Ambar Khaira

Publications (52)30.75 Total impact

• Article: Actinobaculum schaalii pyelonephritis in a kidney allograft recipient.

  Ankur Gupta, Preeti Gupta, Ambar Khaira
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  ABSTRACT: We present a case of a 64-year-old man, a kidney transplant recipient with acute pyelonephritis and acute graft deterioration. He was diagnosed with Actinobaculum schaalii infection in urine cultures. He was treated with antibiotics for 3 weeks and recovered well. The case describes an unusual pathogenic infection in a kidney transplant patient.
  Iranian journal of kidney diseases 09/2012; 6(5):386-8. · 0.87 Impact Factor
• Article: Depression and marital dissatisfaction among Indian hemodialysis patients and their spouses: a cross-sectional Study.

  Ambar Khaira, Sandeep Mahajan, Priyanka Khatri, Dipankar Bhowmik, Sanjay Gupta, Sanjay K Agarwal
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  ABSTRACT: Interaction of patient in marital dyad may have bearing on long-term patient outcome. Depression, subjective stress, and marital discord have been reported in healthy spouses of patients with end-stage renal disease (ESRD). Depressed patients on dialysis along with their spouses can function as depressed dyad. We looked at the incidence and factors associated with depression and marital stress among Indian hemodialysis patients and their spouses. A total of 49 (32 males, 17 females) patients on maintenance hemodialysis and their spouses were independently administered Beck Depression Inventory (BDI), Revised Dyadic Adjustment Scale, and self-rated subjective quality-of-life scale. Their demographic parameters, socioeconomic status, and type of family (nuclear or joint) were also noted. About 57.1% of patients were depressed compared with 42.8% of spouses (p = 0.133). In both patients and spouses, BDI correlated with quality of life and perceived marital stress. About 36.7% of patients and 24.4% of spouses reported marital stress (p = 0.69). Male spouses had more marital stress compared with female spouses (p < 0.0001). Depression and marital stress in patients and spouses was not associated with socioeconomic status, literacy levels, and employment. Depression in patients had direct correlation with depression in spouse (r = 0.572, p < 0.0001) and degree of marital dissatisfaction in spouse (r = 0.623, p < 0.0001). Patients living in nuclear family were more depressed and had more marital stress. Married ESRD patients and their spouses function as a complex psychosocial dyad with significant two-way interactions. Social support, as is seen in joint families, leads to significantly lesser depression and better marital understanding.
  Renal Failure 01/2012; 34(3):316-22. · 0.82 Impact Factor
• Article: Rhabdomyolysis, acute kidney injury and transverse myelitis due to naive heroin exposure.

  Ankur Gupta, Ambar Khaira, Suman Lata, Sanjay Kumar Agarwal, Suresh C Tiwari
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  ABSTRACT: Heroin exposure can cause various complications like seizures, stroke, spongiform encephalopathy, transverse myelopathy, plexopathy, compartment syndrome, rhabdomyolysis and renal failure due to various mechanisms. We report here a young male who smoked heroin for the first time and developed transverse myelitis, rhabdomyolysis and acute kidney injury requiring dialysis. His renal recovery was complete by four weeks, while neurological improvement occurred 8 to 12 weeks later. This case suggests a common pathogenic mechanism of heroin intoxication involving multiple systems of the body.
  Saudi journal of kidney diseases and transplantation: an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 11/2011; 22(6):1223-5.
• Article: Diarrhea-related hemolytic uremic syndrome: unmasking antifactor H antibodies.

  Ankur Gupta, Ambar Khaira, Om P Rathi, Sandeep Mahajan, Dipankar Bhowmik, Sanjay K Agarwal, Suresh C Tiwari
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  ABSTRACT: The cases of hemolytic uremic syndrome (HUS) preceeded by diarrhea are commonly labeled as D+ HUS. However, with severe renal failure or with delayed recovery, such cases should be evaluated for rarer associations like Factor H (FH), I and CD 46 deficiency or mutations. We report such a presentation of a young boy who initially came with diarrhea and had features of HUS with delayed renal recovery. He later turned out to have anti-FH antibody-related HUS.
  Saudi journal of kidney diseases and transplantation: an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 09/2011; 22(5):1017-8.
• Article: Life cycle of chronic kidney disease patients.

  Ankur Gupta, Suresh Chandra Tiwari, Ambar Khaira, Preeti Gupta, Dipankar M Bhowmik, Sandeep Mahajan
  Saudi journal of kidney diseases and transplantation: an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 05/2011; 22(3):564-5.
• Article: Bardoxolone methyl: a targeted antioxidant.

  Ankur Gupta, Ambar Khaira
  Renal Failure 01/2011; 33(10):1051. · 0.82 Impact Factor
• Article: Endothelial function and oxidative stress in chronic kidney disease of varying severity and the effect of acute hemodialysis.

  Ambar Khaira, Sandeep Mahajan, Atin Kumar, Anoop Saraya, Suresh C Tiwari, Shyam Prakash, Ankur Gupta, Dipankar Bhowmik, Sanjay K Agarwal
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  ABSTRACT: Oxidative stress (OS) and endothelial dysfunction are implicated in accelerated atherosclerosis in chronic kidney disease (CKD). We assessed endothelial function, OS, and carotid intimal medial thickness (CIMT) and their correlates in 44 CKD stage 5 patients (group III) before and after hemodialysis (HD), 40 patients of CKD stages 3 and 4 (group II), and 25 matched controls (group I). OS was measured by serum concentration of antioxidants; vitamin C and fractional reducing ability of plasma (FRAP) and pro-oxidant; thiobarbituric acid reactive substances (TBARS). Ultrasonography of carotid artery for CIMT and of brachial artery for flow-mediated dilatation (endothelium-dependent dilatation, EDD) was done. TBARS increased significantly with severity of CKD. Antioxidants FRAP and vitamin C were significantly lower in CKD patients as compared with controls, but there was no significant difference between groups II and III. EDD decreased significantly with severity of CKD, whereas CIMT though higher in CKD patients as compared with controls was not significantly different between groups II and III. After a session of HD as compared with predialysis, levels of TBARS decreased, whereas those of FRAP, vitamin C, and EDD increased. On multivariate analysis, there was negative correlation of TBARS with glomerular filtration rate (GFR), serum albumin, hemoglobin, and EDD. Vitamin C had positive correlations with GFR, serum albumin, hemoglobin, and EDD. EDD had direct correlation with GFR, whereas CIMT correlated negatively with EDD. Endothelial dysfunction and OS occur early in CKD, are closely related to each other and structural atherosclerosis, and are proportional to decline in GFR.
  Renal Failure 01/2011; 33(4):411-7. · 0.82 Impact Factor
• Article: Marfan syndrome and focal segmental glomerulosclerosis: a novel association.

  Ankur Gupta, Jyoti Gaikwad, Ambar Khaira, Devender S Rana
  Saudi journal of kidney diseases and transplantation: an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 07/2010; 21(4):754-5.
• Article: Response to iron sucrose in dialysis patients sensitive to iron dextran.

  Ankur Gupta, Ambar Khaira, Manu Dogra, Sanjay Kumar Agarwal
  Saudi journal of kidney diseases and transplantation: an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 07/2010; 21(4):744-5; author reply 745.
• Article: Release technique: maturing arteriovenous fistula early.

  Ankur Gupta, Ambar Khaira, Anil P Bhatt, Sheel Jain, Suresh C Tiwari
  Saudi journal of kidney diseases and transplantation: an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 07/2010; 21(4):746-7.
• Article: Primary renal lymphoma: a differential diagnosis of renal mass in a young male.

  Ankur Gupta, Anil Bhatt, Ambar Khaira, Ashwini Gupta, Devender S Ran
  Saudi journal of kidney diseases and transplantation: an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 05/2010; 21(3):544-5.
• Article: Transient IgA nephropathy with acute kidney injury in a patient with dengue fever.

  Bala Krishna Upadhaya, Alok Sharma, Ambar Khaira, Amit K Dinda, Sanjay K Agarwal, Suresh C Tiwari
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  ABSTRACT: Dengue virus infection can clinically manifest as dengue fever, dengue shock syndrome and dengue hemorrhagic fever. Acute kidney injury as a result of dengue virus infection can occur due to various reasons including hypotension, rhabdomyolysis, sepsis and rarely immune complex mediated glomerular injury. However, glomerulonephritis associated with IgA Nephropathy in dengue virus infection has not been reported previously. We report a case of 15-year-old boy who was admitted with dengue fever and dialysis dependant acute kidney injury. Urine examination showed microscopic glomerular hematuria and proteinuria. Kidney biopsy showed mesangial proliferation with mesangial IgA dominant immune complex deposits and acute tubular necrosis. A repeated kidney biopsy 6 weeks after clinical recovery showed reversal of glomerular changes as well as resolution of mesangial IgA deposits.
  Saudi journal of kidney diseases and transplantation: an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 05/2010; 21(3):521-5.
• Article: R2 syndrome: religion and renal failure.

  Ankur Gupta, Charanjit Lal, Ambar Khaira, Sanjay K Agarwal, Suresh C Tiwari
  The Journal of the Association of Physicians of India 03/2010; 58:201.
• Article: Hyperkalemia presenting as wide-complex tachycardia in a dialysis patient

  Ankur Gupta, Anil Bhatt, Ambar Khaira, Dipankar Bhowmik, Suresh Tiwari
  Saudi Journal of Kidney Diseases and Transplantation. 01/2010;
• Article: Dent′s disease and lowe′s syndrome: A phenotypic spectrum of one gene

  Ankur Gupta, Dipankar Bhowmik, Ambar Khaira, Bakshish Singh, Suresh Tiwari
  Saudi Journal of Kidney Diseases and Transplantation. 01/2010;
• Article: Arteriovenous shunt and its conversion to arteriovenous fistula: A relook

  Ankur Gupta, Ambar Khaira, Dipankar Bhowmik, Suresh Tiwari
  Saudi Journal of Kidney Diseases and Transplantation. 01/2010;
• Article: Carotid body tumor and amyloidosis: An uncommon association

  Ankur Gupta, Ambar Khaira, Dipankar Bhowmik, Sanjay Agarwal, Suresh Tiwari
  Saudi Journal of Kidney Diseases and Transplantation. 01/2010;
• Article: Primary renal lymphoma: A differential diagnosis of renal mass in a young male

  Ankur Gupta, Anil Bhatt, Ambar Khaira, Ashwini Gupta, Devender Ran
  Saudi Journal of Kidney Diseases and Transplantation. 01/2010;
• Article: Response to iron sucrose in dialysis patients sensitive to iron dextran

  Ankur Gupta, Ambar Khaira, Manu Dogra, Sanjay Agarwal
  Saudi Journal of Kidney Diseases and Transplantation. 01/2010;
• Article: Marfan syndrome and focal segmental glomerulosclerosis: A novel association

  Ankur Gupta, Jyoti Gaikwad, Ambar Khaira, Devender Rana
  Saudi Journal of Kidney Diseases and Transplantation. 01/2010;