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Publications (5)9.48 Total impact

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    ABSTRACT: Our aim of this study was to quantitatively develop an early EDH natural evolutionary curve, and to assess association of the most common radiological signs of initially nonsurgical supratentorial EDHs on early CT, added with their CT time for EDH enlargement. We retrospectively reviewed pertinent data of supratentorial EDH cases with CT ≤ 6h since injury (1997~2013) in three medical institutions in Shanghai. Cases involved were divided into 6 groups according to their initial CT time since injury (≤ 1h, 1~2h, 2~3h, 3~4h, 4~5h, and 5~6h for group 1 through 6, respectively). Time of initial CT, EDH-associated fractures, EDH volume, and EDH locations were the focus in present study. A total of 797 eligible cases were included. EDH growing curve showed EDH reached 98.1% of its final stabilized size by volume in 5~6h since injury. EDH volume and locations on initial CT could be highly associated with subsequent EDH increase ≥ 30ml and EDH increase requiring surgery when CT time was added. Multivariate analysis succeeded in determining two risk factors for EDH enlargement ≥ 30ml and EDH enlargement requiring surgery for EDH cases with an early CT: EDH volume > 10 ml on CT performed ≤ 2h and EDH located on temporal or temporoparietal region on CT ≤ 1h since head injury. Using recursive partitioning analysis, "high risk" identification criteria were derived to predict EDH enlargement ≥ 30ml with sensitivity of 90.5% (95% confidence interval, 77.9%~96.2%), specificity of 60.1% (95% confidence interval, 54.3%~65.7%); and EDH enlargement requiring surgery with sensitivity of 100.0% (95% confidence interval, 89.9%~100.0%), specificity of 59.9% (95% confidence interval, 54.1%~65.4%). A Redo-CT in 5~6 h post-impact for cases at "high risk" was recommended. Key Words: epidural hematoma; computed tomography; hematoma natural evolution; CT timing.
    Journal of neurotrauma. 07/2014;
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    ABSTRACT: Diffuse axonal injury (DAI) is a frequent form of traumatic brain injury, and is usually associated with long-lasting neurological impairments. A new experimental model was developed in the present study to induce DAI in rats by combining low linear and angular accelerations. In most clinical scenarios, DAI is caused by these two forms of acceleration in combination. In the injury-producing facility described here, the rat rotated instantly after it had sustained the impact that produced linear acceleration. Rats rotated rapidly 90 degrees in the coronal plane at a peak angular acceleration of 137 +/- 12 krad/sec(2) with a duration of 33.7 +/- 1.2 msec. The linear acceleration was applied to the rat's head by dropping a 450 g weight from a height of 0.9 m. Rats exposed to the combined accelerations took significantly longer to regain consciousness (11.9 +/- 3.6 min) than control rats (p < 0.01) or rats subjected to purely angular or linear acceleration (p < 0.01). Although macroscopic damage was observed in all brain-injured animals, axonal damage and hemorrhagic tissue tears were only noted in the animals sustaining the combined accelerations. All rats survived the purely linear or angular acceleration, whereas the mortality rate reached 21.7% following the combined accelerations. These results show that this model is capable of reproducing the major histological and neurological changes that are associated with DAI, and that the combination of low linear and angular accelerations can produce non-linear and synergistic effects to induce moderate/severe DAI.
    Journal of neurotrauma 04/2010; 27(4):707-19. · 4.25 Impact Factor
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    ABSTRACT: Epidermoid cysts are uncommon, benign and slow-growing lesions. They often reach an enormous size without producing neurologic symptoms. We describe a 35-year-old female who had a giant intradiploic epidermoid cyst of the occipital bone. She underwent posterior cranial fossa tumor resection. Pathology confirmed epidermoid cyst. There was no recurrence at 13-month follow-up. Total removal of these cysts and repeated washing of the cavity with 0.9% saline may prevent recurrence and aseptic meningitis.
    Journal of Clinical Neuroscience 08/2009; 16(11):1478-80. · 1.25 Impact Factor
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    ABSTRACT: Angiogenesis plays an essential role in tumor growth and metastasis and is a promising target for cancer therapy. c-Met, a receptor tyrosine kinase, and its ligand, hepatocyte growth factor (HGF), are critical in cellular proliferation, motility, invasion, and angiogenesis. The present study was designed to determine the role of c-Met in growth and metastasis of glioma U251 cells using RNA interference (RNAi) technology in vitro. We constructed three kinds of shRNA expression vectors aiming at the c-Met gene, then transfected them into glioma U251 cells by lipofectamine(TM) 2000. The level of c-Met mRNA was investigated by real-time polymerse chain reaction (RT-PCR). The protein expression of c-Met was observed by immunofluoresence staining and western blotting. U251 cell growth and adherence was detected by methyl thiazole tetrazolium assay. The apoptosis of U251 cells was examined with a flow cytometer. The adherence, invasion, and in vitro angiogenesis assays of U251 cells were done. We got three kinds of c-Met specific shRNA expression vectors which could efficiently inhibit the growth and metastasis of U251 cells and the expression of c-Met in U251 cells. RT-PCR, immunofluoresence staining and western blotting showed that inhibition rate for c-Met expression was up to 90%, 79% and 85%, respectively. The expression of c-Met can be inhibited by RNA interference in U251 cells, which can inhibit the growth and metastasis of U251 cell and induce cell apoptosis. These results indicate that RNAi of c-Met can be an effective antiangiogenic strategy for glioma.
    Journal of Neuro-Oncology 02/2009; 93(2):183-9. · 3.12 Impact Factor
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    ABSTRACT: Sinus pericranii is a rare vascular anomaly in which an abnormal communication exists between the extracranial venous system and the underlying dural venous sinus via the diploe of the skull. We describe a case of a spontaneous thrombosis of the sinus pericranii which was located in the right frontal region and presented as a focal, leathery, and noncompressible mass distinguished in character from the typical manifestation of sinus pericranii. In this case, CT, DSA, MRI, MR venography (MRV), and pathologic examination were performed. The CT showed the bone depression in the skull and the MRI demonstrated the mass, but they were not sufficiently sensitive to detect the thrombus. Pathologic examination and MRV were helpful in depicting the thrombus. She underwent a surgical resection, and at the 5-month follow-up there was no evidence of recurrence.
    The International journal of neuroscience 01/2009; 119(12):2262-73. · 0.86 Impact Factor