Bin Liu

Sichuan University, Hua-yang, Sichuan, China

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Publications (18)52.96 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: A family of 2,9-di(3-R-1H-imidazolium-1-yl)-1,10-phenanthroline iodides and hexafluorophosphates (R = allyl, benzyl, mesityl, picolyl) were synthesized from 2,9-diiodophenanthroline and imidazole or N-substituted imidazoles. Simple reactions of these diimidazolium salts with copper powder at room temperature have afforded a series of multinuclear copper(I)-NHC complexes in good yields. The structures vary depending on the N substituents and counterions. [Cu4(L1)2(MeCN)4](PF6)4 (R = allyl) exhibits a zigzag Cu4 chain with two terminal [Cu(NHC)(MeCN)2] and two internal [Cu(phen)(NHC)] moieties. [Cu3(L2)2](PF6)3 (R = benzyl) contains a strictly linear Cu3 framework with two [Cu(NHC)2] units and a [Cu(phen)2] located at the center. Both complexes [Cu3(L4)2](PF6)3 (R = mesityl) and [Cu3(L5)2](PF6)3 (R = picolyl) consist of a triangular Cu3 core in which two copper(I) ions are surrounded by a phen and a NHC group and the third copper(I) is coordinated by two NHC groups. [Cu3(L3)2](PF6)3 derived from 2,9-di(3-benzyl-1H-benzimidazolium-1-yl)-1,10-phenanthroline hexafluorophosphate can undergo transannulation of the benzimidazolylidene ring giving [Cu2(L3')2](PF6)2. The decomposition process might involve solvent-induced rearrangement of the ligand and hydrolysis of carbene moieties. Treatment of 2,9-di(3-mesityl-1H-benzimidazolium-1-yl)-1,10-phenanthroline iodide with copper powder generated dinuclear complex [Cu2(L4)2][Cu2(μ-I)2I2] (R = mesityl) possessing a macrocyclic cation and [Cu2(μ-I)2I2](2-) anion. Tetranuclear complex [Cu4(L5)2(μ-I)2](CuI3) (R = picolyl) has been obtained from its diimidazolium iodide and copper powder. All Cu(I) complexes have been characterized by X-ray single diffraction analysis, elemental analysis, and NMR spectra. Their redox behavior and fluorescent properties have also been studied.
    Inorganic Chemistry 09/2014; 53(19). DOI:10.1021/ic501544d · 4.79 Impact Factor
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    ABSTRACT: This paper is aimed to assess the effects of red blood cell (RBC) transfusion on clinical outcomes in cardiac surgery. Trials were identified by computer searches of the Pubmed, MEDLINE, Cochrane Library (Issue 10, 2012), from January 1980 to October 2012. References in identified trials and review articles were checked and experts contacted to identify any additional trials. The homogeneous randomized controlled trials (RCTs) were analyzed with RevMan 5.1 software. Five trials involving a total of 1,203 patients were identified. The results of meta-analyses showed that restrictive transfusion strategies reduced the risk of receiving a RBC transfusion (MD = - 1.46, 95% CI -1.18(-) -1.1) and the volume of RBCs transfusion (RR = 0.69, 95% CI 0.53-0.89). No significant difference was noted between the two strategies in terms of mortality, adverse events and hospital or intensive care length of stay. Based on the results mentioned above, one can draw a conclusion that restrictive transfusion strategies reduced the risk of receiving RBC transfusion and the volume of RBCs transfused. Restrictive transfusion strategies did not appear to impact on the rate of adverse events and hospital or intensive care length of stay, compared to liberal transfusion strategies.
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    ABSTRACT: BACKGROUND: The noble gas anaesthetic, xenon has previously been shown to protect the adult myocardium from ischaemia/reperfusion (I/R) injury, however its effect on immature myocardium is unclear. The aim of this study was to investigate the effect of xenon on the isolated immature heart. METHODS: Isolated, immature (2-3weeks old) New Zealand rabbit hearts were perfused with Krebs-Henseleit buffer via Langendorff-mode. After 20min of baseline equilibration, hearts were pretreated with 75% xenon, 75% xenon+100μM diazoxide, or 75% xenon+100μM 5-hydroxydecanoate, and then subjected to 1h of global ischaemia and 3h of reperfusion. RESULTS: Pretreatment with 75% xenon significantly improved cardiac function (P<0.01 vs. the I/R group, respectively), limited myocardial infarct size (20.83±2.16%, P<0.01 vs. 35.82±2.14% of the I/R group), reduced cardiac enzyme release (CK-MB, 1.00±0.19IU/L, P<0.01 vs. 0.44±0.14IU/L of the I/R group; LDH, 6.15±1.06IU/L P<0.01 vs. 3.49±0.37IU/L of the I/R group) and decreased apoptosis (6.17±0.56%, P<0.01 vs. 11.31±0.93% of the I/R group). In addition, the mitochondrial structure changes caused by I/R injury were largely prevented by 75% xenon pretreatment (1.37±0.16, P<0.01 vs. 2.32±0.13 of the I/R group). The mitochondrial adenosine triphosphate-sensitive potassium (mitoK(ATP)) channel opener diazoxide did not influence the effect of xenon, but the specific mitoK(ATP) channel blocker 5-hydroxydecanoate completely abolished this effect. CONCLUSIONS: Our study demonstrated that pretreatment with 75% xenon protected immature heart from I/R injury, and this protection was probably mediated by preservation of myocardial mitochondria and opening of mitoK(ATP) channel.
    Heart, Lung and Circulation 12/2012; 22(4). DOI:10.1016/j.hlc.2012.10.016 · 1.17 Impact Factor
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    ABSTRACT: Reactions of [FeL2(CH3CN)2]2+ (L = N-pyrimid-2-ylimidazolylidene) with various N-, P-, O-, and S-donors were investigated. By replacing the labile acetonitrile, various iron-NHC complexes containing additional N-, P-, O-, and S-ligands were prepared. All the iron-NHC complexes were fully characterized by NMR spectroscopy and X-ray crystallography. [FeL2(CH3CN)2]2+ could efficiently catalyze the coupling reactions of various Grignard reagents with heteroaryl bromides or chlorides.
    Chinese Science Bulletin 07/2012; 57(19). DOI:10.1007/s11434-012-5164-5 · 1.37 Impact Factor
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    ABSTRACT: A novel electrochemical procedure for the preparation of metal complexes of N-heterocyclic carbenes using imidazolium salts or corresponding silver-NHC complexes as carbene sources and electrolytes, and metal plates as the sacrificial anodes is described. The procedure is simple and good yielding without the use of expensive or air-sensitive reagents.
    Chemical Communications 03/2011; 47(10):2883-5. DOI:10.1039/c0cc05260d · 6.72 Impact Factor
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    ABSTRACT: 2-(4-Bromophenyl)-3-(4-diphenylaminophenyl)acrylonitrile was prepared by the base catalysed condensation of 4-diphenylaminobenzaldehyde and 2-(4-bromophenyl)acetonitrile. A series of α,β-diarylacrylonitrile derivatives containing both a biphenyl group and a triphenylamine unit were synthesized from 2-(4-bromophenyl)-3-(4-diphenylaminophenyl)acrylonitrile and boronic acids via a Suzuki reaction. The structures of these compounds were characterized using FTIR, 1H NMR, 13C NMR, MS and elemental analysis. The UV–vis absorption and photoluminescent spectra of these derivatives were investigated. These compounds emit green fluorescence with maximum emission peaks of 500–550 nm in CH2Cl2 solution and in the solid state under UV irradiation. Analysis revealed good thermal stability with a decomposition temperature ranging from 279–386 °C.
    Dyes and Pigments 03/2011; 88(3):301-306. DOI:10.1016/j.dyepig.2010.07.010 · 3.47 Impact Factor
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    ABSTRACT: An efficient synthesis of novel phenoxyimine ligands containing a difluorovinylbiphenyl group was based on the Suzuki coupling coupling of 4-bromo-2,6-difluoroaniline with 4-styrylboronic acid followed by a condensation reaction with various arylaldehydes. The structures were established by IR, 1H NMR, 13C NMR spectra and HRMS. The advantages of this synthetic route were its simple operation, mild reaction conditions and good yields.
    Journal of Chemical Research 03/2011; 35(3). DOI:10.3184/174751911X12979306434042 · 0.70 Impact Factor
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    ABSTRACT: (Z)-2-(4-Bromophenyl)-3-(furan-2-yl)acrylonitrile and (Z)-2-(4-bromophenyl)-3- (thiophen-2-yl)acrylonitrile were prepared by condensation of furan-2-carbaldehyde and thiophene-2-carbaldehyde with (4-bromophenyl)acetonitrile in the presence of catalytic amount of NaOCH3 at room temperature. A series of novel biphenyl derivatives containing furan and thiophene groups was synthesised from (Z)-2-(4-bromophenyl)-3-(furan-2-yl)acrylonitrile and (Z)-2-(4-bromophenyl)-3- (thiophen-2-yl)acrylonitrile via Suzuki coupling to arylboronic acids. The structures of these compounds were characterised by FT-IR, 1H NMR, 13C NMR, and HRMS. The UV-Vis absorption and photoluminescence spectra of the novel compounds in CH2Cl2 solution were investigated.
    Journal of Chemical Research 11/2010; 34(11). DOI:10.3184/030823410X12887880118791 · 0.70 Impact Factor
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    ABSTRACT: Synthesis of (E)-2-(4-bromostyryl)quinoline has been easily achieved by an acid catalysed condensation of 2-methylquinoline with 4-bromobenzaldehyde. Various boronic acid derivatives reacted with (E)-2-(4-bromostyryl)quinoline to afford a series of novel quinoline-based aryl substituted styryl derivatives by the catalysis of Pd(PPh3)4 at 85 °C in dimethoxyethane. The UV-Vis absorption and photoluminescent spectra of them in CH2Cl2 were investigated.
    Journal of Chemical Research 06/2010; 34(7):379-381. DOI:10.3184/030823410X12780936189898 · 0.04 Impact Factor
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    ABSTRACT: Reactions of the imidazolium salts or their corresponding silver carbene complexes with copper powder afforded unusual copper(II) hydroxide complexes of N-heterocyclic carbenes: [Cu2(μ-OH)(L1)](PF6)2 (2; L1 = 3,5-bis(N-picolylimidazolylidenylmethyl)pyrazolate), [Cu4(μ3-OH)2(L2)2](PF6)4 (3; L2 = 3,5-bis(N-pyridylimidazolylidenylmethyl)pyrazolate), and [Cu4(μ3-OH)2(L3)2](PF6)4 (4; L3 = 3,5-bis(N-pyrimidylimidazolylidenylmethyl)pyrazolate). The same reaction of 3,5-bis(N-thiophenylimidazoliumylmethyl)pyrazole yielded a dinuclear Cu(II)−NHC complex, [Cu2(L4)2](PF6)2 (5; L4 = 3,5-bis(N-thiophenylimidazolylidenylmethyl)pyrazolate). The complexes have been fully characterized by X-ray diffraction analysis, elemental analysis, and IR and ESI-MS spectra. A catalytic study shows that complex 4 is highly active in the N-arylation reactions of imidazoles and aromatic amines with arylboronic acids in methanol at room temperature under base-free conditions.
    Organometallics 02/2010; 29(6). DOI:10.1021/om100009u · 4.25 Impact Factor
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    ABSTRACT: Cobalt(iii) complexes, [CoCl(2)(L1)(2)](PF(6)) (1, L1 = N-methyl-N-(2-pyrimidinyl)imidazolylidene), [CoCl(L2)(2)](PF(6))(2) (, L2 = N-picolyl-(2-pyrimidinyl)imidazolylidene), [Co(L3)(2)](PF(6))(3) (3, L3 = bis(N-2-pyrimidylimidazolylidenyl)methane) and [CoCl(2)(L3)](PF(6)) (4) have been prepared from the corresponding pyrimidine functionalized imidazolium salts [HL1](PF(6)), [HL2](PF(6)), and [H(2)L3](PF(6))(2)via in situ generated silver carbene complexes under mild conditions. These cobalt complexes were characterized by (1)H and (13)C NMR spectroscopy and X-ray diffraction analysis. The cobalt complexes have been found to be good catalyst precursors for Kumada-Corriu cross-coupling reactions of aryl halides and Grignard reagents at room temperature. Complex 1 is more active under the mild conditions.
    Dalton Transactions 09/2009; DOI:10.1039/b906242d · 4.10 Impact Factor
  • Angewandte Chemie International Edition 07/2009; 48(30):5513-6. DOI:10.1002/anie.200901850 · 11.34 Impact Factor
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    ABSTRACT: A family of tetra-, penta-, and hexacoordinate nickel complexes of functionalized N-heterocyclic carbene (NHC) ligands have been prepared via carbene transfer reactions of Ni(PPh3)2Cl2 and silver-NHC complexes in situ generated from corresponding imidazolium salts and Ag2O. These nickel(II) complexes have been characterized by 1H NMR, 13CNMR, and ESI spectroscopy and X-ray diffraction analysis. Structural analysis revealed that [Ni(L1)3](PF6)2 (L1 = 3-butyl-1-(5,7-dimethyl-1,8-naphthyridin-2-yl)imidazolylidene, 3) is a rare example of a nickel complex with trigonal-bipyramidal geometry. [Ni(L4)2](PF6)2 (L4 = 1-butyl-3-((7-methyl-1,8-naphthyridin-2-yl)methyl)imidazolylidene, 5) and [Ni(L20)2](PF6)2 (L20 = 3-(pyridin-2-ylmethyl)-1-(pyrimidin-2-yl)imidazolylidene, 21) are normal square-planar. [Ni(L8)3](PF6)2 (L8 = 3-methyl-1-(pyrimidin-2-yl)imidazolylidene, 9), [Ni(L10)2(CH3CN)](PF6)2 (L10 = 3-ethyl-1-(pyrimidin-2-yl)imidazol-ylidene, 11), [Ni(L12)2(CH3CN)](PF6)2 (L12 = 3-butyl-1-(pyrimidin-2-yl)imidazolylidene, 13), [Ni(L14)2(CH3CN)](PF6)2 (L14 = 3-benzyl-1-(pyrimidin-2-yl)imidazolylidene, 15), and [Ni(L16)2(CH3CN)](PF6)2 (L16 = 3-isopropyl-1-(pyrimidin-2-yl)imidazolylidene, 17) are pentacoordinate, displaying unusual square-pyramidal geometry. [Ni(L12)3](PF6)2 (L9 = 3-butyl-1-(pyrimidin-2-yl)imidazolylid-ene, 19), [Ni(L22)2(CH3CN)2](PF6)2 (L22 = 3-(2,6-diisopropylphenyl)-1-(pyrimidin-2-yl)imidazolylidene, 23), and [Ni(L24)(CH3CN)(H2O)] (L22 = 3-(2,4,6-trimethylphenyl)-1-(pyrimidin-2-yl)imidazolylidene, 25) are octahedral complexes. The structural diversity of these nickel(II) complexes originating from steric pressure of the ligands is discussed.
    Organometallics 03/2009; 28(5). DOI:10.1021/om800982r · 4.25 Impact Factor
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    ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
    ChemInform 09/2008; 39(38). DOI:10.1002/chin.200838080
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    ABSTRACT: The Kumada cross-coupling reaction of a variety of unactivated aryl chlorides, vinyl chlorides, and heteroaryl chlorides catalyzed by nickel(II) complexes containing pyridine-functionalized NHC ligands is described. The catalysts are so active that the reactions proceed at room temperature in excellent yields.
    The Journal of Organic Chemistry 06/2008; 73(10):3954-7. DOI:10.1021/jo800197u · 4.64 Impact Factor
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    ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
    ChemInform 04/2008; 39(17). DOI:10.1002/chin.200817144
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    ABSTRACT: The imidazolium salts bis(N-(pyridylmethyl)imidazoliumyl)methane hexafluorophosphate (H2L1·(PF6)2), 2,2‘-bis(N-(pyridylmethyl)imidazoliumyl)ethyl ether (H2L2·(PF6)2), 2,6-bis(N-(pyridylmethyl)imidazoliumyl)pyridine (H2L3·(PF6)2), and 3,6-bis(N-(pyridylmethyl)imidazoliumyl)pyridazine (H2L4·(PF6)2) have been prepared and characterized. They reacted with Ag2O in acetonitrile to produce the silver complexes [Ag4(L1)2(CH3CN)2](PF6)4·2CH3CN (1), [Ag4(L2)2](PF6)4·2CH3CN (2), [Ag4(L3)2](PF6)4·Et2O·CH3CN (4), and [Ag6(L4)4](PF6)6 (5), respectively. The reaction of 2 with 4 equiv of Au(Et2S)Cl afforded the dimetallic gold complex [Au2(L2)](PF6)2·2CH3CN (3). Complexes 1−4 were characterized by 1H NMR, 13C NMR, luminescence spectroscopy, elemental analyses, and X-ray crystallography. Complex 1 is a tetrasilver complex consisting of a zigzag silver chain with silver−silver separations of 2.911(1) and 3.288(1) Å. Complexes 2 and 4 have orthogonal tetrasilver cores in which four silver atoms are held together by two L2 or L3 ligands with relatively short Ag−Ag contacts ranging from 2.790(1) to 3.293(2) Å. The digold complex consists of a macrometallocycle formed by two gold atoms and one L2 ligand, and the intramolecular Au−Au bond distance is 3.267(1) Å. Complex 5 is a hexamer with six silver atoms bridged by four L4 ligands forming three silver−silver bonds of distances 3.249(2), 3.014(2), and 3.089(2) Å. ESI-MS spectra show that these multinuclear silver cores are retained in acetonitrile solution. All of these silver complexes are intensely luminescent in their solid state.
    Organometallics 06/2007; 26(15). DOI:10.1021/om0701928 · 4.25 Impact Factor
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    ABSTRACT: An efficient route to synthesize the heteroaryl-substituted 1,8-naphthyridine derivatives was described. Eight 2-heteroaryl- and 2,7-diheteroaryl-1,8-naphthyridine derivatives were obtained through palladium-catalyzed C–N-coupling reactions of chloronaphthyridines with imidazole, benzimidazole, morpholine, 3,5-dimethylpyrazole, and phthalimide in moderate to good yields.
    Chinese Chemical Letters 04/2007; 18(4):383-386. DOI:10.1016/j.cclet.2007.01.024 · 1.18 Impact Factor

Publication Stats

323 Citations
52.96 Total Impact Points


  • 2012
    • Sichuan University
      • Department of Anesthesiology
      Hua-yang, Sichuan, China
  • 2008–2012
    • Zhejiang University
      • Department of Chemistry
      Hang-hsien, Zhejiang Sheng, China