-
[show abstract]
[hide abstract]
ABSTRACT: A study of 100 normal subjects from villages in southern Iran revealed that almost one third of this population had one (or more) absorptive or morphological abnormality of the small-bowel mucosa. The finding of morphologically normal bowel mucosa in stillborn fetuses and in newborns who died within two weeks of birth was consistent with the possibility that the abnormalities noted in the village population were postnatally acquired. Finally, speculations are offered regarding the relationship of idiopathic enteropathy and "immunoproliferative small intestinal disease," which is often seen in the region.
Israel journal of medical sciences 05/1979; 15(4):362-3.
-
[show abstract]
[hide abstract]
ABSTRACT: The patients studied were diagnosed as suffering from alpha-chain disease by their clinicopathological features, malabsorption findings, X-ray, and presence of abnormal alpha-chain protein in their serum. The objective of the study was to determine any possible defect of the immune system in such patients. The rosette technique and surface immunofluorescence were used to enumerate the circulating T and B lymphocytes in these patients. They were also skin-tested with tuberculin and given sensitizing doses of dinitrochlorobenzene. Their serum immunoglobulins were also quantitated. It was found that the proportion of circulating B lymphocytes was much higher than normal, whereas that of T lymphocytes was lower than normal. Furthermore, they could not be sensitized to DNCB and their skin test to tuberculin was negative. It was concluded that the disease was a B-cell disease of IgA type, associated with low level of cellular immunity.
British Journal of Cancer 02/1978; 37(1):48-54. · 5.04 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: A prospective study of 32 patients with primary upper small intestinal lymphoma in our region revealed 10 cases of alpha heavy-chain disease. Patients were mostly in the second and third decades of life and males predominated. Weight loss, diarrhea, and abdominal pain were the most common complaints and clubbing the most frequent physical findings. Laboratory tests revealed a malabsorption pattern on intestinal x-rays, and malabsorption of xylose, fat, and vitamin B12 was frequently noted. Dense plasmacytic infiltrate of the lamina propria of small bowel was the most frequent pathologic finding while true neoplasm of the lymphoid system (ie, immunoblastic sarcoma) was encountered in 20% of the cases.
The American Journal of Digestive Diseases 11/1977; 22(10):866-73.
-
[show abstract]
[hide abstract]
ABSTRACT: A study was made of the prevalence of colorectal polyps (excluding juvenile polyps, familial polyposis coli and villous adenomas) and the minimum frequency of colorectal carcinoma in Southern Iran. A total of 801 large intestines from necropsies performed on individuals 20 years or older was examined with or without magnifying lens for presence of polyps. Our prevalence rate was then compared with those reported on postmortem material from the USA, Australia, South Africa (Bantus), Colombia, and Hawaii (Japanese immigrants). Our surgical pathology files were reviewed for colorectal polyps over a 22-year period (1952-1973). Colorectal carcinomas diagnosed in the Department of Pathology were reviewed over 11 years (1963-1973) and the minimum frequency rates compared with corresponding age- and sex-specific incidence rates from Connecticut, USA. The data indicate 1) a very low prevalence rate for colorectal polyps as well as carcinoma in our region and 2) a rather striking predominance of right-sided colonic carcinoma.
Cancer 02/1977; 39(1):274-8. · 4.77 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Twenty-seven intestinal lymphoma patients were studied. Abnormal alpha-chain immunoglobulin was detected in the sera of seven of these patients. The alpha-chain disease patients were from the rural areas of Southern Iran. They were of low socio-economic status and their age ranged from 15-44 years. Predominant clinical features were malabsorption, diarrhoea , abdominal pain, vomiting, and weight loss. Infiltration of mucosa of the small intestine with plasma cells and also distortion and flattening of the villi were common histopathologic characteristics of these patients. Involvement of mesenteric lymph nodes with infiltration of tumour cells was observed in a number of cases. Protein studies revealed no significant differences between the serum immunoglobulin levels of these patients and normal values. Immunoelectrophoresis using monospecific antiserum against H-chain of human IgA demonstrated the abnormal precipitin band of alpha-chain disease protein.
Clinical & Experimental Immunology 11/1976; 26(1):124-8. · 3.36 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Primary upper small-intestinal lymphoma (PUSIL) has now been recognized as a distinct clinical entity with a distinct geographic distribution. Herewith are presented 40 cases of PUSIL seen at Pahlavi University Hospitals in Southern Iran. The investigation reveals the lymphoma to be predominantly a disease of those under 30 and males; the major complaints and physical findings point to an intraabdominal disease. An exception has been clubbing and osteoarthropathy. Special features of PUSIL include: (1) protein loss into the gastrointestinal tract leading to hypoalbuminemia and edema; (2) an antibiotic-responsive diarrhea and steatorrhea; and (3) an associated abnormal heavy-chain protein. The study further stresses the importance of peroral small-intestinal biopsy and the pathologic features of this condition.
The American Journal of Digestive Diseases 05/1976; 21(4):313-23.
-
[show abstract]
[hide abstract]
ABSTRACT: Idiopathic enteropathy in the rural population of Iran was investigated through evaluation of 100 randomly selected apparently normal subjects. The evaluation included quantitation of the nutrient loss, presence of malabsorption, and small intestinal morphological abnormalities. The results show that: 1) there was no significant loss of major nutrients, 2) severe malabsorption was not present, 3) an enteropathy of unknown etiology was found in nearly one-third of the subjects, and 4) abnormalities in morphology did not necessarily mean presence of malabsorption.
American Journal of Clinical Nutrition 03/1976; 29(2):169-76. · 6.67 Impact Factor
-
Pathology annual 02/1975; 10:177-203.
-
Cancer 12/1974; 34(5):1842-8. · 4.77 Impact Factor
-
The Lancet 03/1973; 1(7798):283-8. · 38.28 Impact Factor
-
Pathology annual 02/1973; 8:231-55.
-
The Journal of tropical medicine and hygiene 04/1972; 75(3):58-61.
-
[show abstract]
[hide abstract]
ABSTRACT: Comparing the minimal incidence of gastrointestinal cancers in Southern Iran to the true incidence of same in Connecticut, it appears that all such cancers with the possible exception of those of the colon and pancreas, are more frequent in the younger population of Iran. Furthermore, upper gastrointestinal cancers seem more frequent in Iran, and of interest is the prevalence of Primary Upper Small Intestinal Lymphoma, a tumor rarely encountered in Western countries. The explanation for the higher frequency of the said cancers is not clear but may include a combination of genetic and environmental factors.
Journal of Chronic Diseases 12/1971; 24(10):625-33.
-
The Journal of tropical medicine and hygiene 06/1971; 74(5):117-9.
-
[show abstract]
[hide abstract]
ABSTRACT: Seven patients with primary lymphoma involving the upper small intestine and presenting with diarrhoea, non-specific abdominal pain, and clubbing are reported. The disease appears to be more prevalent in young women, and clinical and radiological findings can provide an excellent preliminary diagnosis which is usually confirmed by peroral biopsy of the small intestine. This type of lymphoma is found to be clinically distinguishable both from the primary intestinal lymphomas reported from western countries and also from gastrointestinal involvement as part of a more systemic disease. It appears to be prevalent in the Middle East, and because of clear clinical, radiological, and histological features, it can be singled out from other primary intestinal lymphomas and considered as a distinct clinical entity.
Gut 09/1970; 11(8):673-8. · 10.11 Impact Factor
