Davut Albayrak

Karadeniz Technical University, Atrabazandah, Trabzon, Turkey

Are you Davut Albayrak?

Claim your profile

Publications (39)68.25 Total impact

  • 14. Ulusal Aile Hekimliği Kongresi, Halic Congress Center, Istanbul, Turkey; 10/2015
  • [Show abstract] [Hide abstract]
    ABSTRACT: Presenting with severe thrombocytopenia and pancytopenia is rare in children with brucellosis, and at the beginning it can be misdiagnosed as a hematological or a viral hemorrhagic disease. The follow-ups of 52 patients diagnosed with brucellosis from January, 2008, to December, 2013, in our clinic have shown the following results. Eleven out of these 52 patients revealed the fact that they had pancytopenia at the admission phase. Anemia and leukopenia were defined as hemoglobin levels and leukocyte counts below the standard values in terms of ages, thrombocytopenia as thrombocyte counts below 150,000/mm(3), and severe thrombocytopenia as thrombocyte counts below 20,000/mm(3). The most frequent admission symptoms and findings of the patients with pancytopenia were fever (75%), fatigue (50%), splenomegaly (75%), and hepatomegaly (41%). Laboratory results were hemoglobin 9.3±0.96 gram/dL, white blood cell count 2226±735.9/mm(3), and thrombocyte count 70,090±47,961/mm(3). The standard tube agglutination test was positive for all patients, and Brucellosis spp. were isolated in the blood cultures of six (54%) patients. Three of the 11 patients had severe thrombocytopenia, and they were admitted with complaints of epistaxis, gingival bleeding, petechiae, and purpura. At the beginning, two of three cases were misdiagnosed as Crimean-Congo hemorrhagic fever (CCHF), another zoonotic endemic disease in Turkey. Pancytopenia improved with treatment of brucellosis on all patients. In conclusion, brucellosis can show great similarity with hematologic and zoonotic diseases like CCHF. Brucellosis should be considered in the differential diagnosis of pancytopenia, treatment-resistant immune thrombocytopenia, and viral hemorrhagic disease, especially in countries where brucellosis is endemic.
    Vector borne and zoonotic diseases (Larchmont, N.Y.) 09/2015; 15(9). DOI:10.1089/vbz.2015.1775 · 2.30 Impact Factor
  • Esra Pancar Yuksel · Fatma Aydin · Davut Albayrak ·
    [Show abstract] [Hide abstract]
    ABSTRACT: ABSTRACT Background: Different systems have been used for the preparation of Platelet Rich Plasma (PRP), but platelet collection efficiencies of these systems are not clear. Objective: To evaluate the platelet collection efficiencies of three different PRP preparation systems. Materials and Methods: Blood samples were obtained from the same 16 volunteers for each system. The samples were centrifuged and PRP was prepared by three systems. The ratio of the total number of platelets in PRP to the total number of platelets of the venous blood sample of the patient expressed in percentage was named as platelet collection efficiency and calculated for each system. Results: Mean platelet collection efficiencies were 66.6 (min.56.9, max.76.9), 58.3(min.27.3, max.102.8), 50.8(min.27.2, max.73) for top and bottom bag system, system using citrated tube and the system using tube with ficoll and cell extraction kit respectively. Statistically significant difference was only found between the platelet collection efficiencies of systems using the tube with ficoll and cell extraction kit and the top and bottom bag system (p=0.002). Conclusions: All three systems could be used for PRP preparation but top and bottom bag system offers a slight advantage over the system using ficoll and cell extraction kit regarding the platelet collection efficiency.
    Journal of Cosmetic and Laser Therapy 12/2014; 17(3):1-10. DOI:10.3109/14764172.2014.1003237 · 1.11 Impact Factor
  • Canan Albayrak · Davut Albayrak ·
    [Show abstract] [Hide abstract]
    ABSTRACT: Osteoporosis in hemophilic patients is a significant problem. The causes of osteoporosis in hemophilic patients are lack of adequate exercise, multiple hemorrhage and inflammation, and low vitamin D levels. The aim of this study was to retrospectively determine the frequency of vitamin D deficiency and insufficiency in children with severe hemophilia A. Forty-seven children with severe hemophilia were included in the study. None of the patients had previously received vitamin D supplementation. No patient had clinical or radiologic findings of rickets or seropositivity of hepatitis C virus or HIV. The mean age of the patients was 11.64 ± 5.70 (range, 2-18) years. The mean vitamin D level was 16.35 ± 7.49 ng/ml (range, 3.25-33.80). Vitamin D levels were below 10 ng/ml (severe vitamin D deficiency) in 9 cases (19%), between 10 and 19.99 ng/ml (vitamin D deficiency) in 23 cases (49%), between 20 and 29.99 ng/ml (vitamin D insufficiency) in 13 cases (28%), and above 30 ng/ml (normal vitamin D level) in 2 cases (4%). The mean serum levels of 25-hydroxy vitamin D in the children with hemophilia during winter and autumn were significantly lower than that during summer (P = 0.0028 and P = 0.0091, respectively). A majority of our hemophilic patients (96%) had low vitamin D levels. The study showed that the risk of vitamin D deficiency is the most highest during winter and autumn. Normal lifelong vitamin D levels are especially important in hemophilia because of the possible synergistic effect of vitamin D levels on periarticular and general osteoporosis, which is intrinsic to hemophilic conditions. We advise routine checking of vitamin D levels twice a year and vitamin D supplementation to maintain its level between 30 and 100 ng/ml.
    Blood coagulation & fibrinolysis: an international journal in haemostasis and thrombosis 12/2014; 26(3). DOI:10.1097/MBC.0000000000000237 · 1.40 Impact Factor
  • Canan Albayrak · Davut Albayrak ·
    [Show abstract] [Hide abstract]
    ABSTRACT: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked recessive genetic defect that can cause hemolytic crisis. However, this disease affects both males and females. In Turkey, the frequency of this enzyme deficiency was reported to vary, from 0.25 to 18%, by the geographical area. Its prevalence in the northern Black Sea region of Turkey is unknown. The aims of this study were to assess the prevalence of G6PD deficiency in the northern region Turkey in children and adults with hyperbilirubinemia and hemolytic anemia. This report included a total of 976 G6PD enzyme results that were analyzed between May 2005 and January 2014. G6PD deficiency was detected in 5.0% of all patients. G6PD deficiency was significantly less frequent in females (1.9%, 6/323) than in males (6.6%, 43/653). G6PD deficiency was detected in 3.7% of infants with hyperbilirubinemia, 9.2% of children, and 4.5% of adults with hemolytic anemia. In both the newborn group and the group of children, G6PD deficiency was significantly more frequent in males. In the combined group of children (groups I and II), the proportion of males was 74% and 67% in all groups (P = .0008). In conclusion, in northern region of Turkey, G6PD deficiency is an important cause of neonatal hyperbilirubinemia and hemolytic crisis in children and adults. This study suggests that most pediatricians thought that G6PD deficiency is exclusively a male disease. For this reason, some female patients may have been undiagnosed.
    Pediatric Hematology and Oncology 08/2014; 32(2). DOI:10.3109/08880018.2014.940074 · 1.10 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Background: To evaluate the clinical feature and outcome of invasive fungal infections (IFI) in children with hematologic and malign diseases. Patients and methods: The medical records of children with hematologic and malignant diseases, who were hospitalized at our hospital between January 2010 and December 2011, were reviewed. Proven, probable, and possible IFIs were diagnosed according to the revised definitions of the European Organization for Research and Treatment of Cancer/Mycosis Study Group. The demographic, clinical, and laboratory characteristics of the patients who met the study criteria were evaluated. Results: IFI was diagnosed in 67 (7.2%) febrile episodes of 56 patients, of which 10 (1.2%) were proven, 20 (2%) probable, and 37 (4%) possible IFI. Blood culture of 10 cases with proven IFI yielded yeast and the most common isolated agent was Candida parapsilosis. Seventy percent of cases with fungemia had central venous catheter (CVC). Twenty cases with probable IFI had invasive mold infection. The cases with mold infection had higher median C-reactive protein values, lower neutrophil counts, and longer duration of neutropenia compared with the cases with yeast infection. A total of 14 patients (20.9%) died. Presence of CVC, bone marrow transplantation, total parenteral nutrition, prolonged fever, and proven/probable IFI were detected more often in patients who died, compared with patients who survived. Conclusions: IFIs are important causes of death in children with hematologic and malignant diseases. Mold infections are seen more frequently in cases with prolonged and profound neutropenia, and invasive yeast infections, especially with non-albicans Candida species, in cases with CVC. Early and effective treatment considering these findings will help to decrease the mortality.
    Journal of Pediatric Hematology/Oncology 07/2014; 37(2). DOI:10.1097/MPH.0000000000000225 · 0.90 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Human Autosomal Recessive Osteopetrosis (ARO) is a genetically heterogeneous disorder caused by reduced bone resorption by osteoclasts. In 2000, we found that mutations in TCIRG1 gene encoding for a subunit of the proton pump (V-ATPase) are responsible for more than half of ARO cases. Afterwards, five additional genes have been demonstrated to be involved in the pathogenesis of the disease, leaving approximately 25% of cases that could not be associated with a genotype. Very recently, a mutation in the Sorting Nexin 10 (SNX10) gene, whose product is suggested to interact with the proton pump, has been found in three consanguineous families of Palestinian origin, thus adding a new candidate gene in patients not previously classified. Here we report the identification of 9 novel mutations in this gene in 14 ARO patients from 12 unrelated families of different geographic origin. Interestingly, we define the molecular defect in 3 cases of "Västerbottenian osteopetrosis", named for the Swedish Province where a higher incidence of the disease has been reported. In our cohort of more than 310 patients from all over the world, SNX10-dependent ARO constitutes 4% of the cases, with a frequency comparable to the RANKL, RANK and OSTM1-dependent subsets. Although the clinical presentation is relatively variable in severity, bone seems to be the only affected tissue and the defect can be almost completely rescued by Hematopoietic Stem Cell Transplantation (HSCT). These results confirm the involvement of SNX10 gene in human ARO and identify a new subset with a relatively favorable prognosis as compared to TCIRG1-dependent cases. Further analyses will help to better understand SNX10 role in osteoclast physiology and verify whether this protein might be considered a new target for selective anti-resorptive therapies. © 2012 American Society for Bone and Mineral Research.
    Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research 05/2013; 28(5). DOI:10.1002/jbmr.1849 · 6.83 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: We report a RAG2-deficient patient with severe combined immunodeficiency and hemophagocytic bone marrow aplasia with plasma cells after a nonconditioned transplantation from a fully matched sibling. After engraftment, disseminated BCGosis appeared because of graft versus host disease prophylaxis. On the 55th day, eosinophilia, neutropenia, and thrombocytopenia developed. Aplasia, hemophagocytic histiocytes, and plasma cells were found on his bone marrow with very high level of serum immunoglobulin E. We could not discriminate exactly whether BCGosis or alloimmune response is the cause of hemophagocytic aplasia with plasma cells. Despite the second hematopoietic stem cell transplantation with a reduced intensity conditioning regime, his marrow aplasia did not recover and he died. This case suggests that BCGosis might be associated with hemophagocytic marrow aplasia with plasma cells in an alloimmune reaction.
    Journal of Pediatric Hematology/Oncology 02/2013; 35(8). DOI:10.1097/MPH.0b013e31827e8448 · 0.90 Impact Factor
  • Canan Albayrak · Davut Albayrak ·
    [Show abstract] [Hide abstract]
    ABSTRACT: Objective: Beta thalassemia major and intermedia patients show a tendency to osteoporosis and pathologic fractures. Vitamin D deficiency increases osteoporosis and its consequences. The aim of this study was to retrospectively determine the frequency of vitamin D deficiency and insufficiency in children with thalassemia major and intermedia who applied to our Pediatric Hematology department. Material and Metods: Our 42 patients with thalassemia major and intermedia were retrieved from hospital automation records. Blood samples had been taken before transfusion between January to June 2012. Age, gender, serum levels of ferritin, liver enzymes, calcium, phosphorus, alkaline phosphatase, 25-OH vitamin D, and parathormone were recorded. 25-OH vitamin D levels were measured using HPLC. Laboratory normal values for Vitamin D were 30-80 ng/ml. Results: Median vitamin D levels was 12.80 (1.43-47.04). Values were below 10 ng/mL (severe vitamin D deficiency) in 15 cases (36%), between 10 and 20 ng/mL (vitamin D deficiency) in 18 cases (43%), between 20 and 30 ng/mL (vitamin D insufficiency) in 6 cases (14%) and above 30 ng/mL (normal vitamin D level) in 3 cases (7%). No patients had clinical and radiologic findings of rickets. There was no difference in vitamin D level by gender and age. Patients with vitamin D deficiency or insufficiency received 1200 U per day of vitamin D3 supplementation. Conclusion: This is the first report from Turkey about vitamin D levels in thalassemia. Majority of our thalassemia patients (93%) had low vitamin D levels. We advise routine check of vitamin D level and vitamin D supplementation in thalassemia patients.vitamin D supplementation in thalassemia patients.
    Turkiye Klinikleri Journal of Medical Sciences 01/2013; 33(4):1058-1063. DOI:10.5336/medsci.2012-32270 · 0.10 Impact Factor
  • Y Aliyazicioglu · A Dagdemir · C Dilber · D Albayrak ·
    [Show abstract] [Hide abstract]
    ABSTRACT: To evaluate serum prealbumin levels in chemotherapy-induced hepatotoxicity and to compare them with the other tests that are routinely used in children with cancer. We studied serum prealbumin levels before and 1, 3, 7, and 21 days after chemotherapy in addition to other tests (AST, ALT, ALP, total protein, albumin, total and direct bilirubin) in twenty-eight children with cancer receiving various combinations of chemotherapeutics. Serum ALT, AST, ALP, albumin and total and direct bilirubin were determined by enzymatic and photometric methods. Prealbumin was determined by an immunonephelometric method. Total protein and albumin were decreased, AST, ALT, ALP, and total and direct bilirubin levels were increased after chemotherapy and returned to the normal levels on the 21st day of chemotherapy, but these changes were not statistically significant. Prealbumin levels were significantly decreased on the first day of chemotherapy and returned to normal on the 21st day (p=0.001). The sensitivity and specificity of prealbumin were 28.5 % and 66.6 % on the third day and 40.0 % and 73.9 % on the seventh day, respectively. The positive and negative predictive values were 22.2 % and 73.6 % on the third day and 25.0 % and 85.0 % on the seventh day, respectively. Serum prealbumin levels seem not to be a good marker of chemotherapy-induced hepatotoxicity in respect to the other biochemical markers. On the other hand, hepatotoxicity of chemotherapy which may be fatal in severe cases and cessation of the ongoing chemotherapy may be warranted with the early decrease of prealbumin levels but it should be evaluated in larger group of patients before this conclusion (Tab. 4, Fig. 1, Ref. 18).
    Bratislavske lekarske listy 06/2012; 113(6):368-71. DOI:10.4149/BLL_2012_083 · 0.44 Impact Factor
  • Canan Albayrak · Davut Albayrak · Ayşe Ayzit Kilinç · Cengiz Kara ·

    Pediatric Blood & Cancer 04/2012; 58(4):647-8. DOI:10.1002/pbc.23353 · 2.39 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Molluscum contagiosum is an infectious disease presenting with flesh-colored, dome-shaped, umblicated papules. A few atypical presentations have been reported in immunodeficient patients. A 5-year-old boy with acute lymphoblastic leukemia, presented with bright white-colored papular lesions with no umblications on the chin during his continuation chemotherapy. Increased number of the lesions covered almost his entire chin in months. Topical therapies did not improve the lesions. After his bone marrow relapse, induction chemotherapy was withheld because of bronchopneumonia after febrile neutropenia. After initiation of a combination of systemic parenteral antibiotic and antifungal therapies, his parents squeezed one of his papular lesions. Meanwhile, systemic acyclovir was added to his therapy, because of herpes labialis. Despite the large spectrum of his therapies, in 1.5 months, this small lesion progressed to a large lesion with erythematous ground and a central ulceration. Etiology of the lesion could not be enlightened until a skin biopsy that was compatible with the molluscum contagiosum. A partial resolution was achieved by cryotherapy. In conclusion, molluscum contagiosum may present as an ulcerating lesion during childhood leukemia treatment. A skin biopsy should be performed for the accurate diagnosis of atypical cutaneous lesions in immunocompromised patients.
    Journal of Pediatric Hematology/Oncology 03/2011; 33(3):e114-6. DOI:10.1097/MPH.0b013e3182025043 · 0.90 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The objectives of this study was to investigate of the influences of high-dose (20 mg/kg/day) methyl prednisolone (HDMP) and granulocyte colony stimulating factor (G-CSF) in shortening the duration of chemotherapy-induced neutropenia encountered in children with ALL receiving maintenance therapy. Sixty-four non-febrile neutropenic attacks developed in 29 patients with ALL receiving St Jude XIII maintenance protocol were evaluated retrospectively. The patients were clinically followed up without drugs for shortening the duration of neutropenia in 21 (32.8%) attacs, while HDMP and G-CSF were administered in 26 (40.6%) and 17 (26.6%) attacks, respectively. After the detection of neutropenia, restoration of neutrophil counts at 2nd or 4th days to the levels that allow resuming the chemotherapy were considered as success. While second day and overall success rates in patients administered HDMP and G-CSF were significantly higher than the patients who were observed clinically. Both second day and overall neutrophil counts were significantly higher in patients administered G-CSF than the other groups. Methyl prednisolone and G-CSF treatments were well-tolerated by the patients. The cost-per neutropenic attack was significantly higher in G-CSF group than of the HDMP group. Especially in patients experiencing frequent neutropenic attacks and hence interruptions of the therapy, one of the myelopoiesis induction therapies can be used to shorten the duration of neutropenia. For this indication short-course HDMP therapy can be considered as an alternative to G-CSF in this patients due to its relatively low cost, amenability to outpatient administration, and well-tolerability by children.
    Fundamental and Clinical Pharmacology 03/2011; 26(3):418-23. DOI:10.1111/j.1472-8206.2011.00938.x · 2.12 Impact Factor
  • Tunc Fisgin · Sinan Atmaca · Feride Duru · Emel Ozyurek · Recep Cetin · Davut Albayrak ·
    [Show abstract] [Hide abstract]
    ABSTRACT: A 5-year-old boy was admitted to our center with a major complaint of bilateral hearing loss for 2 days. He was diagnosed with acute immune thrombocytopenic purpura 3 months before the admission and treated with high-dose methylprednisolone 2 months ago. Physical examination revealed wet purpura in the oral mucosa, serous nasal discharge, multiple petechiae and ecchymosis of the lower lip. Otomicroscopic ear examination revealed the presence of bilateral hemotympanum. The patient denied head trauma, ear pain, fever, hypertension and medications, including salicylates. The patient received high-dose intravenous methylprednisolone because of low platelet count and wet purpura for 7 days and oral prophylactic amoxicillin-clavulanate for 14 days. The onset of the response to corticosteroids was rapid, and significant hematologic improvement was observed within a few days. The 2-week follow-up examination revealed intact tympanic membranes with normal color and mobility, and the patient restored normal hearing. In this patient, hemotympanum developed rapidly, and no predisposing cause other than immune thrombocytopenic purpura was found. However, presence of a serous nasal discharge may be a sign of viral upper respiratory tract infection. Therefore, it can be speculated that sneezing or coughing might have caused bilateral hemotympanum by increasing the middle ear pressure abruptly. We would like to emphasize that bleeding may occur in unusual sites and, unlike in healthy people, may cause bizarre symptoms in patients with bleeding diathesis. Hemotympanum can be considered among the indications to start treatment in patients with acute immune thrombocytopenic purpura.
    Blood coagulation & fibrinolysis: an international journal in haemostasis and thrombosis 07/2009; 20(4):303-5. DOI:10.1097/MBC.0b013e32831bec37 · 1.40 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Selenium (Se) is a trace element contributing to the structure of antioxidant system that saves cells from reactive oxygen species. Low serum Se levels have been reported in pediatric and adult patients with cancers. On the other hand, hair Se levels, predicting the long-term body Se status, have been reported in only adult patients with cancer. The aim of the study was to investigate the hair Se status in children with newly diagnosed lymphoid malignancies and the relation between malnutrition and Se deficiency. Thirty patients with leukemia (n=17) and lymphoma (n=13), and 25 healthy controls were enrolled to the study. Se was determined with atomic absorption spectrophotometrical method. Hair Se levels of the patients were significantly lower than those of control group [666.96+/-341.46 ng/g vs. 1019.22+/-371.83 ng/g (P<0.001)]. Children with lymphoma had lower Se than the children with acute lymphoblastic leukemia but not statistically significant [547.03+/-283.67 ng/g vs. 758.67+/-361.05 ng/g (P>0.05)]. Malnourished patients (11/30) had lower hair Se levels (483.51+/-235.55 ng/g) than those of the controls (P=0.036), whereas the Se levels of the patients who had no malnutrition (773.17+/-352.92 ng/g) were also lower than those of the controls but not statistically significant (P=0.053). There was no correlation between age, sex, and the hair Se levels. In this study, we found that hair Se levels of the children with leukemia and lymphoma, especially those of malnourished patients, were lower than those of controls. Additional studies are needed to determinate whether low levels of hair Se may play a role in carcinogenesis.
    Journal of Pediatric Hematology/Oncology 09/2007; 29(8):519-22. DOI:10.1097/MPH.0b013e3180f61b3a · 0.90 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Hemostatic alterations due to abnormalities in the coagulation and fibrinolytic system may occur in dialysis patients. Protein Z (PZ) is a vitamin K-dependent coagulation protein promoting assembly of thrombin with phospholipid vesicles. The aim of this study was to investigate PZ and natural anticoagulants in children on hemodialysis (HD) and peritoneal dialysis (PD). Protein Z, protein C (PC), protein S (PS), antithrombin III (AT III), and fibrinogen levels were studied in 24 PD, 13 HD patients and 23 controls. Plasma PZ levels in patients on HD were significantly higher than those on PD and control group (p = 0.04, p = 0.03). We observed elevated PC, PS and AT III activities in children on PD when compared to controls (p = 0.011, p = 0.003, p < 0.001). In HD patients, only PS activity was increased compared to controls (p = 0.016). PC and PS activities did not differ between PD and HD patients whereas AT III activity was higher in PD patients compared to HD patients (p < 0.001). Normal/high levels of PC, PS and AT III suggest that children on PD or HD treatment do not seem to have an increased risk of thrombogenesis due to reduction of these proteins. Increased PZ levels, however, might contribute to the hemostatic alterations in children on HD treatment along with other well known abnormalities.
    Pediatric Nephrology 07/2007; 22(6):881-6. DOI:10.1007/s00467-006-0351-8 · 2.86 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: A 5-year-old girl in whom the diagnosis of inherited factor XIII deficiency was established at the age of 1 day presented with cryptic tonsillitis along with drowsiness and an abrupt occurrence of getting left interior cross eyed. While an intracranial hemorrhage was expected, cerebral imaging studies surprisingly revealed multiple sino venous thrombosis. In prothrombotic screening studies she and her father were both found to be heterozygous for factor V Leiden mutation along with having elevated levels of lipoprotein(a). Low-molecular-weight heparin was started. Ventriculoperitoneal shunt was applied because of persistence of increased intracranial pressure. Thrombosis disappeared and blood flow was normalized by the end of 2 months and the patient was discharged on coumadin therapy as being well. We would like to report this unusual case and to discuss the possible effects of two major genetic prothrombotic risk factors on inherited bleeding tendency or vice versa.
    Blood Coagulation and Fibrinolysis 07/2007; 18(4):371-4. DOI:10.1097/MBC.0b013e3280d5a7be · 1.40 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Acquired deficiency of anticoagulant proteins, due to loss in the urine, has been proposed as one of the major thrombogenic alterations in nephrotic syndrome (NS). Protein Z (PZ) is a single-chain vitamin K-dependent glycoprotein. Low PZ levels are reported to be a risk factor for thrombosis. The aim of this study was to investigate protein Z and other natural anticoagulant levels in children with NS. Thirty children aged between 1.5 and 12 years with NS (Groups I and II) and 19 age-and-sex-matched healthy controls (Group III) were enrolled into the study. Patients were divided into two groups: Group I (proteinuria >40 mg/m2/hr) and Group II (patients in remission). Plasma PZ levels in Group I were significantly lower than Group II (p=0.009) and group III (p=0.018). Plasma levels of AT III for Group I were significantly lower than for Groups II and III (p=0.009, p=0.005, respectively). Protein C levels in Group I were higher than in Group II and Group III (p=0.002, p=0.000, respectively). Protein Z levels positively correlated with serum total protein and albumin levels (p=0.003, p=0.003, respectively) and negatively with the degree of proteinuria (p=0.000). Protein Z levels were positively correlated with AT III (r=0.037, p=0.04). Along with the other coagulation abnormalities, decreased protein Z may contribute to increased risk of thromboembolic complications in children with NS. The negative correlation between proteinuria and PZ level suggests the possibility of renal PZ loss. Further studies are needed to investigate the mechanism and role of decreased PZ in NS.
    Pediatric Nephrology 09/2006; 21(8):1122-6. DOI:10.1007/s00467-006-0167-6 · 2.86 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Fanconi's anemia is an autosomal recessive disorder characterized by progressive pancytopenia and congenital malformation of the skeleton. This study investigated the oral health status of 15 children with Fanconi's anemia, including oral lesions, gingival and periodontal status, and dental abnormalities. All children in the group were found to have a tendency to develop tooth decay and were in need of dental treatment. Two had aggressive periodontitis. In one patient supernumerary teeth were found, while in another teeth were congenitally missing. The increased tendency toward periodontal disease in patients with Fanconi's anemia may be due not only to the anemia, leukopenia, and defective detoxification of oxygen radicals that are characteristic of the disease itself, but also to medications applied during intense immunosuppressive treatment, such as prednisolone.
    Pediatric Hematology and Oncology 10/2005; 22(6):531-9. DOI:10.1080/08880010591002413 · 1.10 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Iron deficiency anaemia is a frequent finding seen in coeliac disease, which can be diagnosed alone or with other findings. In this study, our aim was to determine the prevalence of coeliac disease in children with iron deficiency anaemia without significant gastrointestinal symptoms. There were 135 children with iron deficiency anaemia in the patient group (group 1), and 223 healthy children without iron deficiency anaemia in the control group (group 2) in this study. Antiendomysial antibody (EMA) IgA test was given to both groups. Antiendomysial antibody-positive patients underwent small intestine biopsy. The mean age was 7.2+/-4.6 (2-16) y in the patient group (group 1) and 8.2+/-3.8 (2-16) y in the control group (group 2), and no significant difference between the two groups was detected. In terms of gender, there was a significant difference between groups 1 and 2 (M/F: 74/61 and 98/125, respectively) ( p<0.05). EMA was positive in six cases in group 1 (4.4%), and villous atrophy and/or inflammation in the lamina propria with increased intraepithelial lymphocytes was seen on small intestine biopsy in these patients. In the control group, EMA was negative in all children. In detailed histories of patients with coeliac disease diagnosis, recurrent iron deficiency anaemia/pica was found in four patients (66.7%) and occasionally foul-smelling or watery stool attacks were seen in four patients (66.7%). Three of these six patients (50%) had short stature. The prevalence of coeliac disease was high in patients with iron deficiency anaemia; therefore, gastrointestinal findings should be further examined for coeliac disease, and the possibility of coeliac disease should be investigated in patients with recurrent iron deficiency anaemia and short stature.
    Acta Paediatrica 06/2005; 94(6):678-81. DOI:10.1080/08035250510025879 · 1.67 Impact Factor

Publication Stats

314 Citations
68.25 Total Impact Points


  • 2012
    • Karadeniz Technical University
      • Department of Biochemistry
      Atrabazandah, Trabzon, Turkey
  • 2006-2007
    • Ondokuz Mayıs Üniversitesi
      • Faculty of Medicine
      Djanik, Samsun, Turkey
  • 1999-2001
    • Istanbul 29 Mayis University
      Djanik, Samsun, Turkey
  • 1991-1992
    • Hacettepe University
      • Department of Pediatric Hematology
      Engüri, Ankara, Turkey