Ali Gürbüz

Izmir Katip Celebi Universitesi, Temnos, İzmir, Turkey

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Publications (91)74.51 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Background: Penetrating cardiac injuries are high-risk, high-mortality injuries considering the outcomes. Therefore, it is important to choose the appropriate incision. In general clinical settings, thoracotomy and median sternotomy are choices of incisions to explore the injury. In this study, the results of median sternotomy and thoracotomy in penetrating cardiac injuries were compared. Methods: Between January 2003 and December 2013, forty patients, who underwent either thoracotomy or median sternotomy for penetrating cardiac injury, were retrospectively analyzed, and the collected data were compared. Twenty-six patients underwent thoracotomy (Group 1), and fourteen patients underwent median sternotomy (Group 2). Results: There was no statistically significant gender difference between the groups. However, the mean age in Group 2 was found to be significantly higher than the one in Group 1 (p<0.05). Conclusion: There were no significant survival differences between the groups in the long term. Incision choice should be determined considering the site of injury and whether there is an accompanying pulmonary injury or not. On the other hand, thoracotomy has some draw backs compared to median sternotomy.
    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery: TJTES 09/2015; 21(4):266-70. · 0.38 Impact Factor
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    ABSTRACT: Introduction: It is well known that blood transfusion increase the morbidity and mortality in the cardiac surgery. The impact of transfusion of blood and blood products which were administrated intraoperatively and within the postoperative frst six hours on transfusions in patients underwent CABG surgery was evaluated. Material and Methods: Between January 2011, and November 2012, patients who underwent CABG surgery were included in this study. Patients were divided into groups according to type of blood products and number of units transfused. Renal dysfunction, acute lung injury, new cerebrovascular event, atrial fbrilation, the presence of infection within the postoperative frst 24 hours, duration of intensive care unit stay and mechanical ventilation support and mortality rates were compared between these groups. Daily amount of chest drainage, urine output, fuid intake, and also fuid balance, and, laboratory test results were also evaluated. Results: 317 patients (78%) were male, 90 patients (22%) were female. Mean age was 61.2±9.92. No transfusion was administered in 48 patients (12%). While 359 (88%) patients received at least 1 unit transfusion. In addition patients received 1-2 U (n=164; 40%), 3-4 U (n=102; 25%), 5-7 U (n=66; 16%), and more than 7 units (n=27; 5 %) of blood transfusions. No transfusion of erythrocyte suspension (ERT) was administered in 184 (45.3%) patients. The patients also received 1-2 U (n=196; 48.15), ≥ 3 U (n= 27; 6.6%) of ERT: No transfusion of fresh frozen plasma (FFP) was administered in 140 patients (34.4%). While the patients also received -1-2 U (n=196; 48.2%), and more than 2 units of FFP (n=71; 174 %). Patients receiving transfusions had higher postoperative mortality and complication rates. We observed that when the ERT and FFP units increased, the rates of mortality and complications were also increasing. Multiple logistic regression analyses revealed that FFP transfusion is the foremost risk factor for mortality. Conclusion: Findings of our study revealed that blood and blood product transfusion is associated with a dose dependent increase in the mortality and morbidity in patients who underwent CABG surgery. Whether transfusion causes adverse outcome(s) or is an alternate marker for a sicker patient cannot be deduced from our fndings.
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    ABSTRACT: Background: This study aims to compare intermittent antegrade cardioplegia and antegrade/retrograde continuous cardioplegia in terms of myocardial protection in cardiac surgery. Methods: Hundred six patients who underwent cardiac surgery in our clinic between October 2010 and January 2011 were included in the study. Patients were divided into two groups as patients who received intermittent antegrade cardioplegia (group 1; 18 females, 14 males) and who received antegrade/retrograde continuous cardioplegia (group 2; 16 females, 58 males), and postoperative results were compared. Troponin-I, creatine kinase-myocardial band (CK-MB) levels, durations of cardiopulmonary bypass (CPB) and cross-clamping, total amounts of cardioplegia, and potassium utilization during the process were evaluated. Results: According to our results, mean troponin-I and CK-MB levels were higher in group 1 than group 2. However, this difference was not statistically significant. While troponin-I and CK-MB values were correlated to durations of cross-clamping and CPB in group 1, troponin-I and CK-MB values were not correlated to durations of cross-clamping and CPB in group 2. Conclusion: No correlation was detected between troponin I, CK-MB levels, and durations of CPB and cross-clamping in the group which received anterograde/retrograde continuous cardioplegia. Therefore, troponin-I and CK-MB levels were not affected and myocardial protection was better once effective myocardial protection was obtained by 'antegrade/retrograde continuous cardioplegia. Although antegrade/retrograde continuous cardioplegia provides better myocardial protection, aortic pressure must be monitored to be kept between desired levels during antegrade cardioplegia, and the retrograde cannula must be kept in the appropriate place during retrograde cardioplegia.
    Turkish Journal of Thoracic and Cardiovascular Surgery 01/2015; 23(1). DOI:10.5606/tgkdc.dergisi.2015.10182 · 0.14 Impact Factor
  • Y. Beşir · O. Gökalp · U. Yetkin · E. Çelik · H. Iner · B. Lafçi · O. Tetik · A. Gürbüz
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    ABSTRACT: Background: This study aims to examine the effects of amiodarone versus propafenone for maintenance of stable sinus rhythm after left atrial bipolar radiofrequency ablation combined with a mitral valve procedure in patients with mitral valve disease and persistent atrial fibrillation. Methods: The study included 75 patients (29 males, 46 females; mean age 66,8±7.4 years; range 54 to 82 years) who underwent left atrial bipolar radiofrequency ablation combined with mitral valve surgery between July 2008 and July 2010. Patients were divided into three groups of 25: propafenone group (group 1), amiodarone group (group 2), and control group (group 3). Atrial fibrillation patients with slow ventricular response were excluded from the study. Results: Data was collected at preoperative period, during surgery, prior to discharge from hospital, and at 3, 6, and 18 months after discharge. Patients from all groups were followed for 18 months. In group 1, the number of patients in sinus rhythm was 22 at discharge, 20 at three months, and 21 at six and 18 months. In group 2, the number of patients in sinus rhythm was 18 at discharge, 13 at three months, 15 at six months, and 16 at 18 months. In group 3, the number of patients in sinus rhythm was 16 at discharge, 11 at three months, 12 at six months, and 14 at 18 months. Group 1 had a statistically significantly higher rate of stable sinus rhythm. No hospital mortality was observed in any group. Conclusion: This study revealed that propafenone was more effective than amiodarone in maintenance of stable sinus rhythm at the postoperative period in patients who underwent bipolar radiofrequency ablation combined with a mitral valve procedure.
    Turkish Journal of Thoracic and Cardiovascular Surgery 01/2015; 23(2):258-263. DOI:10.5606/tgkdc.dergisi.2015.10315 · 0.14 Impact Factor
  • Anadolu kardiyoloji dergisi: AKD = the Anatolian journal of cardiology 10/2014; 14(8). DOI:10.5152/akd.2014.5687 · 0.93 Impact Factor
  • Anadolu kardiyoloji dergisi: AKD = the Anatolian journal of cardiology 09/2014; 14(6):564. DOI:10.5152/akd.2014.5651 · 0.93 Impact Factor
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    ABSTRACT: Background The aim of this study was to investigate the protective effects of methylprednisolone (Pn), which is a potent anti-inflammatory agent, and pheniramine maleate (Ph), which is an antihistaminic with some anti-inflammatory effects, on reperfusion injury in brain developing after ischemia of the left lower extremity of rats. Material/Methods Twenty-eight randomly selected male Sprague-Dawley rats were divided into 4 groups: Group 1 was the control group, Group 2 was the sham group (I/R), Rats in Group 3 were subjected to I/R and given Ph, and rats in Group 4 were subjected to I/R and given Pn. A tourniquet was applied at the level of left groin region of subjects in the I/R group after induction of anesthesia. One h of ischemia was performed with no drug administration. In the Ph group, half of a total dose of 10 mg/kg Ph was administered intraperitoneally before ischemia and the remaining half before reperfusion. In the Pn group, subjects received a single dose of 50 mg/kg Pn intraperitoneally at the 30th min of ischemia. Brains of all subjects were removed after 24 h for examination. Results Malondialdehyde (MDA) levels of the prefrontal cortex were significantly lower in the Ph group than in the I/R group (p<0.05). Superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzyme activities were found to be significantly higher in the Ph group than in the I/R group (p<0.05). Histological examination demonstrated that Ph had protective effects against I/R injury developing in the brain tissue. Conclusions Ph has a protective effect against ischemia/reperfusion injury created experimentally in rat brains.
    12/2013; 19:285-90. DOI:10.12659/MSMBR.889570
  • Orhan Gökalp · Gökhan Ilhan · Ali Gürbüz
    Anadolu kardiyoloji dergisi: AKD = the Anatolian journal of cardiology 05/2013; 13(5). DOI:10.5152/akd.2013.153 · 0.93 Impact Factor
  • Orhan Gökalp · Serkan Yazman · Barç N Ozcem · Ali Gürbüz
    Anadolu kardiyoloji dergisi: AKD = the Anatolian journal of cardiology 04/2013; 13(4). DOI:10.5152/akd.2013.119 · 0.93 Impact Factor
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    ABSTRACT: Paragangliomas are rare asymptomatic painless tumors, originating from paraganglionic bodies of autonomous nerve system of the embriological neural crest and increasing gradually. Despite their gradual developing nature, it is critical to reach early diagnosis and tailor surgical plan for carotid body tumors due to their potential of being malignant and local aggressive development, as well as invasion or pressure on the adjacent vascular and neural tissues. In this article, we present seven cases who were admitted with the complaints of pain and swelling in the neck and were diagnosed with carotid body tumor based on the further investigations and were surgically treated in the light of literature review and different surgical modalities were discussed.
    Turkish Journal of Thoracic and Cardiovascular Surgery 01/2013; 21(1):194-200. DOI:10.5606/tgkdc.dergisi.2013.6541 · 0.14 Impact Factor
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    ABSTRACT: Objective: Proliferation of smooth muscle cells leading to intimal hyperplasia developing at vascular intervention sites plays a major role in the development of restenosis. Ascorbic acid is a potent anti-oxidant with antiproliferative properties. The aim of this study was to investigate such effect of ascorbic acid on intimal hyperplasia. Material and Methods: Twenty-one male white New Zealand rabbits weighing 2-3 kg were selected. The animals were allocated to three groups each consisting of seven rabbits. Group 1 was the sham group. Group 2 was the control group and Group 3 consisted of rabbits receiving ascorbic acid. The right carotid arteries of the subjects in Groups 2 and 3 were transected and re-anastomosed. A daily dose of 100 mg ascorbic acid per kg body weight was administered intraperitoneally for 14 days to rabbits in Group 3. Rabbits in Group 2 were not subject to any pharmaceutical agent. All the subjects were sacrificed at the end of postoperative day 28. Their right carotid arteries were resected and were subject to histopathologic examination for smooth muscle cell proliferation and intimal hyperplasia. The arterial segments were fixed in 10% buffered formalin solution until the time of histological analysis. Each vessel was sectioned serially in 2-mm increments from the prepared paraffin blocks. Sections of 5 μm thickness were stained with hematoxylin and eosin (H&E) and Masson Trichrome. The diameters of vessels and their luminal areas, and the areas of tunica intima and tunica media were measured with 10X magnification. The thicknesses of tunica intima and tunica media were measured with 20X magnification. The morphometric measurements were then compared between groups. Results: Intimal thickness and intimal area were significantly lower in Group 1 when compared with the other groups (p=0.004, p=0.003). In Group 3, the ratios of tunica intima thickness/tunica media thickness and area of tunica intima/area of tunica media were significantly lower than those of Group 2 (p=0.015, p=0.046). Conclusion: Ascorbic acid reduces the intimal hyperplasia developing after vascular anastomoses.
    Turkiye Klinikleri Journal of Medical Sciences 01/2013; 33(1):126-131. DOI:10.5336/medsci.2012-29406 · 0.10 Impact Factor
  • World Journal of Cardiovascular Surgery 01/2013; 03(07):225-226. DOI:10.4236/wjcs.2013.37044
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    ABSTRACT: Purpose: To compare the outcomes of vascular access (VA) procedures performed using physical examination (PE) alone to PE and ultrasound vein mapping for assessment of patients needing hemodialysis access. Methods: Comparative analysis of data obtained by retrospective review of records of 63 patients who underwent PE and vascular mapping (VM) using colored Doppler ultrasonography (CDUS) and 76 patients assessed by physical examination alone to schedule vascular access surgery. The parameters assessed to study the impact of these two different pre-operative assessment approaches included selection of surgical site, procedure, construction of arteriovenous fistulas (AVF) and grafts (AVG), negative surgical exploration rates and surgical outcomes (maturation and patency rates). Results: The rate of successfully constructed AVF increased significantly from 75% to 97% (P=.001) with pre-operative ultrasonographic vascular mapping. In 22 patients (34.9%) the access planned with physical examination was modified based on CDUS examination. In 12 patients, the surgical site for AVF creation and type of surgical procedure were modified based on the CDUS results. Permanent access placement rates were significantly higher in patients assessed with CDUS (P=.001). All patients who underwent vascular mapping had successful VA construction while the PE group had a 18.4% negative surgical exploration rate. When fistulas were assessed at six months, the patency rate was 80.7% for the physical examination (PE) group and 93.4% for the vascular mapping (VM) group. Conclusions: Pre-operative vascular mapping using CDUS significantly increases the success of AVF construction and patency.
    The journal of vascular access 09/2012; 14(1). DOI:10.5301/jva.5000097 · 0.85 Impact Factor
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    ABSTRACT: Aim. The aim of this paper was to evaluate our clinical experience and surgical results with oncologic procedures associated with major vascular resection and reconstruction on elective or emergent basis. Methods. A retrospective study was performed on patients who underwent major vascular resection for malignancy in our hospital between January 2000 and January 2011. Data collection was organized for patient demographics, intraoperative findings, and postoperative outcome. Results. Thirty-six patients were treated with 36 reconstructive procedures; 18 (50%) of them were major-vessel reconstruction, 11 (30.6%) of them were bypass procedures, and 7 (19.4%) of them were primary repair. Concomitant vascular interventions were performed electively as part of a planned oncologic procedure in 22 (61.1%) patients or emergently in 14 (38.8%) patients due to a vascular complication that occurred during tumor resection. Postoperative morbidity rate related to vascular intervention was 16.6% and mortality was observed in 2.8% of the patients due to pulmonary embolism. Conclusion. The results reported herein support that the need for resection and reconstruction of a major vascular structure should not prohibit the resection of any given tumor. The study demonstrates that most major vascular reconstructions have a high degree of success, and do not result major complications.
    Italian Journal of Vascular and Endovascular Surgery 09/2012; 19(3):171-176. · 0.08 Impact Factor
  • Orhan Gökalp · Levent Yılık · Ali Gürbüz
    Anadolu kardiyoloji dergisi: AKD = the Anatolian journal of cardiology 06/2012; 12(6):526. DOI:10.5152/akd.2012.166 · 0.93 Impact Factor
  • Orhan Gökalp · Levent Yılık · Ali Gürbüz
    Anadolu kardiyoloji dergisi: AKD = the Anatolian journal of cardiology 05/2012; 12(5):451-2; author reply 452. DOI:10.5152/akd.2012.138 · 0.93 Impact Factor
  • 01/2012; 21(1):47-50. DOI:10.9739/uvcd.2012-28756
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    ABSTRACT: OBJECTIVES: We aimed to assess the suitability of right ventricular outflow tract (RVOT) fractional shortening for estimating low central venous pressure (CVP). To the best of our knowledge, there have been no similar studies in the English language literature. METHODS: In this cross-sectional study, the emergency physicians measured the RVOT fractional shortening on parasternal short-axis view. A receiver operating characteristic curve analysis was conducted to identify the threshold that maximized the sensitivity and specificity for discriminating normal and low CVPs by the RVOT fractional shortening value. The sensitivity, specificity, and the positive and the negative likelihood ratios of RVOT fractional shortening to truly estimate CVP were calculated. RESULTS: Fifty-eight consecutive patients had invasive CVP monitoring. Nine patients with high CVP and eight for other reasons were excluded. Forty-one patients were enrolled in the study, of whom 21 were in low CVP group and 20 were in normal CVP group. RVOT diastolic diameters, RVOT systolic diameters, and RVOT fractional shortening were lower in low CVP group and this difference was statistically significant (P<0.001). The cutoff value for RVOT fractional shortening to differentiate the low and normal CVPs using the highest sensitivity and specificity was 26.44%. Area under the receiver operating characteristic curve was 0.933 (0.810-0.987) with a P value of less than 0.001. The sensitivity and specificity of RVOT fractional shortening to truly estimate CVP were 95 (75-99) and 80% (58-94), respectively. CONCLUSION: In the hands of emergency physicians, a RVOT fractional shortening measurement is a good predictor of low CVP.
    European Journal of Emergency Medicine 12/2011; 20(1). DOI:10.1097/MEJ.0b013e32834f835a · 1.58 Impact Factor
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    ABSTRACT: According to the literature data, the prevalence of restenosis after carotid endarterectomy ranges between 6 and 36%. The etiological factor is intimal hyperplasia for early period, whereas it is atherosclerosis for late period. A 67-year-old male patient admitted to our clinic with a history of headache and minor stroke. His medical history was significant for right carotid endarterectomy 8 years ago. Recent Doppler ultrasound and digital substraction angiography revealed 75% stenosis and kinking corresponding to the segment distal to the endarterectomy region. Surgical endarterectomy is the treatment of choice in critical carotid stenosis. Endovascular therapy is primarily considered for patients if there is restenosis after carotid endarterectomy. However, the treatment modality is controversial in cases with concomitant carotid stenosis and kinking of internal carotid artery. We present our surgical approach to a case with significant stenosis and kinking of internal carotid artery. We performed a 6-mm-PTFE graft interposition between common and internal carotid artery and resection of the kinking segment.
    10/2011; 2011:572454. DOI:10.1155/2011/572454
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    Anadolu kardiyoloji dergisi: AKD = the Anatolian journal of cardiology 03/2011; 11(2):E9-E10. DOI:10.5152/akd.2011.050 · 0.93 Impact Factor

Publication Stats

195 Citations
74.51 Total Impact Points


  • 2011–2015
    • Izmir Katip Celebi Universitesi
      Temnos, İzmir, Turkey
  • 2004–2011
    • Ankara Atatürk Training and Research Hospital
      Engüri, Ankara, Turkey
  • 2003–2010
    • Izmir Bozkaya Research and Training Hospital
      Ismir, İzmir, Turkey
  • 2009
    • Izmir Chest Disease and Surgery Hospital
      Ismir, İzmir, Turkey
  • 2008–2009
    • İzmir Atatürk Eğitim ve Araştırma Hastanesi
      Ismir, İzmir, Turkey
    • Pamukkale University
      • Department of Cardiovascular Surgery
      Denisli, Denizli, Turkey
  • 2005–2007
    • Ataturk Chest Diseases and Chest Surgery Education and Research Hospital
      Engüri, Ankara, Turkey
  • 1999–2000
    • Koşuyolu Kalp ve Araştırma Hastanesi
      İstanbul, Istanbul, Turkey