Huizhou Liu

Chinese Academy of Sciences, Peping, Beijing, China

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Publications (215)512.21 Total impact

  • Xitong Sun · Liangrong Yang · Tingting Dong · Zhini Liu · Huizhou Liu ·

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    ABSTRACT: In this study, a method combined low-field magnetic separation (MS) with flotation, named as gas-assisted magnetic separation (GAMS), was applied for the removal of cadmium from wastewater. With bubbles’ assistance, the speed of magnetic separation can be greatly improved and the limitation of magnetic force on the capture distance can be overcome. Thus, GAMS is much more efficient and easily scalable than MS. In this work, ethanediamine-modified magnetic poly-(glycidyl methacrylate) microspheres (EMPs) were synthesized as the adsorbent for cadmium. And GAMS was used to separate the EMPs and Cd-loaded EMPs. The effects of pH, gas flow rate, concentration of Cd-loaded EMPs, loading volume, and ionic strength on GAMS were investigated. The results indicated that the EMPs and Cd-loaded EMPs could be rapidly and remotely removed from the solution with GAMS. And the separation time decreased with the increase of gas flow rate and NaCl concentration, but grew with the rise of pH value, loading volume, and concentration of the EMPs. This work showed the great potential of GAMS in the area of water treatment.
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    ABSTRACT: In the protein separation, adsorption and desorption of target protein have been using different buffer condition. Different buffer will change the structure and activity of target protein in some cases. This work describes the use of different wavelength light for remote regulation of adsorption and desorption of target protein in the same buffer solutions. A dynamic system that captured and released protein in response to light is reported. Matrix gold nanoparticles and light-responsive affinity ligand comprising thrombin aptamer (APT15), polyethylene glycol linker, and azobenzene-modified complementary sequence were used. UV light induced a trans–cis isomerization of the azobenzene that destabilized the duplex of aptamer and azobenzene-modified complementary sequence, resulting in thrombin binding to aptamer sequence. Visible light irradiation resulted in DNA duplex rehybridization and thrombin released. Our work demonstrates that different light wavelengths effectively regulated the adsorption and desorption of thrombin in the same buffer, and this system also can capture and release prothrombin from plasma with different wavelength light. Furthermore, this method can be widely applied to a variety of different protein separation process.
    Talanta 11/2015; 144. DOI:10.1016/j.talanta.2015.06.053 · 3.55 Impact Factor
  • Xitong Sun · Liangrong Yang · Tingting Dong · Zhini Liu · Huizhou Liu ·

  • ACS Sustainable Chemistry & Engineering 10/2015; DOI:10.1021/acssuschemeng.5b00975 · 4.64 Impact Factor
  • Yuruo Qi · Linqin Mu · Junmei Zhao · Yong-Sheng Hu · Huizhou Liu · Sheng Dai ·
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    ABSTRACT: Na-ion batteries are becoming comparable to Li-ion batteries because of their similar chemical characteristics and abundant sources of sodium. However, the materials production should be cost-effective in order to meet the demand for large-scale application. Here, a series of nanosized high-performance cathode materials, Na3 (VO1-x PO4 )2 F1+2x (0≤x≤1), has been synthesized by a solvothermal low-temperature (60-120 °C) strategy without the use of organic ligands or surfactants. The as-synthesized Na3 (VOPO4 )2 F nanoparticles show the best Na-storage performance reported so far in terms of both high rate capability (up to 10 C rate) and long cycle stability over 1200 cycles. To the best of our knowledge, the current developed synthetic strategy for Na3 (VO1-x PO4 )2 F1+2x is by far one of the least expensive and energy-consuming methods, much superior to the conventional high-temperature solid-state method. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 07/2015; 54(34). DOI:10.1002/anie.201503188 · 11.26 Impact Factor
  • Yuruo Qi · Linqin Mu · Junmei Zhao · Yong-Sheng Hu · Huizhou Liu · Sheng Dai ·

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    ABSTRACT: In this paper, gas-assisted magnetic separation (GAMS), a technique that combines magnetic separation with flotation, was investigated for the potential large-scale separation of proteins. The GAMS process includes adsorption of target proteins and magnetic separation to recover protein-loaded magnetic particles from the dilute biosuspension with the assistance of bubbles. Microsized ethylenediamine-functionalized poly(glycidyl methacrylate) superparamagnetic microspheres (MPMs) and bovine serum albumin (BSA) were used as a model system. The feasibility of GAMS for capturing BSA-loaded MPMs from an appropriate medium was shown. High recovery of BSA-loaded MPMs was obtained by simple adjustment of the initial solution pH without extra detergents and antifoaming agents. The GAMS conditions were consistent with the adsorption conditions, and no proteins were desorbed from the MPMs during this process. Under the optimal conditions, the separation rate and recovery percentage reached 410 mL/min and 98% in 0.61 min, respectively. Conformational changes of BSA during the GAMS process were investigated by fluorescence spectroscopy and circular dichroism spectrometry.
  • Jie Liu · Kun Huang · Huaizhi Wu · Huizhou Liu ·
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    ABSTRACT: Enrichment and recovery of valuable components in industrial waste waters by traditional liquid-liquid solvent extraction is not economic due to extremely low concentrations of those targets. Large-phase-ratio extraction exhibits potential advantages for recovery of small quantities of target components from large volume of aqueous solutions. In present work, a novel bubbling extraction tower is proposed towards performing solvent extraction at large aqueous-to-oil phase ratios. Organic extractants were covered onto surface of gas bubbles to form a layer of organic liquid membrane and the dispersed organic phase in tower could be small enough. The target components are extracted from aqueous feed solution onto the surface of the bubbles, and the enrichment ratios could be extremely high. We develop a feasible methodology to calculate tower height and operation phase ratios of the bubbling extraction tower, which is essential for future industrial scale-up. Experimental results in pilot test are highly consistent with calculations. This article is protected by copyright. All rights reserved.
    AIChE Journal 06/2015; DOI:10.1002/aic.14904 · 2.75 Impact Factor
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    ABSTRACT: Rapid and sensitive detection of thrombin has very important significance in clinical diagnosis. In this work, bare magnetic iron oxide nanoparticles (magnetic nanoparticles) without any modification were used as fluorescence quenchers. In the absence of thrombin, a fluorescent dye (CY3) labeled thrombin aptamer (named CY3-aptamer) was adsorbed on the surface of magnetic nanoparticles through interaction between a phosphate backbone of the CY3-aptamer and hydroxyl groups on the bare magnetic nanoparticles in binding solution, leading to fluorescence quenching. Once thrombin was introduced, the CY3-aptamer formed a G-quartet structure and combined with thrombin, which resulted in the CY3-aptamer being separated from the magnetic nanoparticles and restoration of fluorescence. This proposed assay took advantage of binding affinity between the CY3-aptamer and thrombin for specificity, and bare magnetic nanoparticles for fluorescence quenching. The fluorescence signal had a good linear relationship with thrombin concentration in the range of 1-60 nM, and the limit of detection for thrombin was estimated as low as 0.5 nM. Furthermore, this method could be applied for other target detection using the corresponding fluorescence labeled aptamer.
    The Analyst 04/2015; 140(12). DOI:10.1039/c5an00519a · 4.11 Impact Factor
  • Jieyuan Lin · Kun Huang · Zhicheng Suo · Xiaopei Li · Chuanxu Xiao · Huizhou Liu ·
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    ABSTRACT: Phase separation dynamic processes in Three-Liquid-Phase System (TLPS), composed of organic oil (P507 extractant), water-soluble polymer (PEG2000), ammonium sulfate and water, with the change of mass composition of phase-forming components were investigated. It was found that dynamic separation of three-layered liquid phases in TLPS is in fact a course of dispersive polymer and organic oil droplets aggregated and separated out respectively from continuous salt aqueous bottom phase. Formation rate of organic oil phase was controlled mainly by coalescence rate of dispersed oil droplets, however rate-determining process for formation of polymer middle phase may change from drop sedimentation to coalescence or co-determined by both, when mass composition of the TLPS changed along different operation lines. With the formation of organic oil phase, it becomes another continuous phase, from which dispersive polymer droplets separated out and aggregated into a bulk phase gradually. Phase separation equilibrating time of TLPS, tE, depends on formation rate of the polymer middle phase and its equilibrium volume. A quantitative correlation of phase separation rate of TLPS with its physic-chemical properties was given. The present work promotes further understanding about influence from change in mass composition of phase-forming components in TLPS on three-phase separation dynamic processes.
    Industrial & Engineering Chemistry Research 04/2015; 54(15):150407110931007. DOI:10.1021/acs.iecr.5b00066 · 2.59 Impact Factor
  • Junmei Zhao · Linqing Mu · Yuruo Qi · Yong-Sheng Hu · Huizhou Liu · Sheng Dai ·
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    ABSTRACT: Room temperature sodium-ion batteries with much lower cost relative to lithium-ion batteries have attracted particular interest for large-scale electrical energy storage in the fields of renewable energies and smart grid. However, most reported cathode materials were synthesized through a conventional high-temperature solid-state method. In order to further save energy and reduce cost, here we show that a series of high-performance cathode materials, sodium vanadium polyanionic compounds, Na3(VO1-xPO4)2F1+2x (x = 0, 0.5 and 1), can been synthesized by a phase-transfer assisted solvo-thermal strategy at a rather low temperature (80 - 140 oC) in one simple step, where an acid-base-coupled extractant was used to attain the phase-transfer of phosphoric acid. More importantly, the used extractant in this route can be recycled. The as-synthesized materials (Na3(VPO4)2F3 and Na3(VOPO4)2F) exhibit a high Na storage capacity of ca. 120 mAh/g which is close to the theoretical capacity and excellent cycling performance. This study makes a significant step to extend this strategy in the synthesis of functional materials from simple binary to complex multicomponent compounds.
    Chemical Communications 03/2015; 51(33). DOI:10.1039/C5CC01504A · 6.83 Impact Factor
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    Menghao Zhu · Junmei Zhao · Yingbo Li · Nada Mehio · Yuruo Qi · Huizhou Liu · Sheng Dai ·
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    ABSTRACT: In this work, a novel IL-based synergistic extraction system utilizing the ionic liquid tricaprylmethylammonium nitrate ([A336][NO3]) and the commercial extractant Di(2-ethylhexyl) 2-ethylhexyl phosphonate (DEHEHP) was developed for the extraction of rare earth (RE) nitrates. Pr(III) was used as a model RE and the effects of key factors, i.e. the ratio of [A336][NO3] to DEHEHP, the acidity of feed solutions, and the concentration of a salting-out reagent, were systematically studied. Our results demonstrate that the mixture of [A336][NO3] and DEHEHP had an obviously synergistic extraction effect for the extraction of Pr(III). The maximum synergistic enhancement coefficient of 3.44 was attained at XA = 0.4 (v%). Alternatively, mixture of [A336][Cl] and DEHEHP hardly extracted Pr(III) from chloride media. Moreover, we investigated the Pr(III) extraction mechanism and demonstrated that Pr(III) can be extracted as the neutral complexation species Pr(NO3)3﹒xDEHEHP and the ion-type species [A336]y﹒Pr(NO3)3+y. These extraction processes can effectively hamper the release of organic cation-ligands into the aqueous phase. The synergistic extraction effect is mainly derived from the enhanced solubility of the extracted species in the ionic liquid phase. The extraction behaviors of Pr(III) could be properly described by Langmuir and pseudo-second-order rate equations. Increased temperature was unfavorable for the extraction reaction but greatly improved the extraction rate. Interestingly, the mixed IL extraction system has an obviously synergistic extraction effect for light REs (LREs, La - Eu), but an anti-synergistic effect for heavy REs (HREs, Gd - Lu, Y), thus, indicating that our synergistic extraction system is helpful for the separation of LREs from HREs. In addition, the high selectivity between REs and non-REs suggested that the recovery of REs from a complicated high-salt leachate could be highly possible. It demonstrates that the IL-based synergistic extraction strategy developed in this work is promising and sustainable, and as a result, the development of an IL-based synergistic extraction process for the recovery of REs is straightforwardly envisaged.
    Green Chemistry 03/2015; 17(5). DOI:10.1039/C5GC00360A · 8.02 Impact Factor
  • Junmei Zhao · Qiaoyu Hu · Yingbo Li · Huizhou Liu ·
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    ABSTRACT: Ionic liquid (IL)-based extraction is a promising and environmentally benign separation technology. To develop sustainable extraction technologies, quaternary ammonium-based IL extraction strategy is attractable. In this work, the separation of vanadium(V) from chromium(VI) by pure tricaprylmethylammonium nitrate ([A336][NO3]) and organic acidified primary amine N1923 ([RNH3][NO3]) was systematically investigated. The optimal proportion of [A336][NO3] and [RNH3][NO3] was studied and results showed that the mixed [A336][NO3] and [RNH3][NO3] exhibited an obvious synergistic-effect for V(V). The extraction of V(V) was strongly dependent on the acidity of the aqueous phase and reaches maximum at pH 2.5-3, while the maximum separation coefficient (βV/Cr) was located at about pH 9.0. Moreover, βV/Cr could be improved through adjusting the molar concentration ratio of V/Cr. The interference of coexisting anions (nitrates, chlorides, sulfate and phosphate) on the extraction of V(V) was examined and the results showed that PO43−, NO3− and Cl− had negative effects at various degrees except for SO42−. The V(V) extraction behaviors could be properly described by Langmuir and pseudo-second-order rate equations. The maximum extraction capacity for V(V) was estimated as 1.877 mmol/g at 303 K. Increased temperature had little effect on the extraction capacity, but greatly improved the extraction rate. The typical anion exchange mechanism between NO3− and V4O124− (or V3O93−) was proposed for the current extraction system. The IL phase could be renewed through stripping the loaded vanadium by a 0.5 M NaNO3 solution. This work demonstrated that quaternary ammonium IL containing a commercial organic extractant is an efficient and sustainable IL-based extraction strategy for the separation of vanadium from chromium, and as a result, the development of an IL-based extraction process is straightforwardly envisaged.
    The Chemical Engineering Journal 03/2015; 264:487-496. DOI:10.1016/j.cej.2014.11.071 · 4.32 Impact Factor
  • Xitong Sun · Liangrong Yang · Qian Li · Zhini Liu · Tingting Dong · Huizhou Liu ·
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    ABSTRACT: A novel adsorbent, polyethylenimine-functionalized poly(vinyl alcohol) (PVA-PEI) magnetic microspheres, was prepared by a process involving: (1) synthesis of magnetic poly(vinyl acetate) microspheres (PVAc) using modified suspension polymerization, (2) preparation of PVA magnetic microspheres by methanolysis of PVAc and (3) two-step reaction with epichlorohydrin and polyethylenimine to yield amino groups. Magnetic measurement illustrated that the PVA-PEI microspheres were superparamagnetic, with a high saturated magnetization of 36.7 emu/g. Once generated, the PVA-PEI microspheres were used as adsorbent to remove Cr(VI) from an aqueous solution. The results demonstrated that the optimized pH value was observed at 2.0. The adsorption rate was extremely fast and the equilibrium was reached within 8 min. The adsorption isotherms of the adsorbent were preferably fitted to the Langmuir model, with the maximum adsorption capacity of 88.4 mg/g at 25 °C. Thermodynamic parameters indicated the spontaneous and exothermic nature of adsorption. In addition, the Cr(VI) ions were successfully eluted by a 0.1 mol/L NaOH solution, with the desorption efficiency of over 99%, and the adsorbent exhibited a good reusability. These results implied that the PVA-PEI microspheres should be considered as a potential adsorbent to remove Cr(VI) from wastewater.
    The Chemical Engineering Journal 02/2015; 262:101–108. DOI:10.1016/j.cej.2014.09.045 · 4.32 Impact Factor
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    ABSTRACT: A new approach called "asynchronous spectrum with auxiliary peaks (ASAP)" is proposed for generating a 2D asynchronous spectrum to investigate the intermolecular interaction between two solutes (P and Q) dissolved in the same solution. In the ASAP approach, a virtual substance S with an isolated peak assumed to be at νS is introduced, while the characteristic peaks of P and Q are actually observed at νP and νQ. The concentrations series of P, Q and S are specifically designed so that a spectral portion that has nothing to do with the intermolecular interaction between P and Q is completely removed from the 2D asynchronous spectrum. Auxiliary cross peaks around (νP, νS) and (νQ, νS) can be used to reveal spectral variation caused by intermolecular interaction, which cannot be observed on conventional cross peaks appearing around the spectral coordinates (νP, νP), (νP, νQ), (νQ, νP), (νQ, νQ). For example, variation of the absorptivity of P caused by an intermolecular interaction between P and Q can be probed from the auxiliary cross peaks around (νP, νS) when Q does not even have any characteristic peak in the observed spectral range.
    RSC Advances 01/2015; 5(107). DOI:10.1039/C5RA16062F · 3.84 Impact Factor
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    ABSTRACT: Hydrothermal carbon spherules (HCSs) can be loaded with a variety of metal nanoparticles for various applications. In this work, three types of HCSs were prepared from saccharides (mono-, di- and poly-saccharides) by a modified hydrothermal method taking glucose, sucrose and starch as sources, respectively. The deposition of Au nanoparticles onto them can be realized through a regular adsorption process. For comparison, HCSs made from mono-saccharides glucose (HCSs-M) has a higher adsorption capacity for Au(III) from aqueous acidic chloride media. The adsorption behaviors for AuCl4- by HCSs-M were investigated systematically. It shows a high selectivity for Au(III) towards Pd(II), Pt(VI), Rh(III) and some relevant base metals Fe(III), Co(II), Cu(II) and Ni(II). An extra reductant glycine can not only significantly improve the adsorption capacities and selectivity, but also accelerate the adsorption rate. Langmuir isotherm model and the 2nd-order kinetics model can properly describe the adsorption behaviors of AuCl4-. The adsorption mechanism of Au(III) by HCSs was confirmed by XPS, XRD, TG, FTIR, SEM and TEM techniques. It demonstrates that AuCl4- has been reduced to Au0 deposited onto HCSs. On the basis of this, a reduction-deposition coupled mechanism was proposed. The current research illustrates a prospect for HCSs to be used as effective adsorbents for selective adsorption separation of Au(III) from chloride media. It also demonstrates a possibility to integrate the selective recovery of gold from a complex industrial waste stream and the fabrication of functional carbon materials through loading with gold nanoparticles.
    11/2014; 3(4). DOI:10.1039/C4TA05597G
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    ABSTRACT: A novel Heck reaction catalyst consisting of a palladium(II) complex of meso-tetra(p-hydroxyphenyl)porphyrin (MTP) and cross-linked chloromethylated polystyrene microspheres (PMs) was successfully prepared via covalent ether bonds between the chloride groups in the PMs and the hydroxyl groups in MTP. The catalyst was characterized using scanning electron microscopy, Fourier-transform infrared spectroscopy, and inductively coupled plasma atomic emission spectroscopy (ICP-AES). This polystyrene-supported palladium-complex was an efficient heterogeneous catalyst for cross-coupling of aryl iodides with ethyl acrylate. The reaction of iodobenzene and ethyl acrylate under N2 at 100 °C and a catalyst concentration of 0.1% gave a gas chromatography product yield of 99.8%, which is much higher than that achieved using a free palladium(II) complex of MTP as the catalyst (41.3%). The catalyst was recycled up to six times without significant loss of catalytic activity. These results suggest that the immobilized palladium(II)–MTP catalyst has potential applications in synthetic and industrial chemistry.
    Particuology 11/2014; 22. DOI:10.1016/j.partic.2014.08.003 · 2.11 Impact Factor
  • Xiaopei Li · Kun Huang · Yizhuang Xu · Huizhou Liu ·
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    ABSTRACT: Many papers have reported that salt ions can exert a great influence on the self-assembly behavior of PEO-PPO copolymers in the aqueous solution. Whereas the mechanism through which salt ions influence the self-assembly behavior of PEO-PPO copolymers is unclear and the dispute is mainly focused on whether the salt ions have a direct interaction with PEO-PPO copolymers. In this paper, the interaction of sodium and potassium ions with PEO-PPO copolymer was investigated by using FTIR, Raman and 23Na NMR spectroscopy. Experimental results reveal that direct interactions between salt cations and PEO-PPO macromolecular chains indeed occur in appropriate conditions. The present work highlights the role of cations in the self-assembly process of PEO-PPO copolymer.
    Vibrational Spectroscopy 10/2014; 75. DOI:10.1016/j.vibspec.2014.10.001 · 2.00 Impact Factor
  • Na Sui · Kun Huang · Han Zheng · Jieyuan Lin · Xiaoqin Wang · Chuanxu Xiao · Huizhou Liu ·
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    ABSTRACT: In the present work, three-liquid-phase extraction and separation of rare earths and Fe, Al, and Si by a novel mixersettlermixer three-chamber integrated extractor was investigated. Various three-liquid-phase systems (TLPSs) involving different organic extractants were employed to conduct continuous three-liquid-phase separation of rare earths and Fe, Al, and Si. In the TLPS of PC-88A/PEG 2000/(NH4)(2)SO4H2O, light, middle, and heavy rare-earth ions had different distribution behaviors selectively into the organic top phase and salt-rich bottom phase, while most of Fe, Al, and Si were enriched into the poly(ethylene glycol) (PEG)-rich middle phase. Influences from aqueous pH values, agitation speeds, and flow ratios on three-liquid-phase partition behaviors of rare earths and Fe, Al, Si were evaluated. Experimental results indicated that an increase of the aqueous pH value facilitated the extraction of rare earths into the organic top phase and enrichment of Fe, Al, and Si into the PEG-rich middle phase. An increase of the agitation speed in three-phase mixer resulted in a change in the disappearance time of the dispersion band in a three-phase settler. The agitation speeds in a two-phase mixer and flow ratios of the organic phase to an aqueous biphasic mixture resulted in a change in the phase volumes of three-layered liquid flows in a three-phase settler so as to affect the partition behaviors of rare earths and Fe, Al, and Si. On the basis of analysis of the phase-forming behaviors of TLPSs and partition behaviors of rare earths and Fe, Al, and Si, the novel mixersettlermixer extractor is recommended for future application of continuous and countercurrent TLPE processes.
    Industrial & Engineering Chemistry Research 10/2014; 53(41):16033-16043. DOI:10.1021/ie5025694 · 2.59 Impact Factor

Publication Stats

4k Citations
512.21 Total Impact Points


  • 1999-2015
    • Chinese Academy of Sciences
      • • State Key Laboratory of Biochemical Engineering
      • • Key Laboratory of Green Process and Engineering
      • • Institute of Process Engineering
      Peping, Beijing, China
    • Academia Sinica
      T’ai-pei, Taipei, Taiwan
  • 2001
    • Technical Institute of Physics and Chemistry
      Peping, Beijing, China
  • 1995
    • Peking University
      • Department of Chemistry
      Beijing, Beijing Shi, China