Emilio López Alcina

Consorcio Hospital General Universitario de Valencia, Valencia, Valencia, Spain

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Publications (35)6.27 Total impact

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    ABSTRACT: BACKGROUND: The present study was aimed at determining the prophylactic efficacy of American cranberry (AC) extract (Cysticlean(R)) in women with recurrent symptomatic postcoital urinary tract infections (PCUTI), non-consumer of AC extract in the past 3 months before inclusion, and to determine changes in their quality of life (QoL). METHODS: This was a single center, observational, prospective study in a total of 20 women (mean age 35.2 years; 50.0% were married). Patients were followed up for 3 and 6 months during treatment. RESULTS: The number of PCUTIs in the previous 3 months prior to start the treatment with Cysticlean(R) was 2.8+/-1.3 and it was reduced to 0.2+/-0.5 at Month 6 (P<0.0001), which represent a 93% improvement. At baseline, the mean score on the VAS scale (range from 0 to 100) for assessing the QoL was 62.4+/-19.1, increasing to 78.2+/-12.4 at Month 6 (P=0.0002), which represents a 20% improvement. All patients had an infection with positive urine culture at baseline, after 6 months there were only 3 symptomatic infections (P<0.001). The most common bacterium was Escherichia coli. CONCLUSIONS: Prophylaxis with American cranberry extract (Cysticlean(R)) could be an alternative to classical therapies with antibiotics. Further studies are needed to confirm results obtained in this pilot study.
    BMC Urology 06/2013; 13(1):28. · 1.69 Impact Factor
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    ABSTRACT: IntroductionHigh prevalence of BPH and gradual ageing of the population, combined with the existence of effective medical treatments for this condition, has led to an increasing use of surgery in patients on long-term treatment with 5-alpha reductase inhibitors (5-ARIs). Initially, patients treated with 5-ARIs were not considered good candidates for photoselective vaporization of the prostate with green laser.Objective To assess, using a retrospective study based on our experience, wheter long-term treatment (longer than 6 months) with 5-alpha reductase inhibitors decreases effectivenes of photoselective vaporization of the prostate with green light laser in BPH.Materials and methodsFrom September 2005 to January 2008, 102 patients underwent photoselective vaporization of the prostate with green light laser. Of these, 25 patients (24.5%) had been treated with 5-ARIs for at least 6 months, and the remaining 77 patients (75.5%) were used as controls. A retrospective study was conducted to compare the pre- and postoperative clinical and functional parameters of patients with and without prior 5-RAI therapy.ResultsNo statistically significant differences were found between the treated and control groups in preoperative prostatic volume (50 mL vs 49 mL), IPSS (17.6 vs 17.8), postvoiding residue (16% vs 18%), or PSA (1.4 ng/mL vs 2.2 ng/mL). Similarly, while differences were seen in energy spread (180 kJ vs 175 kJ for the treated and control groups respectively) and operating time (63 min vs 57 min), these were not statistically significant. No between-group differences were found either in clinical or flow rate parameters one month after surgery (IPSS 13.8 vs 14 and Qmax 13.9mL/s vs 14.5 nL/s in the treated and control groups respectively). Surgeons reported a better visualization of the endoscopic field that was attributed to less bleeding during the procedure.Conclusions Our results show no statistically significant differences in peroperative and preoperative parameters between patients with and without treatment with 5-alpha reductase inhibitors. We therefore think that photoselective vaporization of the prostate with green light laser is a safe and effective technique in patients treated with 5-ARIs.
    Actas urologicas españolas 10/2009; 33(9):988–993. · 1.14 Impact Factor
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    ABSTRACT: High prevalence of BPH and gradual ageing of the population, combined with the existence of effective medical treatments for this condition, has led to an increasing use of surgery in patients on long-term treatment with 5-alpha reductase inhibitors (5-ARIs). Initially, patients treated with 5-ARIs were not considered good candidates for photoselective vaporization of the prostate with green laser. To assess, using a retrospective study based on our experience, wheter long-term treatment (longer than 6 months) with 5-alpha reductase inhibitors decreases effectiveness of photoselective vaporization of the prostate with green light laser in BPH. From September 2005 to January 2008, 102 patients underwent photoselective vaporization of the prostate with green light laser. Of these, 25 patients (24.5%) had been treated with 5-ARIs for at least 6 months, and the remaining 77 patients (75.5%) were used as controls. A retrospective study was conducted to compare the pre- and postoperative clinical and functional parameters of patients with and without prior 5-RAI therapy. No statistically significant differences were found between the treated and control groups in preoperative prostatic volume (50 mL vs 49 mL), IPSS (17.6 vs 17.8), postvoiding residue (16% vs 18%), or PSA (1.4 ng/mL vs 2.2 ng/mL). Similarly, while differences were seen in energy spread (180 kJ vs 175 kJ for the treated and control groups respectively) and operating time (63 min vs 57 min), these were not statistically significant. No between-group differences were found either in clinical or flow rate parameters one month after surgery (IPSS 13.8 vs 14 and Qmax 13.9 mL/s vs 14.5 nL/s in the treated and control groups respectively). Surgeons reported a better visualization of the endoscopic field that was attributed to less bleeding during the procedure. Our results show no statistically significant differences in peroperative and preoperative parameters between patients with and without treatment with 5-alpha reductase inhibitors. We therefore think that photoselective vaporization of the prostate with green light laser is a safe and effective technique in patients treated with 5-ARIs.
    Actas urologicas españolas 10/2009; 33(9):988-93. · 1.14 Impact Factor
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    ABSTRACT: It is more and more common to have patients in our clinics with the diagnosis of BPH and indication for surgery who present limitations due to their medications, age, associated morbidity or psychosocial conditions. Transurethral resection of the prostate, though it is the surgical standard of reference, is not free from complications such as reabsorption syndrome, bleeding, or even blood transfusion in a percentage of cases. Laser PVP may be a valid alternative in this subgroup of patients. We review our experience with this procedure, as well as the published articles on this topic, and describe technical recommendations we consider useful to avoid complications when possible during surgery or the immediate postoperative period.
    Archivos españoles de urología 12/2008; 61(9):1029-34.
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    ABSTRACT: Nowadays, there is the high prevalence of sexual intercourse including oral sex, which implies some peculiarities in the infections, balanitis and ceIlulitis they may produce. We report two new cases of penile cellulitis treated in the urology department in our hospital. We review the indications of prophylaxis, and the medical and surgical treatment both referred in the literature and carried out in our patients. When dealing with balanitis and penile cellulitis, the history should include explicit references to the practice of oral sex. Early medical or surgical treatment has a favourable influence on the evolution of the lesions.
    Archivos españoles de urología 11/2008; 61(8):924-9.
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    01/2008;
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    ABSTRACT: Over the last years numerous semiquantitative PSA tests have appeared, based on serum or plasma immunochromatography. We present our experience using the SD BIOLINE PSA test, which is performed with plasma or serum for fast qualitative determination of PSA; the cutpoint is 3 ng/ml. We analized 54 patients who were admitted in our hospital ward. Two blood samples were obtained from every patient, one for cuantitative PSA determination at the hospital laboratory and the other one for qualitative determination with the SD BIOLINE PSA test, and the results were compared.. Two urologists independently interpreted the test without knowing the PSA values from the lab. To calculate the effect of test reading time, readings were performed at 15, 20 and 25 minutes. Results were classified in a classic contingency table, which enabled us to calculate sensitivity and specificity of the test, as well as positive and negative predictive values. Mean age was 71. 1 years (range 43-96 yr). From 54 patients in the study 26 (48. 14%) had a PSA > 3 ng/ml (Mean 18.5 ng/ml, range 3.9-66.9 ng/ml) and 28 (51.86%) PSA < 3 ng/ml (mean 0.8 ng/mL, range 0-2.9 ng/mL), in the conventional test. Results for each interval and observer were: 15 min: Observer 1: Sensitivity (S) 76,92%, specificity (E) 100%, positive predictive value (PPV) 100%, negative predictive value (NPV) 82.35%; Observer 2: S 76.92%, E 100%, PPV 100%, NPV 82.35%. 20 minutes: Observer 1: S 100%, E 93.33%, PPV 92.30%, NPV 100%; Observer 2: S 100%, E 93.33%, PPV 92.30%, NPV 100%. 25 minutes: Observer 1: S 100%, E 85.71%, PPV 86.66%, NPV 100%; Observer 2: S 92.30%, E 92.85%, PPV 92.30%, NPV 92.85%. The SD Bioline PSA test complies with the characteristics required to be used as a test for prostate cancer detection, it is simple, fast, cheap, not much invasive, and has a good efficacy.
    Archivos españoles de urología 01/2008; 61(6):685-90.
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    ABSTRACT: Therapy with protease inhibitors is commonly used in patients infected by human inmunodeficency virus (HIV). 20% of the administered dose is excreted by the kidney, and when alkaline urine is present, indinavir may crystallize forming stones and patients may experience renal colic due to this fact. Between January 1998 and June 2005, 26 patients receiving antiretroviral treatment with protease inhibitors received care at our hospital because of renal colic or flank pain. All of them underwent physical examination, echography and urography as well as blood and urine analysis. Patients were treated ambulatory excepting those in whom oral analgesics were insufficient to control the pain. All patients had been treated with indinavir for longer than 12 months. They represented 4% of all patients treated with the recommended dose of Crivixan. Most of them presented flank pain, associated in most cases to microhaematuria. Five of them required hospitalization because of persistent pain in spite of endovenous analgesia. Imaging tests (echography and urography) showed functional delay of the kidney (2 cases), ureteral stasis (4 cases) and little lithiasic concretions of mild radiologic density (5 cases). Urinalysis revealed suggestive christaluria and alkaline pH. All patients required hidratation and analgesic treatment. In 3 patients indinavir dose was reduced, it was retired in another one, and 100 mg of rito-navir were added in another one. Unsuccesfuly ureteral cateterization was tried in one patient. All of them presented symptomatic improvement. We ought to know the capability of indinavir to form urolithiasis in HIV patients treated with protease inhibitors, although its use is decreasing along time. Prevalence of urolithiasis in these patients seems to be higher as length of treatment becomes longer. Metabolic alterations in urine have been proved in these patients, contributing to a higher incidence of lithiasis than in general population.
    Archivos españoles de urología 01/2008; 61(1):35-40.
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    ABSTRACT: Despite the fact that transurethral resection of the prostate (TURP) continues being the gold standard for the surgical treatment of benign prostatic hyperplasia (BPH), the good results obtained with the use of new energy sources have led to their use in daily practice. Between September 2005 and January 2007, we have treated 63 patients with KTP laser photoselective vaporization of the prostate (PVP) in our service. Preoperatively we asked for IPSS, performed physical exam, digital rectal exam, abdominal , renal, bladder and prostatic ultrasound measuring postvoid residual volume, as well as flowmetry and PSA determination. Patients were revised after 1, 3, 6 and 12 months, undergoing uroflowmetry, IPSS, ultrasound and PSA; a satisfaction survey was also fulfilled at this interviews. Mean age was 67 years (range 58-85) and mean preoperative prostatic volume was 48cc (range 34-67), mean preoperative IPSS was 17.7 and mean maximum flow 8.1 mL/s. 12 patients presented post void residual volume larger than 100 mL. Most patients presented medium or high anaesthetic risk. Mean operative time was 64 minutes (range 45-95). In most cases we used just one fibre, and mean energy released was 175,000 Joules (range 85,000-24,000). Mean hospital stay was 32.2 hours (range 19-55). In postoperative revisions we could state a significant decrease of IPSS, improvement in maximum flow, and also good or very good satisfaction degree in about 80% of the patients. Only 3 of them presented hematuria that needed to be attended by the urologist, none of them needed transfusion. One patient was admitted for severe urinary infection and eight patients referred irritative low urinary tract symptoms in their first postoperative checkup. KTP laser PVP is a safe, reproducible technique with optimal short and middle term outcomes, which should be considered as the first choice surgical treatment in elderly patients, patients with chronic anaemic diseases or anticoagulated, and patients with high anaesthesic or surgical risk.
    Archivos españoles de urología 12/2007; 60(9):1.105-10.
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    ABSTRACT: Despite the high incidence of inguinal hernias. In the general population, only a small percentage of them involve the bladder. Bladder wall weakness and bladder outlet obstruction are involved in its pathogenesis. We present our experience in the diagnosis and treatment of this rare disease. A total of eight patients have been diagnosed of inguinoscrotal bladder hernia and treated in our center over the last 18 years. In most cases, retrograde and voiding cystourethrograms, prostatic and bladder ultrasound, and uroflowmetry have been performed. The treatment varied depending on the characteristics of the herniated bladder tissues and bladder capacity. The treatment of bladder outlet obstruction varied depending on the etiology. Two patients presented at the emergency room of our centre, the others were diagnosed at the outpatient clinics of our department. Resection of the herniated bladder tissue was carried out in four patients due to the quality of the tissue; bladder-pexy to the abdominis rectus muscles was performed in one patient; hernia repair with bladder reintroduction was the treatment in the other four cases. Bladder outlet obstruction was treated in six cases. Seven patients showed clinical improvement, showing normal bladder morphology on post operative cystogram. Bladder hernia is a rare pathology often presenting in mid age males. It should be suspected in every male with lower urinary tract obstructive symptoms and associated inguinal hernia. Retrograde and voiding cystourethrogram are the radiological diagnostic tests of choice to evaluate this disease. The treatment of choice is that of the hernia and bladder outlet obstruction.
    Archivos españoles de urología 05/2007; 60(3):231-6.
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    ABSTRACT: During the second half of the XVIth century the interest of the clinicians moves towards the venereal ailments and the urethral carnosities (narrowness) to the detriment of the litiasic processes. They are of special relevancy for us, in the period summit of the medical sciences in Valencian lands, Miguel Juan Pascual who in his work "Morborum internorum" (1555) there synthesizes everything known on the syphilis in this epoch, its origin, diagnosis and treatment, Juan Calvo considered one of the best surgeons of the XVIth century and Miguel de Leriza author of the "Tractatus of the way of treating the carnosities and corns of the route of the urine". The baroque was an epoch of general crisis in Spain and in the ancient Kingdom of Valencia, specially clear in fields as the anatomy and the surgery. The serious decadence that suffered during these years the scientific Valencian production turns out to be evident. Not even an alone anatomical text was published in the first half of the XVIIth century, whereas in the surgical area the "Summary of everything about the theoretical and practice of Surgery", of Alonso Romano can be considered deigns of mention. The illustration brought new reformists airs and around the flourishing scientific academies, there congregated the most select of the Valencian intellectuality. Andres Piquer Arrufat is considered to be the maximum figure of the Valencian medicine of this period. Not even after the war of independence and the reign of Fernando VII who died in 1833 when there sit down the bases of the modern urology and the consolidation as speciality at the end of the XIXth. The Valencian principal figures of this period are Miguel Más y Soler, Alejandro Settler and especially Rafael Mollá y Rodrigo.
    Actas urologicas españolas 04/2007; 31(3):197-204. · 1.14 Impact Factor
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    ABSTRACT: When we speak about ancient Urology we try to revise the ways of diagnosing and treating during the last epochs the genitourinary diseases, sufferings that are recognizable for us in the classic descriptions. We try to place the urology knowledge in Valencian lands, in the historical general current, relating it to the social, political and economic structure in every moment. Are outlined the innovative legislations that regulated the medical occupation, the influence of the European currents in the development of the medicine and surgery at Valencia up to the renaissance, the creation of the School of Surgery in 1462, the obtaining of the royal privilege in 1478 to dissect human corpses, the foundation of the University of Valencia in 1502, by the Valencian pope Alejandro VI, and license of the king Fernando Catholic and the unification of the set of hospital centres of the city of Valencia in 1512, constituting the General Hospital. In this period they are of special relevancy for us Arnau de Vilanova who wrote the "Tractatus against calculum" the first text related to the urologic pathology, written with monographic character, in the medical European literature, Gaspar Torrella who in 1497 realized the first clinical and therapeutic study of the epoch on the syphilis, considered like the most valuable original description of the new disease and Pedro Jimeno and Luis Collado as visible heads of the flourishing anatomical Valencian school whom Francisco Diaz, author in 1588 of first Urology Tractatus in the History of the medicine, recognizes as his teachers during his staying in Valencia.
    Actas urologicas españolas 03/2007; 31(2):77-85. · 1.14 Impact Factor
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    ABSTRACT: Hernia inguinoescrotal, Vejiga, Diagnóstico, Tratamiento
    Archivos Españoles de Urología (España ) Num.3 Vol.60. 01/2007;
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    ABSTRACT: During the second half of the XVIth century the interest of the clinicians moves towards the venereal ailments and the urethral carnosities (narrowness) to the detriment of the litiasic processes. They are of special relevancy for us, in the period summit of the medical sciences in Valencian lands, Miguel Juan Pascual who in his work “Morborum internorum” (1555) there synthesizes everything known on the syphilis in this epoch, its origin, diagnosis and treatment, Juan Calvo considered one of the best surgeons of the XVIth century and Miguel de Leriza author of the “Tractatus of the way of treating the carnosities and corns of the route of the urine”. The baroque was an epoch of general crisis in Spain and in the ancient Kingdom of Valencia, specially clear in fields as the anatomy and the surgery. The serious decadence that suffered during these years the scientific Valencian production turns out to be evident. Not even an alone anatomical text was published in the first half of the XVIIth century, whereas in the surgical area the “Summary of everything about the theoretical and practice of Surgery”, of Alonso Romano can be considered deigns of mention. The illustration brought new reformists airs and around the flourishing scientific academies, there congregated the most select of the Valencian intellectuality. Andres Piquer Arrufat is considered to be the maximum figure of the Valencian medicine of this period. Not even after the war of independence and the reign of Fernando VII who died in 1833 when there sit down the bases of the modern urology and the consolidation as speciality at the end of the XIXth. The Valencian principal figures of this period are Miguel Más y Soler, Alejandro Settier and especially Rafael Mollá y Rodrigo.
    Actas Urologicas Espanolas - ACTAS UROL ESP. 01/2007; 31(3).
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    ABSTRACT: When we speak about ancient Urology we try to revise the ways of diagnosing and treating during the last epochs the genitourinary diseases, sufferings that are recognizable for us in the classic descriptions. We try to place the urology knowledge in Valencian lands, in the historical general current, relating it to the social, political and economic structure in every moment.Are outlined the innovative legislations that regulated the medical occupation, the influence of the European currents in the development of the medicine and surgery at Valencia up to the renaissance, the creation of the School of Surgery in 1462, the obtaining of the royal privilege in 1478 to dissect human corpses, the foundation of the University of Valencia in 1502, by the Valencian pope Alejandro VI, and license of the king Fernando Catholic and the unification of the set of hospital centres of the city of Valencia in 1512, constituting the General Hospital.In this period they are of special relevancy for us Arnau de Vilanova who wrote the “ Tractatus against calculum “ the first text related to the urologic pathology, written with monographic character, in the medical European literature, Gaspar Torrella who in 1497 realized the first clinical and therapeutic study of the epoch on the syphilis, considered like the most valuable original description of the new disease and Pedro Jimeno and Luis Collado as visible heads of the flourishing anatomical Valencian school whom Francisco Díaz, author in 1588 of first Urology Tractatus in the History of the medicine, recognizes as his teachers during his staying in Valencia.
    Actas Urologicas Espanolas - ACTAS UROL ESP. 01/2007; 31(2).
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    ABSTRACT: Upper urinary tract (UUT) tumors are a relatively low incidence pathology which often represents a diagnostic challenge for the urologist, because several imaging tests are usually necessary to achieve the final diagnosis. Over the last years CT scan has suffered a notable development and nowadays, with the arrival of new image processing hardware and software, it is possible to detect small urothelial lesions and to perform 3-D urinary tract reconstruction and virtual endoscopic navigation. Between January 2004 and June 2005 we performed a total of 15 examinations in 15 patients for the study of asymptomatic hematuria of probable upper urinary tract origin. The technique included three phases to obtain images: basal phase, vascular phase and excretory phase. Processing and image analysis was performed by one radiologist. A total of 10 tumors were diagnosed, with pathological confirmation in all cases. We did not register any complication secondary to the technique, and all patients tolerated well the exam. The CT urography is a safe, well-tolerated, highly sensitive and efficient imaging test, very useful in the diagnosis of renal and UUT pathology. It may become the only imaging test performed in the study of asymptomatic hematuria and the test of choice for the study of urological tumoral pathology.
    Archivos españoles de urología 12/2006; 59(9):867-73.
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    01/2006;
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    ABSTRACT: To evaluate the results of the outpatient surgical treatment of genuine female stress urinary incontinence (SUI) over a five year period since the integration of the Department of Urology in the Ambulatory Surgery Unit at our hospital "Consorcio Hospital General Universitario de Valencia" (CHGUV). Between January 2000 and December 2004 26 patients (ages 49-78; mean age 69.8 yr) with the diagnosis of SUI underwent tension-free suburethral mesh sling (TVT) outpatient operations under local anesthesia-sedation at the ambulatory surgery unit of the CHGUV. All patients had clinical and urodynamic evaluation, excluding those presenting genital prolapse or non compliance with the social requirements for ambulatory surgery. Previous anti-incontinence surgery was not an exclusion criterion. We evaluate inclusion and discharge criteria, results and satisfaction degree measured by a questionnaire. 22 patients (85%) had genuine SUI and 4 (15%) had mixed UI with predominance of the stress component. 54% (14) of the patients were ASA I, 31% (8) ASA II, and 15% (4) well compensated ASA III. Operation tolerance under local anesthesia (20-30 ml 1% lidocaine) was good in all patients, having used additional sedation-analgesia (propofol-remifentanil IV perfusion) in 10 of them (38%). Mean operative time was 30 minutes (25-45) and stay at the unit discharge was 100 min. (80-140). All patients were discharged the same day. None of them required readmission or presented urinary retention after catheter removal. SUI disappeared in all of them. Three patients presented postoperative urge incontinence responsive to oral anticolinergic drugs. Our results are similar to those obtained with epidural anesthesia and hospital admission, being the degree of satisfaction with treatment higher than 95%. The development of new, revolutionary systems for the treatment of SUI has simplified the surgical treatment of this entity, so that we can say a high percentage of patients may be included in an ambulatory surgery program, significantly improving cost-efficacy without diminishment of health-care quality or patient satisfaction.
    Archivos españoles de urología 12/2005; 58(9):915-22; discussion 923-4.
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    ABSTRACT: Urethral pathology has always been an interesting topic for study, being present in texts from 600 years B.C, where wood and metallic dilators are described. First external urethrotomies appear in the Jewish-Muslim period, and Francisco Diaz describes in 1588 the treatment of the prostate in his book "Tratamiento de las carnosidades de la verga". With Civiale and Maisoneuve, between 1700 and 1800, appears the description of the urethrotome, and finally in the middle XIX century starts the search for adequate tissues to replace urethra. We review all articles on the topic of urethral pathology from authors from Valencia in that period, mainly published in the journal "Revista Valenciana de Ciencias Médicas". We emphasize the use of bulbs and sounds in the approach to urethral stenosis by several authors, with their advantages and limitations. We also emphasize the description of external urethrotomy by Prof. Molla. Finally, we point out the treatment of a posterior urethra fracture by tunneling reported by Dr. Alfredo Tramoyeres. Despite not being a topic with a high volume of publications, it has always interested authors. We describe all treatments, and sound insertion and dilation techniques as first option.
    Archivos españoles de urología 12/2005; 58(9):853-8.