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ABSTRACT: This study investigates the application of a modified reversed gradient algorithm to the Propeller-EPI imaging method (periodically rotated overlapping parallel lines with enhanced reconstruction based on echo-planar imaging readout) for corrections of geometric distortions due to the EPI readout.
Propeller-EPI acquisition was executed with 360-degree rotational coverage of the k-space, from which the image pairs with opposite phase-encoding gradient polarities were extracted for reversed gradient geometric and intensity corrections. The spatial displacements obtained on a pixel-by-pixel basis were fitted using a two-dimensional polynomial followed by low-pass filtering to assure correction reliability in low-signal regions. Single-shot EPI images were obtained on a phantom, whereas high spatial resolution T2-weighted and diffusion tensor Propeller-EPI data were acquired in vivo from healthy subjects at 3.0 Tesla, to demonstrate the effectiveness of the proposed algorithm.
Phantom images show success of the smoothed displacement map concept in providing improvements of the geometric corrections at low-signal regions. Human brain images demonstrate prominently superior reconstruction quality of Propeller-EPI images with modified reversed gradient corrections as compared with those obtained without corrections, as evidenced from verification against the distortion-free fast spin-echo images at the same level.
The modified reversed gradient method is an effective approach to obtain high-resolution Propeller-EPI images with substantially reduced artifacts.
Quantitative imaging in medicine and surgery. 04/2013; 3(2):73-81.
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ABSTRACT: BACKGROUND: Due to the different properties of the contrast agents, the lung perfusion maps as measured by 99mTc-labeled macroaggregated albumin perfusion scintigraphy (PS) are not uncommonly discrepant from those measured by dynamic contrast-enhanced MRI (DCE-MRI) using indicator-dilution analysis in complex pulmonary circulation. Since PS offers the pre-capillary perfusion of the first-pass transit, we hypothesized that an inflow-weighted perfusion model of DCE-MRI could simulate the result by PS. METHODS: 22 patients underwent DCE-MRI at 1.5T and also PS. Relative perfusion contributed by the left lung was calculated by PS (PSL%), by DCE-MRI using conventional indicator dilution theory for pulmonary blood volume (PVLL%) and pulmonary blood flow (PVFL%) and using our proposed inflow-weighted pulmonary blood volume (PBViwL%). For PBViwL%, the optimal upper bound of the inflow-weighted integration range was determined by correlation coefficient analysis. RESULTS: The time-to-peak of the normal lung parenchyma was the optimal upper bound in the inflow-weighted perfusion model. Using PSL% as a reference, PBVL% showed error of 49.24% to -40.37% (intraclass correlation coefficient RI = 0.55) and PBFL% had error of 34.87% to -27.76% (RI = 0.80). With the inflow-weighted model, PBViwL% had much less error of 12.28% to -11.20% (RI = 0.98) from PSL%. CONCLUSIONS: The inflow-weighted DCE-MRI provides relative perfusion maps similar to that by PS. The discrepancy between conventional indicator-dilution and inflow-weighted analysis represents a mixed-flow component in which pathological flow such as shunting or collaterals might have participated.
Journal of Cardiovascular Magnetic Resonance 02/2013; 15(1):21. · 3.72 Impact Factor
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ABSTRACT: Purpose: Of the myocardial T(1) mapping techniques, the modified Look-Locker inversion recovery (MOLLI) sequence is accurate and highly reproducible. The MOLLI sequence requires patients to hold their breath for 17 heartbeats during the scanning process to minimize respiratory motion-related artifacts. However, some patients are unable to hold their breath because of illness or limited breath-hold capacity. This study, therefore, aimed to develop a robust myocardial T(1) mapping method based on the MOLLI sequence for patients unable to perform voluntary breath-holds.Methods: This study presents a free-breathing MOLLI (FB-MOLLI) sequence and an optimized reconstruction method to allow myocardial T(1) mapping in vivo without breath-hold. Nine healthy volunteers participated in this study after providing institutionally approved consent. The FB-MOLLI sequence acquires 20 images within 29 heartbeats. The reconstruction program employs a two-step automatic image registration technique and an image selection method inspired by the self-gating cardiac imaging method.Results: Results indicate that the proposed reconstruction method increases the accuracy and reproducibility of free-breathing T(1) measurements significantly (p < 0.001).Conclusions: The FB-MOLLI method provides a robust tool for clinical application in free-breathing myocardial T(1) mapping, and could greatly facilitate acquisition procedures during routine examinations.
Medical Physics 12/2012; 39(12):7291-302. · 2.83 Impact Factor
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ABSTRACT: Purpose: Previous studies have identified that impaired cerebral vasomotor reactivity (VMR) is associated with a higher risk of stroke and transient ischemic attack. This study aims to evaluate VMR by measuring the blood flow waveforms of the supplying arteries and dural sinuses using cine phase contrast MRI (PC MRI) and hypercapnic challenge.Methods: PC MRI flow quantification was performed on an oblique slice approximately perpendicular to the target vessels to include the left (LICA) and right internal carotid artery (RICA), basilar artery (BA), sinus rectus (SR), and superior sagittal sinus (SSS). A total of four PC MRI scans were performed at different CO(2) concentrations (room air and 3%, 5%, and 7% CO(2)).Results: The analyses obtained the flow parameters and cerebrovascular resistance parameters for all five vessels. Results indicated that the vascular resistance indices decreased with increasing CO(2) concentration in four vessels (LICA, RICA, BA, and SR). The obtained VMR parameters demonstrated exponential increases with increasing CO(2) concentration.Conclusions: Using entire blood flow waveforms, this study applied separate flow dynamics during systolic and diastolic periods to obtain cerebrovascular resistance parameters and extensive flow-related information. It is the first to investigate the cerebrovascular resistance parameters under hypercapnic challenge using cine MRI. This technique could provide a useful tool for clinical application in cerebrovascular disease.
Medical Physics 11/2012; 39(11):6534-41. · 2.83 Impact Factor
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ABSTRACT: Clinical cardiac MR imaging techniques generally require patients to hold their breath during the scanning process to minimize respiratory motion-related artifacts. However, some patients cannot hold their breath because of illness or limited breath-hold capacity. This study aims to optimize the PROPELLER reconstruction for free-breathing myocardial T1-weighted imaging.
Eight healthy volunteers (8 men; mean age 26.4 years) participated in this study after providing institutionally approved consent. The PROPELLER encoding method can reconstruct a low-resolution image from every blade because of k-space center oversampling. This study investigated the feasibility of extracting a respiratory trace from the PROPELLER blades by implementing a fully automatic region of interest selection and introducing a best template index to account for the property of the human respiration cycle.
Results demonstrated that the proposed algorithm significantly improves the contrast-to-noise ratio and the image sharpness (p < 0.05).
The PROPELLER method is expected to provide a robust tool for clinical application in free-breathing myocardial T1-weighted imaging. It could greatly facilitate the acquisition procedures during such a routine examination.
Medical Physics 08/2012; 39(8):4896-902. · 2.83 Impact Factor
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ABSTRACT: To implement a flow-gating method to acquire phase-contrast (PC) images of carotid arteries without use of an electrocardiography (ECG) signal to synchronize the acquisition of imaging data with pulsatile arterial flow. The flow-gating method was realized through radial scanning and sophisticated post-processing methods including downsampling, complex difference, and correlation analysis to improve the evaluation of flow-gating times in radial phase-contrast scans. Quantitatively comparable results (R = 0.92-0.96, n = 9) of flow-related parameters, including mean velocity, mean flow rate, and flow volume, with conventional ECG-gated imaging demonstrated that the proposed method is highly feasible. The radial flow-gating PC imaging method is applicable in carotid arteries. The proposed flow-gating method can potentially avoid the setting up of ECG-related equipment for brain imaging. This technique has potential use in patients with arrhythmia or weak ECG signals.
The international journal of cardiovascular imaging 05/2012; · 2.15 Impact Factor
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ABSTRACT: This study uses the k-space center over-sampling property of PROPELLER encoding to detect cardiac and respiratory motion using raw k-space data. Using the motion information, cine cardiac imaging is self-gated. The data acquisition process requires neither electrocardiography triggering nor patient breath-holding. Using physiology motion information, this post-processing method rearranges the k-space data into groups corresponding to cardiac and respiratory phases. The PROPELLER blades of the same groups are combined to produce cine high-resolution images. This approach reduces the potential discrepancy of the k-space data and the motion-related artifacts in the reconstructed image because all blades in a group are acquired at consistent cardiac and respiratory phases. The study concludes that self-gated cine cardiac imaging is feasible using PROPELLER encoding. It is a potentially practical tool for cine cardiac imaging.
The international journal of cardiovascular imaging 11/2011; 28(6):1477-85. · 2.15 Impact Factor
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ABSTRACT: BACKGROUND AND PURPOSE: The combination of phase demodulation and field mapping is a practical method to correct echo planar imaging (EPI) geometric distortion. However, since phase dispersion accumulates in each phase-encoding step, the calculation complexity of phase modulation is Ny-fold higher than conventional image reconstructions. Thus, correcting EPI images via phase demodulation is generally a time-consuming task. METHODS: Parallel computing by employing general-purpose calculations on graphics processing units (GPU) can accelerate scientific computing if the algorithm is parallelized. This study proposes a method that incorporates the GPU-based technique into phase demodulation calculations to reduce computation time. The proposed parallel algorithm was applied to a PROPELLER-EPI diffusion tensor data set. RESULTS: The GPU-based phase demodulation method reduced the EPI distortion correctly, and accelerated the computation. The total reconstruction time of the 16-slice PROPELLER-EPI diffusion tensor images with matrix size of 128 × 128 was reduced from 1,754 seconds to 101 seconds by utilizing the parallelized 4-GPU program. CONCLUSIONS: GPU computing is a promising method to accelerate EPI geometric correction. The resulting reduction in computation time of phase demodulation should accelerate postprocessing for studies performed with EPI, and should effectuate the PROPELLER-EPI technique for clinical practice. J Neuroimaging 2011;XX:1-5.
Journal of neuroimaging: official journal of the American Society of Neuroimaging 09/2011; · 1.72 Impact Factor
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ABSTRACT: To combine temperature-related information of phase images and magnitude images acquired from an MR spoiled gradient echo sequence using a postprocessing method referred to as PRF-shift-weighted imaging (PRFSWI).
Phase images are capable of detecting shifts in proton resonance frequency (PRF) caused by local changes in temperature. Magnitude images provide anatomical information for treatment planning and positioning as well as temperature-related contrast. We used PRFSWI to produce a phase-mask and performed multiplication on the magnitude image to increase temperature-related contrast.
Through MRI-guided focused ultrasound (MRIgFUS) experiments (both ex vivo and in vivo), we determined that PRFSWI is capable of enhancing the contrast of a heated area even in the initial stages of transmitting high-intensity focused ultrasound energy.
The PRFSWI images are sensitive to changes in temperature and display the heated spot directly in the magnitude images. Although the images do not provide quantitative data related to temperature, this method could be used as a complement to the phase temperature mapping method in the real-time monitoring of MRIgFUS experiments.
Journal of Magnetic Resonance Imaging 06/2011; 33(6):1474-81. · 2.70 Impact Factor
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ABSTRACT: Phase contrast MRI with multidirectional velocity encoding requires multiple acquisitions of the same k-space lines to encode the underlying velocities, which can considerably lengthen the total scan time. To reduce scan time, parallel imaging is often applied. In dynamic phase contrast MRI using standard generalized autocalibrating partially parallel acquisitions (GRAPPA), several central k-spaces for autocalibration of the reconstruction (autocalibrating signal lines (ACS)) are typically acquired, separately for each velocity direction and each cardiac timeframe, for calculating the reconstruction weights. To further accelerate data acquisition, we developed two methods, which calculated weights with a substantially reduced number of ACSl lines. The effects on image quality and flow quantification were compared to fully sampled data, standard GRAPPA, and time-interleaved sampling scheme in combination with generalized autocalibrating partially parallel acquisitions (TGRAPPA). The results show that the two proposed methods can clearly improve scan efficiency while maintaining image quality and accuracy of measured flow or myocardial tissue velocities. Compared to TGRAPPA, the proposed methods were more accurate in evaluating flow velocity. In conclusion, the proposed reconstruction strategies are promising for dynamic multidirectionally encoded acquisitions and can easily be implemented using the standard GRAPPA reconstruction algorithm.
Magnetic Resonance in Medicine 08/2010; 64(2):472-80. · 2.96 Impact Factor
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ABSTRACT: To report possible erroneous estimates of diffusion parameters in the twice-refocused spin-echo (TRSE) technique, proposed to eliminate eddy-current-induced geometric distortions in diffusion-weighted echo-planar imaging, when stimulated echo signals are inappropriately included.
Eleven subjects were included for imaging experiments on two 1.5 Tesla systems using the TRSE sequence. Three versions, two with unbalanced crusher gradients inserted to dephase the stimulated echo from the b = 0 images and one with balanced crusher gradients, were implemented. The apparent diffusion coefficients (ADC) and fractional anisotropy (FA) were derived and compared.
The ADCs obtained with unbalanced crusher gradients were closer to values reported in the literature. Stimulated echo led to ADC over-estimations by 34.2%, 50.4%, 54.0%, 51.5%, 24.0%, and 41.9% in the genu of corpus callosum, splenium of corpus callosum, bilateral corona radiata, internal capsule, mediofrontal gyrus, and the cuneus, respectively (P < 0.01), with concomitant reduction in FA in highly anisotropic regions. Over-estimations of diffusion coefficients were found to be roughly equal along all directions.
Formation of stimulated echo in the TRSE technique can lead to erroneous estimations of the diffusion parameters, even if no prominent morphological artifacts are seen.
Journal of Magnetic Resonance Imaging 06/2010; 31(6):1522-9. · 2.70 Impact Factor
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ABSTRACT: To measure temperature change and magnetization transfer ratio (MTR) simultaneously during high-intensity focused ultrasound (HIFU) treatment.
This study proposed an interleaved dual gradient-echo technique to monitor the heat and tissue damage brought to the heated tissue. The technique was applied to tissue samples to test its efficacy.
Ex vivo experiments on the porcine muscle demonstrated that both temperature changes and MTR exhibited high consistency in localizing the heated regions. As the heat dissipated after the treatment, the temperature of the heated regions decreased rapidly but MTR continued to be elevated. Moreover, thermal dose (TD) maps derived from the temperature curves demonstrated a sharp margin in the heated regions, but MTR maps may show a spatial gradient of tissue damage, suggesting complimentary information provided by these two measures.
In a protocol of spot-by-spot heating over a large volume of tissue, MTR provides additional values to mark the locations of previously heated regions. By continuously recording the locations of heated spots, MTR maps could help plan the next target spots appropriately, potentially improving the efficiency of HIFU treatment and reducing undesirable damage to the normal tissue.
Journal of Magnetic Resonance Imaging 08/2009; 30(3):596-605. · 2.70 Impact Factor
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ABSTRACT: A fast and motion-insensitive technique suitable for myocardial BOLD contrast imaging is presented. The method, termed T2-TrueFISP, combines T2 magnetization preparation with steady-state free precession (SSFP) imaging for T2 relaxation mapping of the myocardium in healthy volunteers. The T2 contrast-to-noise ratio (CNR) was optimized with the use of transient-state TrueFISP readout and half-Fourier readout with linear phase encoding. Single-slice myocardial T2-weighted image was obtained within one heartbeat, and a single slice T2 map of the myocardium was obtained in under 5-7 s. A respiratory navigator-gating method was incorporated for serial measurements and signal averaging, with the subjects breathing freely. The mean myocardial T2 relaxation time measured in 12 healthy volunteers was 54 +/- 5.7 ms. Regional variations of T2 values across the myocardium were 7%. Temporal variations across serial T2 measurements in a transmural region covering approximately 0.5 cc of the left ventricular (LV) wall were 3.6% without signal averaging (number of excitations (NEX) = 1) and 1.7% with signal averaging (NEX = 10). According to our preliminary results, the T2-TrueFISP method is expected to provide a robust and sensitive tool for clinical application of myocardial BOLD contrast imaging.
Magnetic Resonance in Medicine 06/2007; 57(5):960-6. · 2.96 Impact Factor
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ABSTRACT: The steady-state free precession (SSFP) method has been shown to exhibit strong potential for distortion-free functional magnetic resonance imaging (fMRI). One major challenge of SSFP fMRI is that the frequency band corresponding to the highest functional sensitivity is extremely narrow, leading to substantial loss of functional contrast in the presence of magnetic field drifts. In this study we propose a frequency stabilization scheme whereby an RF pulse with small flip angle is applied before each image scan, and the initial phase of the free induction decay (FID) signals is extracted to reflect temporal field drifts. A simple infinite impulse response (IIR) filter is further employed to obtain a low-pass-filtered estimate of the central reference frequency for the upcoming scan. Experimental results suggest that the proposed scheme can stabilize the frequency settings in accordance with field drifts, with oscillation amplitudes of <0.5 Hz. Phantom studies showed that both slow drifts and fast fluctuations were prominently reduced, resulting in less than 5% signal variations. Visual fMRI at submillimeter in-plane resolution further demonstrated 15% activation signals that were nicely registered in the microvessels within the sulci. It is concluded that the IIR-filtered frequency stabilization is an effective technique for achieving reliable SSFP fMR images at high field strengths.
Magnetic Resonance in Medicine 02/2007; 57(2):369-79. · 2.96 Impact Factor
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ABSTRACT: A technique integrating multishot periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) and parallel imaging is presented for diffusion echo-planar imaging (EPI) at high spatial resolution. The method combines the advantages of parallel imaging to achieve accelerated sampling along the phase-encoding direction, and PROPELLER acquisition to further decrease the echo train length (ETL) in EPI. With an eight-element circularly symmetric RF coil, a parallel acceleration factor of 4 was applied such that, when combined with PROPELLER acquisition, a reduction of geometric distortions by a factor substantially greater than 4 was achieved. The resulting phantom and human brain images acquired with a 256 x 256 matrix and an ETL of only 16 were visually identical in shape to those acquired using the fast spin-echo (FSE) technique, even without field-map corrections. It is concluded that parallel PROPELLER-EPI is an effective technique that can substantially reduce susceptibility-induced geometric distortions at high field strength.
Magnetic Resonance in Medicine 01/2007; 56(6):1352-8. · 2.96 Impact Factor
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Shang-Yueh Tsai,
Ming-Ting Wu,
Yi-Ru Lin,
Kai-Sheng Hsieh,
Chu-Chuan Lin, Teng-Yi Huang,
Hsiao-Wen Chung,
Jun-Yen Pan,
Yi-Luan Huang,
Huay-Ben Pan,
Chien-Fang Yang
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ABSTRACT: A temporal correlation (TC) mapping method is proposed to help bolus chasing during dynamic contrast-enhanced (DCE) MRI of complex pulmonary circulation (CPC) in patients with congenital heart disease. DCE-MRI was performed on five healthy male subjects (23-24 years old) and 25 patients (nine males and 16 females, 0.25-44 years old), and TC maps were generated by performing pixel-based computation of cross-correlations to the pulmonary artery with a series of time shifts in all subjects. Qualitative and quantitative evaluations were performed in comparison with original DCE images. TC maps exhibited a better signal-to-noise ratio (SNR) by factors of 4.3 and 1.3 in the lung parenchyma, pulmonary veins, and superior artery/vein; a better intraparenchymal contrast-to-noise ratio (CNR) by factors of 1.5-5.4; and a significantly higher conspicuity in all regions except the pulmonary arteries when graded with a five-point score. TC maps evaluated by two experienced clinicians significantly added relevant information (P<0.001), and in some cases affected the final diagnosis. We conclude that TC maps facilitate bolus chasing for DCE-MRI by reducing recirculation effects and interframe fluctuations, and hence complements morphological imaging of CPC in patients with complex congenital heart disease.
Magnetic Resonance in Medicine 09/2006; 56(3):517-26. · 2.96 Impact Factor
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ABSTRACT: To develop an adaptive subvoxel stepping scheme, as an adjunct to tensor deflection (TEND) tractography, that automatically adjusts the stepping size by considering the tensor linearity to properly trace fiber bundles in regions with different degrees of tensor anisotropy.
A theoretical investigation of the TEND algorithm was performed to assess the degree of deflection of the propagation vector toward the major eigenvector. Mathematically generated phantoms (one with curved fibers and the other with crossing fibers) at wide ranges of signal-to-noise ratio (SNR), and human brain images obtained in vivo were used to test the performance of the adaptive stepping algorithm.
The degree of deflection was found to be inversely related to the stepping size. A small stepping size was advantageous for tracing single curved fiber bundles, whereas a large stepping size was beneficial for passing through fiber crossing regions. The performance of the adaptive stepping algorithm was superior to fixed stepping in both situations, leading to an approximately 0.17 voxel of deviation in curved fibers and a nearly 100% successful tracking rate in crossing fibers at typical SNR. Human brain images demonstrated similar results.
The adaptive stepping algorithm is a helpful adjunct to TEND tractography.
Journal of Magnetic Resonance Imaging 09/2006; 24(2):451-8. · 2.70 Impact Factor
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ABSTRACT: A technique suitable for diffusion tensor imaging (DTI) at high field strengths is presented in this work. The method is based on a periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) k-space trajectory using EPI as the signal readout module, and hence is dubbed PROPELLER EPI. The implementation of PROPELLER EPI included a series of correction schemes to reduce possible errors associated with the intrinsically higher sensitivity of EPI to off-resonance effects. Experimental results on a 3.0 Tesla MR system showed that the PROPELLER EPI images exhibit substantially reduced geometric distortions compared with single-shot EPI, at a much lower RF specific absorption rate (SAR) than the original version of the PROPELLER fast spin-echo (FSE) technique. For DTI, the self-navigated phase-correction capability of the PROPELLER EPI sequence was shown to be effective for in vivo imaging. A higher signal-to-noise ratio (SNR) compared to single-shot EPI at an identical total scan time was achieved, which is advantageous for routine DTI applications in clinical practice.
Magnetic Resonance in Medicine 12/2005; 54(5):1232-40. · 2.96 Impact Factor
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ABSTRACT: Parallel MRI techniques reconstruct full-FOV images from undersampled k-space data by using the uncorrelated information from RF array coil elements. One disadvantage of parallel MRI is that the image signal-to-noise ratio (SNR) is degraded because of the reduced data samples and the spatially correlated nature of multiple RF receivers. Regularization has been proposed to mitigate the SNR loss originating due to the latter reason. Since it is necessary to utilize static prior to regularization, the dynamic contrast-to-noise ratio (CNR) in parallel MRI will be affected. In this paper we investigate the CNR of regularized sensitivity encoding (SENSE) acquisitions. We propose to implement regularized parallel MRI acquisitions in functional MRI (fMRI) experiments by incorporating the prior from combined segmented echo-planar imaging (EPI) acquisition into SENSE reconstructions. We investigated the impact of regularization on the CNR by performing parametric simulations at various BOLD contrasts, acceleration rates, and sizes of the active brain areas. As quantified by receiver operating characteristic (ROC) analysis, the simulations suggest that the detection power of SENSE fMRI can be improved by regularized reconstructions, compared to unregularized reconstructions. Human motor and visual fMRI data acquired at different field strengths and array coils also demonstrate that regularized SENSE improves the detection of functionally active brain regions.
Magnetic Resonance in Medicine 09/2005; 54(2):343-53. · 2.96 Impact Factor
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ABSTRACT: This study investigated the effects of flip angle setting in 3D balanced steady-state free precession (SSFP) imaging on CSF-parenchyma contrast and section aliasing artifacts. Theoretical derivations indicated that the extent of section aliasing artifacts decreased as the flip angle was lowered, at the expense of a sacrifice in CSF-parenchyma contrast. Experimental data agreed closely with theoretical predictions. A flip angle of about 40 degrees is therefore recommended for 3D balanced SSFP MR ventriculocisternography.
American Journal of Neuroradiology 06/2005; 26(5):1170-3. · 2.93 Impact Factor
