K Ben Romdhane

Institut Salah-Azaïz de Cancerologie, Tunis-Ville, Tūnis, Tunisia

Are you K Ben Romdhane?

Claim your profile

Publications (142)44.86 Total impact

  • Annales de Pathologie 01/2013; 33(6):437. · 0.24 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: La variante « Ewing-like » de l’adamantinome est une entité exceptionnelle, posant des problèmes diagnostiques notamment avec le sarcome d’Ewing. Nous rapportons le cas d’un homme de 20 ans, ayant consulté pour une tuméfaction de la jambe gauche évoluant depuis deux ans. La radiologie a montré une tumeur tibiale, intracorticale, ostéolytique, multiloculée, envahissant les parties molles. Une biopsie chirurgicale a été effectuée. L’examen anatomopathologique a montré une prolifération tumorale à petites cellules rondes exprimant le CD99. Le diagnostic de sarcome d’Ewing a été retenu. Le patient ayant refusé le traitement chirurgical, une chimiothérapie a été administrée. Deux ans après, il a reconsulté devant l’augmentation de la taille de la tumeur. Une seconde biopsie a été réalisée. L’étude microscopique a montré une prolifération tumorale associant un contingent ostéofibreux et un contingent épithélial, exprimant la pancytokératine et la vimentine et négative pour le CD99. Le diagnostic d’adamantinome de type « Ewing-like » a été retenu.
    Revue de Chirurgie Orthopédique et Traumatologique 11/2012; 98(7):760–764.
  • [Show abstract] [Hide abstract]
    ABSTRACT: The Ewing-like variation of adamantinoma is a rare entity, leading to challenge its differential diagnosis, notably with Ewing's sarcoma. We are reporting a case of a 20-year-old male who presented with swelling in the left leg that had progressed over a 2-year period. X-rays revealed a tumour in the tibia that was intracortical, osteolytic, multilocular and invaded the soft tissues. A surgical biopsy was performed. Histopathology examination showed a tumour growth with small round cells expressing CD99. A diagnosis of Ewing's sarcoma was made. Since the patient declined surgical treatment, chemotherapy was administered. Two years later, the patient returned because the tumour had grown in size. A second biopsy was performed. Microscopic evaluation showed a tumour growth with osteofibrous and epithelial components, which expressed pankeratin and vimentin, but was negative for CD99. A diagnosis of Ewing-like adamantinoma was made.
    Orthopaedics & Traumatology Surgery & Research 10/2012; · 1.06 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Notch pathway plays a pivotal role in cell fate determination. There is much interest surrounding its therapeutic potential, in osteoarthritis, but the expression profile of Notch-related molecules, as well as their relation with cartilage pathological parameters, remains unclear. The purpose of our study is to analyze the expression pattern of Notch family members, type II and type I collagen, in normal (healthy) and osteoarthritic human knee cartilage. Osteoarthritic cartilages were obtained from 3 patients undergoing a total knee replacement. Macroscopically normal cartilage was dissected from 3 human knees at the time of autopsy or surgery. Immunohistochemical staining was performed using Notch1,2,3 and 4, Delta, Jagged, type II collagen and type I collagen antibodies. In healthy cartilage, type II collagen was abundantly expressed while type I was absent. This latter increased proportionally to the osteoarthritic grade. Type II collagen expression remained intense in osteoarthritic cartilage. In healthy cartilage as well as in cartilage with minor lesions, Notch family member's proteins were not or just weakly expressed at the surface and in the cells. However, Notch molecules were over-expressed in osteoarthritic cartilage compared to healthy one. This expression pattern was different according to the cartilage zone and the severity of OA. Our data suggest that Notch signaling is activated in osteoarthritic cartilage, compared to healthy cartilage, with a much more abundant expression in the most damaged areas.
    Tissue and Cell 03/2012; 44(3):182-94. · 1.04 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Dermatofibrosarcoma protuberans (DFSP) is a relatively rare skin neoplasm. Usually affecting adults, the incidence in children is even less frequent. Through a report of three pediatric cases of DFSP, we describe the particularities of this tumor in children. Three boys aged 8, 9, and 15 years presented with a firm nodular skin lesion of the trunk, varying in size from 1 to 5 cm. No previous trauma event had occurred. Diagnosis was confirmed in all cases by immunohistological study. Surgical excision was performed in all cases. No recurrence was evident during the follow-up period of, respectively, 15, 36, and 49 months. The DFSP is an infiltrative tumor of intermediate malignancy, with a limited potential for metastasis (< 5%) but a high rate of local recurrence (≥ 50%). The incidence in children is even less frequent. In children, its seemingly benign clinical appearance may explain delays in diagnosis; the majority of lesions affect the extremities, suggesting a potential role-played by injury. In our observations, however, as in adults, the trunk was the site of occurrence. Despite the uncertain pathogenesis of this tumor, the finding of certain characteristic histopathological features helps establish an accurate diagnosis. As in adults, surgical treatment with large surgical margins remains the best practice for children with DFSP, directly affecting the prognosis.
    Archives De Pediatrie - ARCHIVES PEDIATRIE. 01/2011; 18(1):23-27.
  • Annales De Pathologie - ANN PATHOL. 01/2011; 31(5).
  • La Tunisie médicale 01/2011; 89(1):119.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Dermatofibrosarcoma protuberans (DFSP) is a relatively rare skin neoplasm. Usually affecting adults, the incidence in children is even less frequent. Through a report of three pediatric cases of DFSP, we describe the particularities of this tumor in children. Three boys aged 8, 9, and 15 years presented with a firm nodular skin lesion of the trunk, varying in size from 1 to 5 cm. No previous trauma event had occurred. Diagnosis was confirmed in all cases by immunohistological study. Surgical excision was performed in all cases. No recurrence was evident during the follow-up period of, respectively, 15, 36, and 49 months. The DFSP is an infiltrative tumor of intermediate malignancy, with a limited potential for metastasis (<5%) but a high rate of local recurrence (≥ 50%). The incidence in children is even less frequent. In children, its seemingly benign clinical appearance may explain delays in diagnosis; the majority of lesions affect the extremities, suggesting a potential role-played by injury. In our observations, however, as in adults, the trunk was the site of occurrence. Despite the uncertain pathogenesis of this tumor, the finding of certain characteristic histopathological features helps establish an accurate diagnosis. As in adults, surgical treatment with large surgical margins remains the best practice for children with DFSP, directly affecting the prognosis.
    Archives de Pédiatrie 10/2010; 18(1):23-7. · 0.36 Impact Factor
  • Archives De Pediatrie - ARCHIVES PEDIATRIE. 01/2010; 17(6):100-101.
  • Archives de Pédiatrie 07/2009; 16(8):1150; 1186-8. · 0.36 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The goal of this study is to analyze certain epidemiologic characteristics of breast cancer in Tunisia and to foresee the consequences that will arise from the trends in incidence of this cancer. Data obtained from the North-Tunisia Cancer Registry (NTCR) and from the Salah AZAIZ Institute (SAI) Registry is used to estimate the different incidence rates and to compare these rates with those of other countries. In 15 years the crude incidence rate for breast cancer in the North Tunisia almost doubled to reach 21.5 cases/100,000 women per year during 1994-1998. The high rate of this cancer among women younger than 35 years (11%) could be related to a relatively low incidence among post-menopausal women. The clinical profile of breast cancer remains quite alarming: 40.2% of cases have a tumor with a clinical diameter equal or greater than 5 cm. Birth cohort effect, also know as the generation effect, is expected to lead to an increase of cancer incidence in the future. The rather high number of young cases is a source of additional cost on social and financial level. The priority is now to solve the problem of late diagnosis it has aggravated the prognosis of this cancer in Tunisia.
    La Tunisie médicale 07/2009; 87(7):417-25.
  • [Show abstract] [Hide abstract]
    ABSTRACT: To report the results of breast ultrasonographically-guided fine needle aspirations and needle biopsies within the breast cancer screening program of L'Ariana state in Tunisia. Our retrospective study include 143 patients, with mammographically detected lesions, which underwent a diagnostic percutanous ultrasonographically guided procedures. 57 patients underwent a fine needle aspiration, 25 underwent a needle biopsy and 61 patients underwent both procedures. Sensitivity and specificity of fine needle aspiration are of 84.2% and 98.5%. We report 13.5% of non contributive results. The needle biopsy have a sensitivity of 97.3% and a specificity of 100% with one false negative corresponding to an atypical ductal hyperplasia at the excisional biopsy. Fine needle aspiration is a reliable method of accurately establishing a diagnosis. Needle biopsy is recommended for a preoperative lesion characterisation before adequate treatment.
    La Tunisie médicale 07/2009; 87(7):463-70.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Les ostéosarcomes constituent un groupe hétérogène de tumeurs ayant des particularités anatomocliniques et évolutives diverses. L’ostéosarcome parostéal ou ostéosarcome juxtacortical est une forme rare d’ostéosarcome développée à la surface de l’os. Il se caractérise par son meilleur pronostic. Nous rapportons l’observation d’une patiente âgée de 22 ans qui présentait une énorme tuméfaction du genou évoluant de façon progressive depuis dix ans. La biopsie a conclu à un ostéosarcome parostéal du tiers inférieur du fémur. Le bilan d’extension était négatif. La tumeur a atteint des dimensions énormes imposant une désarticulation du membre inférieur gauche avec utilisation d’une prothèse de marche. À huit ans de l’intervention, aucune récidive locale, ni métastase à distance n’a été détectée. L’ostéosarcome parostéal est une forme rare d’ostéosarcome osseux qui se caractérise par une évolution très lente, particulièrement spectaculaire dans notre observation, un bon pronostic et des métastases très rares.
    Revue de Chirurgie Orthopédique et Traumatologique. 06/2009; 95(4).
  • [Show abstract] [Hide abstract]
    ABSTRACT: Endometrial stromal sarcoma (ESS) is rarely localized in extrauterine sites if metastasis or local extension of the primary uterine tumour are excluded, and diagnosis can be delayed because of the unusual site. We report a case of abdominal ESS in a 45-year-old woman who presented with an abdominal complaint. Ultrasound of the abdomen showed a large multiloculated cystic mass. The complete excision of the tumour revealed ESS arising in endometriosis. The tumour expressed hormonal receptors and the patient was administered hormonal therapy. ESS has a better prognosis than the sarcoma that is part of differential diagnosis, and is associated with endometriosis in about one-half of cases.
    Pathologica 04/2009; 101(2):93-6.
  • [Show abstract] [Hide abstract]
    ABSTRACT: According to the WHO-EORTC classification of cutaneous lymphomas, primary cutaneous marginal zone B-cell lymphoma are now well characterized. We report here a case of primary cutaneous marginal zone B-cell lymphoma in a 51 year-old man in which the diagnosis was made using both histology and immunopathology. The patient had no remarkable medical history, no history of either acute inflammation or insect bite, and presented with a 5 cm solitary asymptomatic erythematous firm, multinodular and infiltrated plaque on the back for 12 months. Histological examination and immunohistochemical study of a cutaneous biopsy provided a differential diagnosis between B cell lymphoma and lymphocytoma cutis. Full body work up revealed no signs of extracutaneous dissemination. The patient underwent surgical excision of the nodule. Histological examination showed a histological and immunophenotyping profile typical of primary cutaneous marginal zone B-cell lymphoma. The lesion was completely excised with clear margins and no recurrence occurred after a 12 month-follow-up period. Primary cutaneous marginal zone B-cell lymphoma are low-grade lymphomas that have an indolent course and a high tendency to recur. They should be differentiated from lymphocytoma cutis and from the other types of cutaneous B cell lymphomas that have a different course and prognosis.
    Pathologica 02/2009; 101(1):18-20.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Squamous cell carcinoma arising in mature cystic teratoma of the ovary is an uncommon complication occurring usually in elderly woman. We present an unusual case of a post-menopausal woman with a synchronous mediastinum teratoma. While ovary tumor was symptomatic, mediastinal teratoma was an incidental finding. To the best of our knowledge, this association is the first to be reported in literature.
    Revue De Medecine Interne - REV MED INTERNE. 01/2009; 30(4):369-371.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Le polymorphisme du système HLA est corrélé à la survenue de plusieurs types de tumeurs, du fait de son rôle clé dans la présentation des antigènes au système immunitaire. L’efficacité de cette présentation est définie par le type des molécules HLA impliquées ainsi que leur niveau d’expression à la surface cellulaire. Une combinaison des molécules HLA pourrait induire une bonne réponse ou un échappement de lȉantigène au système immunitaire, puisque ces molécules déclenchent la cytotoxicité spécifique, suite à la présentation des antigènes endogènes aux lymphocytes TCD8+. Dans la présente étude, nous nous proposons de rechercher d’éventuelles associations entre les allèles du gène HLA B et les paramètres histopronostiques du cancer du sein en Tunisie. Soixante-quatre femmes tunisiennes atteintes du cancer du sein et 74 femmes tunisiennes saines et non apparentées ont été typées par la technologie luminex pour le gène HLA B. La valeur de p et l’Odds Ratio (OR) ont été calculés pour définir les allèles de protection ou de risque à l’occurrence, l’évolution et la gravité du cancer du sein en Tunisie. Les résultats montrent un rôle protecteur de l’allèle B*40 contre l’occurrence du cancer du sein chez la femme tunisienne (OR = 0; IC 95 %: ]0–0,66[). Cette corrélation négative a été faiblement démontrée en relation avec la présentation la plus grave (EE III) et le stade le plus avancé de la pathologie (N+). Par ailleurs, une corrélation positive entre l’allèle B*18 et un bon pronostic EE I et II est démontrée (OR = 3,85; IC 95 %: ]1,09–13,82[). Cependant, l’association de cet allèle à l’envahissement ganglionnaire n’est pas confirmée. HLA polymorphism is correlated with many types of tumour because of its key role in antigen presentation to the immune system. The efficacy of this presentation may be related to the expressed HLA molecules and the level to which they are expressed on the cell surface. A given HLA combination might contribute to tumour destruction or might escape the immune system, since antigenic presentation to TCD8+ triggers specific cytotoxicity. In the present work, we aimed to find possible associations between HLA B alleles and histo-prognostic factors related to breast cancer in Tunisia. Sixty-four patients and 74 healthy, unrelated controls were genotyped for HLA B locus. The P value and Odds Ratio were calculated in order to define HLA B correlations with the occurrence, the evolution and the histological grading of breast tumours in Tunisian women. Results show a protective effect for B*40 against breast cancer occurrence (OR = 0; 95% CI: ]0–0,66[). This correlation is poorly demonstrated for EE grading and lymph node invasion, whereas a positive association is found for B*18 allele with good and medium prognoses (OR = 3,85; 95% CI: ]1,09–13,82[). The risk effect is not confirmed for lymph node attack.
    Journal africain du cancer / African Journal of Cancer 01/2009; 1(1):36-41.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: BRCA1 is a tumor suppressor gene which is inactivated by mutation in familial breast and ovarian cancers. Over 300 different disease causing germ-line mutations have been described; 60% are unique to an individual family. This diversity and the large size of the gene lead us to search for a prescreening method for BRCA1 mutations. Since BRCA1 is a nuclear protein in normal cells, but reported by some authors to be cytoplasmic in breast tumor cells of patients with BRCA1 mutation, we evaluated immunohistochemistry as a prescreening technique to identify BRCA1 mutations in patients with familial presentation of breast cancer. Using a monoclonal antibody against the carboxy-terminal region of BRCA1, we performed immunohistochemistry on 18 tumor samples from patients with hereditary breast cancer. Cytoplasmic staining of BRCA1 was observed in 10 cases. Of the 18 tumors, 12 (66%) showed either BRCA mutation or BRCA1 accumulation or both, indicating that BRCA1 function might be lost in breast tumor cells not only through mutation, but also via abnormal cytoplasmic location. The immunohistochemical test used in this study would not be efficient as a pre-screening method of deleterious mutations, but it appeared useful to investigate tumor physiology.
    European journal of histochemistry: EJH 01/2009; 51(3):219-26. · 2.41 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Osteosarcomas are a heterogeneous group of tumors with diverse anatomical, clinical, and progressional characteristics. Parosteal osteosarcoma, or juxtacortical osteosarcoma, is a rare form of osteosarcoma that develops at the bone surface, but has a better prognosis than other conventional osteosarcomas. We report the observation of a 22-year-old female patient whose initial presentation was an enormous tumefaction of the knee that had been progressing for 10 years. The biopsy concluded in PO of the lower third of the femur. Staging was negative. The tumor had reached an enormous size and required amputation of the left lower extremity. A custom external prosthesis was manufactured to get her back to walking. Eight years after surgery, no local recurrence or metastasis has been detected. Parosteal osteosarcoma is a rare form of osteosarcoma with very slow progression (in spite of the particularly dramatic presentation in our observation), with an excellent prognosis and very rare metastasis.
    Orthopaedics & Traumatology Surgery & Research 01/2009; · 1.06 Impact Factor
  • Archives De Pediatrie - ARCHIVES PEDIATRIE. 01/2009; 16(8):1186-1188.

Publication Stats

175 Citations
44.86 Total Impact Points

Institutions

  • 1993–2012
    • Institut Salah-Azaïz de Cancerologie
      Tunis-Ville, Tūnis, Tunisia
  • 1995
    • State University of New York Downstate Medical Center
      • Department of Radiology
      Brooklyn, NY, United States
  • 1987–1990
    • Hopital Habib Thameur
      Tunis-Ville, Tūnis, Tunisia