Publications (24)37.28 Total impact
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Article: Complications in the Treatment of Intracranial Aneurysms with Silk Stents: an Analysis of 30 Consecutive Patients.
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ABSTRACT: Flow-diverting stents (Silk and PED) have radically changed the approach to intracranial aneurysm treatment from the use of endosaccular materials to use of an extraaneurysmal endoluminal device. However, much debate surrounds the most appropriate indications for the use of FD stents and the problems raised by several possible complications.We analysed our technical difficulties and the early (less than ten days after treatment) and late complications encountered in 30 aneurysms treated comprising 13 giant lesions, 12 large, five with maximum diameters <10 mm and one blister-like aneurysm. In our experience the primary indications for the use of FD stents can be the symptomatic intracavernous giant aneurysms. Although the extracavernous carotid siphon aneurysms have major risk of bleeding, FD stents are indicated clearly explaining the risks to the patient in case of severe mass effect. There is a very complex assessment for aneurysms of the vertebrobasilar circulation.Interventional Neuroradiology 12/2012; 18(4):413-425. · 0.56 Impact Factor -
Article: Treatment of intracranial aneurysms using flow-diverting silk stents (BALT): a single centre experience.
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ABSTRACT: The Silk stent (Balt, Montmorency, France) is a retractable device designed to achieve curative reconstruction of the parent artery associated with an intracranial aneurysm. We present our initial experience with the Silk flow-diverting stent in the management and follow-up of 25 patients presenting with intracranial aneurysms.Twenty-five patients (age range, 34-81 years; 24 female) were treated with the Silk flow-diverting device. Aneurysms ranged in size from small (5), large (10) and giant (10) and included wide-necked aneurysms, multiple, nonsaccular, and recurrent intracranial aneurysms. Nine aneurysms were treated for headache, 14 for mass effect. None presented with haemorrhage. All patients were pretreated with dual antiplatelet medications for at least 72 hours before surgery and continued taking both agents for at least three months after treatment. A total of 25 Silk stents were used. Control MR angiography and/or CT angiography was typically performed prior to discharge and at one, three, six and 12 months post treatment. A follow-up digital subtraction angiogram was performed between six and 19 months post treatment.Complete angiographic occlusion or subtotal occlusion was achieved in 15 patients in a time frame from three days to 12 months. Three deaths and one major complication were encountered during the study period. Two patients, all with cavernous giant aneurysms, experienced transient exacerbations of preexisting cranial neuropathies and headache after the Silk treatment. Both were treated with corticosteroids, and symptoms resolved completely within a month.In our experience the Silk stent has proven to be a valuable tool in the endovascular treatment of intracranial giant partially thrombosed aneurysms and aneurysms of the internal carotid artery cavernous segment presenting with mass effect. The time of complete occlusion of the aneurysms and the risk of the bleeding is currently not predictable.Interventional Neuroradiology 09/2011; 17(3):306-15. · 0.56 Impact Factor -
Article: Slowly progressive aphemia: a neuropsychological, conventional, and functional MRI study.
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ABSTRACT: Slowly progressive aphemia (SPA) is a rare focal degenerative disorder characterized by severe dysarthria, frequent orofacial apraxia, dysprosody, phonetic and phonemic errors without global cognitive deterioration for many years. This condition is caused by a degeneration of anterior frontal lobe regions, mainly of the left frontal operculum. We report a case of SPA with a course of 8 years, evaluated by repeated neuropsychological, conventional, and functional MRI examinations. In our case, neuropsychological examinations showed a progressive impairment of speech articulation including dysprosody, phonetic and phonemic errors, and slight writing errors. No global cognitive deterioration was detected and the patient is still completely autonomous. Morphological and functional investigations showed, respectively, a progressive atrophy and progressive impairment of the left frontal region, confirming the role of the opercular region in determining this rare syndrome. During verbal task generation as the cortical activation of this region gradually decreased, the language articulation worsened.Neurological Sciences 05/2011; 32(6):1179-86. · 1.32 Impact Factor -
Article: Quantitative cervical spinal cord 3T proton MR spectroscopy in multiple sclerosis.
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ABSTRACT: Brain proton MR spectroscopy ((1)H-MR spectroscopy) is a useful technique for evaluating neuronal/axonal damage and demyelization in multiple sclerosis (MS). Because MS disability is frequently related to spinal cord lesions, potential markers for MS stage differentiation and severity would require in vivo quantification of spinal integrity. However, few spectroscopy studies have investigated cervical disease due to technical difficulties. The present study used 3T (1)H-MR spectroscopy to measure the main metabolites in cervical spinal cord plaques of a group in patients with relapsing-remitting MS (RRMS) and compared them with metabolite measurements in healthy volunteers. A (1)H-MR point-resolved spectroscopy sequence volume of interest was prescribed along the main axis of the cord between C2 and C3 levels on a plaque in a group of 15 patients with RRMS for a total acquisition time of approximately 14 minutes. MR spectroscopy data were analyzed by the user-independent fitting routine LCModel, and relative metabolite concentrations were expressed by the absolute concentration ratios. A Student t test was used to evaluate the difference compared with the healthy metabolite content previously published. We found a significant decrease of total N-acetylaspartate/choline and an increase in choline/creatine and myo-inositol/creatine content on MS plaques in comparison with healthy cervical spine tissue. In vivo (1)H-MR spectroscopy, if confirmed by other similar studies, should be as reliable for clinical studies as it is in brain imaging. Moreover, (1)H-MR spectroscopy allows examination of spinal cord integrity at a biochemical level and may be sensitive to subtle changes occurring during the course of MS disease.American Journal of Neuroradiology 10/2009; 31(1):180-4. · 2.93 Impact Factor -
Article: Metabolic findings on 3T 1H-MR spectroscopy in peritumoral brain edema.
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ABSTRACT: Little is known about the metabolic properties of brain edema associated with tumors. This work was conducted on the basis of the assumption that, in the presence of intra-axial and extra-axial brain tumors, the white matter involved by the edema is a site of metabolic change that involves the structure of the myelin sheath. Thirteen patients comprised our cohort affected by intra-axial and extra-axial cerebral tumors with a peritumoral T2-weighted MR signal hyperintensity as a result of edema, where MR spectroscopy showed no increase in choline-containing compounds. Measurements on proton MR spectroscopy (1H-MR spectroscopy) were performed with a 3T whole-body scanner with use of a point-resolved spectroscopy sequence for localization (TR, 2000 ms; TE, 35 ms), and the metabolites were quantified with the SAGE method. Peak intensities of the main metabolites were expressed as ratios of one another and were compared with values obtained in the white matter of the left frontal region in a control group of 16 healthy volunteers. Choline-to-creatine (Cho/Cr) and myo-inositol-to-creatine (mIns/Cr) signal intensity ratios were normal in all patients. N-acetylaspartate-to-creatine (NAA/Cr) and N-acetylaspartate-to-choline (NAA/Cho) ratios decreased in 4 patients. Glutamate plus glutamine-to-creatine (Glx/Cr) was increased in 10 patients. A resonance peak at 3.44 ppm, strongly suggesting the presence of glucose, was detected in all but 1 patient. Lactate was detected in 12 patients and lipids in 5. Moreover, the resonances that pertained to the aliphatic amino acids valine, leucine, and isoleucine were present in 12 patients. Our findings on MR spectroscopy confirmed the hypothesis that in the edema surrounding brain tumors, an energy-linked metabolic alteration was associated with injury to the myelin sheath.American Journal of Neuroradiology 09/2007; 28(7):1287-91. · 2.93 Impact Factor -
Article: CE-MR Angiography at 3.0 T Magnetic Field in the Study of Spinal Dural Arteriovenous Fistula. Preliminary Results.
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ABSTRACT: We report technical data and results in eight patients studied with spinal contrast-enhanced MR angiography (CE-MRA). We used a 3.0 Tesla device, dedicated phased array coil and time resolved imaging of contrast kinetics (TRICKS) sequences to visualize the feeder vessels in patients with vascular malformations. TRICKS is a method of 3D CE-MRA providing temporal information. Thanks to its high temporal and spatial resolution and high signal/noise ratio the TRICKS optimized sequence at 3.0 T yielded very encouraging results in disclosing the origin of arteriovenous malformations.Interventional Neuroradiology 03/2007; 13(1):13-8. · 0.56 Impact Factor -
Chapter: MRI in Haemorrhage
12/2005: pages 83-92; -
Chapter: Use of fMRI Activation Paradigms: A Presurgical Tool for Mapping Brain Function
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ABSTRACT: fMRI has proved to be a reliable, safe, reproducible method with which to presurgically define eloquent areas. This technique gives us the opportunity to know in advance the actual situation of a lesion so that the surgeonsmay plan their approach strategy. This technique also allows the establishment of a presurgical evaluation of risk and enables the patient to be fully aware at the moment of informed consent. Despite the increase in its clinical applications, fMRI is still underused in the clinical field and should be performed almost routinely before surgery.12/2005: pages 221-234; -
Article: Three-Year Retrospective Study of Complications Arising during Interventional Procedures.
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ABSTRACT: This retrospective study aimed to assess the percentage of complications arising in our daily practice of interventional procedures, comparing our findings with those of leading international reference centers and accepted guidelines for endovascular treatment. During the threeyear period considered (2000-2002), we performed 246 interventional procedures, divided into seven different pathological conditions: aneurysms, brain AVMs dural and carotid cavernous fistulae, spine-spinal cord tumours, headneck tumours, carotid stenosis and thrombolysis. Aneurysmal disease accounted for 45% of all endovascular procedures. In conclusion, four periprocedural complications arose in the course of 246 procedures resulting in one death and three cases of permanent neurological deficit (2%).Interventional Neuroradiology 12/2003; 9(4):395-406. · 0.56 Impact Factor -
Article: Neuroradiology of spine degenerative diseases.
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ABSTRACT: Degenerative disease of the spine is one of the most common clinical entities and affects the intervertebral discs, including opposing vertebral endplates, the intervertebral posterior joints and the ligaments. The most severe primary spinal degenerative changes are found in the lower cervical and lumbar spine regions. The spine contains three different types of joints, each of which presents its own pattern of degenerative disease: (i) cartilaginous joints, represented by the intervertebral disc or, more specifically, the functional unit defined as the 'vertebro-disc connection'; (ii) synovial joints, represented by the posterior intervertebral joints, sacro-iliac and costovertebral joints; (iii) fibrous joints, mainly found in the principal ligaments such as the posterior longitudinal ligament and the yellow ligaments. With regard to radicular pain, root compression alone does not fully account for root pain following disc-root conflict, but it is, nevertheless, considered to be the main cause of pain. We will try to explain that the origin of pain is multi-factorial and that inflammation probably predominates over merely mechanical mechanisms. To conclude, we will consider whether vertebral arthrosis can be construed as the body's decision to favour the spine's static function over its dynamic role when joint 'hypermobility' linked to chronic load in old age could cause severe structural damage to the bony vertebral structures. This hypothesis should also embrace a further concept: ageing of the spine is not merelychronological. Themostaccurate interpretation tha tcan account for similar degenerative phenomena encountered in the young is that of abnormal static and dynamic loading stress.Bailliè re s Best Practice and Research in Clinical Rheumatology 02/2002; 16(1):59-87. · 2.65 Impact Factor -
Article: Endovascular treatment of vertebrobasilar aneurysms. Occlusion of the vertebral arteries and flow inversion.
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ABSTRACT: In posterior circulation aneurysms, GDC endosaccular occlusion is the treatment of choice, when indicated. This report assessed anatomical, morphological and clinical criteria in the choice of vertebral or basilar artery occlusion in posterior circulation aneurysms, when GDC endosaccular treatment, with or without the "remodelling technique", is not indicated, as in giant or wide-neck aneurysms. Over five years we observed eleven patients harboring posterior circulation aneurysms with no indication for treatment with GDC, or only vertebral occlusion. In our experience, the endovascular occlusion of a single or both vertebral arteries or basilar artery, following a detailed anatomical and clinical assessment, has proved a good, reliable treatment in large or giant vertebrobasilar aneurysms or those without a neck.Interventional Neuroradiology 11/1999; 5 Suppl 1:71-8. · 0.56 Impact Factor -
Article: Interobserver variability in CT assessment of brain atrophy.
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ABSTRACT: To assess interobserver variability in estimation of brain atrophy based on CT, four neuroradiologists examined CT brain images of 150 consecutive patients without focal lesions. An independent neuroradiologist made the following quantitative measurements: frontal horn index, subarachnoid space area and the ratio between subarachnoid space area and inner skull space area. Level of agreement was fair for the presence (k = 0.24), slight for the degree (mild, moderate, severe) (k = 0.24) and moderate for the type (cortical, subcortical, mixed) of atrophy (k = 0.59). There was a highly significant correlation between the number of observers agreeing and quantitative measurements. We concluded that neuroradiologists' subjective estimation of brain atrophy alone is not reliable. Quantitative measurements would be needed in cases where the presence of brain atrophy might determine clinical decisions.Neuroradiology 02/1994; 36(1):17-9. · 2.82 Impact Factor -
Article: Leukoaraiosis and dementia.
Stroke 04/1990; 21(3):502. · 5.73 Impact Factor -
Article: Normal muscle mitochondrial function in Ramsay-Hunt syndrome.
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ABSTRACT: Mitochondrial encephalomyopathies may display clinical features similar to Ramsay-Hunt syndrome (RHS). We studied muscles mitochondrial function in 2 patients with RHS. Histochemical and ultrastructural studies of muscle biopsies and biochemical analysis of muscle mitochondrial enzymes were normal. There is no evidence for a disturbance of muscle mitochondrial function in RHS.The Italian Journal of Neurological Sciences 03/1989; 10(1):73-5. -
Article: Binswanger's disease: a review of the literature and a personal contribution.
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ABSTRACT: Binswanger's disease is the name which has been given to a form of subcortical vascular dementia. These patients have a particular clinical profile which progressively includes strokes, gait disorder, pseudobulbar signs and cognitive impairment suggesting dysfunction of the prefrontal cortex. The radiological pattern of hypodensity of the white matter on CT scan (or an increased MRI signal), albeit much debated, seems to be more closely associated with hypertension, previous strokes and neuropsychological defects. Binswanger's disease probably represents the end stage of a pathological process in which hypertensive arteriolopathy, demyelination of the centra semiovale and deep infarcts all play a role.European Neurology 02/1989; 29 Suppl 2:20-2. · 1.81 Impact Factor -
Article: Episodic cluster headache: short and long term results of prophylactic treatment.
Headache The Journal of Head and Face Pain 09/1988; 28(7):475-6. · 2.52 Impact Factor -
Article: Nimodipine in episodic cluster headache: results and methodological considerations.
Headache The Journal of Head and Face Pain 08/1987; 27(7):397-9. · 2.52 Impact Factor -
Article: The natural history of episodic cluster headache.
Headache The Journal of Head and Face Pain 08/1987; 27(7):370-1. · 2.52 Impact Factor -
Article: Binswanger’s Disease: A Review of the Literature and a Personal Contribution
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ABSTRACT: Binswanger’s disease is the name which has been given to a form of subcortical vascular dementia. These patients have a particular clinical profile which progressively includes strokes, gait disorder, pseudobulbar signs and cognitive impairment suggesting dysfunction of the prefrontal cortex. The radiological pattern of hypodensity of the white matter on CT scan (or an increased MRI signal), albeit much debated, seems to be more closely associated with hypertension, previous strokes and neuropsychological defects. Binswanger’s disease probably represents the end stage of a pathological process in which hypertensive arteriolopathy, demyelination of the centra semiovale and deep infarcts all play a role.European Neurology. 08/1970; 29(2):20-22. -
Article: Familial hypokalemic paralysis: a case study.
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ABSTRACT: A case of hypokalemic periodic paralysis, is reported, characterized by a positive family history and by repeated attacks of transient motor weakness since the age of 14 involving one all limbs. An induction test under ECG and EMG monitoring, carried out by infusing glucose and insulin when the patient was symptom-free, provoked motor paresis comparable to the spontaneous attacks and confirmed the diagnosis.Rivista di patologia nervosa e mentale 105(3):113-8.
Top co-authors
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Institutions
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2007–2012
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University of Bologna
- Department of Biomedical Science and Neuromotor Sciences DIBINEM
Bologna, Emilia-Romagna, Italy
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2002–2003
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Azienda Unità Sanitaria Locale di Bologna
Bologna, Emilia-Romagna, Italy
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