Hakki Dogan

Erciyes Üniversitesi, Caesarea, Kayseri, Turkey

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Publications (23)33.03 Total impact

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    ABSTRACT: Abstract Purpose: To investigate compatibility of spectacles with their prescriptions. Methods: This study was conducted prospectively between October 2007 and March 2009. A total of 1002 spectacles of 1002 individuals were included in the study. First right and then left lenses of the spectacles were measured with a Topcon CL-200 digital lensmeter. Interpupillary distance (PD) of the subjects was measured. Spherical, cylindrical, and axial differences between the prescription and the spectacles were separately calculated for the left and right lenses. Prismatic effect (PE) of the lenses, with decentralized focus according to the pupil, its base direction, and amount of decentralization, were measured. Results: A total of 505 (50.4%) of the subjects were female and 497 (49.6%) were male. The mean age was 37.0 (range 3-81). The mean PD of the subjects was 59.9 ± 4.09 mm, and mean optical center distance (OCD) of the lenses was 65.6 ± 4.07 mm. The difference between PD and OCD was significant (p < 0.001). While the right spherical, cylindrical, and axial differences and left spherical, cylindrical, and axial differences between the prescription and the spectacles were not significant, the left axial difference was statistically significant (p < 0.001). The decentralization direction was towards the lower temporal with a percentage of 76.8% on the right and 80.3% on the left lenses. The mean amount of the decentralization was 4.37 ± 2.39 mm on the right and 4.63 ± 2.36 mm on the left. Conclusion: Dioptric error in the spectacles was quite low. However, there may be a small amount of axis deviation at the time of mounting the lens to the frame. We conclude that asthenopic complaints due to PE caused by the decentralization of the optic center of the lenses are quite important. Examination of the spectacles after they are prepared can be deemed as a solution to reduce asthenopic complaints due to improper spectacles.
    Seminars in ophthalmology 08/2013; · 1.09 Impact Factor
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    ABSTRACT: Postoperative vomiting is a common complication after strabismus surgery in children. The serotonin 5-HT(3) receptor antagonists have proven to be a particularly valuable addition to the armamentarium against postoperative nausea and vomiting (PONV). Palonosetron is a second-generation 5-HT(3) receptor antagonist that has recently been approved for prophylaxis against PONV. The aim of this study was to evaluate the efficacy of different doses of palonosetron for the prevention of PONV in children undergoing strabismus surgery. A total of 150 children who were classified with an American Society of Anesthesiologists physical status of I, were aged between 2 and 12 years, and were undergoing strabismus surgery under general anesthesia were enrolled in the study. A random numbers table was used to assign each child to receive palonosetron 0.5, 1.0, or 1.5 μg/kg (n = 50 in each group). All episodes of PONV at the intervals of 0-2, 2-6, 6-24, and 24-48 hours were evaluated using a numeric scoring system for PONV. A p-value of <0.05 was considered statistically significant. The percentage of children with PONV during 0-48 hours after anesthesia was 24% with palonosetron 0.5 or 1.0 μg/kg, and 20% with palonosetron 1.5 μg/kg. There was no statistically significant difference between the study groups with respect to the number of children with PONV scores of 1, 2, or 3 during 0-48 hours after anesthesia. There was no statistically significant difference between the study groups with respect to the number of children with postoperative vomiting during all time periods after anesthesia. The percentage of children aged >6 years with postoperative nausea during 0-48 hours after anesthesia was 8.6%, 18.2%, and 15.4% with palonosetron 0.5, 1.0, or 1.5 μg/kg, respectively, but there was no statistically significant difference between the study groups. Palonosetron doses of 0.5, 1.0, and 1.5 μg/kg are recommended for further evaluation, as they appear to be the effective doses for the prevention of PONV following strabismus surgery in children.
    Drugs in R&D. 01/2011; 11(1):29-36.
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    ABSTRACT: To describe figure-of-eight vertical mattress suture technique in external dacryocystorhinostomy for a combined one-step closure of anterior mucosal flaps and overlying wound tissues and to evaluate its effectiveness on surgical outcome. A prospective, single surgeon, uncontrolled, interventional case series. A total of 112 consecutive lacrimal drainage systems of 106 patients (84 women, 22 men; 100 unilateral, six bilateral) from June 2002 to January 2006 with acquired nasolacrimal duct obstruction without canalicular disease underwent external dacryocystorhinostomy with this modified technique. Relief of epiphora and anatomic patency were defined as success. Operative time and success rate were evaluated and advantages were stressed and compared with our previous reports. Mean age was 40.1 years (range, 6 to 75). The etiology was idiopathic in 109 patients and traumatic in three cases. Of 112 lacrimal drainage systems, epiphora was the presenting symptom in 88, combined epiphora and recurrent dacryocystitis in 15, and combined epiphora and mucocele in nine cases. Seven lacrimal drainage systems were revision cases. Mean follow-up was 26.3 months (range, 6 to 48). Success rate was 99.1% (111/112) and mean operative time was 38.2 minutes (range, 28 to 69). Such a modified suture technique reveals a rapid and simultaneous one-step closure of two different layers that speeds up surgical procedure; simplifies closure process as the knots are tied completely outside the wound, avoiding the disadvantages of suture tying in a small and deep area; eliminates the dead space between anterior flaps and overlying wound tissues; keeps anterior mucosal flap complex away from posterior flaps that prevents collapse back onto the anastomosis and decreases the possibility of mucosal adhesions and, therefore, fibrotic band formation with underlying tissues that may also be useful in cases with small sacs or osseous openings and in revision cases where scarring is a large concern.
    American Journal of Ophthalmology 03/2007; 143(2):328-333. · 3.63 Impact Factor
  • Ayse Oner, Ozgur Ilhan, Hakki Dogan
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    ABSTRACT: We examined a 14-year-old girl with bilateral hyperplastic persistent pupillary membranes, present since birth, with poor visual acuity. The membranes were excised surgically; visual acuity improved. Extensive persistent pupillary membranes can be removed safely by surgical methods if they are large enough to obscure the pupillary axis and affect visual acuity.
    Journal of Pediatric Ophthalmology & Strabismus 01/2007; 44(1):57-8. · 0.86 Impact Factor
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    ABSTRACT: This study evaluates the effect of different doses of tropisetron to prevent postoperative vomiting, which frequently occurs in children following strabismus surgery. One hundred twenty-five American Society of Anesthesiologists' classification (ASA) I-II group patients 2-12 years of age were randomized to this prospective, single-blind, placebo-controlled clinical study. Patients were placed in groups of 5 and did not receive any premedication. The first group received placebo, and the 2nd, 3rd, 4th, and 5th groups received 0.5 mg/m(2), 1 mg/m(2), 1.5 mg/m(2), and 2 mg/m(2) of tropisetron, respectively, following anesthesia induction. The same anesthetic technique and analgesia were used for all groups. The patients were examined for the presence of vomiting and for any complaints and side effects at 2, 6, and 24 hours after surgery. The incidence of postoperative vomiting (POV) was statistically more significant in the placebo group at 2, 6 and 24 hours, when compared to the study groups (p< 0.001), but there was no significant difference among tropisetron groups at 6-24 hours (p>0.05). There was no significant difference in terms of the incidence of POV among the study groups (16%, 16%, 24%, 20% respectively) at all periods (p>0.05). The number of patients with POV score of 3 was 10 in the placebo group, while it was 1, 2, 0 and 1 in the 2nd, 3rd, 4th, and 5th groups, respectively (p<0.01). Tropisetron (0.5, 1.0, 1.5 and 2.0 mg/m(2)) decreased the incidence and severity of POV following strabismus surgery in children. All of the doses seemed to be equally effective. There was no difference in POV control between placebo and any of the doses of the tropisetron after six hours. So we suggest that 0.5 mg/m(2) single-dose tropisetron is enough for preventing POV following strabismus surgery in children.
    Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine 12/2006; 73(8):1106-11. · 1.99 Impact Factor
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    ABSTRACT: To investigate blood flow velocity changes and resistivity index values of orbital vessels in Behçet disease with or without ocular involvement, in uveitis patients with different etiologies, and in healthy volunteers. Subjects were divided into four groups: those with ocular involvement in Behçet disease (group I), those without ocular involvement in Behçet disease (group II), uveitis patients with different etiologies (group III), and a control group (group IV). Twenty-seven eyes in group I, 14 eyes in group II, 25 eyes in group III, and 27 eyes in group IV were investigated. The blood flow in the central retinal artery (CRA), ophthalmic artery (OA), nasal posterior ciliary artery (NPCA), and the temporal posterior ciliary artery (TPCA) was measured using color Doppler ultrasonography (CDU) to determine the peak systolic velocity (PSV), end diastolic velocity (EDV), and resistivity index (RI). The PSV and EDV value of CRA in groups I, II, and III were found to be significantly lower than those in the control group (p < 0.05 for each). The PSV and EDV values of TPCA and NPCA in groups I, II, and III were significantly lower than those in the control group (p < 0.05 for each). Resistivity indexes of all arteries were higher in groups I, II, and III than the control group. The PSV and EDV in CRA, TPCA, and NPCA in Behçet disease patients with ocular involvement were significantly lower than all other groups (p < 0.05). There are significant reductions in the blood flow values of the orbital arteries in patients with Behçet disease and uveitis patients with different etiologies when compared with healthy volunteers. The decrease in blood flow values in Behçet disease is more evident in patients with ocular involvement than the patients without ocular involvement. This might be the result of occlusive vasculitis, which is frequently seen in the retinal vessels of patients with Behçet disease.
    Current Eye Research 06/2006; 31(6):519-23. · 1.71 Impact Factor
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    ABSTRACT: To evaluate the efficacy of intravitreal triamcinolone acetonide injection on persistent macular oedema in branch retinal vein occlusion that fails to respond to previous laser photocoagulation. A total of 19 eyes of 19 patients with persistent macular oedema due to branch retinal vein occlusion were treated with 8 mg/0.2 ml of intravitreal triamcinolone acetonide injection. The main outcome measures included best-corrected visual acuity, intraocular pressure, and macular oedema map values of Heidelberg Retinal Tomograph II (HRT II) before and after intravitreal triamcinolone injection. The mean follow-up time was 6.2+/-1.0 months. The mean baseline best-corrected logarithm of minimal angle of resolution (LogMAR) value for visual acuities of the patients before intravitreal triamcinolone injection was 1.01+/-0.16. After treatment, it was 0.55+/-0.22 at the 1-month, 0.56+/-0.22 at 3-month, and 0.62+/-0.22 at the last visits and the differences were statistically significant when compared with baseline values (for each, P<0.001). The mean oedema map values on HRT II significantly decreased by 28.5% at 1-month, 23.8% at 3-month, and 23.8% at the last visit when compared with preinjection values (for each, P<0.001). Intraocular pressure elevation exceeding 21 mmHg was observed in 26.3% of eyes at 1-month, 15.7% at 3-month, and 5.2% at the last visit, but was controlled with topical anti-glaucomatous medications in all eyes. Intravitreal triamcinolone acetonide application is a promising approach in the treatment of persistent macular oedema due to branch retinal vein occlusion non-respondent to laser photocoagulation.
    Eye 02/2006; 20(1):13-7. · 1.82 Impact Factor
  • Retina 01/2006; 25(8):1089-90. · 2.83 Impact Factor
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    ABSTRACT: To evaluate the effectiveness and clinical significance of pattern visual evoked potential (P-VEP) parameters on visual acuity in amblyopic patients under occlusion therapy. A total of 34 consecutive children with anisometropic amblyopia were included in this study. All patients underwent a full initial ophthalmologic and orthoptic evaluation. P-VEP test was performed in all cases and binocular vision was tested and recorded with Worth's four-dot test and Bagolini striated glasses at each visit. Part-time occlusion therapy was performed by using adhesive patches. The mean (+/- SEM) cycloplegic refractive error was + 5.6 +/- 0.6 diopters (D) in the amblyopic eyes and + 1.8 +/- 0.2 D in the normal eye. The mean levels of best-corrected visual acuity were statistically differed between each measurement for occlusion therapy (for each, p < 0.05). The ratio of the patients with binocular vision increased after 6 months occlusion therapy and the difference was statistically significant (p < 0.05). In addition, P100 amplitude improved at each visit and the difference was significant when compared with baseline values (for each, p < 0.05). P100 amplitude of the P-VEP test parallels the improvement in subjective visual acuity in amblyopic eyes under occlusion therapy. Therefore, this test may be useful in monitoring the visual acuity in the preverbal or non-verbal patched patients.
    Documenta Ophthalmologica 11/2004; 109(3):223-7. · 1.54 Impact Factor
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    ABSTRACT: To investigate the effectiveness of various implants used in experimental deep sclerectomy and to report tissue reactions developed to these implants histopathologically. Forty eyes of 40 New Zealand white albino rabbits underwent deep sclerectomy with various implants. The rabbits were divided into four groups; each consisted of 10 eyes. Deep sclerectomy was performed using copolymer materials in group 1, silicone materials in group 2 and chromic catgut suture in group 3. No implants were used in the control group (group 4). Clinical and histopathological examinations were performed to investigate the effectiveness of implants. Mean preoperative intraocular pressure (IOP) was 14.4 +/- 1.6 mm Hg in group 1, 14.5 +/- 1.8 mm Hg in group 2, 13.8 +/- 1.5 mm Hg in group 3 and 14.5 +/- 1.2 mm Hg in group 4. The final postoperative IOPs were 10.7 +/- 0.9, 10.6 +/- 0.8, 13.5 +/- 1.0, and 14.5 +/- 1.4 mm Hg, respectively. At 2 months, the decrease in IOPs from baseline and the persistence of the filtering bleb were significantly marked in group 1 and group 2 (p < 0.001). Histopathological evaluation revealed that copolymer and silicone materials formed a smooth and regular intrascleral space. There were no foreign body reaction, tissue destruction or fibrosis in group 1 and group 2, but chromic catgut sutures caused severe fibrosis and inflammatory reaction in group 3. Mean histopathologic score of group 1, group 2, group 3 and group 4 was 0.7 +/- 0.5, 0.8 +/- 0.5, 2.4 +/- 0.6, and 0.1 +/- 0.3, respectively. Copolymer or silicone materials may increase the success rate of surgery by maintenance of a large and regular intrascleral space after deep sclerectomy and prevention of collapse of the flap.
    Ophthalmologica 01/2004; 218(4):264-9. · 1.41 Impact Factor
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    ABSTRACT: Purpose: To determine the electroretinographic responses in patients with Bietti's crystalline dystrophy and to compare them with normal values. Materials-Methods: After a complete ophthalmologic examination, fundus fluorescein angiography (FFA), visual field examination and electrophysiological tests were performed in 11 patients with Bietti's crystalline dystrophy. Visual field examination was performed with Goldmann perimeter and electrophysiological examination with full-field electroretinogram (ERG). ERG values of these patients were compared with normal values of age-and sex matched 15 individuals. Results: There were diffuse or focal pigment epithelial atrophies determined by FFA in all patients with Bietti's crystalline dystrophy. Visual field examination revealed various defects except in two cases. Mean b-wave amplitudes of rod response, maximal combined response and cone response of ERG were 79.1±35.0 mV, 163.0±76.0 mV, and 69.0±27.0 mV, respectively. The values of these parameters in normal individuals were 114.8±38.7 mV, 231.1±26.4 mV and 88.0±13.9 mV, respectively, and the differences were statistically significant for all responses (for each, P<0.05). Conclusion: ERG values are reasonably low in patients with Bietti's crystalline dystrophy when compared with normal values. ERG may be very useful in evaluation of visual prognosis and follow-up of these patients.
    Erciyes Medical Journal. 01/2004;
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    ABSTRACT: BACKGROUND: Previous studies have documented that elevated plasma homocysteine is a risk factor for cardiovascular, cerebrovascular and peripheral vascular disease. In a case-control study, we sought to determine whether elevated homocysteine (HCY) is a risk factor for retinal artery occlusive disease PATIENTS AND METHODS. Study subjects consisted of 20 patients (12 male, 8 female) (mean age, 55.8; range 42-70 years) with clinical and objective evidence of retinal vascular occlusive disease and 20 age-matched control subjects (9 males, 11 females) (mean age, 55.3 years; range 50-68 years). Hyperhomocysteinemia was defined as a plasma HCY level >15 micromol/L by HPLC. We also measured concentrations of triglycerides, and total cholesterol, LDL cholesterol, and HDL cholesterol. RESULTS: The mean plasma HCY level in the patient group was 21.23+/-9.53 micromol/L (range, 8.00-43.99 micromol/L) compared with 12.59+/-4.97 micromol/L (range, 6.38 to 22.88 micromol/L) in the control group (P<0.008). There was no correlation between HCY and serum triglycerides or cholesterol levels within each group. We conclude that high plasma HCY level may be a risk factor for retinal artery occlusive disease.
    Annals of Saudi medicine 01/2004; 24(3):186-8. · 1.10 Impact Factor
  • Acta Ophthalmologica Scandinavica 07/2003; 81(3):312-4. · 1.85 Impact Factor
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    ABSTRACT: To report a case of Rieger anomaly associated with bilateral choroidal osteoma. An 18-year-old woman presented with corectopia, iridocorneal adhesions, and stromal hypoplasia of the iris, and was diagnosed with Rieger anomaly. Fundus examination revealed bilateral yellowish-orange, placoid degenerative fundus lesions with pseudopod-like edges associated with the areas of retinal pigment epithelium atrophy, indicating choroidal osteoma. Fundus fluorescein angiography showed bilateral early patchy and late diffuse hyperfluorescence. B-scan echography revealed placoid lesion at the posterior ocular coats characterized by localized areas of high ultrasound reflectivity with a corresponding retrobulbar orbital shadowing. This indicated a dense calcium foreign body. In addition, computed tomography of the orbit demonstrated bilateral plate-like thickening with calcification of the choroid that was isodense with the normal skeletal bone. Although Rieger anomaly is classically known as a disease of the anterior segment of the eye, choroidal osteoma may be a posterior segment finding of the disease that has not previously been reported.
    European journal of ophthalmology 07/2003; 13(5):496-9. · 0.91 Impact Factor
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    ABSTRACT: Behçet's disease (BD) is an inflammatory vasculitis with immunologic, endothelial and neutrophil alterations. Adenosine deaminase (AD) is a marker of T-cell activation and is related to the production of reactive oxygen species by neutrophils with the production of NO(*), O(2)(*-), H(2)O(2) and OH(*). We reported increased tumour necrosis factor-alpha, soluble interleukin-2 receptor, interleukin-6, interleukin-8 and NO(*) in active BD. As there is a relation between cytokines, T cells and oxidative stress in inflammatory diseases, this study further evaluated: (1) plasma AD activity and its correlation with acute phase reactants; (2) thiobarbituric acid-reactive substances (TBARS) as an indicator for lipid peroxidation; and (3) antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GSHPx) and catalase in patients with BD. The effect of disease activity and correlations between the measured parameters were explored. A total of 35 active (n=17) or inactive (n=18) patients with BD (16 men, 19 women) satisfying International Study Group criteria, and 20 age-matched and sex-matched controls (nine men, 11 women) were included in this cross-sectional case-control study. AD and TBARS were measured in plasma, catalase in red blood cells (RBC), and SOD and GSHPx in both plasma and RBC in both groups. Acute phase reactants (alpha(1)-antitrypsin, alpha(2)-macroglobulin, neutrophils, erythrocyte sedimentation rate) were used to classify patients as active or inactive. Plasma AD (mean+/-standard error of the mean, 36.1+/-0.7 U/l) and TBARS (4.2+/-0.1 nmol/ml) levels were significantly (for each, p<0.001) higher in BD than in controls (24.1+/-0.8 U/l and 1.6+/-0.1 nmol/ml, respectively). RBC catalase activity was significantly (p<0.001) lower in BD than in controls (120.9+/-3.8 versus 160.3+/-4.1 k/g haemoglobin). SOD and GSHPx activities were significantly lower in both plasma and erythrocytes of patients with BD than in controls (plasma SOD, 442.4+/-8.6 versus 636.4+/-9.2 U/ml, p<0.001; RBC SOD, 3719.2+/-66.0 versus 4849.7+/-49.0 U/g haemoglobin, p<0.001; plasma GSHPx, 73.1+/-1.5 versus 90.6+/-2.9 U/ml, p<0.001; RBC GSHPx, 600.7+/-8.0 versus 670.6+/-10.1 U/g haemoglobin, p<0.001). Active BD patients had significantly lower antioxidant enzymes (except RBC catalase) and higher AD and TBARS levels than inactive subjects (for each, p<0.01). When considering all BD patients, a significant positive correlation was present between AD and TBARS (p<0.001) whereas both AD and TBARS were negatively correlated with antioxidant enzymes (for each, p<0.05). AD and lipid peroxidation are increased and associated with defective antioxidants in BD, suggesting interactions between activated T cells and neutrophil hyperfunction. Measures of pro-oxidative stress and antioxidative defence with AD activity as an indicator of T-cell activation can be considered as significant supportive diagnostic indicators, especially in active disease. In addition, strengthening the antioxidant defence may contribute to treatment modalities.
    Mediators of Inflammation 04/2003; 12(2):107-16. · 3.88 Impact Factor
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    ABSTRACT: Hallermannn-Streiff syndrome is a rare congenital syndrome. This syndrome is usually sporadic' and characterized by a bird-like face, mandibular and maxillary hypoplasia, ocular and dental abnormalities, skin atrophy and short stature. In this repon the clinical characteristics of an 11 year old case were presented.
    Erciyes Medical Journal. 01/2003;
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    ABSTRACT: In a patient with ocular melanoma scintigraphy obtained with 99mTc-GSH clearly demonstrated the histologically proven ocular lesion both in planar and SPECT images. 99mTc-sestamibi study obtained in the same patient three days later was negative. 99mTc-GSH is a potential alternative to the currently used radiopharmaceuticals for imaging both cutaneous and ocular melanomas and their metastases.
    Annals of Nuclear Medicine 06/1997; 11(2):143-6. · 1.41 Impact Factor
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    ABSTRACT: Prostaglandin F2 alpha (PGF2 alpha) as its tromethamine salt was topically applied, and hypotensive and other ocular effects were studied, in glaucomatous human eyes. After baseline intraocular pressure (IOP) measurements, 100 micrograms PGF2 alpha tromethamine salt dissolved in 50 milligrams saline was applied to 23 glaucomatous eyes of 20 patients. The pretreatment diurnal IOP values of the same eye served as control group. It was found that in comparison with baseline values, PGF2 alpha caused significant but transient elevation in IOP in the first half-hour (mean 1.95 mm Hg, p < 0.01), but it decreased below baseline values at the first hour. A significant decrease in IOP from baseline was observed at the 2nd hour (p < 0.05), which became more prominent between the 4th and 24th hours (p < 0.001). PGF2 alpha produced a maximal IOP reduction of 10.21 mm Hg at the 12th hour (p < 0.001). The IOP differences between PGF2 alpha-treated and control groups were significant between the 4th and 24th hours (p < 0.001), with the maximal IOP difference of 9.21 mm Hg at the 12th hour (p < 0.001). PGF2 alpha caused marked conjunctival hyperaemia in all eyes. Aqueous flare and cellular response were not seen in any of the eyes. Half of the patients experienced ocular smarting or a foreign-body sensation, periocular pain and headache. PGF2 alpha reduced IOP effectively in glaucomatous human eyes.
    International journal of clinical pharmacology research 02/1996; 16(2-3):51-5.
  • H. Dogan, S. Karaküçük
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    ABSTRACT: The authors present new mucosa separators to be used in Toti's classical dacryocystorhinostomy. The details of the instruments have been described.
    European Journal of Plastic Surgery 01/1996; 19(3):166-166.
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    ABSTRACT: The ocular effects of topical prostaglandin F2 alpha (PGF2 alpha) were studied in normotensive human eyes. PGF2 alpha as tromethamine salt, 100 micrograms, was applied to one eye of 23 normotensive subjects, intraocular pressure (IOP) and pupil size were measured, objective and subjective findings recorded during the first 24 h. Tonography was performed in 10 subjects. As compared with the baseline, PGF2 alpha caused a significant IOP reduction between 1 and 24 h (p < 0.001), being maximal (4.9 +/- 0.5 mm Hg, mean +/- SEM, p < 0.001) between 4 and 8 h. As compared with the contralateral control eyes, which received 50 microliters of saline, treated eyes exhibited significant IOP reduction between 1 and 24 h (p < 0.001), being maximal (4.2 +/- 0.4 mm Hg, mean +/- SEM, p < 0.001) at 4 h. PGF2 alpha caused marked conjunctival hyperemia in all eyes. Pupillary diameter was not altered. Aqueous flare and cellular response were not seen. Half of the subjects complained of ocular smarting, mild ocular pain or headache. Total outflow facility did not change (p > 0.05).
    Ophthalmic Research 01/1996; 28(6):351-5. · 1.56 Impact Factor