Publications (11)24.42 Total impact
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Article: Population genetic data for 17 STR markers from Lebanon.
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ABSTRACT: Seventeen autosomal STRs were analyzed (D2S1338, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D19S433, D21S11, CSF1PO, FGA, TH01, TPOX, vWA, Penta D, and Penta E) in the Lebanese population. A total of 192 unrelated individuals were genotyped for the 15 autosomal STRs in the Promega PowerPlex 16 STR kit. An additional 275 unrelated individuals were genotyped for the Applied Biosystems AmpFlSTR Identifiler and SGM+STR kits. Allele frequencies for the shared CODIS 13 loci among the three STR kits tested were not significantly different among individuals within the Lebanese population. Forensic and population genetic parameters for the 17 loci were calculated. We also compared the allele frequencies from this population with other populations in the same geographic vicinity.Legal Medicine 11/2010; 12(6):324-6. -
Article: Population genetics of Y-chromosome STRs in a population of Northern Greeks.
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ABSTRACT: Seventeen Y STR loci were typed in a population sample of 191 unrelated male individuals from Northern Greece. Haplotypes are presented for the following loci: DYS456, DYS389I, DYS390, DYS389II, DYS458, DYS19, DYS385a/b, DYS393, DYS391, DYS439, DYS635, DYS392, Y GATA H4, DYS437, DYS438 and DYS448. The overall haplotype diversity was 0.9992. This database study provides significant additional information for the application of Y-chromosomal STRs to forensic identification efforts in Greece by nearly doubling both the number of individuals and the number of Y-loci typed from Greek populations. These samples have been previously typed for autosomal STRs [L. Kovatsi, T.J. Parsons, R.S. Just, J.A. Irwin, Genetic variation for 15 autosomal STR loci (PowerPlex 16) in a population sample from northern Greece, Forensic Sci. Int. 159 (2006) 61-63] and the mitochondrial DNA control region [J. Irwin, J. Saunier, K. Strouss, C. Paintner, T. Diegoli, K. Sturk, L. Kovatsi, A. Brandstatter, M.A. Cariolou, W. Parson, T.J. Parsons, Mitochondrial control region sequences from northern Greece and Greek Cypriots, Int. J. Legal Med. 122 (2008) 87-89].Forensic science international. Genetics 12/2009; 4(1):e21-2. · 2.42 Impact Factor -
Article: Mitochondrial control region sequences from an African American population sample.
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ABSTRACT: Entire mitochondrial control region data were generated for 248 African American individuals, which had been previously typed for 15 autosomal STRs [J.M. Butler, R. Schoske, P.M. Vallone, J.W. Redman, M.C. Kline, Allele frequencies for 15 autosomal STR loci on U.S. Caucasian, African American, and Hispanic populations, J. Forensic Sci. 48 (2003) 908-911].Forensic science international. Genetics 12/2009; 4(1):e45-52. · 2.42 Impact Factor -
Article: Mitochondrial DNA control region variation in a population sample from Hong Kong, China.
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ABSTRACT: Entire mitochondrial control region sequences were generated from 377 unrelated individuals from urban Hong Kong. In line with other control region datasets from China, the sample from Hong Kong exhibited significant genetic diversity that was reflected in a random match probability of 0.19% and a mean pairwise difference of 13.14. A total of 305 haplotypes were identified, of which 262 were unique. These sequences will be made publicly available to serve as forensic mtDNA reference data for China.Forensic science international. Genetics 10/2009; 3(4):e119-25. · 2.42 Impact Factor -
Article: Mitochondrial control region sequences from an Egyptian population sample.
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ABSTRACT: Entire mitochondrial control region data was generated for 277 unrelated Egyptian individuals. High-throughput robotics, a redundant sequencing approach, and several quality control checks were implemented to generate a high-quality database. The data presented here will augment the limited Egyptian mtDNA reference data currently available for forensic comparisons.Forensic science international. Genetics 07/2009; 3(3):e97-103. · 2.42 Impact Factor -
Article: Complete mitochondrial genome sequences for 265 African American and U.S. "Hispanic" individuals.
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ABSTRACT: Entire mitochondrial genome (mtGenome) sequences of 265 unrelated African American and U.S. "Hispanic" individuals were generated.Forensic science international. Genetics 07/2008; 2(3):e45-8. · 2.42 Impact Factor -
Article: Mitochondrial control region sequences from a Vietnamese population sample.
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ABSTRACT: Entire mitochondrial control region data were generated for 187 individuals from Vietnam. These samples have been previously typed for 16 autosomal short-tandem repeats (STRs) [1].Deutsche Zeitschrift für die Gesamte Gerichtliche Medizin 06/2008; 122(3):257-9. · 2.59 Impact Factor -
Article: Mitochondrial control region sequences from a Vietnamese population sample
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ABSTRACT: Entire mitochondrial control region data were generated for 187 individuals from Vietnam. These samples have been previously typed for 16 autosomal short-tandem repeats (STRs) [1].Deutsche Zeitschrift für die Gesamte Gerichtliche Medizin 04/2008; 122(3):257-259. · 2.59 Impact Factor -
Article: Mitochondrial control region sequences from a U.S. "Hispanic" population sample.
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ABSTRACT: Entire mitochondrial control region data was generated for 128 "Hispanics" from the United States. These samples have been previously typed for 15 autosomal STRs [J.M. Butler, R. Schoske, P.M. Vallone, J.W. Redman, M.C. Kline, Allele frequencies for 15 autosomal STR loci on U.S. Caucasian, African American, and Hispanic populations, J. Forensic Sci. 48 (2003) 908-911]. High-throughput robotics, a redundant sequencing approach, and several quality control checks were implemented to generate a high-quality database. The data presented here will augment Hispanic reference data available for forensic mtDNA comparisons.Forensic science international. Genetics 04/2008; 2(2):e19-23. · 2.42 Impact Factor -
Article: Development and expansion of high-quality control region databases to improve forensic mtDNA evidence interpretation.
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ABSTRACT: In an effort to increase the quantity, breadth and availability of mtDNA databases suitable for forensic comparisons, we have developed a high-throughput process to generate approximately 5000 control region sequences per year from regional US populations, global populations from which the current US population is derived and global populations currently under-represented in available forensic databases. The system utilizes robotic instrumentation for all laboratory steps from pre-extraction through sequence detection, and a rigorous eight-step, multi-laboratory data review process with entirely electronic data transfer. Over the past 3 years, nearly 10,000 control region sequences have been generated using this approach. These data are being made publicly available and should further address the need for consistent, high-quality mtDNA databases for forensic testing.Forensic science international. Genetics 07/2007; 1(2):154-7. · 2.42 Impact Factor -
Article: Toward increased utility of mtDNA in forensic identifications.
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ABSTRACT: The utility of mtDNA in forensic identifications is limited by its low power of discrimination and the absence of high quality mtDNA databases. Single nucleotide polymorphisms (SNPs) in the control region outside of hypervariable regions I and II (HVI/HVII), and in the coding region of the mtDNA genome, can provide additional discrimination in mtDNA testing. We have identified particularly useful SNP sites via high throughput sequencing of the entire mtDNA genome. We report here two cases in which an 11-plex SNP assay (panel "A") targeting the most common HVI/HVII type successfully resolved two cases in which identifications could not be made on the basis of HVI/HVII sequencing. Additionally, we established a database of 286 samples for SNP panel "A" generated with robotic protocols. We have addressed the need for high quality mtDNA control region (CR) databases by developing robotic protocols for lab processing, and a carefully devised electronic data review process. A large-scale databasing effort targeting several populations underrepresented in current mtDNA databases is underway.Forensic Science International 01/2005; 146 Suppl:S147-9. · 2.30 Impact Factor
Top co-authors
Top Journals
Institutions
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2009
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United States Army
Washington, WV, USA
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2005
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Armed Forces Institute of Pathology
Rāwalpindi, Punjab, Pakistan
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