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Cirugía Española 06/2012; · 0.87 Impact Factor
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ABSTRACT: Several studies have been performed to evaluate the usefulness of neoadjuvant treatment using oxaliplatin and fluoropyrimidines for locally advanced rectal cancer. However, preoperative biomarkers of outcome are lacking. We studied the polymorphisms in thymidylate synthase, epidermal growth factor receptor, glutathione S-transferase pi 1 (GSTP1), and several DNA repair genes to evaluate their usefulness as pharmacogenetic markers in a cohort of 128 rectal cancer patients treated with preoperative chemoradiotherapy.
Blood samples were obtained from 128 patients with Stage II-III rectal cancer. DNA was extracted from the peripheral blood nucleated cells, and the genotypes were analyzed by polymerase chain reaction amplification and automated sequencing techniques or using a 48.48 dynamic array on the BioMark system. The germline polymorphisms studied were thymidylate synthase, (VNTR/5'UTR, 2R G>C single nucleotide polymorphism [SNP], 3R G>C SNP), epidermal growth factor receptor (Arg497Lys), GSTP1 (Ile105val), excision repair cross-complementing 1 (Asn118Asn, 8092C>A, 19716G>C), X-ray repair cross-complementing group 1 (XRCC1) (Arg194Trp, Arg280His, Arg399Gln), and xeroderma pigmentosum group D (Lys751Gln). The pathologic response, pathologic regression, progression-free survival, and overall survival were evaluated according to each genotype.
The ∗3/∗3 thymidylate synthase genotype was associated with a greater response rate (pathologic complete remission and microfoci residual tumor, 59% in ∗3/∗3 vs. 35% in ∗2/∗2 and ∗2/∗3; p=.013). For the thymidylate synthase genotype, the median progression-free survival was 103 months for the ∗3/∗3 patients and 84 months for the ∗2/∗2 and ∗2/∗3 patients (p=.039). For XRCC1 Arg399Gln SNP, the median progression-free survival was 101 months for the G/G, 78 months for the G/A, and 31 months for the A/A patients (p=.048).
The thymidylate synthase genotype and XRCC1 Arg399Gln polymorphism might help to identify Stage II-III rectal cancer patients with a better outcome after preoperative concomitant chemoradiotherapy.
International journal of radiation oncology, biology, physics 05/2011; 81(5):1319-27. · 4.59 Impact Factor
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Cirugía Española 08/2009; 87(5):328-30. · 0.87 Impact Factor
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Joaquín M Rodríguez Santiago,
Marta Clemares,
Josep Roig-Garcia,
Jose Ignacio Asensio,
Xavier Feliu,
Ernesto Toscano,
Joaquín Resa, Eduardo Targarona,
Javier Ibáñez-Aguirre,
Jose Castell,
Gaspar Sanfeliu,
Juan Jose Sánchez Cano,
Jose Manuel Ramón,
Miguel Félix Del Olmo,
Alberto Gutiérrez,
Juan Arteaga,
Jaime Vázquez,
Fernando López Mozos,
Francisco Mateo Vallejo
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ABSTRACT: To study the data from the Laparoscopic Gastric Surgery Spanish National Register of laparoscopic Gastric Surgery and to analyse the type of surgery, the conversion to laparotomy, postoperative complications and mortality.
From March 2005 to July 2008, details of 302 laparoscopic gastric surgical interventions were sent to the Association of Spanish Surgeons web-site. Details of surgical technique, reconversion, clinical and pathological data, morbidity and mortality were collected and analysed.
A total of 245 patients had gastric adenocarcinoma, 35 of them stromal tumours and 22 other gastric pathologies. In gastric adenocarcinoma patients, resection was performed in 232 cases (95%). The most frequent histology was intestinal, mainly located in the distal third of the stomach, with 34% of the tumours being locally advanced. D2 lymphadenectomy was performed in 117 cases, D1 in 105, and D0 in 6. Reconversion was needed in 21 cases (9%), with technical difficulty being the most frequent cause. Postoperative complications were reported in 72 patients (31%), with anastomotic leak being one of the most significant. Postoperative mortality was 6%, with sepsis due to anastomotic leak and cardiac or respiratory complications the most frequent causes. The mean hospital stay of patients without complications was 9.2 +/- 3 days.
Laparoscopic gastrectomy for gastric cancer is a feasible but technically demanding procedure. Potential benefits of minimal invasive surgery can be reduced due to a high rate of postoperative complications.
Cirugía Española 05/2009; 85(5):280-6. · 0.87 Impact Factor
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Laureano Fernández-Cruz,
Fernando Pardo,
Esteban Cugat,
Vicente Artigas,
Jorge Olsina,
Fernando Rotellar,
Angel Carrillo,
Hermógenes Díaz,
José Hernández, Eduardo Targarona,
Manuel Miras,
Salvador Morales-Conde,
Salvador Morales-Méndez,
Fernando Pereira,
Juan Calafell
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ABSTRACT: The reported experience with laparoscopic pancreatic surgery remains limited to case reports or small series of patients. A recent European multicenter study has allowed the limits and results of this technique to be known. This article presents an analysis of the results of the Spanish National Registry of Laparoscopic Pancreatic Surgery.
A total of 132 patients with lesions in the left pancreas were included in this series. The final diagnosis included 42 neuroendocrine tumors, 40 cystic neoplasms, 24 cysts and pseudocysts, 8 inflammatory tumors, 8 ductal carcinomas, 7 intraductal papillary mucinous tumors, 1 acinar carcinoma and 2 solid pseudopapillary tumors.
The conversion rate was 9.7%. Tumor enucleation was performed only in patients with insulinomas. The most frequent technique was spleen-preserving distal pancreatectomy. There were no postoperative deaths. The overall rate of postoperative pancreatic-related complications was 16%.
Although only a few Spanish hospitals participated in the registry, a greater number of hospitals are expected to enroll patients in the very near future.
Cirugía Española 06/2006; 79(5):293-8. · 0.87 Impact Factor
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ABSTRACT: Solid-pseudopapillary tumor of pancreas is a very rare neoplasm of low malignant potential and unknown origin. It generally occurs in young women and the prognosis is usually good after complete surgical removal. Two cases of solid pseudopapillary tumor with distinct disease duration are reported.
Cirugía Española 05/2005; 77(4):233-5. · 0.87 Impact Factor
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Laureano Fernández-Cruz,
Fernando Pardo,
Esteban Cugat,
Vicente Artigas,
Jorge Olsina,
Fernando Rotellar,
Ángel Carrillo,
Hermógenes Díaz,
José Hernández, Eduardo Targarona,
Manuel Miras,
Salvador Morales-Conde
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Joaquin M. Rodriguez Santiago,
Marta Clemares,
Josep Roig-Garcia,
Jose Ignacio Asensio,
Xavier Feliu,
Ernesto Toscano,
Joaquin Resa, Eduardo Targarona,
Javier Ibanez-Aguirre,
CIRUGIA ESPANOLA,
Gaspar Sanfeliu,
Juan Jose Sanchez Cano
