Shyam Rathi

Publications of Shyam Rathi

• Treatment of acute myeloid leukemia in children: experience from a tertiary care hematology centre in India.

  Authors: Nitin Gupta, Tulika Seth, Pravas Mishra, Manoranjan Mahapatra, Shyam Rathi, Rajan Kapoor, Narendra Agarwal, Suman Kumar, Renu Saxena

  Indian journal of pediatrics. 05/2011; 78(10):1211-5.

  To assess the treatment and outcome of children with acute myeloid leukemia. The Primary objectives were to assess remission rates, treatment related toxicity and disease free survival. SecondaryTo assess the treatment and outcome of children with acute myeloid leukemia. The Primary objectives were to assess remission rates, treatment related toxicity and disease free survival. Secondary objective was to assess prognostic factors associated with poor outcome. A retrospective analysis of all treated patients with acute myeloid leukemia, less than 18 year of age from Sept 2005 to Aug 2009 was done. Clinical laboratory, treatment and follow up records retrieved to calculate remission rate, treatment related toxicity, disease free survival and poor prognostic factors. This analysis included thirty five patients (male : female; 23:12), twenty seven (77.1%) achieved remission after one 3 + 7 induction and seven required two inductions. High dose cytosine arabinoside consolidation was given in thirty one patients while one underwent allogenic stem cell transplantation. Two patients died during chemotherapy (TRM- 5.7%), two did not complete the therapy, seventeen relapsed (48.5%) with 80% of relapses occurring within first year of remission and no relapse occurred after 2 years. Fourteen patients are in remission (40%, follow up 5-54 months) and cumulative median disease free survival is of 13 months. The present data suggests that 3 + 7 induction, followed by high dose cytarabine consolidation has low treatment related toxicity and resource utilization; however, relapse free survival is inferior to more intensive regimens, highlighting the need to intensify chemotherapy regimen once the treatment related mortality has been minimized.

• Acute renal failure following antithymocyte globulin therapy for aplastic anaemia-report of two cases and review of literature.

  Authors: Nitin Gupta, Manoranjan Mahapatra, Shyam Rathi, Rajan Kapoor, Avinash Singh, Tulika Seth, Pravas Mishra

  Annals of hematology. 02/2011; 90(2):239-41.

• Acute lymphoblastic leukemia presenting as non-oliguric renal failure and hypertension.

  Authors: Nitin Gupta, Sanjeev Kumar Gupta, Shyam Rathi, Sanjeev Kumar Sharma, Manoranjan Mahapatra, Tulika Seth, Pravas Mishra, Renu Saxena

  Leukemia research. 07/2010; 34(7):e150-1.

• An unusual presentation of eosinophilic variant of chronic myeloid leukemia (eoCML).

  Authors: Devender Aggrawal, Rahul Bhargava, Tuphan Dolai, Deepak Singhal, Manoranjan Mahapatra, Shyam Rathi, Bijender Bohra, Niranjan Rathod

  Annals of hematology. 08/2008;

• Pure red cell aplasia associated with thymoma: Is thymectomy the cure?

  Authors: Rahul Bhargava, Tuphan K Dolai, Deepak Singhal, Manoranjan Mahapatra, Pravas Mishra, Niranjan Rathod, Shyam Rathi

  Leukemia research. 06/2008;