Chun-xiao Liu

Southern Medical University, Guangzhou, Guangdong Sheng, China

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Publications (20)5.89 Total impact

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    ABSTRACT: To investigate the expression of CD33(+) HLA-DR(-) myeloid-derived suppressor cells (MDSCs) in the peripheral blood of patients with renal carcinoma and its correlation with the clinicopathological features of renal cancer. Forty-four patients with renal carcinoma treated in our hospital between June, 2011 and October, 2012 and 18 healthy volunteers were enrolled in this study. Flow cytometry was performed to detect CD33(+) HLA-DR(-) MDSCs in the peripheral blood, and its correlation with the clinicopathological features of the patients were analyzed. The positivity rate of CD33(+) HLA-DR(-) MDSCs in the peripheral blood was significantly higher in the cancer patients than in the healthy controls [(1.91∓0.66)% vs (0.62∓0.22)%, P<0.001]. The expression levels of CD33(+) HLA-DR(-) MDSCs in patients with renal carcinoma showed significant differences between stage I+II [(1.46∓0.44)%] and stage III [(2.04∓0.35)%] patients (P<0.01) and between stage III and stage IV patients [(2.50∓0.64)%] (P<0.05), but did not differ significantly in respect of age or gender. CD33(+) HLA-DR(-) MDSCs expression in the peripheral blood is associated with tumor stage and differentiation in renal carcinoma and may play an important role in predicting the prognosis and tumor immunology of renal carcinoma.
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University 04/2013; 33(4):550-3.
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    ABSTRACT: PURPOSE: Orthotopic neobladder (ON) has gained increasing popularity in patients undergoing radical cystectomy (RC) in recent years. There are, however, few reports only on ON reconstructed from sigmoid without detubularization. We investigated complications and functional outcomes of orthotopic sigmoid neobladder reconstructed with detaenial technique. MATERIALS AND METHODS: A retrospective study was carried out to investigate detaenial sigmoid neobladder (DSN) in 210 patients who underwent RC at our institution consecutively from January 2003 to March 2010. Analysis of variance (ANOVA) was performed to investigate the differential of urodynamic findings over time. Univariable and multivariable analysis were used to determine factors influencing continence. RESULTS: The median followup was 48 months. Early complications (≤90d) were observed in 65 patients (31%). Late complications (>90 d) were observed in 45 patients (21.5%). A 5-year daytime and nighttime complete continence rates were 74.6% and 57.1% respectively. Younger age was the only independent factor prompting the daytime (odds ratio [OR]: 2.342; 95% confidence interval [CI], 1.803-3.041; p<0.001) and nighttime (OR: 1.193; 95% CI, 1.087-1.310; p<0.001) complete continence. The mean maximal capacity and postvoid residual were 328.8 ml and 22.2 ml respectively. The mean maximal flow rate was 18.5 ml/s. The mean end filling pressure, pressure at maximal capacity and maximal intravesical pressure were 35.8 cmH2O, 55 cmH2O and 60.6 cmH2O respectively. All of these parameters remained stable over time (all p>0.05). CONCLUSIONS: This study confirms that DSN is a safe and feasible alternative for urinary diversion.
    The Journal of urology 03/2013; · 3.75 Impact Factor
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    ABSTRACT: To construct three-dimensional (3D) models of renal stones and perform percutaneous nephrolithotomy (PCNL) virtual surgery simulation. Methods CT images were obtained from 8 patients with renal stones. Images segmentation and reconstruction were performed using MIMICS 10.0 software to construct the 3D model of the renal stones, which provided the anatomical relationships between the kidney and the adjacent organs. The optimal PCNL virtual surgery simulation for each individual case was performed using FreeForm Modeling System on the basis of the 3D model. Eight 3D models of renal stone were constructed. The 3D model of the renal stones represented the interrelationships of the stones, intrarenal vessel, and the collecting system with the adjacent anatomical structures. Individualized PCNL virtual surgery simulations including percutaneous puncture, dilatation and pneumatic lithotripsy were performed successfully in all the 8 3D models. Digital 3D model of renal stone provides the reliable and comprehensive imaging information for surgical design, and PCNL virtual surgery simulation has important clinical significance to improve the stone clearance rate and reduce the surgical complications.
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University 02/2013; 33(2):267-70.
  • Tong Si, Chun-Xiao Liu, Kai Xu, Yao-Ting Gui
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    ABSTRACT: To investigate the association of miR-199a expression with the clinicopathologic characteristics and the survival of patients with renal cell carcinoma (RCC). Real-time quantitative RT-PCR was used to detect the expression of miR-199a in the tumor tissues and paired adjacent normal tissues from 67 patients with RCC. The correlations of miR-199a expression with the clinicopathologic characteristics and survival of RCC patients were analyzed. Positive miR-199a expression was detected in both the RCC and adjacent normal tissues, but the tumor tissues showed a significantly lower expression level by a mean of 13.7 folds (P=0.003). The expression of miR-199a was negatively correlated with tumor recurrence in RCC patients in T stage (P<0.05), but showed no significant correlations with the patients age, histological type of the tumor, lymph node metastasis, distal metastasis, or Fuhrman grade (P>0.05). The patients with lowered miR-199a expression in the tumor tissue had a significantly shorter mean survival time than those without miR-199a down-regulation (P=0.017 by Log-rank test). A decreased expression of miR-199a is significantly correlated with a higher tumor stage, a greater likeliness of tumor recurrence, and a poorer prognosis in RCC patients. miR-199a can serve as a promising prognostic factor of renal cell carcinoma.
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University 11/2012; 32(11):1568-71.
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    ABSTRACT: To investigate the effect of docetaxel on the interaction between C-jun and androgen receptor (AR) in prostate cancer LNCaP cells and its androgen-independence subtype LNCaP-bic cells. LNCaP and LNCaP-bic cells were treated with docetaxel and the changes in AR and AP-1 expression were evaluated using luciferase assay. Western blotting and immunoprecipitation assay were employed to analyze the effects of docetaxel on the expressions of C-jun and AR and their interaction. Luciferase assay showed that LNCaP and LNCaP-bic cells expressed higher levels of AR and C-jun after docetaxel treatment. Docetaxel induced a higher level of p-c-jun expression in LNCaP-bic cells than in the parental LNCaP cells. Western blotting showed a strong PSA protein expression in LNCaP-bic cell after docetaxel treatment. Docetaxel caused a stronger interaction between AR and C-jun in LNCaP-bic cells. Docetaxel activates ligand-independent AR transcription, and the interaction between AR and C-jun may affect the outcome of docetaxel chemotherapy.
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University 10/2012; 32(10):1461-4.
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    ABSTRACT: Vasectomy is a simple and reliable method of male contraception. A growing number of men after vasectomy request vasectomy reversal due to various reasons. The pregnancy rate is lower than the patency rate after vasovasostomy and the pregnancy rate is time dependent. In this study, we evaluated the influence of reproductive tract obstruction on expression of epididymal proteins and their restoration after patency. Adult male Wistar rats were studied 30, 60 and 120 days after vasectomy, 30 days after vasovasostomy or after sham operations. Two-dimensional gel electrophoresis, mass-spectrometric technique, multidatabase search, Western blotting and real-time PCR were used to analyze the expression regulation of epididymal proteins. Total integrated intensity and total spot area of autoradiograms showed a consistent downward trend with time after obstruction, and this trend remained after patency. The intensity of the autoradiographic spots in three patency groups showed three trends: a downward trend, similar intensity and an upward trend compared with the correspondent obstruction group, respectively. Further verified experiments on human epididymis 2 (HE2), fertilization antigen-1 (FA-1), clusterin and PH20 demonstrated that compared with the correspondent obstruction group, the translation levels of HE2 and the mRNA transcription levels of HE2 showed an upward trend in patency groups, especially in the groups of obstruction for 60 days where the expression levels of HE2 were significantly upregulated after patency (P<0.05). Reproductive tract obstruction provokes a disregulation of gene expression in the epididymis and this disregulation remained after patency. Successful reversal may recover some proteins and the recovery is time dependent. Obstruction differentially alters mRNA transcription of different proteins and the content of proteins seemed to be easier to be influenced than the gene transcription.Asian Journal of Andrology advance online publication, 27 August 2012; doi:10.1038/aja.2012.64.
    Asian Journal of Andrology 08/2012; · 2.14 Impact Factor
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    ABSTRACT: To discuss the optimal approach of percutaneous nephrolithotomy (PCNL) for treatment of complicated renal calculi. A total of 581 patients with complicated renal calculus were treated by PCNL through the upper pole calix access. Of the 581 patients, 55 had multiple upper pole calculi, 136 had staghorn stones, 145 had partial staghorn stones, and 245 had multiple renal calculi. PCNL through the upper pole calix access was completed successfully in all the cases. Of these patients, 90.3% (525/581) were stone-free after a single access, with a total stone-free rate of 94.6% (550/581). Thirty-five patients needed two accesses, 10 needed 3 accesses, 2 required 4 accesses, and 1 patients had 5 accesses. The operative time ranged from 30 to 150 min (mean 45 min). The successful rate of puncture was 100% without occurrence of severe injury of the pleura, intestine, peritoneum or other adjacent organs. Percutaneous nephrolithotomy through the upper pole calix access allows greater stone clearance rate due to its easy access into the intrarenal collecting system and can be an ideal approach for PCNL for complicated renal calculi.
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University 12/2011; 31(12):2079-81.
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    ABSTRACT: To evaluate the therapeutic effect of laparoendoscopic single-site surgery (LESS) for treatment of male pseudohermaphroditism. A 17-year-old patient with male pseudohermaphroditism and a female social sex was admitted. According to the request by the patient and the relatives for a female gender, LESS vaginoplasty and cryptorchidectomy were performed using a single multilumen port inserted through a 2.5 cm incision below the umbilicus, followed by reconstruction of the perineal region by open surgery. The total operative time was 7 h, and the LESS procedure lasted for about 3.5 h. No other port incision was needed. The estimated intraoperative blood loss was 400 ml. No electrolyte or metabolic acid-base balance disorders were observed perioperatively. In the follow-up examination at 6 months after the operation, the reconstructed vagina healed smoothly without obvious contraction or fixation failure, and the perineal region showed good appearance. With minimal invasiveness, LESS surgery produces good cosmetic effect and allows rapid postoperative recovery, thus may become a promising alternative to the management of pseudohermaphroditism.
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University 06/2011; 31(6):933-6.
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    ABSTRACT: To evaluate the therapeutic effect of transurethral enucleation of the prostate for treatment of benign prostatic hyperplasia in patients below 50 years of age. Twelve patients with benign prostatic hyperplasia patients (mean age 48.2 years, range 46-49 years) underwent transurethral enucleation of the prostate. The middle lobe and two lateral lobes were enucleated with the preprostatic sphincter and anterior fibromuscular stroma prereserved during the operation. The patients were followed up to evaluate the lower urinary tract symptoms and sexual activity after the surgery. The 12 patients were followed up for 3 to 6 months. The symptoms of lower urinary tract obstruction were improved obviously after the surgery, and the International Prostate Symptom Score (IPSS) decreased from 24±5.1 to 8.8±1.4 and peak urine flow rate (Qmax) increased from 8.1±4.2 ml/s to 20.1±4.2 ml/s at 3 months postoperatively. All the 12 cases had residual urine (12-44 ml) preoperatively, but after the surgery, only 4 still had residual urine of less than 30 ml. All the patients had normal erection function postoperatively, and 10 had normal ejaculation; the other 2 patients recovered normal ejaculation 3 and 5 months after the operation, respectively. Transurethral enucleation can alleviate the low urinary tract obstruction symptom and improve the sexual function by avoiding preprostatic sphincter injury in relatively young patients with benign prostatic hyperplasia.
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University 12/2010; 30(12):2708-10.
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    ABSTRACT: To detect the expression of special AT-rich sequence-binding protein (SATB1) in bladder urothelial carcinoma and investigate its correlation to the biological behavior of the carcinoma. The expression of SATB1 mRNA was detected in 34 cases of bladder urothelial carcinoma and 14 normal bladder tissues by RT-PCR, and the protein expression of SATB1 was detected in 68 cases of bladder urothelial carcinoma and 17 normal bladder tissues by immunohistochemistry. The correlation between SATB1 expressions and the biological behavior of the tumor was analyzed. The expression of SATB1 was significantly higher in bladder urothelial carcinoma tissues than in normal bladder tissues (P<0.05). and the expression of SATB1 in the tumor tissues was correlated to the clinical stage and metastasis of the tumor. SATB1 expression can be associated with the development and metastasis of bladder urothelial carcinoma and may potentially serve as an indicator for predicting the prognosis of bladder urothelial carcinoma.
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University 06/2010; 30(6):1389-91, 1394.
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    ABSTRACT: To report the first case and detailed techniques of laparoendoscopic single-site surgery (LESS) radical cystectomy with orthotopic taenia myectomy sigmoid neobladder for organ-confined bladder cancer. A 74-year-old man presented with gross hematuria for 2 months and biopsy revealed bladder cancer. LESS radical cystectomy and bilateral pelvic lymphadenectomies were performed using a single multilumen port inserted through a solitary 3.5 cm lower abdominal incision with conventional laparoscopic instruments. The taenia myectomy sigmoid pouch was then constructed by open procedure. The total operative time was 9.5 h, and the LESS procedure lasted for about 5.5 h. No other port incision was added. The final pathology revealed urothelial carcinoma. The estimated intraoperative blood loss was 600 ml with blood transfusion of 400 ml. The pelvic lymph nodes and the surgical margins of the ureters and urethra were all free of tumor invasion. No water electrolyte and metabolic acid-base balance disorders were observed perioperatively. The neobladder capacity was about 280 ml, with a residual urine volume of 10 ml and peak flow rate of 11.1 ml/s 3 months postoperatively. Although with a steep learning curve, LESS surgery can be a less invasive and promising alternative to muscle-invasive bladder carcinoma.
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University 06/2010; 30(6):1385-8.
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    ABSTRACT: To investigate the methylation status of the promoter of resion death associated protein kinase (DAPK) gene in bladder cancer cell (T24), and study the effect of 5-aza-2'-deoxycytidine (5-aza-dc) on DAPK gene reactive expression in T24 and its inhibitory effect on T24. The bladder cancer cell T24 was treated with different doses of 5-aza-dc. The inhibitory effect and apoptosis rate were detected by MTT and flow cytometry, and the changes of DAPK mRNA and protein expression and the methylation status of DAPK promoter were assessed by RT-PCR, Western blotting, and methylation specific PCR, respectively. The growth of bladder cancer cell was inhibited significantly and the maximal apoptosis rate detected by flow cytometry was (24.12-/+1.4)%. DAPK mRNA was not expressed in bladder cancer cell T24 in normal conditions. DAPK mRNA and protein re-expressed after 5-aza-dc (12.5 micromol/L) treatment in cell line T24 for 24 h, and DAPK promoter became unmethylated. The promoter methylation can be an important factor for silencing the expression of DAPK in bladder cancer cell. 5-aza-dc can inhibit the growth and induce apoptosis of bladder cancer cells through reversing unmethylation status of DAPK promoter.
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University 09/2009; 29(9):1882-6.
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    ABSTRACT: To prepare rat whole-kidney acellular matrix (ACM) scaffolds using fluid perfusion method. The kidneys with ureters and renal vessels were harvested from 12-week-old Wistar rats. Intravenous catheters were inserted through the renal arteries to establish channels for whole-kidney retrograde perfusion successively with heparinized PBS, 1% SDS, deionized water, 1% TritonX-100 and antibiotic-containing PBS under a pressure of 100 cmH2O. After decellularization, the scaffolds were observed under microscope with HE staining, scanning electron microscope, and fluorescence microscope with DAPI fluorescence staining. No cell residue was found in the scaffolds under microscope. Scanning electron microscope identified reticular structures consisting of basilar membrane and collagen without normal cellular structures in the scaffolds, and no strong fluorescence due to the binding of DAPI to the cell nuclei was observed under fluorescence microscope. Fluid perfusion is simple and reliable to prepare rat whole-kidney acellular matrix, which may serve as an ideal cell-free scaffold.
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University 06/2009; 29(5):979-82.
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    ABSTRACT: To present a case of laparoscopic radical cystectomy and detenial sigmoid colon orthotopic neobladder reconstruction for bladder tumor in a child. A 3-year-old boy with bladder rhabdomyosarcoma underwent laparoscopic radical cystectomy and detenial sigmoid colon orthotopic neobladder reconstruction. The bilateral pelvic lymphadenectomy and cystectomy were performed laparoscopically, and removal of the mobilized specimens and urinary diversion operation were managed through enlarged abdomen incision. The urinary diversion procedure included construction of the detenial sigmoid pouch, bilateral stented antiflux implantation of the ureters in the pouch and orthotopic anastomosis of the neobladder with the urethra. The total operative time was 6 h, and the laparoscopic procedure lasted for about 3.5 h. The intraoperative blood loss was 50 ml, and 200 ml concentrated red blood cell transfusion was used for the safety of the patient. Six dissected lymph nodes in each pelvic side and the surgical margins of the ureter and urethra were all free of tumor invasion. Bowel peristalsis recovered 3 days after the operation, and the pelvic drainage and the neobladder drainage tubes were removed on day 7 and 14, respectively. The urethral catheter and ureteral stents were removed 25 days after the operation. The daytime urine control and micturition recovered 1 week after the operation. The neobladder capacity was about 110 ml, with residual urine volume of 10 ml and peak flow rate of 12 ml/s after 5 months. No perioperative complications occurred such as water-electrolyte and metabolic acid-base balance disorders, urinary leakage, reflux or bowel obstruction. Laparoscopic radical cystectomy is minimally invasive, reduces intraoperative blood loss and allows rapid postoperative recovery, and can be a promising approach to management of bladder rhabdomyosarcoma in children.
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University 02/2009; 29(1):105-8.
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    ABSTRACT: To obtain large quantities of well differentiated urinary bladder transitional epithelial cells for used as the seed cells in bladder tissue engineering, and evaluate the cytocompatibility of silk fibroin film with the transitional cells in vitro to assess the possibility of tissue-engineered urinary organ construction. The urinary bladder transitional epithelial cells were isolated from the bladders of New Zealand rabbits and cultured in vitro as the seed cells, whose morphology was observed and the specific protein (cytokeratin) expression identified by immunofluorescence assay. The cells were seeded in 96-well plates at 1 x 10(>4)/ml and incubated with silk fibroin film leaching solution or culture medium (negative control). MTT assay was performed to determine the cell proliferation rates of the wells and evaluate the cytotoxicity and cytocompatibility of the silk fibroin film. The isolated urinary bladder transitional epithelial cells reached confluence after 9-10 days of culture, which showed positive staining for immunocytochemistry with monoclonal antibody against cytokeratin. The absorbance of the cells culture in the presence of silk fibroin film leaching solution averaged 0.424-/+0.020, 0.996-/+0.118 and 1.285-/+0.048 after at 24, 72 and 120 h of cell culture, and that of the negative control group at the time points was 0.419-/+0.030, 1.105-/+0.098 and 1.228-/+0.052, respectively, showing no significant difference between the two groups (P>0.05). Silk fibroin film has good cytocompatibility with rabbit urinary bladder transitional epithelial cells, and may serve as good scaffold material for urologic tissue engineering.
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University 02/2008; 28(2):216-8.
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    ABSTRACT: To evaluate the effect of silk fibroin film for repairing urethral defect in rabbits. Twenty-four male New Zealand rabbits were randomized into experimental group, control group I and control group II. In the experimental group, a urethral defect of 1.5 cm was induced in the 12 rabbits and repaired with silk fibroin film. The 6 rabbits in control group I without the surgically induced defect served as the sham operation group, and in control group II consisting of 6 rabbits the urethral defect of 1.5 cm was induced without repair. Histological observation and immunohistochemistry were conducted to examine the regenerative segments of the urethra at regular time points between 2 and 16 weeks postoperatively. The 12 rabbits in the experimental group did not show signs of urethral stricture following the surgery. The implanted silk fibroin film for defect repair was degraded completely at 16 weeks and the defect was repaired with smooth urethral mucous membrane lining and orderly arranged smooth muscle cells. Immunohistochemistry identified the cells lining the defect area as the urethral epithelial cells. Silk fibroin film can promote the repair of urethral defect by inducing the growth of the urethral epithelial cells and smooth muscle cells.
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University 03/2007; 27(2):184-7.
  • Shao-bo Zheng, Chun-xiao Liu, Ya-wen Xu
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    ABSTRACT: To evaluate the effect of intracavitary retrograde dissection during transurethral vaporization resection of the prostate (TUVRP). The efficacy of intracavitary retrograde dissection of the prostate with PK bipolar generation was evaluated in 260 cases in view of the volume of intraoperative bleeding, operation time, safety and postoperative bleeding, catheterization time and prognosis in comparison with the results of exclusive use of TUVRP. Intracavitary retrograde dissection of the prostate provided good operative view as compared with conventional TUVRP. Intracavitary retrograde dissection is a practically feasible procedure for benign prostatic hyperplasia.
    Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 07/2005; 25(6):734-5, 738.
  • Shao-Bo Zheng, Chun-Xiao Liu, Ya-Wen Xu
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    ABSTRACT: To review our experience with intracorporeal laparoscopic radical cystectomy and sigmoid colon orthotopic neobladder reconstruction. The clinical data of 26 cases of bladder carcinoma treated with the indicated surgical procedures were reviewed. The surgeries were successful in all the cases with the operating time ranging from 240 to 390 min, blood loss of 400 to 800 ml and red-cell transfusion of 0-4 U. Oral food intake was allowed 4-8 days after the operation, ureteral stents were removed in weeks 3 to 8 and the pouch catheter was removed in week 4 postoperatively. Daytime urinary continence was excellent and urinary incontinence at night occurred in 8 patients 3 months after the operation. Sigmoid colon orthotopic neobladder reconstruction can be effective for urinary diversion to ensure good quality of life of the patients.
    Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 03/2005; 25(2):231-3.
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    ABSTRACT: To improve the success rate of one-stage urethral fistula repair by modifying the surgical procedures, suture material and application of urethral stent. The clinical data of 56 cases of urethral fistula following correction of hypospadias were analyzed. The case group consisted of 38 cases with large fistula (over 3 mm in diameter) and 18 cases of small fistula (less than 3 mm). For the former cases, double skin flaps or pedicled skin flap from the scrotum were adopted for the repair; in the latter cases, transverse Y- or V-shaped skin flaps were used. Porous silica gel cannula was adopted for the stents. A success rate of one-stage repair as high as 87.50% was achieved in these cases, with a rate for large fistula of 86.84%. Rich blood supply of the flaps, application of absorbable suture and urethral stent can improve the success rate of fistula repair.
    Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 02/2004; 24(1):113-4.
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    ABSTRACT: Our experience of sclerotherapy for renal cyst injection of erythromycin and procaine via ultrasound-guided renal puncture is reported. The total efficiency reached 96% with low recurrence rate in the 1,000 cases receiving this therapy, suggesting that this approach is a simple, accurate and effective renal cysts with minimized postoperative complications treatment.
    Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 06/2003; 23(5):490, 493.

Publication Stats

19 Citations
5.89 Total Impact Points

Institutions

  • 2005–2010
    • Southern Medical University
      • Department of Urology
      Guangzhou, Guangdong Sheng, China