Ji Young Song

Sungkyunkwan University, Sŏul, Seoul, South Korea

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Publications (22)49.27 Total impact

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    ABSTRACT: Blue fluorescent emitters based on anthracene-aryl amine-anthracene derivatives were studied for efficient OLEDs. Compound 1 exhibited efficient EL propereties with luminous and power efficiencies of 4.50 cd/A and 1.75 lm/W at 200 mA/cm2, respectively and CIE coordinates of (0.18, 0.26) at 7.0 V.
    Journal of Nanoscience and Nanotechnology 07/2015; 15(7):5238-5241. DOI:10.1166/jnn.2015.10391 · 1.34 Impact Factor
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    ABSTRACT: This paper reports the synthesis and electroluminescence properties of new blue-emitting materials based on anthracene-fluorene derivatives with triphenylsilane groups for organic light-emitting diodes. To study the electroluminescence properties, OLEDs were fabricated in the following sequence: ITO/4,4-Bis(N-(1-naphthyl)-N-phenylamino)biphenyl (50 nm)/newly designed blue materials (30 nm)/4,4-bis(N-(1-naphthyl)-N-phenylamino)biphenyl (30 nm)/8-Hydroxyquinolinolato-lithium (2 nm)/Al (100 nm). All devices exhibited blue electroluminescence. In particular, the device using 10-(9,9-dimethyl-2-(triphenylsilyl)-9H-fluoren-7-yl)-9-(4-(triphenylsilyl)phenyl) anthracene as the emitting material exhibited the deepest blue-emission with CIE coordinates of (x = 0.15, y = 0.09). Also, the device using (9,9-dimethyl-2-(10-(10-phenylanthracen-9-yl)anthracen-9-yl)-9H-fluoren-7-yl)triphenylsilane exhibited high luminous, power and quantum efficiencies of 2.53 cd/A, 1.94 Im/W and 1.72% at 20 mA/cm(2), respectively.
    Dyes and Pigments 03/2015; 114:40-46. DOI:10.1016/j.dyepig.2014.11.003 · 3.97 Impact Factor
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    ABSTRACT: A series of 9-(2-naphthyl)anthracene derivatives with a triphenylsilane unit, which prevented molecular aggregation and self-quenching effect, was designed and synthesized. By using various bridges between the 9-(2-naphthyl)anthracene group and the triphenylsilane unit, five deep-blue emitters were obtained and applied as non-doped emitting materials in organic light-emitting diodes (OLEDs) with a device structure of indium–tin-oxide (ITO) (180 nm)/4,4-bis(N-(1-naphthyl)-N-phenylamino)biphenyl (NPB) (50 nm)/emitting materials (30 nm)/4,7-diphenyl-1,10-phenanthroline (Bphen) (30 nm)/lithium quinolate (Liq) (2 nm)/Aluminium (100 nm). All devices showed blue emissions and their electroluminescence efficiencies are sensitive to the structural changes of the emitting materials. In particular, a device using 9-(2-naphthalenyl)-10-[6-(triphenylsilyl)-2-naphthalenyl]-anthracene (4) exhibited high luminous, power and quantum efficiencies of 2.28 cd/A, 1.42 lm/W and 2.40% at 20 mA/cm2, respectively, and this device showed the deep blue emission with the CIE coordinates of (0.16, 0.10) at 6.0 V.
    Thin Solid Films 02/2015; 577. DOI:10.1016/j.tsf.2015.01.050 · 2.13 Impact Factor
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    ABSTRACT: A blue fluorescent emitting material for organic light emitting diodes (OLEDs) based on anthracene derivatives, 10-(4-(triphenylsilyl) phenyl)-9-(10-(4-(triphenylsilyl) phenyl) anthracen-9-yl) anthracene (1), was designed and synthesized via Suzuki coupling reaction. Multilayered OLED was fabricated with a device structure of: ITO (180 nm)/NPB (50 nm)/blue material (30 nm)/Bphen (30 nm)/Liq (2 nm)/Al (100 nm). A device using 1 exhibits high efficiencies (1.85 cd/A,1.05 lm/W and 0.63% at 100 mA/cm(2)). Also, the device incorporating 1 shows sky-blue emission with the CIEx,y coordinates of (0.26, 049) at 6.0V.
    Materials Research Bulletin 10/2014; 58:145-148. DOI:10.1016/j.materresbull.2014.03.021 · 2.29 Impact Factor
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    ABSTRACT: Blue fluorescent materials based on diphenylaminofluorenylstyryl derivatives connected with the various end-capping aromatic groups were synthesized and characterized. An OLED, using (E)-9,9-diethyl-7-(4-(4-fluoronaphthalen-1-yl)styryl)-N,N-diphenyl-9 H-fluoren-2-amine(5) in emitting layer, was fabricated. This device showed the highly efficient blue emission with the maximum luminance of 5138 cd/m2, the luminous efficiency of 3.92 cd/A, the power efficiency of 3.17 lm/W, the external quantum efficiency of 2.90% at 20 mA/cm2 and CIE x, y coordinates of (0.14, 0.17).
    Journal of Nanoscience and Nanotechnology 08/2014; 14(8):6217-6220. DOI:10.1166/jnn.2014.8311 · 1.34 Impact Factor
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    ABSTRACT: MET, a cell surface receptor for hepatocyte growth factor, is involved in the development of triple-negative/basal-like breast cancer (TNBC/BLBC). However, its utility as a therapeutic target in this subtype of breast cancer is poorly understood. To evaluate MET fully as a potential therapeutic target for TNBC/BLBC, we investigated the relationship between MET expression and clinical outcomes of patients with breast cancer and the functional effect of MET inhibition. Using automated immunohistochemistry (Ventana), we analyzed MET expression in 924 breast cancer patients with relevant clinicopathologic parameters. BLBC showed the strongest relationship with MET expression (57.5%, p < 0.001). High expression of MET in breast cancer resulted in poor overall survival (p = 0.001) and disease-free survival (DFS, p = 0.010). MET expression was relatively high in TNBC cell lines, and the silencing of MET via small interfering RNA reduced cell proliferation and migration. We observed reduced TNBC cell viability after treatment with the MET inhibitor PHA-665752. In the most drug-resistant cell line, MDA-MB-468, which showed elevated epidermal growth factor receptor (EGFR) expression, silencing of EGFR resulted in increased sensitivity to PHA-665752 treatment. We confirmed that PHA-665752 synergizes with the EGFR inhibitor erlotinib to decrease the viability of MDA-MB-468 cells. TNBC patients coexpressing MET and EGFR showed significantly worse DFS than that in patients expressing EGFR alone (p = 0.021). Our findings strongly suggest that MET may be a therapeutic target in TNBC and that the combined therapy targeting MET and EGFR may be beneficial for the treatment of TNBC/BLBC patients.
    International Journal of Cancer 05/2014; 134(10). DOI:10.1002/ijc.28566 · 5.01 Impact Factor
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    ABSTRACT: A series of phosphorescent iridium(III) complexes 1-4 based on phenylpyrazole were synthesized and their photophysical properties were investigated. To evaluate their electroluminescent properties, OLED devices with the structure of ITO/NPB/mCP: 8% Iridium complexes (1-4)/TPBi/Liq/Al were fabricated. Among those, the device with 3 showed the most efficient white emission with maximum luminance of 100.6 cd/m(2) at 15 V, maximum luminous efficiency of 1.52 cd/A, power efficiency of 0.71 lm/W, external quantum efficiency of 0.59%, and CIE coordinates of (0.35, 0.40) at 15.0 V, respectively.
    Bulletin- Korean Chemical Society 05/2013; 34(5):1366-1370. DOI:10.5012/bkcs.2013.34.5.1366 · 0.84 Impact Factor
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    ABSTRACT: Hemophagocytic lymphohistiocytosis (HLH) can develop following strong activation of the immune system and the cardinal symptoms are a prolonged fever, hematological abnormalities, hepatosplenomegaly, and hemophagocytosis. HLH can be classified as primary or secondary HLH, associated with infections, malignancy and autoimmune disease. There is no consensus on the primary treatment regimen in systemic lupus erythematosus (SLE)-associated HLH. We experienced a case of SLE-associated HLH in a previously healthy adult. She was initially treated with intravenous immunoglobulin, cyclosporine, and high-dose steroid, but had a poor clinical response. After intravenous etoposide, the patient stabilized and has been followed for 1 year without reactivation of the HLH or SLE.
    01/2013; 84(4):613. DOI:10.3904/kjm.2013.84.4.613
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    ABSTRACT: Necrotizing fasciitis usually occurs after dermal injury or through hematogenous spread. To date, few cases have been reported as necrotizing fasciitis of the thigh secondary to rectal perforation in rectal cancer patients. A 66-year-old male complained of pelvic and thigh pain and subsequently developed necrotizing fasciitis in his right thigh. Four years earlier, he had undergone a low anterior resection and radiotherapy due to of rectal cancer. An ulcerative lesion had been observed around the anastomosis site during the colonoscopy that had been performed two months earlier. Pelvic computed tomography and sigmoidoscopy showed rectal perforation and presacral abscess extending to buttock and the right posterior thigh fascia. Thus, the necrotizing fasciitis was believed to have occurred because of ulcer perforation, one of the complications of chronic radiation colitis, at the anastomosis site. When a rectal-cancer patient complains of pelvic and thigh pain, the possibility of a rectal perforation should be considered.
    Journal of the Korean Society of Coloproctology 12/2012; 28(6):325-9. DOI:10.3393/jksc.2012.28.6.325
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    ABSTRACT: Foamy urine is widely regarded as a sign of proteinuria. However, there is no objective definition of foamy urine and there are no reports on the proportion of involved patients who have overt proteinuria or microalbuminuria. We performed this study to investigate this proportion and to identify possible risk factors for these two conditions. We reviewed all new outpatients from 1 November 2011 to 30 April 2012 and identified patients complaining of foamy urine. Their demographic data and medical records were examined. In particular, we tabulated the patients' spot urinary protein to creatinine ratio, spot urinary microalbumin to creatinine ratio (ACR), blood urea nitrogen (BUN), and serum levels of creatinine (Cr), uric acid, calcium, phosphate, and glucose. In addition, we calculated estimated glomerular filtration rates (eGFRs) by using the CKD-EPI equation. We also performed risk factor analysis with the Chi-squared test and by logistic regression. Seventy-two patients (6.3% of total new outpatients) complained of foamy urine; of these, there were 59 males with a median age of 65.5 years (range, 36-87 years). Of the 72 patients, 16 (22.2%) had overt proteinuria. We found that diabetes, poor renal function (high Cr, BUN, low eGFR), increased serum phosphate, and increased serum glucose were associated with overt proteinuria. Multiple logistic regression analysis showed that serum Cr and serum phosphate were associated with overt proteinuria. The ACR was available for 38 patients, and in this subgroup, 12 (31.6%) showed microalbuminuria or overt proteinuria. In this subgroup, a high serum Cr was the only statistically significant risk factor. Among patients who complained of foamy urine, approximately 20% had overt proteinuria, and increased serum Cr and phosphate were statistically significant risk factors.
    12/2012; 48(3):164-8. DOI:10.4068/cmj.2012.48.3.164
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    ABSTRACT: The α-amino-3-hydroxy-5-methyl-4-propionic acid (AMPA) receptors are important for glutamate synaptic transmission in the central nervous system. Glutamate receptor, ionotropic, AMPA receptor 1 gene (GRIA1) belongs to the family of AMPA receptors. There is increasing evidence that AMPA receptors dysfunction may be related to an increased susceptibility to schizophrenia. The aim of this study was therefore to investigate whether genetic polymorphisms of GRIA1 are associated with schizophrenia and their clinical symptoms (hallucinations and delusions) in Korean population. Five single nucleotide polymorphisms (rs1428920, rs1552834, rs1422889, rs10035143, and rs2926835) of the GRIA1 were genotyped in 218 schizophrenia patients and 380 healthy controls, using a direct sequencing. All patients were evaluated by the Operational Criteria Checklist for Psychotic Illness. The genotype and allelic frequencies of rs1428920 and rs2926835 showed significant association between schizophrenia and controls (rs1428920, permutation p = 0.008, 0.008; rs2926835, permutation p = 0.038, 0.041, respectively). A significantly increased risk of schizophrenia was associated with the A allele of rs1428920 and rs2926835 of GRIA1. Furthermore, we found that rs1428920 was weakly associated with hallucinations of schizophrenia, but this significance disappeared after multiple testing (permutation p = 0.119). These results suggest that GRIA1 polymorphism may have influence upon the risk of developing schizophrenia.
    Molecular Biology Reports 10/2012; DOI:10.1007/s11033-012-1960-x · 1.96 Impact Factor
  • Psychiatry Research 03/2012; 198(2). DOI:10.1016/j.psychres.2011.12.048 · 2.68 Impact Factor
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    ABSTRACT: Background: The Ambulatory arterial stiffness index (AASI) and abnormal blood pressure (BP) variability patterns have been suggested as a stroke risk factor [1-4]. Recent studies reported that AASI might be confounded by BP variability as a prognostic marker [5,6]. We aimed to evaluate the association of stroke with AASI and BP variability in hypertensive patients. Methods: We retrospectively analyzed the data of 885 hypertensive patients. Patients were classified as dippers, extreme-dippers, nondippers and reverse-dippers. AASI was defined as 1 minus the regression slope of diastolic over systolic BP. Results: Eight patients with stroke (30.1%) were extreme-dippers, 35 (16.5%) dippers, 102 (25.1%) nondippers and 40 (41.3%) reverse-dippers (p < 0.001). AASI was higher in patients with stroke than in patients without stroke (0.48 +/- 0.01 vs.0.45 +/- 0.01; p = 0.065). AASI was inversely related with nocturnal systolic BP reduction (r = -0.21; p < 0.001). In multiple linear regression analysis, independent predictors of AASI were 24-hour pulse pressure ([beta]=0.447, p < 0.001) and nocturnal dipping ([beta]=-0.178, p < 0.001). The odds ratio (OR) for stroke associated with AASI was 0.86 (95% confidence interval (CI), 0.29-2.5; P = 0.777) after multivariate adjustment. Nondippers, extreme-dippers and reverse-dippers have higher OR than dippers (OR 1.57; 95% CI 1.02-2.4, p = 0.04, OR 2.71; 95% CI 1.06-6.88, p = 0.037, OR 2.56; 95% CI 1.56-4.2, p < 0.001, respectively). Conclusions: AASI is strongly affected by BP variability. The result of this study shows that circardian blood pressure variation has stronger association with stroke than AASI in hypertensive patients. References Shimada K, Kawamoto A, Matsubayashi K, Nishinaga A, Kimura S, Ozawa T. Diurnal blood pressure variations and silent cerebrovascular damage in elderly patients with hypertension. J Hypertens 1992; 10:875-878. Kario K, Matsuo T, Kobayashi H, Imiya M, Matsuo M, Shimada K. Relation between nocturnal fall of blood pressure and silent cerebrovascular damage in elderly hypertensives: advanced silent cerebrovascular damage in extreme-dippers. Hypertension 1996; 27:130 -135. Dolan E, Thijs L, Li Y, McCormack P, Staessen JA, O'Brien E, et al. Ambulatory arterial stiffness index as a predictor of cardiovascular mortality in the Dublin Outcome Study. Hypertension 2006; 47:365-370. Kikuya M, Staessen JA, Ohkubo T, Thijs L, Metoki H, Asayama K, et al. Ambulatory arterial stiffness index and 24-hour ambulatory pulse pressure as predictors of mortality in Ohasama, Japan. Stroke 2007; 38:1161-1166. Schillaci G, Parati G, Pirro M, Pucci G, Mannarino MR, Sperandini L, et al. Ambulatory arterial stiffness in[not sign]dex is not a specific marker of reduced arterial compliance. Hypertension 2007; 49:986-991.
    Journal of Hypertension 01/2012; 30:e224-e225. DOI:10.1097/01.hjh.0000420777.04516.d2 · 4.22 Impact Factor
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    ABSTRACT: To investigate CTNNB1 mutation and β-catenin expression in resected breast fibromatosis and to identify potential molecular markers of fibromatosis of the breast. We selected 12 patients with fibromatosis of the breast who underwent surgical resection and were confirmed by histological examination. Ultrasonography findings for 10 patients were reviewed and only two cases were suspicious for fibromatosis on imaging. On core needle biopsy for pre-operative diagnoses, only three cases were histologically suspicious for fibromatosis. Mutations in exon 3 of CTNNB1 were detected by direct DNA sequencing in nine (75.0%) cases: all were c.121G>A (p.T41A), which was much more frequent in breast fibromatoses than in other soft tissue lesions. Nuclear β-catenin expression was observed in all cases and the level of expression was higher in cases with mutation. In eight of nine cases, the matched biopsy specimen showed the same CTNNB1 mutation status as the pre-operative specimen. In the majority of cases, clinical presentation and breast imaging are highly suspicious for carcinoma. Definitive pre-operative pathological diagnosis by core needle biopsy is difficult. CTNNB1 mutation and nuclear β-catenin expression are frequently detected in sporadic breast fibromatoses, suggesting their potential as a useful tool to distinguish breast fibromatoses from other neoplasms.
    Histopathology 01/2012; 60(2):347-56. DOI:10.1111/j.1365-2559.2011.04072.x · 3.30 Impact Factor
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    ABSTRACT: Extraskeletal osteosarcoma (ESOS) is a very rare malignant tumor of mesenchymal origin. It is rarer than osseous osteosarcoma and there are very few reports of the skin being a primary site. Most reported cutaneous ESOS were accompanied with metastasis in other organs. A 56-year-old man presented with a painful, 1.5×0.8 cm sized, brown-colored nodule on the right girdle area for 3 months. The histologic findings revealed a tumor that was confined to the dermis without connection to the subcutaneous tissue. In addition, there were large amounts of thin and lace-like bony trabeculae and osteoid with neoplastic cells in a highly pleomorphic sarcomatous stroma.
    Annals of Dermatology 10/2011; 23(Suppl 2):S160-4. DOI:10.5021/ad.2011.23.S2.S160 · 0.95 Impact Factor
  • Ji‐Young Song, Jin‐Hee Park, Malshick Shin
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    ABSTRACT: The effects of ANN prior to cross-linking of non-wx rice starches on a RS level and granular shape were investigated to apply them for a fat replacer with RS in a liquid food system. Acid hydrolysis and sonication were also evaluated to improve RS quality. The RS level was also compared with AOAC and P/G methods. The RS levels of CRS analyzed with the AOAC method were higher than those analyzed with the P/G method, but the differences in the RS level of CRS affected an ANN condition and starch content during cross-linking. When ANN was conducted at 50°C for 12 h using the AOAC method, and starch content (40%) used in cross-linking was at 45°C for 3 h, the highest RS level of CRS treated with ANN was 69.4% compared to 38.3% RS level of CRS without ANN. The 1 h acid hydrolysis (pH 4.0) of CRS treated ANN increased 114.5% of the RS level (79.4% compared to 69.4% in CRS treated ANN), regardless of which analytical methods were used. CRS granules remained the same as native ones with a polygonal shape and A type crystallinity even after being treated with ANN, and acid hydrolysis. The sonication before cross-linking reaction increased the RS level and prevented increase in size from aggregating CRS granules.
    Starch - Starke 03/2011; 63(3). DOI:10.1002/star.201000097 · 1.40 Impact Factor
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    ABSTRACT: We investigated the association of single nucleotide polymorphisms of solute carrier family 6 member 11 (SLC6A11) (rs2304725, rs2272400, and rs2245532), SLC6A12 (rs216250 and rs557881) and SLC6A13 (rs2289954) with schizophrenia and its clinical symptoms. We found that rs216250 of SLC6A12 was correlated with the Scale for the Assessment of Negative Symptoms (SANS) scores.
    Psychiatry Research 03/2011; 189(3):478-9. DOI:10.1016/j.psychres.2011.01.023 · 2.68 Impact Factor
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    ABSTRACT: Vascular endothelial growth factor (VEGF)-loaded core/shell nanoparticles were prepared and their gelation behavior in response to temperature was characterized for the regeneration of ischemic heart. The core is composed of lecithin containing VEGF and the shell is composed of Pluronic F-127 (poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer). When Capryol 90 (propylene glycol monocaprylate) was added to an aqueous solution of the core/shell nanoparticles, a temperature-induced gel composed of core/shell nanoparticles was observed to form at body temperature. This phenomenon was utilized for the stable localization of core/shell nanoparticles at the ischemic area. For an in vivo assessment, VEGF-loaded core/shell nanoparticles with and without inducement of the gel formation were applied to a subacute myocardial infarction model in rats and functional analysis of the heart was monitored by means of a PV catheter four weeks later. The results showed that the VEGF-loaded core/shell nanoparticles and their gel improved the heart functions, particularly with regard to the ejection fraction and cardiac output.
    Journal of Controlled Release 09/2010; 146(2):207-11. DOI:10.1016/j.jconrel.2010.04.014 · 7.26 Impact Factor
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    ABSTRACT: Wingless-type MMTV integration site family member 2 (WNT2) has a potentially important role in neuronal development; however, there has yet to be an investigation into the association between single nucleotide polymorphisms (SNPs) of WNT2 and schizophrenia. This study aimed to determine whether certain SNPs of WNT2 were associated with schizophrenia in a Korean population. e genotyped 7 selected SNPs in the WNT2 gene region (approximately 46 Kb) using direct sequencing in 288 patients with schizophrenia and 305 healthy controls. Of the SNPs examined, one SNP showed a weak association with schizophrenia (p = 0.017 in the recessive model). However, this association did not remain statistically significant after Bonferroni correction. The present study does not support a major role for WNT2 in schizophrenia. This could be due to the size of the population. Therefore, additional studies would be needed to definitively rule out the gene's minor effects.
    BMC Medical Genetics 05/2010; 11:78. DOI:10.1186/1471-2350-11-78 · 2.45 Impact Factor
  • Ji‐Myoung Kim, Ji‐Young Song, Malshick Shin
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    ABSTRACT: The physicochemical and pasting properties of high amylose rice starches isolated using alkaline steeping method from different Korean rice cultivars, Goamy2 and Goamy, and from imported Thai rice were examined. The protein and lipid contents of the Goamy2 starch were higher than those of the other two starches. The amylose and total dietary fiber contents were ranged from 31.4 to 36.8% and from 6.3 to 8.6%, respectively. Total dietary fiber was positively correlated to amylose content. Water binding capacity was higher in the Goamy2 starch (172.2%) than in the Goamy and Thai rice starches (112.7–115.6%). The swelling power of the Goamy2 starch showed lower values, but its value at 95°C was similar to others because of its rapid increment at 85°C. The granular size of Goamy2 starch was widely distributed compared to those of others. The Goamy2 starch showed a high initial pasting temperature (92.0°C) and low breakdown and setback viscosities. The Goamy and Thai rice starch granules were polygonal-shaped with A-type crystals, whereas the Goamy2 starch granules were round-shaped with B-type crystals. Goamy and Goamy2 starches showed a single endotherm at 60.8 and 76.0°C for peak temperature and 10.0 and 11.5 J/g for gelatinization enthalpies, respectively. The Thai rice starch presented an endotherm with a shoulder peak at 68.3°C (75.3°C for the main peak) and a gelatinization enthalpy of 12.4 J/g.
    Starch - Starke 05/2010; 62(5):262 - 268. DOI:10.1002/star.200900230 · 1.40 Impact Factor

Publication Stats

109 Citations
49.27 Total Impact Points

Institutions

  • 2012–2015
    • Sungkyunkwan University
      • Department of Chemistry
      Sŏul, Seoul, South Korea
    • Seoul Veterans Hospital
      Sŏul, Seoul, South Korea
  • 2014
    • MEDIPOST Biomedical Research Institute
      Sŏul, Seoul, South Korea
  • 2005–2012
    • Kyung Hee University
      • • Department of Medicine
      • • College of Medicine
      Sŏul, Seoul, South Korea
  • 2011
    • Chosun University
      • Department of Medicine
      Gwangju, Gwangju, South Korea
  • 2010–2011
    • Chonnam National University
      • Division of Food and Nutrition
      Gwangju, Gwangju, South Korea
    • Hannam University
      • Department of Advanced Materials
      Daiden, Daejeon, South Korea