFS cycle, patients with an EFS cycle should be counselled regarding the possibility of recurrence of such an event in future cycles.
Journal of endocrinological investigation 03/2004; 27(2):187-91. · 1.57 Impact Factor
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Journal of Obstetrics and Gynaecology 10/2003; 23(5):572-3. · 0.54 Impact Factor
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ABSTRACT: The aim of this study was to evaluate serum leptin levels in women with polycystic ovary syndrome (PCOS) and in controls with normal or abnormal body mass index (BMI), since the literature data are contradictory. The study population comprised 34 women with PCOS and 30 regularly cycling women, with normal or abnormal BMI. PCOS was defined by clinical, ultrasonographic, and hormonal findings. The women were divided into four groups according to the diagnosis of PCOS and their BMI values. In all women serum levels of FSH, LH, prolactin, testosterone, androstenedione, DHEA-S, 17alpha-OH progesterone, SHBG, insulin, glucose and leptin were determined. It was found that: (a) there was a significant interaction between BMI and PCOS in increasing serum leptin levels; (b) the dominant factor for serum leptin levels in women of all Groups was BMI, followed by insulin; (c) once we corrected for BMI, it was found that there was a significant correlation between serum leptin levels and insulin values, as well as between serum leptin levels and testosterone concentrations; and (d) the QUICKI IR formula presented the most significant correlation with serum leptin levels than the other measures of insulin sensitivity. Our results showed that serum leptin levels in a subgroup of overweight women with PCOS and insulin resistance were higher than those expected for their BMI, and therefore leptin might interfere in the pathogenesis of this syndrome.
Clinical and experimental obstetrics & gynecology 02/2003; 30(4):207-10. · 0.43 Impact Factor
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ABSTRACT: The aim of this study was to monitor serum leptin concentrations after altering the levels of testosterone, by intramuscular administration of human chorionic gonadotropin (hCG), in eugonadal men. A 7-day monitoring of hCG, testosterone and leptin levels was performed after intramuscular administration of a dose of 5000 IU hCG in these men. Thirty fertile men aged 23-38 years were studied. In addition, 30 women aged 18-34 years with normal ovulatory cycles were studied, to verify reports of sexual dimorphism in serum leptin levels. These 60 individuals were divided into four groups, according to their sex and body mass index (BMI) values. In men, blood samples were collected at 09.00, after an overnight fast, for the determination of hCG, testosterone and leptin levels, and, immediately thereafter, a dose of 5000 IU hCG was administered intramuscularly. Further blood samples were collected at 24-h intervals for a period of 7 days for determination of the same hormones. In women, blood samples were collected only once, at 09.00, after an overnight fast between the 3rd and the 6th day of the menstrual cycle, for determination of serum estradiol and leptin levels. Our results showed that the mean value of leptin in thin men and women was significantly lower than that in obese men and women, respectively. The mean value of leptin in thin women was significantly higher than that in obese men. Serum leptin concentrations decreased significantly, 168 h after short-term hCG administration. There was a significant positive correlation between BMI values and serum leptin concentrations, in both men and women. Our results support the view that hCG administration in eugonadal men does not influence serum leptin levels. Moreover, a short-term increase of serum testosterone levels, after one dose of hCG, is not sufficient to affect and modify leptin secretion mechanisms in vivo.
Gynecological Endocrinology 03/2002; 16(1):75-81. · 1.58 Impact Factor
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ABSTRACT: The management of postmenopausal women has become a major focus for the medical profession. The menopause era should progress from a period of "chaos" to an orderly understanding of the many issues related to the menopause and hormone replacement therapy (HRT). Although HRT has beneficial clinical effect and positive benefit/risk ratio, understanding of the side effects and weight gain, and, especially, a fear of cancer limit compliance. New data from long-term, controlled, prospective studies on the effects of different HRT schedules on cancer, cardiovascular disease and osteoporotic fracture risk are needed. HRT should be considered either as for prevention or for individualized care since women experience menopause as individuals, care should be taken not to make inappropriate generalizations. The priority should be the administration of appropriate medication to women with the best result in order to improve health care and quality of life. New therapeutic options will offer substantial medical advancement for the treatment of postmenopausal women.
European Journal of Obstetrics & Gynecology and Reproductive Biology 01/2002; 99(2):154-64. · 1.97 Impact Factor
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ABSTRACT: To investigate the frequency of headless, or unnucleated, spermatozoa, determine its percentage and evaluate its possible correlation with other semen parameters.
Semen specimens from 94 subfertile men, aged 24-53 years (mean +/- SD 33.3 +/- 6.3) and from 52 fertile men, aged 24-44 (33.3 +/- 4.1) were studied. Two semen specimens were examined from each individual, with a six- to eight-week interval. Sperm morphology was evaluated from Papanicolaou-stained smears, and the classification of abnormal sperm forms was made according to the guidelines of the World Health Organization.
The percentage of headless spermatozoa was 9.0% +/- 8.8 in subfertile and 2.7% +/- 3.1 in fertile men. Headless spermatozoa existed in semen specimens from 90% of subfertile and 70% of fertile men. Of subfertile men, 23.4% had headless spermatozoa at a higher percentage than the highest normal limit found in sperm smears from fertile men.
In some cases of subfertile men with a high percentage of headless spermatozoa, their infertility can be attributed to the cause of this morphological abnormality. Moreover, tails but not heads were found in semen specimens from subfertile and fertile men.
The Journal of reproductive medicine 12/2001; 46(11):947-50. · 0.87 Impact Factor
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ABSTRACT: The aim of this study was to estimate the percentage of women who asked for pregnancy termination as an alternative to using family planning. The reasons given for requesting termination were documented and evaluated. During a 4-year period, 663 women came to the Family Planning Department. Four hundred and ninety-one (77.6%) were pregnant, in the first trimester of pregnancy and requesting an induced abortion. Consultation and counselling resulted in a 25% decrease in the number who finally had their pregnancies terminated. The low socio-economic status of most of the women and the negative attitude of our society towards an unmarried mother remain the main reasons for a high rate of therapeutic abortion.
Journal of Obstetrics and Gynaecology 11/2000; 20(6):618-9. · 0.54 Impact Factor
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Supplement to International journal of gynecology and obstetrics 01/2000;
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ABSTRACT: Although male subfertility has been reported in a variety of malignancies, most notably testicular carcinoma, the literature that refers to semen quality in males with testicular seminoma is very limited. This study was designed to evaluate the effect of testicular seminoma in semen quality and especially in its three main parameters. Semen specimens from 12 men, aged 24-38 years, with testicular seminoma before they underwent orchidectomy and adjuvant radiotherapy to the ipsilateral para-aortic and pelvic lymph nodes, and from 60 fertile men, aged 24-44 years, were studied. The results support the view that testicular seminoma exerts a deleterious effect on spermatogenesis and consequently to the three main parameters of the semen. The mechanism though of the deleterious effect of seminoma on spermatogenesis remains unclear.
European Journal of Obstetrics & Gynecology and Reproductive Biology 05/1999; 83(2):219-22. · 1.97 Impact Factor
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ABSTRACT: Headless or unucleated spermatozoa were evaluated in semen specimens of 52 fertile men in order to investigate the frequency and the percentage of this morphological abnormality and to estimate the probable correlation of the abnormality with other semen parameters, since there are no available data. The only sperm parameter which correlated with the number of headless spermatozoa was the number of micro round-headed spermatozoa (r= + 0.4432, P<0.001). It is concluded that the high frequency of headless or unucleated spermatozoa in the semen specimens of fertile men, albeit in low percentage, does not seem to have any biological significance. Moreover headless and round-headed spermatozoa could be the outcome of the same pathogenetic mechanism.
Journal of Obstetrics and Gynaecology 11/1998; 18(6):581-3. · 0.54 Impact Factor
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ABSTRACT: Twenty patients with polycystic ovarian syndrome and with or without insulin resistance, and 20 healthy women (controls) underwent an oral glucose tolerance test, which resulted in a short duration but significant increase of serum insulin levels. Serum testosterone, androstenedione and dehydroepiandrosterone sulfate levels were estimated before and 180 minutes after administration of 75 gr. dextrose. Our results, three hours after dextrose administration, showed that: (1) serum testosterone levels decreased significantly, (2) serum androstenedione levels decreased but not significantly, and (3) serum dehydroepiandrosterone sulfate levels were not altered. The observation of decreased ovarian androgen levels after induced hyperinsulinemia is very interesting, the explanation, however, is quite difficult. This unexpected ovarian androgen response needs further investigation.
Clinical and experimental obstetrics & gynecology 02/1997; 24(2):88-91. · 0.43 Impact Factor
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ABSTRACT: In order to assess if an oral glucose load has any effect on serum prolactin levels in patients with polycystic ovary syndrome (PCOS), an oral glucose tolerance test (OGTT) was performed in 30 patients with PCOS and 20 controls, with normal or abnormal body mass index (BMI). OGTT resulted in decreased prolactin levels, being significant only in patients with PCOS and in controls with normal BMI. Our results show that obesity is an important inhibiting factor of serum prolactin level suppression which occurs with a mild suppressive test, as the OGTT; however, hyperandrogenemia may also play an inhibiting role in serum prolactin level suppression.
Gynecologic and Obstetric Investigation 02/1997; 44(2):120-3. · 1.28 Impact Factor
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Journal of Obstetrics and Gynaecology 01/1997; 17(1):62-3. · 0.54 Impact Factor
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ABSTRACT: This study was designed to explore the association of insulin resistance and acanthosis nigricans (AN) in patients with polycystic ovary syndrome (PCOS). Fifty women, 18-37 years old, were included in the study, and divided into five groups consisting of: (I) 10 women with PCOS, abnormal body mass index (BMI) and AN; (II) 10 women with PCOS and abnormal BMI, but without AN; (III) 10 women with PCOS, normal BMI, and no AN; (IV) 10 women with abnormal BMI, but without PCOS or AN; and (V) 10 healthy women with normal BMI. Measurement of fasting glucose and insulin levels before and after oral glucose challenge was performed. Fasting serum insulin levels were found to be significantly lower in groups III, IV and V than in groups I and II, with no significant difference between groups I and II, or between groups III, IV and V. Total insulin response following administration of glucose did not differ significantly between the groups. These findings support the view that obese PCOS patients with AN do not have significantly higher insulin resistance than obese patients without AN. Insulin resistance is a necessary, but not the only, factor leading to the development of AN in patients with PCOS. Other factors should also be considered in the pathogenesis of this cutaneous reaction.
British Journal of Dermatology 07/1995; 132(6):936-41. · 3.67 Impact Factor
