Sükrü Yildirim

Publications (11)17.51 Total impact

• Article: Influence of the c-erb B-2, nm23, bcl-2 and p53 protein markers on colorectal cancer.

  Sezai Demirbaş, Ilker Sücüllü, Sükrü Yildirim, Tuncay Celenk
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  ABSTRACT: Under stringent intra-laboratory conditions we evaluated the relationship between the expression of four protein markers and clinicopathologic characteristics of colorectal tumors. 124 patients with colorectal cancer from 1999 to 2002 were assessed. The expression of cerb B-2, nm23 and p53 was mostly determined in tumors located in the rectum. However, about 20% of the rectal lesions had bcl-2 expression. p53 and c-erb B-2 expression was significantly demonstrated in the lesions with vascular and lymph node involvement. However, the difference between the markers and staging was not statistically significant (p=0.388, p=0.301). Cerb B-2 and p53 were more frequently expressed in the patients with large tumors (more than 5 cm) with moderate and poor differentiation grade. About half of the tumors expressing c- erb B- 2 and p53 had vascular invasion and more than 70% had N1 and N2 lymphatic invasion as well. In the patients with tumors expressing c-erb B-2 and p53, recurrences often occurred and both disease-free survival (DFS) and overall survival (OS) in the first two years after surgery were shorter than of the patients with tumors expressing nm23 and bcl-2. In this study, c-erb B-2 and p53 were frequently expressed in the Astler- Coller stage C large tumors located in the rectum and a high degree of vascular and lymphatic invasion was observed. In the patients with tumors expressing c-erb B-2 and p53, recurrences were determined more frequently and DFS and OS were shorter than in patients with tumors expressing nm23 and bcl-2. Thus, two different protein markers should be taken into consideration when evaluating the clinical outcome of patients with colorectal cancer.
  The Turkish journal of gastroenterology: the official journal of Turkish Society of Gastroenterology 04/2006; 17(1):13-9. · 0.47 Impact Factor
• Article: Effective dose of 5-fluorouracil for myringotomy in rats.

  Hakan Cincik, Atila Güngör, Omer Sağlam, Engin Cekin, Sükrü Yildirim, Ethem Poyrazoğlu
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  ABSTRACT: The purpose of this study is to compare the effects of two different doses of 5-fluorouracil (5-FU) on closure rates and histopathological findings in myringotomy to those of simple myringotomy with saline application. 36 rats were divided into two study groups and a control group of 12 rats each. After bilateral myringotomy, we applied 5-FU 50 mg/ml in group A, 10 mg/ml in group B and saline in the control group for 10 minutes. Examination was made by otoendoscopy on days 1, 3, 5, 7, 10, 15, 20, 25. After the follow up examination, two rats from each group were randomly sacrificed on days 7, 15, 25 and 35. Both tympanic membranes were investigated for fibrosis and inflammation by light microscopy. Most of the tympanic membranes from group B and the control group healed on the 10th day, but 16 myringotomies were patent in group A; by the 25th day, all myringotomies in all three groups were completely healed. The mean healing time was 14.62 days, 10.20 days and 10.40 days respectively in groups A, B and control. Fibrosis and inflammation were less in group A than in group B and the controls. 5-FU at a concentration of 50 mg/mL is effective in prolonging the patency of myringotomies in rat tympanic membranes, while a concentration of 10 mg/mL has no greater effect than a simple myringotomy procedure with saline application.
  Medical science monitor: international medical journal of experimental and clinical research 10/2005; 11(9):BR330-4. · 1.70 Impact Factor
• Article: Ulcerative necrosis of the glans penis resulting from polyarteritis nodosa.

  Kenan Karademir, Temuçin Senkul, Enes Atasoyu, Sükrü Yildirim, Selim Nalbant
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  ABSTRACT: Polyarteritis nodosa (PAN) may be systemic or isolated in distribution and may involve virtually any organ or tissue in the body. We report an unusual case of PAN with the clinical features of both penile and renal involvement in a 21-year-old man diagnosed incidentally by pathologic examination of the nephrectomized left kidney. Systemic and surgical therapeutic procedures were applied and his symptoms resolved within 6 weeks. Penile ulceration is a rare but serious manifestation of PAN that needs prompt and aggressive treatment.
  JCR Journal of Clinical Rheumatology 07/2005; 11(3):167-9. · 1.36 Impact Factor
• Article: The effects of incisional myringotomy and CO2 laser myringotomy on rat tympanic membranes.

  Ethem Poyrazoglu, Hakan Cincik, Atila Gungor, Berk Gurpinar, Sükrü Yildirim, Hasan Candan
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  ABSTRACT: The purpose of this study was to compare closure rates and histopathological findings of carbon dioxide (CO(2)) laser myringotomies to those of incisional myringotomy. We performed CO(2) laser round myringotomy on left ears and incisional round myringotomy on the right ears of 34 rats on the same day. The incisions were 2mm in size on both ears. Examination was made with otoendoscope on days 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 25, 30, 35, 40, 45, 50 with videorecording. Two rats were sacrificed every 2 days for 25 days and every 5 days thereafter, randomly. The tympanic membranes (TM) were excised and hyalinization, fibrosis and inflammation were assessed with light microscope. Most of the CO(2) laser myringotomies healed after day 15, and all of them healed by day 50. Three of the incisional myringotomy perforations were closed at day 3, and the rest by day 15. Patency of CO(2) laser myringotomies was significantly longer than that of incisional myringotomies. Hyalinization, fibrosis and inflammation of the incisional myringotomy group were significantly less than those of the laser myringotomy group. CO(2) laser myringotomies remain patent for a longer period of time than the incisional procedure, however, they cause more tissue inflammation. We believe that CO(2) laser myringotomy is an effective method, however, additional studies are needed to identify its complications.
  International Journal of Pediatric Otorhinolaryngology 07/2004; 68(6):811-5. · 1.17 Impact Factor
• Article: [Primary Hodgkin's lymphoma of the parotid gland: a case report].

  Ethem Poyrazoğlu, Hakan Cincik, Atila Güngör, Adem Cakmak, Sükrü Yildirim
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  ABSTRACT: Primary Hodgkin's lymphoma of the parotid gland is rare. A twenty-one-year-old man presented with a lesion that recurred two years after an excisional biopsy for a parotid gland mass. He underwent superficial parotidectomy. Frozen section examination suggested a diagnosis of Hodgkin's lymphoma. The patient was treated by radiotherapy. A complete recovery was obtained after a 27-month follow-up.
  Kulak burun bogaz ihtisas dergisi: KBB = Journal of ear, nose, and throat 08/2003; 11(1):21-4.
• Article: Does N-acetyl cystein affect the sensitivity and specificity of Helicobacter pylori stool antigen test?

  Levent Demirtürk, Yusuf Yazgan, Orhan Tarçin, Melih Ozel, Muhittin Diler, Oral Oncül, Sükrü Yildirim
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  ABSTRACT: N-acetyl cystein, a mucolytic agent, might make Helicobacter pylori antigens shed more easily to stool, and might therefore contribute to the diagnostic accuracy of the Helicobacter pylori stool antigen test. The aim of this study is to investigate if N-acetyl cystein contributes to the diagnostic accuracy of the Helicobacter pylori stool antigen test by increasing the sensitivity and specificity of the test. 107 patients were separated into treatment and placebo groups. The AC group (n = 53) was given 5 ml of acetyl cystein (4%) t.i.d. and the Placebo group (n = 54) was given placebo, for 3 days. Helicobacter pylori status was determined by both histology and CLOtest. Stool samples were assayed using a specific ELISA kit for Helicobacter pylori stool antigen. The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of Helicobacter pylori stool antigen test were 76%, 79%, 90%, 55%, and 77%, respectively, in AC group; and 85%, 89%, 93%, 76% and 86%, respectively, in placebo group. N-acetyl cystein did not increase, and actually decreased, the sensitivity and specificity of the Helicobacter pylori stool antigen test according to our results. We believe that this finding can be taken into consideration when setting up the exclusion criteria for future studies, which will use Helicobacter pylori stool antigen tests.
  Helicobacter 05/2003; 8(2):120-3. · 3.15 Impact Factor
• Article: Oral colonization of Helicobacter pylori: risk factors and response to eradication therapy.

  Ahmet Kemal Gürbüz, A Melih Ozel, Yusuf Yazgan, Murat Celik, Sükrü Yildirim
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  ABSTRACT: Dental plaque is considered by some to be a secondary reservoir for Helicobacter pylori and thus responsible for gastric reinfection. The aim of this study was to investigate whether testing dental plaque using a rapid urease test (CLOtest) can be used to determine gastric H. pylori status. We investigated dental plaque colonization by H. pylori and its correlation with gastric infection in 75 dyspeptic patients. CLOtest was used to determine H. pylori positivity. Tests for H. pylori were positive in dental plaque samples from 68 patients and in stomach samples from 65 patients. The sensitivity of using CLOtest in dental plaque to determine gastric H. pylori status was 89.7%, with a diagnostic accuracy of 86.7%. Gastric eradication was achieved in 83% of patients, but efforts to eradicate dental plaque colonization were unsuccessful in all patients. Using CLOtest to detect H. pylori in dental plaque is a reliable first-line diagnostic approach for gastric H. pylori infection. Dental plaque might be a sanctuary for H. pylori, leading to gastric recurrence.
  Southern Medical Journal 04/2003; 96(3):244-7. · 0.83 Impact Factor
• Article: Does high albumin gradient ascites accompany tuberculous peritonitis?

  Ahmet Kemal Gürbüz, Yusuf Yazgan, Melih A Ozel, Saban Cavuşlu, Hüsnü Altunay, Sükrü Yildirim
  Journal of Clinical Gastroenterology 02/2003; 36(1):82-3. · 3.16 Impact Factor
• Article: Histopathologic changes in the mucosa of ileal orthotopic neobladder--findings in 24 patients followed up for 5 years.

  Temuçin Senkul, Sükrü Yildirim, Cüneyt Işeri, Kenan Karademir, Doğan Erden, Kadir Baykal
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  ABSTRACT: To evaluate changes occurring in the mucosa of the neobladder over a period of 60 months in 24 patients with orthotopic ileal neobladder. A total of 36 male patients have undergone radical cystoprostatectomy and received an orthotopic ileal neobladder in our hospital during the last 10 years; 24 of these patients, all of whom completed a follow-up period of 60 months, are included in this study. All cases underwent a biopsy of the ileal mucosa at the time of surgery and their neobladder mucosa was then biopsied at 6, 12, 24, 36 and 60 months. The specimens were stained with hematoxylin-eosin in order to examine the changes in the thickness of the mucosa and its villi. Sections were also stained with Alcian blue and periodic acid-Schiff in order to determine the number of goblet cells. A morphometric scoring system was created to quantify the change in villi size. The mean thickness of the ileal mucosa at the initial biopsy was 270.9 +/- 35.9 microm and displayed a continuous decrease at all of the subsequent biopsies. The number of luminal goblet cells increased during follow-up. Villus atrophy was found to be a continuous process during follow-up. No dysplasia or malignancy was detected in any of the biopsies. During a follow-up period of 5 years, there were no neoplastic changes in our patients, but instead a protective response of the mucosa to its new environment was observed.
  Scandinavian Journal of Urology and Nephrology 02/2003; 37(3):202-4. · 0.99 Impact Factor
• Article: Impact of imprint cytology in detecting short segment Barrett's esophagus.

  Yusuf Yazgan, Levent Demirtürk, A Melih Ozel, Sükrü Yildirim, Mustafa Ercan
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  ABSTRACT: Short-segment Barrett's esophagus (SSBE) is defined by the presence of columnar-appearing mucosa in distal esophagus (involving less than 2 to 3 cm), with intestinal metaplasia on biopsy. Its potential to develop dysplasia and cancer may require a surveillance program with better diagnostic tools to detect intestinal metaplasia. To investigate the role of imprint cytology as a diagnostic tool either alone or combined with histology in SSBE. Seventy-nine patients (46 men, 33 women) with SSBE diagnosed during elective upper gastroscopy were included. Patients with serrated z-line with short tongues of pink mucosa and patients with a circular non-serrated z-line that extended less than 2 cm above the esophagogastric junction were biopsied on four quadrants just distal to z-line. Four slides of imprint preparation (including 1, 2, 3, and 4 touching of each biopsy specimen) was made for cytologic examination. Hematoxylin and eosin and Alcian blue staining for histologic examinations and Alcian Blue for cytologic evaluations were used to find evidence of intestinal metaplasia. Intestinal metaplasia was detected in 15 (19%), 21 (27%), and 30 (38%) patients by histologic examination with hematoxylin and eosin alone, by Alcian blue alone, and by histologic plus cytologic examination with Alcian blue, respectively. Nine patients with negative histologic but positive cytologic results were positive for intestinal metaplasia when they were reevaluated after further sectioning and staining. Sensitivity of imprint cytology alone was 53%. When imprint cytology was combined with the histologic evaluation, the prevalence of intestinal metaplasia increased from 27% to 38% (p < 0.05). Imprint cytology might be a complementary diagnostic tool for histology in detecting patients with SSBE.
  Journal of Clinical Gastroenterology 02/2003; 36(2):126-9. · 3.16 Impact Factor
• Article: Mönckeberg's sclerosis: an unusual presentation--a case report.

  Cihan Top, Zeki Cankir, Emir Silit, Sükrü Yildirim, Mehmet Danaci
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  ABSTRACT: Calcification of the media of peripheral arteries is referred to as Mönckeberg's sclerosis and occurs commonly in aged individuals. However, it also occurs in younger patients with diabetes mellitus and chronic renal failure. In diabetic patients, medial calcification appears to be a strong independent predictor of cardiovascular mortality. In this report, we have presented a 20 year-old-patient with extensive peripheral artery calcification. The etiology of calcification was not identified. It has been suggested that this was an unusual form of Mönckeberg's sclerosis.
  Angiology 53(4):483-6. · 1.51 Impact Factor