Vincent Minville

University of Toulouse, Tolosa de Llenguadoc, Midi-Pyrénées, France

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Publications (160)340.47 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Diabetic neuropathy is one of the most common complications of diabetes and causes various problems in daily life. The aim of this study was to assess the effect of regional anaesthesia on post surgery opioid induced hyperalgesia in diabetic and non-diabetic mice. Diabetic and non-diabetic mice underwent plantar surgery. Levobupivacaine and sufentanil were used before surgery, for sciatic nerve block (regional anaesthesia) and analgesia, respectively. Diabetic and non-diabetic groups were each randomly assigned to three subgroups: control, no sufentanil and no levobupivacaine; sufentanil and no levobupivacaine; sufentanil and levobupivacaine. Three tests were used to assess pain behaviour: mechanical nociception; thermal nociception and guarding behaviours using a pain scale. Sufentanil, alone or in combination with levobupivacaine, produced antinociceptive effects shortly after administration. Subsequently, sufentanil induced hyperalgesia in diabetic and non-diabetic mice. Opioid-induced hyperalgesia was enhanced in diabetic mice. Levobupivacaine associated to sufentanil completely prevented hyperalgesia in both groups of mice. The results suggest that regional anaesthesia can decrease opioid-induced hyperalgesia in diabetic as well as in non-diabetic mice. These observations may be clinically relevant for the management of diabetic patients.
    Journal of Translational Medicine 07/2015; 13(1):208. DOI:10.1186/s12967-015-0575-0 · 3.99 Impact Factor
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    ABSTRACT: To evaluate whether the Script Concordance Test (SCT) can discriminate between levels of experience among anesthesiology residents and attending physicians. Multicenter (Toulouse, Nantes, Bordeaux and Limoges), prospective, observational study. A SCT made of 60 items was used to evaluate "junior residents" (n=60), "senior residents" (n=47) and expert anesthesiologists (n=10). There were no missing data in our study. Mean scores (±SD) were 69.9 (±6.1), 73.1 (±6.5) and 82.0 (±3.5) out of a potential score of 100 for "junior residents", "senior residents" and expert anesthesiologists, respectively. Results were statistically different between the 3 groups (P=0.001) using the Kruskall-Wallis test. The Cronbach's α score was 0.63. The SCT is a valid and useful tool for discriminating between anesthesia providers with varying levels of experience in anesthesiology. It may be a useful tool for documenting the progression of reasoning during anesthesia residency. Copyright © 2015 Société française d’anesthésie et de réanimation (Sfar). Published by Elsevier Masson SAS. All rights reserved.
    02/2015; 34(1). DOI:10.1016/j.accpm.2014.11.001
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    ABSTRACT: Le choc hémorragique est une urgence pouvant bénéficier d’une prise en charge préhospitalière médicalisée en France. Notre objectif était de réaliser un état des lieux des moyens disponibles dans les 370 Services mobiles d’urgence et de réanimation (Smur) français pour la prise en charge des situations hémorragiques en préhospitalier.
    Annales francaises d'anesthesie et de reanimation 10/2014; DOI:10.1016/j.annfar.2014.09.002 · 0.84 Impact Factor
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    ABSTRACT: Hemorrhagic shock is an emergency, which may benefit from a medicalized prehospital care. Our goal was to survey the means available in the 370 French prehospital medicalized emergency services (SMUR) for hemorrhagic situations. Multicenter descriptive observational study by email then phone with all the 370 French SMUR leaders. The questionnaire was created by investigators of the project through a Delphi method, and was about service protocols concerning hemorrhagic patient care, hemorrhagic parameters measure equipment available, intravenous solutes and drugs as well as various medical devices useful or perceived to be useful to support prehospital hemorrhagic shock. The results are expressed in numbers and percentages. The overall response rate was 48% (n=178). Protocols were established in between 43% (n=76) and 47% (n=83) according to etiology, measuring devices were available in 5% (n=9) of the Smur for hemostasis up to 89% (n=158) for hemoglobin measurement. Available intravenous solutes were mainly isotonic salty serum (95%, n=169), hydroxylethylstarch (83%, n=148) and Ringer lactate (73%, n=130). Tranexamic acid was available in 84 (47%) Smur. The teams had access to erythrocytes concentrates, fresh frozen plasma and platelets in 84% (n=150), 44% (n=79) and 23% (n=41) respectively. Eighty-one (46%) Smur had tourniquets and 127 (71%) anti-shock trousers. Finally, 57 (32%) had a pelvic restraint belt. There is a great disparity in the means available in the French Smur for the support of prehospitalization bleeding. The majority the Smur physicians can transfuse in a prehospital setting. On the other hand, a minority of teams can actively warm patients, employ tranexamic acid or use pelvic restraint belts. Copyright © 2014 Société française d’anesthésie et de réanimation (Sfar). Published by Elsevier SAS. All rights reserved.
    Annales francaises d'anesthesie et de reanimation 10/2014; · 0.84 Impact Factor
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    ABSTRACT: Perioperative blood pressure management is a key factor of patient care for anesthetists, as perioperative hemodynamic instability is associated with cardiovascular complications. Hypertension is an independent predictive factor of cardiac adverse events in noncardiac surgery. Intraoperative hypotension is one of the most encountered factors associated with death related to anesthesia. In the preoperative setting, the majority of antihypertensive medications should be continued until surgery. Only renin-angiotensin system antagonists may be stopped. Hypertension, especially in the case of mild to moderate hypertension, is not a cause for delaying surgery. During the intraoperative period, anesthesia leads to hypotension. Hypotension episodes should be promptly treated by intravenous vasopressors, and according to their etiology. In the postoperative setting, hypertension predominates. Continuation of antihypertensive medications and postoperative care may be insufficient. In these cases, intravenous antihypertensive treatments are used to control blood pressure elevation.
    Integrated Blood Pressure Control 09/2014; 7:49-59. DOI:10.2147/IBPC.S45292
  • Annales Françaises d Anesthésie et de Réanimation 09/2014; 33:A132-A133. DOI:10.1016/j.annfar.2014.07.219 · 0.84 Impact Factor
  • Annales Françaises d Anesthésie et de Réanimation 09/2014; 33:A229-A230. DOI:10.1016/j.annfar.2014.07.387 · 0.84 Impact Factor
  • Annales Françaises d Anesthésie et de Réanimation 09/2014; 33:A105. DOI:10.1016/j.annfar.2014.07.173 · 0.84 Impact Factor
  • Annales Françaises d Anesthésie et de Réanimation 09/2014; 33:A304-A305. DOI:10.1016/j.annfar.2014.07.514 · 0.84 Impact Factor
  • Annales Françaises d Anesthésie et de Réanimation 09/2014; 33:A197-A198. DOI:10.1016/j.annfar.2014.07.332 · 0.84 Impact Factor
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    ABSTRACT: Introduction Le patient polytraumatisé présente une dépense énergétique majeure, un hypercatabolisme associé à une protéolyse, une lipolyse et un déficit en micronutriments. Son statut en carnitine a été peu étudié. Cette amine quaternaire est pourtant l’élément clé de la β-oxydation des acides gras à chaînes longues et la lipolyse est une source majeure d’énergie durant cette phase d’hypercatabolisme liée à l’agression tissulaire aiguë. Chez l’Homme, 75 % de la carnitine provient de l’alimentation mais les produits de nutrition artificielle en sont dépourvus. Matériel et méthodes Étude observationnelle sur 38 patients polytraumatisés (dont 18 avec traumatisme crânien) hospitalisés en réanimation polyvalente. La carnitine plasmatique libre a été dosée au 3e jour post-traumatique, sur des reliquats de prélèvements de sang restant issus des bilans réalisés pour la prise en charge habituelle, chez ces patients recevant progressivement une nutrition entérale à partir de j2. Résultats La carnitine plasmatique est abaissée chez 95 % des patients avec une médiane est de 18 μmol/L [11–47] pour une norme entre 36 et 46 μmol/L. Cette diminution est plus importante chez les polytraumatisés cérébro-lésés : 7,72 [11–36] vs 21,5 [11–47] μmol/L (p = 0,031). En analyse univariée, on observe une relation entre la carnitinémie et l’IMC (p = 0,049), le DFG estimé par le CKD-EPI (p = 0,0171) et l’urée sanguine (p = 0,0022). Pour les patients présentant les carnitinémies les plus diminuées (< 18 μmol/L), en analyse multivariée, les facteurs en cause sont l’association à un traumatisme crânien (p = 0,0151) et l’urée plasmatique (0,0371) ( Fig. 1). Discussion La concentration plasmatique de carnitine libre est abaissée précocement chez le patient polytraumatisé et de façon significativement plus importante chez les cérébro-lésés. Différents mécanismes peuvent être évoqués : diminution de la synthèse de novo et des apports exogènes, augmentation de l’élimination, majoration de l’utilisation et/ou association des divers mécanismes. La relation entre la carnitinémie et le DFG évoque augmentation de l’excrétion urinaire déjà montrée par Cerderblad puis Davis. La majoration de l’utilisation de la carnitine peut être incriminée chez les traumatisés crânien présentant la dépense énergétique la plus élevée. Une adaptation métabolique ne peut être exclue. Les conséquences de ce déficit peuvent être évoquées en prenant en compte l’effet neuro-protecteur potentiel de la carnitine.
    Annales francaises d'anesthesie et de reanimation 09/2014; 33:A24–A25. DOI:10.1016/j.annfar.2014.07.049 · 0.84 Impact Factor
  • Annales Françaises d Anesthésie et de Réanimation 09/2014; 33:A68-A69. DOI:10.1016/j.annfar.2014.07.109 · 0.84 Impact Factor
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    ABSTRACT: BACKGROUND: Postoperative acute kidney injury (AKI) is a cause of morbidity and mortality. Its diagnosis requires better markers than variations in diuresis or postoperative serum creatinine. OBJECTIVES: The aim of this study was to evaluate the accuracy of Doppler renal resistive index for early detection of AKI after hip or knee arthroplasty. DESIGN: A prospective observational study. SETTING: A single-centre study in a university hospital. PATIENTS: Fifty men and women older than 65 years, requiring hip or knee replacement with at least two perioperative AKI risk factors, including diabetes, arteritis, chronic heart or renal dysfunction, and prescription of angiotensin-converting enzyme (ACE) inhibitors. Exclusion criteria were poor abdominal echogenicity, arrhythmia, respiratory failure or agitation. INTERVENTION: Renal resistive index was measured preoperatively and in the postanaesthesia care unit. RESULTS: Sixteen patients presented with AKI in the postoperative period. Resistive index was increased in this group in both the preoperative [0.72 (0.69 to 0.73) vs. 0.66 (0.58 to 0.71); P = 0.01] and postoperative periods [0.75 (0.71 to 0.75) vs. 0.67 (0.62 to 0.72); P = 0.0001]. Resistive index evaluated by ROC curves and AUC to detect AKI was 0.862 [95% confidence interval (95% CI) 0.735 to 0.943]. The most accurate cut-off value was a postoperative resistive index of 0.705 (sensitivity = 94%, specificity = 71%, LR+ = 3.19 and LR– = 0.09). The grey area between 0.705 and 0.73, corresponding to the inconclusive zone, included 26% (13/50) of all the patients. CONCLUSION: Postoperative resistive index appears to be effective for early detection of AKI after major orthopaedic surgery. Resistive index can be measured in the postoperative care unit in patients at risk of AKI. TRIAL REGISTRATION NUMBER: 29-0512.
    European Journal of Anaesthesiology 07/2014; 32(1). DOI:10.1097/EJA.0000000000000120 · 3.01 Impact Factor
  • Annales francaises d'anesthesie et de reanimation 06/2014; DOI:10.1016/j.annfar.2014.05.013 · 0.84 Impact Factor
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    ABSTRACT: Accidental dural puncture (ADP) is a common complication of epidural catheter insertion, and may lead to post-dural puncture headache (PDPH), especially in obstetric patients. Epidural blood patch (BP) is the most effective treatment of PDPH. Prophylactic BP has shown its efficacy to prevent PDPH; nevertheless, this method may be insufficient. We report an ADP case before induction of labor in a 28-year-old parturient. To avoid PDPH, an intrathecal catheter was immediately inserted after ADP and an epidural catheter was also inserted at the interspace above. Catheters were kept in place for more than 24hours. A prophylactic BP was performed immediately after removal of the intrathecal catheter. The patient did not experience any headache. This combination of treatments (intrathecal catheter insertion+prophylactic BP) may be a good alternative approach to prevent PDPH, even if it has to be warranted by other clinical studies.
    Annales francaises d'anesthesie et de reanimation 05/2014; DOI:10.1016/j.annfar.2014.03.019 · 0.84 Impact Factor
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    ABSTRACT: Preoperative flushing of an anesthesia workstation is an alternative for preparation of the anesthesia workstation before use in malignant hyperthermia-susceptible patients (MHS). We studied in vitro, using a test lung, the washout profile of sevoflurane in 7 recent workstations during adult and, for the first time, pediatric ventilation patterns. Anesthesia workstations were first primed with 3% sevoflurane for 2 hours and then prepared according to the recommendations of the Malignant Hyperthermia Association of the United States. The flush was done with maximal fresh gas flow (FGF) with a minute ventilation equal to 600 mL × 15, to reach a sevoflurane concentration of <5 parts per million. After flush, 2 clinical situations were simulated in vitro to test the efficiency of preparation: decrease of FGF from max to 10 L/min, or decrease of minute ventilation to 50 mL × 30, to simulate the ventilation of an MHS infant. We report washout delays for MHS patients for previously studied workstations (Primus®, Avance®, and Zeus®) and more interestingly, for machines not previously tested (Felix®, Flow-I®, Perseus®, and Leon®). An increase of sevoflurane concentration was observed when decreasing FGF (except for flow-I® and Leon®) and during simulation of MHS infant ventilation (except for Felix®). This descriptive study strongly suggests that washout profiles may differ for each anesthesia workstation. We advise the use of maximal FGF during preparation and anesthesia. Required flushing times are longer when preparing an anesthesia workstation before providing anesthesia for MHS infants.
    Anesthesia and analgesia 05/2014; 119(1). DOI:10.1213/ANE.0000000000000208 · 3.42 Impact Factor
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    ABSTRACT: Data from previous studies indicate that optimal conditions for intubation are met 120 seconds after administration of 0.15 mg.kg-1 cisatracurium (ED95 x 3) following the induction of anesthesia. The aim of this study was to compare the doses required for complete paralysis after induction of anesthesia in ICU patients with the dose used in patients undergoing elective surgery. Seventeen ICU patients undergoing percutaneous tracheostomy and 17 patients undergoing an elective surgical procedure under muscle relaxation were included. In both groups, an initial intravenous bolus of cisatracurium besylate was given at a dose of 0.15 mg.kg-1 followed by repeated boluses of 0.03 mg.kg-1 every four minutes. The objective was to obtain no response to the train-of-four (TOF). The contractile response of the corrugator supercilii muscle was monitored every minute by observing the TOF in response to a peripheral nerve stimulator with a constant current set to 60 mA. After the initial dose of cisatracurium, none of ICU patients (0/17) versus 15/17 of the elective surgery patients were completely paralyzed (P < 0.0001). There was a delay in the onset of neuromuscular blockade among the ICU patients. The cumulative doses of cisatracurium were significantly higher in the ICU group with 38 +/- 14 mg (that is, 10 +/- 4.7 ED95) versus 11 +/- 2 mg (that is, 3 +/- 0.3 ED95) in the elective surgery group (P < 0.0001). The dosing of cisatracrurium for ICU patients, which is based on the dose recommended for elective anesthesia, is unsuitable because the onset is too slow. This phenomenon is probably caused by changes in the pharmacodynamics and pharmacokinetics. These data suggest that neuromuscular monitoring should be used in the ICU.
    02/2014; 4(1):3. DOI:10.1186/2110-5820-4-3
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    ABSTRACT: La brèche durale accidentelle est une complication commune lors des abords périduraux ; elle peut être à l’origine de céphalées post-brèche durale (CPBD), en particulier en obstétrique. Le « blood patch » (BP) est le traitement le plus efficace des CPBD. Le BP préventif a fait preuve d’efficacité pour prévenir les CPBD ; néanmoins, cette technique est parfois insuffisante. Nous rapportons un cas de brèche durale accidentelle, survenue avant l’induction du travail chez une femme de 28 ans. Pour éviter les CPBD, nous avons immédiatement introduit un cathéter intrathécal, puis inséré un second cathéter dans l’espace péridural sus-jacent. Les deux cathéters étaient laissés en place pendant plus de 24 heures. Un BP prophylactique, via le cathéter péridural, était pratiqué immédiatement après le retrait du cathéter intrathécal. La patiente n’a pas présenté de CPBD. Cette combinaison de traitement (insertion d’un cathéter intrathécal + BP préventif) pourrait être une solution pour éviter l’apparition de CPBD, mais elle doit être confirmée par des études cliniques.
    Annales francaises d'anesthesie et de reanimation 01/2014; · 0.84 Impact Factor
  • A G M Aya, V Minville, J Ripart
    Annales francaises d'anesthesie et de reanimation 10/2013; 32(10). DOI:10.1016/j.annfar.2013.09.003 · 0.84 Impact Factor
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    ABSTRACT: To evaluate the feasibility of guidewire detection in right cardiac cavities by transthoracic echocardiography (TTE) in order to detect catheter misplacement and to optimize central venous catheter (CVC) positioning. Ultrasonic control for catheter tip positioning was compared to that by chest X-ray (CXR). We conducted a monocentric prospective observational study (January-November 2010). All consecutive patients undergoing CVC insertion were included. The puncture was performed using the landmark method or ultrasound guidance. TTE was performed during the procedure to follow the arrival of the guidewire in the right cardiac cavities. Catheter misplacement was defined as an aberrant position on the postprocedural CXR (catheter positioning in ipsilateral or contralateral veins). The primary endpoint was the prediction of catheter misplacement by guidewire detection in the cardiac cavities. The secondary endpoint was the optimization of the catheter tip placement in the superior vena cava. A total of 98 patients received 101 CVC. The guidewire was visualized in 92 cases. In five cases, the guidewire was not seen in the right cardiac cavities and CXR showed catheter misplacement. In four cases, poor echogenicity led to the ultrasound examination being abandoned. Catheter misplacement was detected by TTE with a sensitivity of 96 % (CI 90-98 %), a specificity of 83 % (CI 44-97 %), a positive predictive value of 98 %, and a negative predictive value of 55 %. Likelihood ratios were LR+ 5.7 (CI 0.96-34.4) and LR- 0.05 (CI 0.02-0.14). Guidewire removal under TTE avoided an excessively distal position of the catheter tip in all cases. TTE is a reliable tool to detect catheter misplacement and to optimize catheter tip positioning during the procedure of CVC insertion.
    Intensive Care Medicine 09/2013; 39(11). DOI:10.1007/s00134-013-3097-3 · 7.21 Impact Factor

Publication Stats

727 Citations
340.47 Total Impact Points

Institutions

  • 2005–2015
    • University of Toulouse
      Tolosa de Llenguadoc, Midi-Pyrénées, France
    • Université Paris-Sud 11
      Orsay, Île-de-France, France
    • Université Paris 13 Nord
      Île-de-France, France
    • Assistance Publique – Hôpitaux de Paris
      Lutetia Parisorum, Île-de-France, France
  • 2005–2014
    • Paul Sabatier University - Toulouse III
      Tolosa de Llenguadoc, Midi-Pyrénées, France
  • 2013
    • University Hospital Estaing of Clermont-Ferrand
      Clermont, Auvergne, France
  • 2005–2012
    • Centre Hospitalier Universitaire de Toulouse
      Tolosa de Llenguadoc, Midi-Pyrénées, France
  • 2006
    • Hôpital Paul-Brousse – Hôpitaux universitaires Paris-Sud
      Villejuif, Île-de-France, France