Javad Behravan

Mashhad University of Medical Sciences, Mashad, Razavi Khorasan, Iran

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Publications (85)97.08 Total impact

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    ABSTRACT: Although cyanoacrylate glues are widely used in medicine, cyanoacrylate based nanocomposites have been recently suggested for dental restorative/filling applications. In the present research, SiO2 nanoparticles were used as filler for development of a novel dental nanocomposite base on alkoxy-ethyl-cyanoacrylate. The nanocomposite samples filled with different levels of nano-sized SiO2 (wt %) were made the mechanical properties were evaluated and comparisons were made with the neat cyanoacrylate. The hardness and wear behavior of the samples were measured using Vickers hardness and pin-on-disk tester, respectively. The wear mechanism of the samples was also evaluated using scanning electron microscopy (SEM). Furthermore, cell biocompatibility of the samples using MTT and LDH assays as well as inflammatory cytokine expression interleukin-6 (IL-6) from L929 cells were investigated. The results showed that an increase in nano-sized SiO2 content improves hardness and wear resistance of the cyanoacrylate based nanocomposites and changes the wear mechanism from adhesive to abrasive. The results of cytotoxicity analysis showed a significant reduction in cell viability and IL-6 produced from the samples-exposed L929 cells compared with untreated control cells. Moreover, increasing in nano SiO2 powder content caused a decrease in the released formaldehyde.
    International Journal of Adhesion and Adhesives 10/2014; · 2.22 Impact Factor
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    ABSTRACT: Abstract Context: Scutellaria lindbergii Rech. f. (Lamiaceae) is an Iranian species of Scutellaria which has been shown to exert antimicrobial, antioxidant and cytotoxic effects. Objective: The protective properties of total methanol extract (TME) of S. lindbergii and its fractions (defatted and CH2Cl2) were investigated against cytotoxic and genotoxic effects of H2O2 in NIH 3T3 cell line as non-malignant cells. Materials and methods: The cells were incubated with different concentrations of S. lindbergii root extracts [TME (15-250 μg ml(-)(1)), defatted fraction (15-500 μg ml(-)(1)) and CH2Cl2 fraction (5-40 μg ml(-)(1))] and toxic concentration of H2O2 (200 µM) at 37 °C for 2 h concurrently and Cell viability was quantitated by MTT assay. The antigenotoxic effect of extracts was investigated using comet assay. The cells were incubated with extracts [TME (25-250 μg ml(-)(1)), defatted fraction (25-500 μg ml(-)(1)) and CH2Cl2 fraction (5-40 μg ml(-)(1))] and H2O2 (25 µM) at 4 °C for 20 min, then the comet assay was performed. DNA damage was expressed as percentage tail DNA. Results: Total methanol extract of S. lindbergii and its fractions had a significant inhibitory effect on DNA damage. The IC50 values of TME, defatted fraction and CH2Cl2 fraction against DNA damage were determined as 48, 138 and 8 μg ml(-)(1), respectively. Conclusion: S. lindbergii extracts can prevent oxidative DNA damage, which is likely due to its flavonoids and phenolic compounds as antioxidant constituents.
    Drug and Chemical Toxicology 09/2014; · 1.29 Impact Factor
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    ABSTRACT: Ferula szowitsiana has been widely used for medicinal purposes around the world. The anti-oxidant effect of F. szowitsiana had been proved. The current study aims to determine the protective effects of galbanic acid, a sesquiterpene coumarin from F. szowitsiana, against hydrogen peroxide (H2O2) - induced oxidative DNA damage in human lymphocytes.
    Avicenna Journal of Phytomedicine 09/2014; 4(5):337-42.
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    ABSTRACT: Abstract Background: Despite the wide range of investigations on the therapeutic potentials of herbal extracts in cancer cell lines, there is not usually enough data on their probable effects on normal cells. Recently, both anti-tumoral and anti-oxidant properties of Scutellaria litwinowii extracts have been reported on different cancer cell lines. In the present study, the possible protective effects of S. litwinowii root extracts against cytotoxicity and DNA damage induced by hydrogen peroxide (H2O2) on normal cells were investigated using MTT and Comet assays, respectively. Methods: A method of sequential extraction with solvents of different polarities was used to generate methanolic, de-fatted, and dichloromethane fractions. Both MTT and Comet assays were performed here to assess, respectively, changes in cell viability and levels of DNA damage from H2O2. In a pre-treatment regimen, test materials were applied to the cells prior to H2O2 treatment, while in a co-treatment protocol, cells were treated simultaneously with H2O2 and extracts. Results: In the co-treatment studies, only methanolic extract at 1,000 μg/mL (p<0.001) imparted a significant protective effect as shown in the MTT assay. Pre-treatment of cells for 24 h with different concentrations of the test materials did not lead to any significant protection. Results from the Comet assays in the co-treatment studies suggested a significant (p<0.01) protective effect of the test materials against DNA damage caused by H2O2. However, in the pre-treatment studies, only methanolic extract at ≥500 μg/mL showed a protective effect (p<0.01). Conclusions: Considering the probable high levels of phenolic and flavonoid compounds in the methanolic extract, these compounds may impart the noted protective effects of the S. litwinowii root through the scavenging of free radicals.
    Journal of Complementary and Integrative Medicine 04/2014;
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    ABSTRACT: Abstract Background: Rosemary (Rosmarinus officinalis) possesses various pharmacological properties such as antioxidant, anti-tumorigenesis and anti-mutagenesis activities. In this study, we investigated the possible protective effects of ethanol and aqueous extracts of rosemary on human lymphocyte DNA damage induced by H2O2. The extent of DNA lesions was measured using comet assay. Methods: Blood samples were taken from healthy volunteers and lymphocytes were isolated. The lymphocytes were then incubated in aqueous and ethanol extract of rosemary (0.05, 0.1, 0.5, 1 and 2.5 mg/mL) and H2O2 (50, 100 and 200 mM). Lymphocytes were also incubated with a combination of H2O2 (100 mM) with either 1 or 2.5 mg/mL of both extracts for 30 min at 4°C. Results: Our findings showed that H2O2 treatment led to a significant concentrate-dependent DNA damage in human lymphocyte when compared to respective controls (p<0.001). The DNA damage which was initially occurred as the result of 100 µM H2O2 (Percentage tail DNA 55.1%) was inhibited due to the ethanol extract of rosemary at the doses tested (percentage tail DNA 4.7% and 4.03%). However, the aqueous extract has no effects on H2O2 genotoxicity. Conclusions: We suggest that antioxidant constituents in ethanol extract of rosemary can prevent human lymphocytes oxidative DNA damage which is due to its free radical scavenging activity.
    Journal of Complementary and Integrative Medicine 02/2014;
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    ABSTRACT: Abstract The antigenotoxic activity of glucosamine (GlcN) and N-acetylglucosamine (GlcNAc) in human peripheral lymphocytes exposed to oxidative stress was investigated. Human lymphocytes were treated with different concentrations of these aminosugars (0, 2.5, 5, 10, 20 and 40 mM) and 25 µM H2O2 simultaneously and evaluated by single cell gel electrophoresis technique (Comet assay). The single cells were analyzed using "TriTek Cometscore version 1.5" software and the data were presented as % DNA in tail. Both GlcN and GlcNAc at examined concentrations (2.5, 5, 10, 20 and 40 mM) did not reveal any genotoxicity compared to the vehicle control (PBS). Glucosamine at all concentrations (2.5, 5, 10, 20 and 40 mM) showed a significant protective activity (% DNA in tail ranging from 16.07 ± 0.85 to 5.47 ± 0.26, p < 0.001) against H2O2 induced DNA damage (% DNA in tail = 38 ± 0.65) while its N-acetylated analog only indicated a slight DNA protection at concentration of 40 mM (% DNA in tail = 33.4 ± 1.17, p < 0.01). We concluded that GlcN at tested concentrations exhibited potent antigenotoxic effect and its protection activity might be related to the presence of 2-NH2 moiety in its chemical backbone.
    Drug and Chemical Toxicology 01/2014; · 1.29 Impact Factor
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    ABSTRACT: Histopathological evaluation and grading of meningioma give important prognostic information. We evaluated retrospectively monotonous sheeting, necrosis, hypercellularity, nuclear pleomorphism, small cell changes, brain invasion, mitosis, mast cells, psammoma bodies, MIB-1 labeling index (MIB-1 LI) and histological grade of 230 primary meningioma tumors according to the latest World Health Organization (WHO) classification. To reveal any possible association between clinical features and promoter hypermethylation of O(6)-methylguanine-DNA methyltransferase (MGMT) as an important epigenetic modification in many human cancers, we also evaluated the methylation status of MGMT in meningiomas by a SYBR-green-based real-time PCR method. There was a female predominance (2.38 to 1) in the meningiomas. The mean age of the patients was 49.9 ± 12.6 years (range 16 to 78 years). Transitional meningiomas were the most common subtype of the meningiomas (35.21%, n = 81). Most of the meningiomas were located in the falx and parasagital area. There was a significant correlation between histopathological features of malignancy. These features were observed more frequently and with statistical relation to grade II rather than grade I. Mast cells, psammoma bodies and nuclear pleomorphism had poor associations (P > 0.05). When we re-evaluated the tumor grading, 31 patients with grade I meningiomas were upgraded to grade II. None of the meningiomas tested by MSQP were methylated in MGMT promoter sequence. High MIB-1 LI could be indicative for higher grade of meningioma. Continuous revision of the classification system is needed to improve the accuracy of prognostic judgments in meningioma. The data confirm that there is no rationale to test meningiomas for MGMT methylation status.
    Gene 01/2014; · 2.20 Impact Factor
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    ABSTRACT: Abstract The antigenotoxic effects of umbelliferone (UMB), herniarin (HER) and 7-isopentenyloxy coumarin (7-IP), common natural dietary coumarins, were evaluated on the human lymphocyte DNA damage using single-cell gel electrophoresis. H2O2-induced DNA break was measured based on the percentage of DNA in tail, and the antigenotoxic effects of the tested compounds were compared with that of ascorbic acid (10, 25, 50, 100 and 200 μM). UMB, HER and 7-IP did not show any genotoxicity, as compared to phosphate-buffered saline. Treatment with UMB, HER and 7-IP led to a significant reduction in the percentage of DNA in tail induced by H2O2 (p < 0.001) at all concentrations. The presence of prenyl moiety in the chemical structure of 7-IP may contribute to its better antigenotoxic property, compared to UMB. The results of this study showed that 7-IP possessed the best antigenotoxic activity among the tested compounds.
    Drug and Chemical Toxicology 10/2013; · 1.29 Impact Factor
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    ABSTRACT: In this study, a methanolic extract and an essential oil of Artemisia kopetdaghensis were tested for possible Cytotoxic activity using potato disk assay. Seven concentration of methanolic extract and four concentration of the essential oil were applied on potato discs. The methanolic extract and essential oil of A. kopetdaghensis exhibited tumor growth induction at different concentrations but at concentration equal to 0.01 % (v/v) the essential oil of A. kopetdaghensis exhibited tumor growth inhibition (52 %). A dose activity relationship between methanolic extract and essential oil concentration with tumor growth on potato discs was observed.
    Journal of essential oil-bearing plants JEOP 03/2013; 13(6):732-737. · 0.29 Impact Factor
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    ABSTRACT: The essential oil components of Ziziphora clinopodioides Lam. from Iran were isolated via hydrodistillation and analyzed by GC-MS. Twenty seven components were identified in the essential oil of the plant. The main compounds consisted of pulegone (44.5 %), terpineol (14.5%) methyl acetate (10.9%), iso-neomenthol (7.1%) and 1, 8-cineole (4.1%). Antifungal and antimicrobial acitivities of different concentrations of the essential oil of Ziziphora clinopodioides Lam. was also evaluated. The antifungal tests were conducted by a poisoned food technique against the filamentous fungi (Aspergillus niger, Trichophyton rubrum, Trichoderma reesei and Microsporum gypseum). antimicrobial tests were carried out against four Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi and Klebsiella pneumonia) and one Gram positive pathogen (Staphyloccocus aureus) using a microdilution assay. The essential oil was found to be fungicidal at >1 μl/ml against T. rubrum and M. gypseum. The minimum inhibitory concentration of the oil against Escherichia coli, Staphyloccocus aureus, Pseudomonas aeruginosa, Salmonella typhi and Kleb-siella pneumonia were found to be 0.003, 0.033, 0.033, 0.067 and 0.067 % (v/v) respectively.
    Journal of essential oil-bearing plants JEOP 03/2013; 10(4):339-345. · 0.29 Impact Factor
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    ABSTRACT: The composition and antimicrobial activity of the essential oil of Pistacia vera L., grown in Iran, was studied. The oil was obtained from the resin and analyzed by GC-MS. Twenty compounds, accounting for 99.5 % of the total components, were identified. The main constituents were α-pinene, β-pinene , and α-thujene. The antimicrobial effects of the essential oil of Pistacia vera L. gum and its major constituents ((+)α-pinene, (-)α-pinene, (-)β-pinene, (-)α-thujene and α, β-thujene) were investigated. Antibacterial assays were performed using broth microdilution assays to determine the minimum inhibitory concentrations (MICs) against two Gram positive bacteria (Staphylococcus aureus, Bacillus subtilis) and three Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Klebsiela pneumoniae). The antifungal activity against Candida albicans was determined by the agar dilution method. The essential oil of Pistacia vera L. gum exhibited strong inhibitory effects against Gram positive bacteria and C. albicans. Moreover, The results indicated that (-)β-pinene had the most inhibitory effects against Gram positive bacteria and C. albicans while α, β-thujene was more active against Gram negative bacteria.
    Journal of essential oil-bearing plants JEOP 03/2013; 11(4):376-383. · 0.29 Impact Factor
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    ABSTRACT: Bioautography is a method to localize antimicrobial activity on a chromatogram. A modified agar overlay bioautographic method was used to investigate the antibacterial activities of essential oils of Zataria multiflora, Carum copticum and Thymus vulgaris. The essential oils of all the plants exhibited activity against Bacillus subtilis and Escherichia coli at R F ~ 0.4 which represented the R F for Thymol and carvacrol in petroleum ether chloroform (50:50 as solvent system). Twenty two components were identified in the essential oil of Carum copticum. The main compounds consisted of Thymol (71.07%), terpinolene (13.08%) and cymene (10.20%). It could be concluded that the observed antibacterial activity was mainly due to the presence of Thymol and carvacrol in the essential oils.
    Journal of essential oil-bearing plants JEOP 03/2013; 10(3):259-264. · 0.29 Impact Factor
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    ABSTRACT: The cytotoxic and anti-fungal activities of Artemisia turanica essential oil were investigated. Also the composition of the essential oil of the plant was determined. For cytotoxic activity tests, a potato disc tumor inhibition method was exploited. For antifungal activity tests, a poisoned food technique against standard strains of Trichophyton rubrum, Trichoderma reesei, Microsporum gypseum and Aspergillus niger was adopted. The essential oils of A. turanica exhibited tumor growth inhibition (100 % ) inhibition at concentrations equal to 0.02 % (w/v) and higher. Thirteen components were identified in the essential oil of Artemisia turania. The main compounds consisted of 1,8-cineol (40.9 %), cis-verbenyl actate (19.0 %) and camphor (11.0 %). A dose activity relationship between the essential oil concentrations with inhibition of tumor growth on potato discs, and between the essential oil concentrations with antifungal activities was observed.
    Journal of essential oil-bearing plants JEOP 03/2013; 9(2):196-203. · 0.29 Impact Factor
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    ABSTRACT: The purpose of this study was the evaluation of two different temperatures on antibacterial activity of the biosynthesized silver nanoparticles. 38 silver nanoparticles-producing bacteria were isolated from soil and identified. Biosynthesis of silver nanoparticles by these bacteria was verified through visible light spectrophotometry. Two strains were relatively active for production of silver nanoparticles. These strains were subjected for molecular identification and recognized as Bacillus sp. and Acinetobacter schindleri. In the present study, the effect of temperatures was evaluated on structure and antimicrobial properties of the silver nanoparrticles by transmission electron microscopy (TEM), X-ray diffraction (XRD) analysis and antimicrobial Agar well diffusion methods. The silver nanoparticles showed antibacterial activity against all the pathogenic bacteria; however, this property was lost after treatment of the silver nanoparticles by high temperatures (100 and 300 °C). TEM images showed that the average sizes of heated silver nanoparticles were >100 nm. However, these were <100 nm for non-heated silver nanoparticles. Although, XRD patterns showed the crystalline structure of heated silver nanoparticles, their antibacterial activities were less. This was possible because of the sizes and accordingly less penetration of the particles into the bacterial cells. In addition, elimination of the capping agents by heat might be considered another reason.
    Biology of Metals 01/2013; · 3.17 Impact Factor
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    ABSTRACT: امروزه چسبهاي سيانواكريلات كاربردهاي گستردهاي در پزشكي و دندانپزشكي پيدا كردهاند. هدف پژوهش حاضر، بررسي نقش بر رفتار سايش چسب سيانواكريلات در محيط شبيه سازي شده بزاق مصنوعي ميباشد. رفتار سايش سيانواكريلات SiO نانو ذرات 2 توسط آزمون سايش ميله بر صفحه مطالعه شده و مكانيزم سايش نمونه ها با استفاده از تصاوير SiO با مقادير متفاوت نانو ذرات 2 مورد بررسي قرار گرفته است. علاوه بر اين، تغييرات در ميزان سختي، دماي افت جرم ناشي از تخريب حرارتي و ميز ان SEM حرارت آزاد شده در اثر خودگيري مورد مطالعه قرار گرفته است. همچنين به منظور بررسي زيست سازگاري اين مواد ، آزمون 1 انجام شده است. نتايج نشان داده اند كه MTT با استفاده از روش L سميت سلولي بر روي سلولهاي فيبروبلاست لثه موش رده 929 افزايش در ميزان نانوذرات تقويت كننده در كامپوزيت زمينه سيانواكريلات، منجر به افزايش مقاومت به سايش و سختي سيانواكريلات شده و افزايش دما ناشي از خودگيري چسب را بهشدت كاهش ميدهد. علاوه بر اين، كامپوزيت حاصله درجات پائينتري از سميت سلولي نسبت به پايه سيانواكريلات خود نشان ميدهد
    MJME. 01/2013; 7(2).
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    ABSTRACT: OBJECTIVE: A -30G>A single nucleotide polymorphism in the promoter region of the glucokinase gene has been previously associated with obesity, insulin resistance and diabetes. The present study aimed to evaluate the association of this polymorphism with obesity and its comorbidities in a population from Northeast Iran. METHODS: Five hundred and forty-two subjects aged 18 to 65 years were included in the study and divided into normal (BMI<25, n=220), overweight (25<BMI<30, n=135) and obese (BMI>30, n=187) groups. All subjects were genotyped for the -30G>A polymorphism using the polymerase chain reaction-restriction fragment length polymorphism technique. RESULTS: The genotypes and allele frequencies of the three groups did not differ significantly (p>0.05). When the study population was categorized according to diabetes mellitus, hyperlipidemia, hypertension and metabolic syndrome status, no significant difference in -30G>A genotypes and alleles was found between the subgroups with and without these disorders (p>0.05), apart from a significantly higher frequency of the G allele in the hyperlipidemic vs. non-hyperlipidemic subgroup (p<0.05). CONCLUSION: The findings of the present study do not support an association between the -30G>A polymorphism and high body mass index in the Iranian population.
    Revista de Nutrição 08/2012; 25(4):487-495. · 0.28 Impact Factor
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    ABSTRACT: In this study we aimed to evaluate PXR and ABCG2 gene expression patterns and NF-κB activity induced by proinflammatory cytokines in different breast normal and carcinoma cells. The effects of proinflammatory cytokines on ABCG2 and PXR mRNA expression were studied using real-time PCR. Western blot analysis used for evaluating the protein levels of ABCG2, PXR and the active form of NF-κB (p65 in nuclear protein extract). Significant inductions in the ABCG2 and PXR mRNA and protein levels and NF-κB activity, were observed in MCF7, BT-474, CAL51, 184A1 and HBL100 cells, upon treatment with 50 ng/ml of IL-1β and TNF-α. On the contrary significant reduction of the ABCG2 and PXR mRNA and protein levels and NF-κB activity, were observed in MDA-MB-435 cell line. In conclusion, IL-1β and TNF-α induced ABCG2 and PXR expression and NF-κB activity in some breast cancer and normal cell lines. Similar patterns of induction and reduction in PXR and ABCG2 genes and NF-κB activity suggest a probable relationship between ABCG2, PXR and NF-κB.
    European journal of pharmaceutical sciences: official journal of the European Federation for Pharmaceutical Sciences 06/2012; 47(2):474-80. · 2.61 Impact Factor
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    ABSTRACT: In this study, the antigenotoxic effects of diversin, a prenylated coumarin obtained from Ferula diversivittata roots were evaluated using comet assay. Isolated lymphocytes from healthy volunteers' blood samples were incubated with diversin (10, 25, 50, 100, 200 and 400 µM) alone, or in the presence of H(2)O(2) (25 µM). DNA break was measured based on the %tail DNA and compared with different concentrations of curcumin (10, 25 and 50 µM) as the positive control. It was shown that all concentrations of diversin significantly reduce DNA damage caused by H(2)O(2).
    Natural product research 05/2012; · 1.01 Impact Factor
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    ABSTRACT: Cyclooxygenase-2 (COX-2) inhibitors including celecoxib inhibit cell growth and induce apoptosis in cancer cells. In this study, the relation of Bax (an apoptosis promoter) to Bcl-2 (an apoptosis inhibitor) ratio with the apoptosis co-ordination enzyme, caspase-3 was investigated in correlation with the treatment of 4,5-bisaryl imidazolyl imidazoles as novel selective COX-2 inhibitors in Caco-2 colorectal cancer cells . Recently, the organic reactions under microwave irradiation attracted attention of scientists due to their high reaction rate, mild reaction conditions and the formation of clean products. Therefore, a microwave-assisted method was used to synthesize our compounds. The effects of these COX-2 inhibitors on the proliferation of Caco-2 cells were evaluated by MTT assay. cDNA microarray and clustering analysis were used to evaluate effects of our synthetic compounds on gene expression pattern of 112 genes involved in apoptosis pathways. Bax, Bcl-2 and caspase-3 mRNA expression and their relationship were analyzed by quantitative real-time PCR. Results indicated that proliferation of Caco-2 cells after treatment with 4,5-bisaryl imidazolyl imidazoles on Caco-2 cells were time and dose dependent. We conclude that increase in Bax/Bcl-2 ratio leads to an up-regulation in caspase-3 mRNA expression.
    Genes and Genomics 04/2012;
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    ABSTRACT: The edible red seaweed Eucheuma cottonii is abundantly cultivated for carrageenan production. This study investigated the effects of dietary E. cottonii polyphenol-rich extract (ECME) on breast cancer. In vitro assays showed that ECME was antiproliferative against oestrogen-dependent MCF-7 and oestrogen-independent MB-MDA-231 human breast-cancer cells (IC50 values of 20 and 42 μg/ml, respectively) but was non-toxic to normal cell lines. The ECME (150 and 300 mg/kg BW) was fed to female rats and, after 4 weeks, rat mammary tumour was induced using LA7 cells (inoculated subcutaneously). The ECME inhibited tumour development and erythrocyte lipid peroxidation in the cancer-induced rats, dose-dependently. It showed anti-oestrogenic effects on the rat estrous cycle and serum hormone levels. Electron microscopy and histopathology observations confirmed apoptosis in the rat mammary tumours. The polyphenol-rich ECME was tumour-suppressive via apoptosis induction, downregulating the endogenous oestrogen biosynthesis, and improving antioxidative status in the rats.
    Food Chemistry. 01/2012; 130(2):376–382.

Publication Stats

373 Citations
97.08 Total Impact Points

Institutions

  • 2004–2014
    • Mashhad University of Medical Sciences
      • • Biotechnology Research Center
      • • Department of Pharmacology
      • • Immunology Research Center
      • • Pharmaceutical Research Center
      Mashad, Razavi Khorasan, Iran
  • 2011
    • Kermanshah University of Medical Sciences
      Bākhtarān, Kermānshāh, Iran
    • Avicenna Research Institute
      Teheran, Tehrān, Iran
  • 2006–2008
    • University of Toronto
      Toronto, Ontario, Canada