Vedat Davutoglu

University of Gaziantep, Ayıntap, Gaziantep, Turkey

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Publications (249)521.11 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: The aim of this study is to investigate possible factors influencing glomerular filtration rate (GFR) in obstructive sleep apnea (OSA). Data of OSA patients admitted to Gaziantep University sleep clinic from January 2005 to January 2010 were retrospectively evaluated. GFR is calculated with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Patients younger than 18 years old were excluded. The mean age of OSA (n = 634) and control group (n = 62) were 51.13 ± 11.61 and 50.69 ± 13.88 years, respectively (p = 0.81). The mean estimated GFR (eGFR) was 90.73 ± 19.59 ml/min/1.73 m(2) in OSA patients and 94.14 ± 18.81 ml/min/1.73 m(2) in control subjects (p = 0.19). GFR was 84.25 ± 20.87 ml/min/1.73 m(2) in patients with left ventricular hypertrophy (LVH) while it was 93.94 ± 18.44 ml/min/1.73 m(2) in patients without LVH (p = 0.00). GFR of male subjects was 92.1 ± 19.23 in OSA and 95.84 ± 20.08 ml/min/1.73 m(2) in controls (p = 0.33). GFR of female and male patients in the OSA were 87.45 ± 20.10 and 92.91 ± 18.02 ml/min/1.73 m(2), respectively (p = 0.13). Serum creatinine was higher in OSA patients compared to controls (p = 0.01). GFR was 92.30 ± 19.27 in male and 88.33 ± 19.84 ml/min/1.73 m(2) in female subjects (p = 0.01). GFR was 84.86 ± 19.95 in hypertensive patients while it was 95.11 ± 18.20 ml/min/1.73 m(2) in normotensive subjects (p = 0.00). GFR was 89.30 ± 19.96 in patients with metabolic syndrome (MetS) and it was 93.46 ± 18.68 ml/min/1.73 m(2) in patients without MetS (p = 0.00). GFR values were lower in sleep apneic patients with MetS as well as in patients with hypertension and LVH.
    Sleep And Breathing 06/2015; DOI:10.1007/s11325-015-1204-0 · 2.87 Impact Factor
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    I Sari · K Aykent · V Davutoglu · M Yuce · O Ozer · M Kaplan · H Alici · S Ercan · M Sunbul · K Tigen
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    ABSTRACT: We aimed to investigate whether there is an association between male pattern baldness and angiographic coronary artery disease (CAD) severity and collateral development, which has not been reported previously. Coronary arteriograms, CAD risk factors, lipid parameters and presence and severity of baldness in 511 male patients were prospectively evaluated. Baldness was classified into five groups. Severity of CAD was evaluated with the Gensini scoring system and collateral development with Rentrop scores. Although subjects with a higher Gensini score had more frequent and severe baldness, they were older than the group with lower Gensini scores. Bald patients had a higher Gensini score when compared with their non-bald counterparts. In univariate analysis, age more than 60, body mass index more than 30, smoking and baldness were predictors of high Gensini scores. In multivariate analysis, only age more than 60, body mass index more than 30 and smoking were independent predictors of a high Gensini score. There were no differences in terms of presence and severity of baldness in subjects with and without adequate collateral development. There was no relation between presence, severity and age of occurrence of male pattern baldness and Gensini and Rentrop scores, which are important measures of presence and severity of CAD.
    Netherlands heart journal: monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation 05/2015; 23(5):265-274. DOI:10.1007/s12471-015-0688-3 · 2.26 Impact Factor
  • International journal of cardiology 03/2015; 186:109-110. DOI:10.1016/j.ijcard.2015.03.224 · 6.18 Impact Factor
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    ABSTRACT: Atrial fibrillation (AF) is one of the most common causes of preventable ischemic stroke and is related to increased cardiovascular morbidity and mortality. There is a lack of data in Turkey on the use of new oral anticoagulants (NOACs), and time in therapeutic INR range (TTR) in vitamin K antagonist users and AF management modality. In this multi-center trial, we aimed to analyze, follow and evaluate the epidemiological data in non-valvular AF patients. Four thousand one hundred consecutive adult patients from 42 centers with at least one AF attack identified on electrocardiography will be included in the study. Patients with rheumatic mitral valve stenosis and prosthetic valve disease will be excluded from the study. At the end of one year, the patients will be evaluated in terms of major cardiac end points (death, transient ischemic attack, stroke, systemic thromboembolism, major bleeding and hospitalization). First results are expected in June 2015. Data about major cardiovascular end-points will be available in January 2016. The rates and kind of oral anticoagulant use, TTR in vitamin K antagonist users and main management modality applied in non-valvular AF patients will be determined by AFTER-2 study. In addition, the rate of major adverse events (MACEs) and the independent predictors of these MACEs will be detected (AFTER-2 Study ClinicalTrials.gov number, NCT02354456.).
    Turk Kardiyoloji Dernegi arsivi: Turk Kardiyoloji Derneginin yayin organidir 03/2015; 43(2):169-177.
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    ABSTRACT: Background We aimed to analyze ventricular repolarization in neurucardiogenic syncope (NCS) patients by using Tpeak-Tend interval, Tpeak-Tend/QT ratio, Tpeak-Tend/QTc ratio and corrected QT interval (QTc), QT dispersion(QTd), QT index (QTI) and corrected QT interval index (QTcI) and to compare it with the corrected JT dispersion (JTcd), corrected JT (JTc) and the corrected JT interval index (JTcI), by inspecting ventricular activation until termination of repolarization. These parameters are used as an index of potential ventricular arrhythmogenesis.Methods We have studied patients with head-up tilt table test (HUTT) (+) (33 patients; mean age: 28±11 years) and HUTT(–) as control group (33 patients; mean age: 30±11 years). In all patients, Tpeak-Tend interval, Tpeak-Tend/QT ratio, Tpeak-Tend/QTc ratio, QT, QTd, QTI, QTc, QTcI, JTd, JTc, JTcI were measured on ECG.ResultsThe following parameters were statistically significant between groups: QTd (22,72±17,54 msn, 11,21±13,40 msn, P = 0.004), QTc (424,27±33,75 msn; 403,66±38,08 msn, P = 0,023), QTcI (114,09±14, 29%; 106,71±15, 33%, P = 0,047), QTI (100,72±7,19%; 97,14±7,13%, P = 0.046). Furthermore; Tpeak-Tend interval was significantly prolonged in the study group (93,78±20,27 msn; 81,21±11,66 msn, P = 0.003). Tpeak-Tend/QT ratio was significantly higher in the study group (0,24±0,04; 0,22±0,04 msn, P = 0.030). Tpeak-Tend/QTc ratio was significantly higher in the study group (0,22±0,04 msn; 0,20±0,03 msn, P = 0.015). The JTc and JTd were also significantly higher in the study group [(103,00±9, 72%; 95,44±10, 26%, P = 0.003), (27,57±16,01 msn; 10,45±16,08 msn, P <0.001) respectively].Conclusions Electrocardiographic ventricular repolarization parameters including Tpeak-Tend interval, Tpeak-Tend/QT ratio, Tpeak-Tend/QTc ratio, QTc, QTd, QTI, QTcI, JTc, JTd, and JTI are prolonged in NCS.This article is protected by copyright. All rights reserved.
    Pacing and Clinical Electrophysiology 01/2015; 38(5). DOI:10.1111/pace.12599 · 1.25 Impact Factor
  • 12/2014; 5(6):183-187. DOI:10.14740/cr367w
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    ABSTRACT: Objective: It was the aim of this study to investigate the effects of the right lateral decubitus, left lateral decubitus and supine lying position on P-wave dispersion (PWD) in patients with heart failure (HF). Subjects and Methods: Seventeen patients with HF whose ejection fraction was <35% were included in the study. Right lateral decubitus, left lateral decubitus and supine electrocardiogram (ECG) recordings were obtained. The recordings for each of the three positions were taken after the patients had maintained each position for 30 min to ensure a stabilized hemodynamic position. For the baseline recording, in supine position, there was no 30-min waiting period before the ECG. Results: After the right lateral decubitus position, there was a statistically significant reduction in the longest P-wave duration (100.0 ± 14.5 and 84.7 ± 16.2 ms; p = 0.001) and a significant decrease in PWD (41.7 ± 8.0 and 24.1 ± 7.1 ms; p < 0.0001). After the left lateral decubitus position, there was no significant change between the baseline PWD values (41.7 ± 8.0 and 40.2 ± 9.7 ms; p = 0.606). After the supine position, there was no significant change between the baseline PWD values (41.7 ± 8.0 and 39.7 ± 9.4 ms; p = 0.427). Conclusion: Our study revealed that patients' PWDs and maximum P-wave durations were lower in the right lateral decubitus lying position than in other positions. The clinical implication of this study needs to be further explored. © 2014 S. Karger AG, Basel.
    Medical Principles and Practice 09/2014; 23(6). DOI:10.1159/000365510 · 1.11 Impact Factor
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    ABSTRACT: In-stent restonosis is an important limitation for coronary stenting. The cause of in-stent restenosis is neointimal hyperplasia developed from smooth muscle and matrix. We aimed to investigate the association between urotensin II (U-II) and in-stent restenosis after coronary stenting, which causes endothelial and muscle proliferation and accumulation of collagen. Total 153 patient was enrolled to the study who meet criteria for angiographic indication underwent coronary artery angiography. All patients have history undergone for coronary stent implantation 3 to 9 months ago. In-stent restenosis is identified as ≥50% narrowing inside the stent. In-stent restenosis was observed in 73 and remaining of 80 patients revealed no critical lesion in stent on angiographic evaluation. Plasma level measurement of U-II was performed in all subjects. Urotensin II levels were found to be significantly higher in Group I compared to Group II (1.44±0.74 ng/mL and 1.21±0.59 ng/mL, respectively, P=0.03). In a subgroup analysis, U-II levels were significantly higher in group I than group II in patients treated with bare metal stent (BMS) (1.50±0.76 ng/mL and 1.18±0.56 ng/mL, P=0.016); however, there was not significant change in patients treated with drug-eluted stent (1.26±0.64 ng/mL and 1.27±0.63 ng/mL, P=0.9). Multivariate statistical significance: negative correlation was found between in-stent restenosis and renin-angiotensin-system (RAS) blocker usage (P=0.040) and right coronary artery (RCA) lesion interventions (P=0.018). This study revealed high plasma U-II level might be accepted as a risk factors for in-stent restenosis with BMS. In-stent restenosis is less developed after RCA interventions and taking drug of RAS blockages. Our study findings need to be confirmed in further studies.
    06/2014; 62(3):297-303. DOI:10.1016/j.jacc.2013.08.044
  • Hayri Alici · Suleyman Ercan · Demet Alici · Vedat Davutoglu
    Angiology 05/2014; 65(8). DOI:10.1177/0003319714535483 · 2.37 Impact Factor
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    ABSTRACT: Objective: To investigate the effects of recurrent electroconvulsive therapy (ECT) on cardiac function as assessed by echocardiography. Subjects and Methods: Twenty-three patients (11 males and 12 females) with different psychiatric disorders who were apparently free of any cardiovascular disorders and underwent ECT were enrolled in the study. Echocardiographic findings including diastolic mitral inflow and tissue Doppler features were recorded at baseline and at the end of the 7th and last ECT in all patients. Results: The mean age of the patients was 37.95 ± 13.28 years (range 19-71). There was no significant difference in mitral E wave velocities and tissue Doppler E' velocities between the baseline and after the 1st ECT (p = 0.161 and p = 0.083, respectively). The results were similar after the last ECT session (p = 0.463 and p = 0.310, respectively). However, there was a significant increase in transmitral A wave velocity after the 1st and 7th ECT session compared to the values at baseline (p = 0.008 and p = 0.017, respectively). Conclusion: The mitral diastolic inflow A wave velocity increased 20 min after ECT, and this increase persisted after recurrent ECT sessions. This finding could be considered as an indicator of acutely increased sympathetic tone. © 2014 S. Karger AG, Basel.
    Medical Principles and Practice 04/2014; 23(3):225-228. DOI:10.1159/000361030 · 1.11 Impact Factor
  • Muhammed Oylumlu · Adnan Dogan · Suleyman Ercan · Vedat Davutoglu
    Case Reports 04/2014; 2014(apr10 1). DOI:10.1136/bcr-2013-202760
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    ABSTRACT: We aimed to determine long-term prognostic role of echocardiographic and hematologic parameters in heart failure patients complicated with incidental pleural effusion (PE) diagnosed during echocardiographic evaluation. The study was performed by evaluating patient records in which PE was incidentally detected during echocardiographic examination in a tertiary teaching hospital between Jan 2002 and Dec 2012. Total 151 patients with heart failure complicated with PE were analyzed. All patients' mortality data were collected from registry center of Social Insurance Institution which is officially responsible for recording all mortality data in Turkey. Detailed echocardiographic and hematologic parameters including creatinine, uric acid, albumin, sodium, potassium, hemoglobin at the time of hospital admission were analyzed. Data from 151 eligible patients were analyzed. We compared patients who died (n = 51) during follow-up with the survivors (n = 100) in terms of patients' echocardiographic and hematological features. Mean duration of follow-up was 71.5 ± 45.6 months. Fifty-one patients (33.8 %) died during this follow-up period. From all echocardiographic parameters only dilated left atrium (LA) diameter was found to be associated with a poor prognosis (p = 0.034). Low albumin, sodium and hemoglobin levels were associated with poor prognosis (p < 0.001, p = 0.002 and p = 0.007, respectively). We showed that dilated LA, as well as low albumin, low sodium and low hemoglobin levels had a worse prognostic significance than patients with normal LA size, within normal limits of albumin, sodium and hemoglobin levels in patients with heart failure complicated with PE determined incidentally by echocardiography.
    The international journal of cardiovascular imaging 04/2014; 30(5). DOI:10.1007/s10554-014-0421-0 · 2.32 Impact Factor
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    04/2014; 5(1):10-12. DOI:10.5152/jaemcr.2014.50251
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    ABSTRACT: Objective: Cardiac effects of chemotherapy are usually recognized after clinical symptom or sign occurrence in patients with breast cancer. In this study, we aimed to determine the potential subclinical cardiotoxic effects of chemotherapy that were given lower dosage than well known cardiac safety dosage limits in patients with breast cancer during early period. Methods: Fifty-one patients consecutively enrolled to this prospective cohort study. All patients were diagnosed as breast cancer at oncology hospital in University of Gaziantep. Before chemotherapy, all of the patients underwent to detailed ECG and echocardiography (ECHO) examinations. After 6 months, detailed ECG and ECHO examinations were repeated and compared with baseline values. Statistical analysis was performed using Shapiro-Wilk tests, Student t-test and Spearman correlation test. Results: The average age of patients was 51 and one was male. Statistically significant decrease in ejection fraction was found after treatment (62.3%+/- 3.3 and 59.9%+/- 5.9, p=0.002). Evaluation of diastolic parameters; significant increase in the transmitral A flow velocity and significant decrease of E/A ratio were observed on Doppler ECHO analysis (77.4 +/- 19.1 cm/sec versus 86 +/- 18 cm/sec, p<0.001; 1.01 +/- 0.3 versus 0.9 +/- 0.2, p=0.03, respectively). On tissue Doppler analysis we observed that significant reduction in the value of E' and significantly increase E/E' ratio were present (12.5 +/- 3.6 cm/sec versus 10.7 +/- 2.9 cm/sec, p=0.001; 6.6 +/- 2.9 versus 7.7 +/- 3.3, p=0.04, respectively). Conclusion: Chemotherapy has detrimental subclinical effect on both of systolic and diastolic function in early six months period despite the prescription of lower dosage of chemotherapy than well-known cardiac safety dosage limits. Tissue Doppler imaging may be more sensitive than ECG, conventional ECHO and Doppler for determining the subclinical cardiac damage.
    Anadolu kardiyoloji dergisi: AKD = the Anatolian journal of cardiology 04/2014; 15(1). DOI:10.5152/akd.2014.5185 · 0.76 Impact Factor
  • M.M. Sucu · B. Kısacık · V. Davutoğlu · Y. Pehlivan · M. Kaplan
    The American Journal of Cardiology 04/2014; 113(7):S72-S73. DOI:10.1016/j.amjcard.2014.01.197 · 3.43 Impact Factor
  • M.M. Sucu · Ö. Uku · V. Davutoğlu · H.O. Özer
    The American Journal of Cardiology 04/2014; 113(7):S38. DOI:10.1016/j.amjcard.2014.01.108 · 3.43 Impact Factor
  • M.M. Sucu · V. Davutoğlu · H.O. Özer · M. Yüce · S. Ercan
    The American Journal of Cardiology 04/2014; 113(7):S38-S39. DOI:10.1016/j.amjcard.2014.01.109 · 3.43 Impact Factor
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    ABSTRACT: To investigate electrocardiogram changes due to scorpion stings and association between oxidative stress index, body oxidant/antioxidant system and the electrocardiogram changes.
  • M.M. Sucu · V. Davutoğlu
    The American Journal of Cardiology 04/2014; 113(7):S86. DOI:10.1016/j.amjcard.2014.01.229 · 3.43 Impact Factor
  • M. Oylumlu · A. Yıldız · S. Ercan · V. Davutoğlu
    The American Journal of Cardiology 04/2014; 113(7):S92. DOI:10.1016/j.amjcard.2014.01.243 · 3.43 Impact Factor

Publication Stats

843 Citations
521.11 Total Impact Points

Institutions

  • 2002–2015
    • University of Gaziantep
      • Department of Cardiology
      Ayıntap, Gaziantep, Turkey
  • 2013
    • State Hospital of Ercis, Turkey
      Arcis, Van, Turkey
    • Adiyaman University
      Carbanum, Adıyaman, Turkey
    • Marmara University
      • Department of Cardiology
      İstanbul, Istanbul, Turkey
  • 2011–2013
    • Dicle University
      • • Faculty of Medicine
      • • Department of Obstetrics and Gynecology
      • • Department of Cardiology
      Amida, Diyarbakır, Turkey
  • 2005
    • Istanbul University
      • Department of Radiology
      İstanbul, Istanbul, Turkey
  • 2004
    • Abant İzzet Baysal Üniversitesi
      Claudiopolis, Bolu, Turkey