Bin Liu

Sichuan University, Hua-yang, Sichuan, China

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Publications (27)68.77 Total impact

  • Bo Liu · Shanfei Pan · Bin Liu · Wanzhi Chen ·
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    ABSTRACT: A family of 2,9-di(3-R-1H-imidazolium-1-yl)-1,10-phenanthroline iodides and hexafluorophosphates (R = allyl, benzyl, mesityl, picolyl) were synthesized from 2,9-diiodophenanthroline and imidazole or N-substituted imidazoles. Simple reactions of these diimidazolium salts with copper powder at room temperature have afforded a series of multinuclear copper(I)-NHC complexes in good yields. The structures vary depending on the N substituents and counterions. [Cu4(L1)2(MeCN)4](PF6)4 (R = allyl) exhibits a zigzag Cu4 chain with two terminal [Cu(NHC)(MeCN)2] and two internal [Cu(phen)(NHC)] moieties. [Cu3(L2)2](PF6)3 (R = benzyl) contains a strictly linear Cu3 framework with two [Cu(NHC)2] units and a [Cu(phen)2] located at the center. Both complexes [Cu3(L4)2](PF6)3 (R = mesityl) and [Cu3(L5)2](PF6)3 (R = picolyl) consist of a triangular Cu3 core in which two copper(I) ions are surrounded by a phen and a NHC group and the third copper(I) is coordinated by two NHC groups. [Cu3(L3)2](PF6)3 derived from 2,9-di(3-benzyl-1H-benzimidazolium-1-yl)-1,10-phenanthroline hexafluorophosphate can undergo transannulation of the benzimidazolylidene ring giving [Cu2(L3')2](PF6)2. The decomposition process might involve solvent-induced rearrangement of the ligand and hydrolysis of carbene moieties. Treatment of 2,9-di(3-mesityl-1H-benzimidazolium-1-yl)-1,10-phenanthroline iodide with copper powder generated dinuclear complex [Cu2(L4)2][Cu2(μ-I)2I2] (R = mesityl) possessing a macrocyclic cation and [Cu2(μ-I)2I2](2-) anion. Tetranuclear complex [Cu4(L5)2(μ-I)2](CuI3) (R = picolyl) has been obtained from its diimidazolium iodide and copper powder. All Cu(I) complexes have been characterized by X-ray single diffraction analysis, elemental analysis, and NMR spectra. Their redox behavior and fluorescent properties have also been studied.
    Inorganic Chemistry 09/2014; 53(19). DOI:10.1021/ic501544d · 4.76 Impact Factor
  • Qinjuan Wu · Ronghua Zhou · Bin Liu ·
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    ABSTRACT: This paper is aimed to assess the effects of red blood cell (RBC) transfusion on clinical outcomes in cardiac surgery. Trials were identified by computer searches of the Pubmed, MEDLINE, Cochrane Library (Issue 10, 2012), from January 1980 to October 2012. References in identified trials and review articles were checked and experts contacted to identify any additional trials. The homogeneous randomized controlled trials (RCTs) were analyzed with RevMan 5.1 software. Five trials involving a total of 1,203 patients were identified. The results of meta-analyses showed that restrictive transfusion strategies reduced the risk of receiving a RBC transfusion (MD = - 1.46, 95% CI -1.18(-) -1.1) and the volume of RBCs transfusion (RR = 0.69, 95% CI 0.53-0.89). No significant difference was noted between the two strategies in terms of mortality, adverse events and hospital or intensive care length of stay. Based on the results mentioned above, one can draw a conclusion that restrictive transfusion strategies reduced the risk of receiving RBC transfusion and the volume of RBCs transfused. Restrictive transfusion strategies did not appear to impact on the rate of adverse events and hospital or intensive care length of stay, compared to liberal transfusion strategies.
    Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 04/2014; 31(2):319-26.
  • Xiao-Fei Zhong · Da Zhu · Qiang Lu · Bin Liu · Yu-Lan Peng ·
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    ABSTRACT: To investigate the monitoring of renal microcirculation perfusion alteration with contrast-enhanced ultrasound (CEU) during cardiopulmonary bypass (CPB). Renal microcirculation perfusion before and during CPB was assessed by CEU. Time-intensity curve (TIC) were derived from three region of interest (ROI) using QLAB post-analysis software. Parameters such as TIC curve wash in slope (A), area under curve (AUC), peak intensity (DPI) as well as time to peak intensity (TTP) were then calculated. Contrast-enhanced ultrasound showed a significant reduction (or elongation) of perfusion parameter (A, AUC, DPI, TTP) in all three regions (superficial cortex, deep cortex and medulla) during cardiopulmonary bypass in comparison with normal cardiac cycle. Cardiopulmonary bypass (CPB) has a dramatic impact on renal microcirculation in pediatric patients which manifest as global reduction in renal perfusion as well as significant region perfusion difference. Contrast-enhanced ultrasound (CEU) could detect the renal microcirculation alteration during CPB.
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 07/2013; 44(4):646-50.
  • Qian Li · Da Zhu · Jun Zeng · Qi Li · Bin Liu ·
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    ABSTRACT: To evaluate the feasibility of using trans-esophageal echocardiogram (TEE) in dynamic monitoring of renal blood flow (RBF) in pediatric patient undergoing cardiac surgery and to identify potential factors that affect RBF during cardiopulmonary bypass (CPB). Pediatric patient (n = 46) undergoing open surgical repair for congenital heart defect were recruited in this study. Velocity of RBF and renal artery diameter were measured during surgery for calculating volumetric RBF. Cardiopulmonary bypass and hemodynamic data were recorded. RBF was measured successfully in 42 patients (91%). Resistance index of renal artery increased significantly after CPB compared to the preoperative stage. A strong linear correlation was found between perfusion volume (Vmean) and RBF. Non-linear correlation was found between mean arterial pressure and RBF. Perfusion volume is the major factor that determines RBF during CPB. Measuring renal blood flow using TEE in pediatric patient is highly feasible and it can serve as dynamic renal perfusion monitoring during CPB.
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 04/2013; 44(1):89-93.
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    ABSTRACT: : Peripheral nerve injuries that provoke neuropathic pain are associated with chronic inflammation and nervous lesions. The authors hypothesized that chronic neuropathic pain might be caused by chronic inflammation resulting from a nervous autoimmune reaction triggered by nerve injury. : The authors observed chronic inflammation and neuropathic behaviors for up to 12 weeks after nerve injury in T lymphocyte-deficient nude mice and their heterozygous littermates. Lymphocyte proliferation and Schwann cell apoptosis were examined after coculture of each population with various neural tissues from normal rats and those with nerve injury. : Nude mice recovered faster and exhibited less thermal hyperalgesia after nerve injury compared to their heterozygous littermates. A large number of IL-17 cells indicative of lymphocyte activation were found in the injured sciatic nerve and spinal cord (L4-6) of heterozygous littermates, but far fewer of these populations were found in nude mice. In vitro lymphocyte proliferation was enhanced after coculture with nerve tissues from normal rats compared to nerve tissue-free phosphate-buffered saline controls. In particular, coculture with sciatic nerve tissue enhanced proliferation by 80%, dorsal root ganglion by 46%, and spinal cord by 14%. Moreover, neural tissues from rats with nerve injury markedly increased the lymphocyte proliferation compared to coculture with tissues from corresponding normal rats. Schwann cell apoptosis was triggered in vitro when cocultured with lymphocytes from neuropathic rats. : Our study suggests that chronic neuropathic pain might be caused by chronic inflammation resulting from a nervous autoimmune reaction triggered by nerve injury.
    Anesthesiology 02/2013; 118(2):416-29. DOI:10.1097/ALN.0b013e31827d4b82 · 5.88 Impact Factor
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    ABSTRACT: We used 3-dimensional computed tomographic images to create a disease-based transesophageal echocardiographic simulation system for complex congenital heart defects. We enrolled 7 pediatric patients with complex congenital heart defects in this proof-of-concept study. Preoperative computed tomographic images and intraoperative transesophageal echocardiographic images were acquired for all patients. Two- and 3-dimensional computed tomographic cross-sectional images were created to simulate the process of transesophageal echocardiographic image acquisition. Computed tomographic images simulating the midesophageal 4- and 5-chamber views, aortic valve short-axis views, long-axis views, and ascending aortic short-axis views were created to correspond with the actual transesophageal echocardiographic images from each patient. Four reviewers then evaluated the image quality of the computed tomographic images, the agreement between the echocardiographic and tomographic images, and the ability of the 3-dimensional computed tomographic full-volume and cross-sectional images to yield the spatial and temporal congruence of transesophageal echocardiograms. In most of the patients, computed tomography yielded images of good-to-excellent quality. Strong agreement was noted between the computed tomographic and transesophageal echocardiographic images acquired in the same patients. The ability of 3-dimensional computed tomography to yield the spatial and temporal congruence of transesophageal echocardiography in selected planes was also good to excellent. We found that 3-dimensional computed tomographic images can simulate the process of transesophageal echocardiography in acquiring the echocardiographic image clearly. This imaging method has the potential to be applied successfully to a disease-based transesophageal echocardiographic simulation system.
    Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital 01/2013; 40(3):250-5. · 0.65 Impact Factor
  • Qian Li · Chunwei Lian · Ronghua Zhou · Tao Li · Xujin Xiang · Bin Liu ·
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    ABSTRACT: Background: The noble gas anaesthetic, xenon has previously been shown to protect the adult myocardium from ischaemia/reperfusion (I/R) injury, however its effect on immature myocardium is unclear. The aim of this study was to investigate the effect of xenon on the isolated immature heart. Methods: Isolated, immature (2-3weeks old) New Zealand rabbit hearts were perfused with Krebs-Henseleit buffer via Langendorff-mode. After 20min of baseline equilibration, hearts were pretreated with 75% xenon, 75% xenon+100μM diazoxide, or 75% xenon+100μM 5-hydroxydecanoate, and then subjected to 1h of global ischaemia and 3h of reperfusion. Results: Pretreatment with 75% xenon significantly improved cardiac function (P<0.01 vs. the I/R group, respectively), limited myocardial infarct size (20.83±2.16%, P<0.01 vs. 35.82±2.14% of the I/R group), reduced cardiac enzyme release (CK-MB, 1.00±0.19IU/L, P<0.01 vs. 0.44±0.14IU/L of the I/R group; LDH, 6.15±1.06IU/L P<0.01 vs. 3.49±0.37IU/L of the I/R group) and decreased apoptosis (6.17±0.56%, P<0.01 vs. 11.31±0.93% of the I/R group). In addition, the mitochondrial structure changes caused by I/R injury were largely prevented by 75% xenon pretreatment (1.37±0.16, P<0.01 vs. 2.32±0.13 of the I/R group). The mitochondrial adenosine triphosphate-sensitive potassium (mitoKATP) channel opener diazoxide did not influence the effect of xenon, but the specific mitoKATP channel blocker 5-hydroxydecanoate completely abolished this effect. Conclusions: Our study demonstrated that pretreatment with 75% xenon protected immature heart from I/R injury, and this protection was probably mediated by preservation of myocardial mitochondria and opening of mitoKATP channel.
    Heart, Lung and Circulation 12/2012; 22(4). DOI:10.1016/j.hlc.2012.10.016 · 1.44 Impact Factor
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    Yin Zhang · Bin Liu · HuaYue Wu · WanZhi Chen ·
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    ABSTRACT: Reactions of [FeL2(CH3CN)2]2+ (L = N-pyrimid-2-ylimidazolylidene) with various N-, P-, O-, and S-donors were investigated. By replacing the labile acetonitrile, various iron-NHC complexes containing additional N-, P-, O-, and S-ligands were prepared. All the iron-NHC complexes were fully characterized by NMR spectroscopy and X-ray crystallography. [FeL2(CH3CN)2]2+ could efficiently catalyze the coupling reactions of various Grignard reagents with heteroaryl bromides or chlorides.
    Chinese Science Bulletin 07/2012; 57(19). DOI:10.1007/s11434-012-5164-5 · 1.58 Impact Factor
  • Kaiyu Tao · Da Zhu · Qi An · Bin Liu · Ke Lin ·
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    ABSTRACT: Transcatheter closure is the mainstay of treatment for patent ductus arteriosus (PDA) in the pediatric patient but it is technically challenging and does not always succeed, especially in a younger age child with a large PDA. We present a technique of using a transesophageal echocardiogram-guided minimally invasive perventricular closure for the pediatric patient with a large PDA who failed transcatheter closure.
    The Annals of thoracic surgery 03/2012; 93(3):1007-9. DOI:10.1016/j.athoracsur.2011.10.047 · 3.85 Impact Factor
  • Da Zhu · Bin Liu · Hong Tang ·
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    ABSTRACT: A postoperative acquired left ventricular (LV) to right atrium (RA) shunt in a pediatric patient is a rare complication, which requires immediate intervention. We report a case of successful management of an acquired LV-RA shunt using an intraoperative closure device.
    Journal of Cardiac Surgery 02/2012; 27(2):235-7. DOI:10.1111/j.1540-8191.2011.01407.x · 0.89 Impact Factor
  • Jing Lin · Bin Liu · Ling Tan · Yun-Xia Zuo ·

    Anesthesia and analgesia 07/2011; 113(1):204-5. DOI:10.1213/ANE.0b013e31821ad6ec · 3.47 Impact Factor
  • Bao Li · Qian Li · Bin Liu · Youfeng Yue · Mingxin Yu ·
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    ABSTRACT: 2-(4-Bromophenyl)-3-(4-diphenylaminophenyl)acrylonitrile was prepared by the base catalysed condensation of 4-diphenylaminobenzaldehyde and 2-(4-bromophenyl)acetonitrile. A series of α,β-diarylacrylonitrile derivatives containing both a biphenyl group and a triphenylamine unit were synthesized from 2-(4-bromophenyl)-3-(4-diphenylaminophenyl)acrylonitrile and boronic acids via a Suzuki reaction. The structures of these compounds were characterized using FTIR, 1H NMR, 13C NMR, MS and elemental analysis. The UV–vis absorption and photoluminescent spectra of these derivatives were investigated. These compounds emit green fluorescence with maximum emission peaks of 500–550 nm in CH2Cl2 solution and in the solid state under UV irradiation. Analysis revealed good thermal stability with a decomposition temperature ranging from 279–386 °C.
    Dyes and Pigments 03/2011; 88(3):301-306. DOI:10.1016/j.dyepig.2010.07.010 · 3.97 Impact Factor
  • Bin Liu · Qian Li · Mingxin Yu · Jiaojiao Liang · Hong Fan · Bogeng Li ·
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    ABSTRACT: An efficient synthesis of novel phenoxyimine ligands containing a difluorovinylbiphenyl group was based on the Suzuki coupling coupling of 4-bromo-2,6-difluoroaniline with 4-styrylboronic acid followed by a condensation reaction with various arylaldehydes. The structures were established by IR, 1H NMR, 13C NMR spectra and HRMS. The advantages of this synthetic route were its simple operation, mild reaction conditions and good yields.
    Journal of Chemical Research 03/2011; 35(3). DOI:10.3184/174751911X12979306434042 · 0.63 Impact Factor
  • Bin Liu · Yin Zhang · Daichao Xu · Wanzhi Chen ·
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    ABSTRACT: N-heterocyclic carbene ligands( NHCs) are playing an increasingly important role in many areas such as organometallic, organic synthetic, pharmaceutical and polymer chemistry. While numerous powerful catalytic systems incorporating NHC ligands have been described, methods of synthesizing them have advanced more slowly. This review describes the recent progress of the methods used in the preparation of N-heterocyclic carbene complexes. According to the nature of the NHC precursor and to the activation method employed, the common routes for preparing NHC-metal complexes are insertion of metal ions into the carbon-carbon double bonds of highly electron-rich alkenes, coordination of preformed, isolated free carbenes, deprotonation of an Imidazolium salt with an external base or with metal complex having a basic ligand, thermal decomposition of corresponding carbene adducts, transmetallation from a silver-NHC complex or from a gold-NHC complex, oxidative addition of the C2-X (X= Me, halogen, H) bond of an imidazolium precursor. In addition, our research group firstly found that iron, cobalt, nickel, and copper complexes of N-heterocyclic carbenes can be directly synthesized by using commercially available metal powders.
    Chemical Communications 03/2011; 47(10):2883-5. DOI:10.1039/c0cc05260d · 6.83 Impact Factor
  • Bao Li · Bin Liu · Qian Li · Haiyan Fang · Mingxin Yu ·
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    ABSTRACT: (Z)-2-(4-Bromophenyl)-3-(furan-2-yl)acrylonitrile and (Z)-2-(4-bromophenyl)-3- (thiophen-2-yl)acrylonitrile were prepared by condensation of furan-2-carbaldehyde and thiophene-2-carbaldehyde with (4-bromophenyl)acetonitrile in the presence of catalytic amount of NaOCH3 at room temperature. A series of novel biphenyl derivatives containing furan and thiophene groups was synthesised from (Z)-2-(4-bromophenyl)-3-(furan-2-yl)acrylonitrile and (Z)-2-(4-bromophenyl)-3- (thiophen-2-yl)acrylonitrile via Suzuki coupling to arylboronic acids. The structures of these compounds were characterised by FT-IR, 1H NMR, 13C NMR, and HRMS. The UV-Vis absorption and photoluminescence spectra of the novel compounds in CH2Cl2 solution were investigated.
    Journal of Chemical Research 11/2010; 34(11). DOI:10.3184/030823410X12887880118791 · 0.63 Impact Factor
  • Qian Li · Bao Li · Bin Liu · Mingxin Yu ·
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    ABSTRACT: Synthesis of (E)-2-(4-bromostyryl)quinoline has been easily achieved by an acid catalysed condensation of 2-methylquinoline with 4-bromobenzaldehyde. Various boronic acid derivatives reacted with (E)-2-(4-bromostyryl)quinoline to afford a series of novel quinoline-based aryl substituted styryl derivatives by the catalysis of Pd(PPh3)4 at 85 °C in dimethoxyethane. The UV-Vis absorption and photoluminescent spectra of them in CH2Cl2 were investigated.
    Journal of Chemical Research 06/2010; 34(7):379-381. DOI:10.3184/030823410X12780936189898 · 0.04 Impact Factor
  • Bo Liu · Bin Liu · Yongbo Zhou · Wanzhi Chen ·
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    ABSTRACT: Reactions of the imidazolium salts or their corresponding silver carbene complexes with copper powder afforded unusual copper(II) hydroxide complexes of N-heterocyclic carbenes: [Cu2(μ-OH)(L1)](PF6)2 (2; L1 = 3,5-bis(N-picolylimidazolylidenylmethyl)pyrazolate), [Cu4(μ3-OH)2(L2)2](PF6)4 (3; L2 = 3,5-bis(N-pyridylimidazolylidenylmethyl)pyrazolate), and [Cu4(μ3-OH)2(L3)2](PF6)4 (4; L3 = 3,5-bis(N-pyrimidylimidazolylidenylmethyl)pyrazolate). The same reaction of 3,5-bis(N-thiophenylimidazoliumylmethyl)pyrazole yielded a dinuclear Cu(II)−NHC complex, [Cu2(L4)2](PF6)2 (5; L4 = 3,5-bis(N-thiophenylimidazolylidenylmethyl)pyrazolate). The complexes have been fully characterized by X-ray diffraction analysis, elemental analysis, and IR and ESI-MS spectra. A catalytic study shows that complex 4 is highly active in the N-arylation reactions of imidazoles and aromatic amines with arylboronic acids in methanol at room temperature under base-free conditions.
    Organometallics 02/2010; 29(6). DOI:10.1021/om100009u · 4.13 Impact Factor
  • Hai Yu · Xiao-Yun Yang · Da Zhu · Run-Zi Du · Yan Yin · Rong-Hua Zhou · Bin Liu ·
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    ABSTRACT: To compare the efficiency and accuracy of electroencephalographic nonlinear index (ENI) and bispectral index (BIS) in monitoring depth of anesthesia during general anesthesia. Thirty patients undergoing elective abdominal surgery were recruited. The ability of ENI and BIS to distinguish between the anesthetic states (awake, loss of eyelash reflex, loss of response, steady anesthesia, first reaction and extubation) was analyzed with prediction probability (Pk). Correlation between ENI and BIS was tested by nonparametric Spearman rank correlation analysis, with data paired from awake through to extubation. The clinical performances of ENI and BIS were evaluated with success rate, responsiveness, and recovery time. ENI and BIS were better than mean arterial pressure (MAP) and heart rate (HR) for distinguishing between the states of anesthesia. ENI correlated strongly with BIS from the stage of awake through to extubation (r = 0.93). No differences were found between ENI and BIS in success rate and responsiveness; but the recovery time was shorter with ENI than with BIS. ENI and BIS provide similar information reflecting the states of anesthesia, which allows accurate distinguishment between different states of anesthesia. The clinical performance of ENI is better than that of BIS.
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 01/2010; 41(1):140-4.
  • Zhenxing Xi · Bin Liu · Chunxin Lu · Wanzhi Chen ·
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    ABSTRACT: Cobalt(iii) complexes, [CoCl(2)(L1)(2)](PF(6)) (1, L1 = N-methyl-N-(2-pyrimidinyl)imidazolylidene), [CoCl(L2)(2)](PF(6))(2) (, L2 = N-picolyl-(2-pyrimidinyl)imidazolylidene), [Co(L3)(2)](PF(6))(3) (3, L3 = bis(N-2-pyrimidylimidazolylidenyl)methane) and [CoCl(2)(L3)](PF(6)) (4) have been prepared from the corresponding pyrimidine functionalized imidazolium salts [HL1](PF(6)), [HL2](PF(6)), and [H(2)L3](PF(6))(2)via in situ generated silver carbene complexes under mild conditions. These cobalt complexes were characterized by (1)H and (13)C NMR spectroscopy and X-ray diffraction analysis. The cobalt complexes have been found to be good catalyst precursors for Kumada-Corriu cross-coupling reactions of aryl halides and Grignard reagents at room temperature. Complex 1 is more active under the mild conditions.
    Dalton Transactions 09/2009; 35(35):7008-14. DOI:10.1039/b906242d · 4.20 Impact Factor
  • Bin Liu · Qinqin Xia · Wanzhi Chen ·
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    ABSTRACT: Move to the first row: Simple and practical synthetic methods have been developed for metal complexes of Nheterocyclic carbenes. A number of Fe II, CoII, NiII, as well as divalent and mixed-valent Cu carbene complexes were obtained in good yields by treating metal powders with imidazolium salts in the presence of Ag2O or air.
    Angewandte Chemie International Edition 07/2009; 48(30):5513-6. DOI:10.1002/anie.200901850 · 11.26 Impact Factor

Publication Stats

449 Citations
68.77 Total Impact Points


  • 2010-2013
    • Sichuan University
      • Department of Anesthesiology
      Hua-yang, Sichuan, China
  • 2008-2012
    • Zhejiang University
      • Department of Chemistry
      Hang-hsien, Zhejiang Sheng, China