B F Jones

Publications of B F Jones

• The renal medulla in acute renal allograft rejection: comparison with renal cortex.

  Authors: H Wang, R S Nanra, S L Carney, A H Gillies, A D Hibberd, B F Jones, R Murugasu, A Price, P R Trevillian

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 01/1995; 10(8):1428-31.

  A retrospective cohort study was undertaken to evaluate the diagnostic value of the renal medulla in acute renal allograft rejection (ARAR). One hundred and ninety-five biopsies from 98 patients wereA retrospective cohort study was undertaken to evaluate the diagnostic value of the renal medulla in acute renal allograft rejection (ARAR). One hundred and ninety-five biopsies from 98 patients were randomly selected out of 565 transplant biopsies. Biopsies were graded blindly from Grade 0 (no rejection) to Grade 3 (severe rejection) using standard criteria; ARAR was confirmed by a fall in all cases of mean serum creatinine concentration from 0.331 +/- 0.182 to 0.184 +/- 0.079 mmol/l, with anti-rejection therapy. In the 43 biopsies which contained both cortex and medulla, the ARAR grades and the intensities of mononuclear cell, plasma cell, polymorphonuclear cell and eosinophil infiltrates, and of interstitial oedema and haemorrhage, were similar in cortex and medulla (Spearman's Rank Correlation r = 0.55-0.81, P < 0.001). The sensitivity, specificity and overall accuracy of medullary changes in predicting ARAR changes in the cortex were 77%, 100% and 38%, respectively. Acute vascular rejection changes could not be compared between renal cortex and renal medulla because of the anatomical differences between cortex and medulla. Further evaluation of ARAR in the all 195 biopsies, of which 188 had cortical tissue and 50 had medullary tissue, showed no significant differences in histological features (P > 0.05), except for more cortical biopsies with plasma cells (29%) than medullary biopsies with plasma cells (10%; P < 0.02). It is concluded that: (1) ARAR histological changes are similar in cortex and medulla; (2) the predictive value of ARAR medullary changes for cortical rejection changes has low sensitivity (77%) and high specificity (100%).(ABSTRACT TRUNCATED AT 250 WORDS)

• Variability of urinary chloride--a clue to diuretic abuse.

  Authors: B F Jones, P R Trevillian

  Nephron. 02/1992; 61(4):472.

• Acute renal failure due to acute pyelonephritis.

  Authors: B F Jones, R S Nanra, K H White

  American journal of nephrology. 02/1991; 11(3):257-9.

  We report a case of biopsy-proved acute pyelonephritis which caused acute renal failure. Despite appropriate antibiotic therapy, recovery of renal function was slow and incomplete. Renal papillaryWe report a case of biopsy-proved acute pyelonephritis which caused acute renal failure. Despite appropriate antibiotic therapy, recovery of renal function was slow and incomplete. Renal papillary necrosis was an apparent complication, which the patient may have been predisposed to by alcoholism. Although rare, acute pyelonephritis is an important consideration in the differential diagnosis of acute renal failure because of the need for specific therapy.

• Xanthogranulomatous pyelonephritis in a renal allograft: a case report.

  Authors: B F Jones, R S Nanra, A B Grant, N W Ferguson, K H White

  The Journal of urology. 05/1989; 141(4):926-7.

  We report a case of xanthogranulomatous pyelonephritis in a renal allograft. The kidney was not removed and there was an initial response to antibiotic therapy, with amelioration of toxicity andWe report a case of xanthogranulomatous pyelonephritis in a renal allograft. The kidney was not removed and there was an initial response to antibiotic therapy, with amelioration of toxicity and improvement in renal function. However, the kidney failed 10 months later in association with histological changes of chronic rejection.

• Serum sickness due to Rh(anti-D) immunoglobulin.

  Authors: B F Jones, P R Trevillian, R S Nanra

  The Australian & New Zealand journal of obstetrics & gynaecology. 03/1984; 24(1):49-50.

  Considerable attention has been given recently to antepartum Rh immunoprophylaxis. We report here a case of serum sickness due to repeated administration of Rh (anti-D) immunoglobulin.

• Post-obstructive diuresis.

  Authors: B F Jones, R S Nanra

  Australian and New Zealand journal of medicine. 11/1983; 13(5):519-21.

  A patient with post-obstructive diuresis is described. Inappropriate losses of salt and water occurred, with urine volume exceeding half the glomerular filtration rate. Additionally, excessiveA patient with post-obstructive diuresis is described. Inappropriate losses of salt and water occurred, with urine volume exceeding half the glomerular filtration rate. Additionally, excessive urinary excretion of potassium, bicarbonate, calcium, phosphate, magnesium and urate took place in the presence of subnormal blood levels. Transient proteinuria was also observed. This case demonstrates that serious electrolyte disturbances can occur after relief of urinary tract obstruction and the evidence suggests these may be due to disordered proximal tubule function.

• Unusual radiological changes associated with probable Bartter's syndrome.

  Authors: B F Jones, R S Nanra

  The Journal of urology. 03/1982; 127(2):306-8.

  We report 2 cases that fulfill some of the criteria for the diagnosis of Bartter's syndrome and were associated with marked radiological changes. Both patients demonstrated distortion of the calicealWe report 2 cases that fulfill some of the criteria for the diagnosis of Bartter's syndrome and were associated with marked radiological changes. Both patients demonstrated distortion of the caliceal pattern with medullary cavities and loss of cortical substance in the absence of vesicoureteral reflux. However, the glomerular filtration rate was well preserved. It seems unlikely that known organic renal disease was responsible for these changes and the potassium-losing state. These radiological findings also do not appear to be a consequence of hypokalemia and their pathogenesis remains uncertain.

• Idiopathic ascites of haemodialysis: response to treatment.

  Authors: B F Jones, P R Trevillian, R S Nandra

  British medical journal. 05/1976; 1(6014):877.