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Journal of the European Academy of Dermatology and Venereology 12/2009; · 2.98 Impact Factor
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British Journal of Dermatology 11/2009; 162(2):458-9. · 3.67 Impact Factor
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ABSTRACT: Kaposi's sarcoma is a vascular tumour characterized by a proliferation of spindle cells and endothelial cells to form closely arranged slit-like vascular spaces. Currently, the definitive diagnosis of Kaposi's sarcoma relies on histology. The dermoscopic features of Kaposi's sarcoma are not clearly defined in the scientific literature.
We seek to evaluate the dermoscopic features of Kaposi's sarcoma and compare them with other vascular tumours.
One hundred forty-one lesions from seven patients with histologically proven Kaposi's sarcoma were evaluated using polarized light dermoscopy for the presence of various dermoscopic features. Twenty patients with other vascular tumours were also examined.
Dermoscopic examination revealed bluish-reddish coloration (84% of lesions), multicoloured areas showing various colours of the rainbow spectrum (36%), scaly surface (29%), and small brown globules (15%). The 'rainbow pattern' was found in six out of seven patients with Kaposi's sarcoma and was not observed in other vascular tumours. In addition, there was an absence of dermoscopic features specific for other vascular and non-vascular skin tumours, such as well-defined lacunae or structured vascular pattern, in most of the Kaposi's sarcoma lesions.
The most frequent dermoscopic patterns in Kaposi's sarcoma were found to be bluish-reddish coloration, the 'rainbow pattern', and scaly surface. The rainbow pattern is a dermoscopic feature which has not been previously described. We propose that dermoscopy, as an adjunct to clinical examination, may enhance accuracy in the preoperative diagnosis of Kaposi's sarcoma.
Journal of the European Academy of Dermatology and Venereology 05/2009; 23(10):1128-32. · 2.98 Impact Factor
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Journal of the European Academy of Dermatology and Venereology 04/2009; 23(4):463-5. · 2.98 Impact Factor
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ABSTRACT: We found previously that the features of Kaposi's sarcoma (KS) under polarized dermoscopy are characterized by a bluish-reddish coloration, a scaly surface, small brown globules and, most distinctively, the multicoloured 'rainbow pattern'.
To evaluate the significance of the rainbow pattern on dermoscopy as a diagnostic feature in KS, and to demonstrate that it is associated with the unique vascular structure of the tumour.
More than 100 lesions from seven patients with histologically proven KS were examined with polarized light dermoscopy. Sixty-three patients with various other cutaneous vascular and nonvascular tumours were also examined. KS lesions exhibiting the rainbow pattern and KS lesions lacking the rainbow pattern on dermoscopy were excised, and dermoscopic features were compared with histopathological structures. The dermoscopic patterns of other vascular tumours were also compared with histological features. In addition, the changes in dermoscopic features and histological structures were assessed before and after surgical therapy in one patient with KS.
On the basis of evaluations with polarized dermoscopy, the rainbow pattern was found to be a highly specific dermoscopic feature for KS. Histology of KS lesions showing the rainbow pattern under polarized light dermoscopy demonstrated a vascular lumen-rich pattern of closely arranged 'back-to-back' vascular structures, whereas histology of KS lesions without the rainbow pattern showed a vascular lumen-poor pattern with vascular lumina separated further apart by intervening stromal and cellular tissue. Other vascular tumours did not exhibit the rainbow pattern and were characterized histologically by variably sized vascular structures separated by substantial amounts of stromal and cellular tissue. In one patient with KS, disappearance of the rainbow pattern was associated with obliteration of the vascular structure following surgical ablation therapy.
The rainbow pattern in KS is associated with the vascular lumen-rich histological subtype, is not manifest in the vascular lumen-poor subtype and disappears following total tumour removal. Therefore, the underlying structural arrangement of the vessels in KS may determine whether or not the rainbow pattern can be seen on polarized dermoscopy.
British Journal of Dermatology 12/2008; 160(4):801-9. · 3.67 Impact Factor
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ABSTRACT: Inverted follicular keratosis (IFK) is a benign skin lesion that typically presents as an asymptomatic, solitary nodule on the face of middle-aged and older individuals. IFK may mimic malignant lesions, especially squamous cell carcinoma (SCC), both clinically and pathologically. We report a 35-year-old male patient who had an exophytic nodule with papillary surface on his right nasal ala of 3 months' duration. The nodule was solitary, flesh colored, 5 mm in diameter and tended to bleed. The patient received shave excision with cautery under the clinical impression of pyogenic granuloma. Pathologically, diagnostic confusion existed between IFK and SCC. Squamous eddy formation and lack of epithelial dysplasia were suggestive of IFK. The tissue was investigated for the presence of human papillomavirus (HPV) DNA sequences by polymerase chain reaction (PCR) and negative result was obtained. This patient healed satisfactorily after removal of the lesion and no visible recurrence occurred during the following 10 months. The possibility of histologically confusing IFK with SCC, leading to unwarranted disfiguring treatments of a benign lesion, is emphasized.
The Kaohsiung journal of medical sciences 02/2001; 17(1):50-4. · 0.61 Impact Factor
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ABSTRACT: The effects of components of the Health Belief Model and optimism on preventive intention were examined in 144 Hong Kong Chinese. Two variables related to the Health Belief Model, susceptibility and severity, were experimentally manipulated for an imaginary flu outbreak and a hypothetical vaccine. Participants indicated their intention to take the hypothetical vaccine after reading each of the 4 combinations of high versus low susceptibility and severity. Analysis suggested that both higher susceptibility and higher severity were associated with stronger behavioral intention to take the vaccine. Higher optimism scores were significantly associated with lower intention to take preventive action. In addition, a significant interaction was observed for optimism and severity. The effect of optimism was higher when severity was low than when it was high. Implications of these findings for research among Chinese were discussed.
Psychological Reports 07/2000; 86(3 Pt 2):1059-70. · 0.44 Impact Factor
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ABSTRACT: One of the alleged reasons that males report lower intimacy in same-sex friendships than females is that males tend to be more competitive than females, but this assumption has not been empirically tested. In the current study, 121 Hong Kong adolescents filled out Chinese versions of the Intimate Friendship Scale and the Competitiveness Index. As predicted, females reported having more intimate same-sex relationships than males, and they scored lower on competitiveness than males. However, the correlations between scores on the Competitiveness Index and the Intimate Friendship subscales were small and nonsignificant, suggesting that the sex difference in intimacy was not a function of competitiveness.
Psychological Reports 03/1999; 84(1):45-8. · 0.44 Impact Factor
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Journal of the American Academy of Dermatology 03/1999; 40(2 Pt 1):250-1. · 3.99 Impact Factor
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S T Cheng
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ABSTRACT: In Hong Kong secondary schools, students in the senior forms take competitive examinations to proceed to the next level, whereas those in the junior forms have to attend school regardless of their ability and motivation. It was hypothesized that this produces different classroom climates. To test this hypothesis, 602 Chinese secondary school students were administered the short version of the Classroom Environment Scale. Significant differences were found, varying by type of school, on the dimensions of Involvement, Task Orientation, Teacher Support, Competition, Order and Organization, Affiliation, Innovation, Rule Clarity, and Teacher Control. These findings are discussed.
Adolescence 02/1999; 34(136):793-8. · 0.64 Impact Factor
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ABSTRACT: A 46-year-old man presented with left cavernous sinus syndrome and subsequent right leg pain proved clear cell type hepatocellular carcinoma metastasis. An initial liver function test was normal and alpha-fetoprotein was only 15 ng/ml but they increased rapidly and he progressed to hepatic failure 2 weeks later. Therefore, a subclinical hepatoma with metastasis should be differentiated in cavernous sinus syndrome, even in cases of normal hepatic enzymes, because hepatoma is prevalent in Taiwan.
The Kaohsiung journal of medical sciences 02/1998; 14(2):117-20. · 0.61 Impact Factor
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S T Cheng
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ABSTRACT: The self-esteem and fear of negative evaluation of 77 fan-club members age 16 or below and 128 age-equivalent secondary school students who had never joined a fan club were investigated. Consistent with common observations, fan-club respondents were mostly females. Significant differences were found between the two samples. Logistic regression analysis showed that being a fan-club member was associated with poor self-esteem and strong fear of negative evaluation, while the bias toward females in the fan-club sample could be attributed to the effects of these two variables.
Adolescence 02/1997; 32(127):687-92. · 0.64 Impact Factor
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S T Cheng
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ABSTRACT: Koro is generally considered a culture-bound psychiatric syndrome, the dominant feature of which is anxiety or dissociation. A close examination of koro epidemics in China, where koro cases appear to be more frequent than other parts of the world, shows that koro has a sociocultural component which has not been sufficiently taken into account in previous formulations. This article analyzes koro in the natural environment in which it appears and dispels the notion of koro being individual psychopathology. Koro, at least the way it is manifested in China, is a social malady maintained by cultural beliefs which affect the whole community and not just those diagnosed with it. Further directions for research into the subject are discussed.
Culture Medicine and Psychiatry 04/1996; 20(1):67-82. · 1.29 Impact Factor
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S T Cheng
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ABSTRACT: Hong Kong experienced a rapid increase in private homes for elderly people in recent years. This paper examines the social background of that development. Private elderly homes thrived in a context of rising demand due to changing demographics, particularly massive emigration secondary to political instability, which created a large potential market of elderly people in need of residential care. However, entrepreneurs would not be attracted unless it is a profitable business, and much of that profit is likely derived from social security payments to elderly people. Because the amount of social security benefits is way below the level required for purchasing good quality service in the private sector, many elderly people are bound to ive in very poor residential settings.
American Journal of Community Psychology 09/1993; 21(4):449-67. · 1.74 Impact Factor
