J García Castell

Publications (10)5.5 Total impact

• Article: [Dietetic factors associated with prostate cancer: protective effects of Mediterranean diet].

  J Ferrís-Tortajada, O Berbel-Tornero, J García-Castell, J A Ortega-García, J A López-Andreu
  [show abstract] [hide abstract]
  ABSTRACT: To review diet risk factors (RF) implied, more or less evidence-based, in the etiopathology of prostate carcinoma (PC), especially those that characterize the traditional Mediterranean diet (MD). Literature review of PC related diet RF in MedLine, CancerLit, Science Citation Index y Embase. Search profiles were "Dietetic Factors/Nutritional Factors/Mediterranean Diet/Primary Prevention", and "Prostate Cancer". Diet RF are associated with 35% of cancer mortality and 10-12% of PC mortality. The main diet RF, implied in the development of PC but with a protective effect, which are considered characteristic of MD are: high daily ingestion of vegetarian products (cereals, legumes, dried and fresh fruits, tubers, vegetables..); olive oil as main lipid source; low intake of animal saturated fat, processed red meat, milk and dairy products; regular consumption of small fish; and low alcohol intake (wine with meals). The MD contains many phytoactive compounds (lycopene, lupeol, quercetin, genistein, carnosol, resveratrol, catechins, vitamins..) with PC protective effects. Diet RF have a role on prostatic carcinogenesis. Further epidemiologic studies with better designs are needed to clarify PC related diet RF. PC risk is reduced in persons on MD compared with those on Western diet. The preventive effect of MD is due to the great number and quality of phytochemicals with antioxidant and antinflammatory properties that contains.
  Actas urologicas españolas 09/2011; 36(4):239-45. · 0.46 Impact Factor
• Article: [Neonatal tumours and congenital malformations].

  O Berbel Tornero, J A Ortega García, J Ferrís i Tortajada, J García Castell, J Donat i Colomer, O P Soldin, J L Fuster Soler
  [show abstract] [hide abstract]
  ABSTRACT: The association between pediatric cancer and congenital abnormalities is well known but, there is no exclusive data on the neonatal period and the underlying etiopathogenic mechanisms are unknown. First, to analyze the frequency of neonatal tumours associated with congenital abnormalities; and second, to comment on the likely etiopathogenic hypotheses of a relationship between neonatal tumours and congenital abnormalities. Historical series of neonatal tumours from La Fe University Children's Hospital in Valencia (Spain), from January 1990 to December 1999. Histological varieties of neonatal tumours and associated congenital abnormalities were described. A systematic review of the last 25 years was carried out using Medline, Cancerlit, Index Citation Science and Embase. The search profile used was the combination of "neonatal/congenital-tumors/cancer/neoplasms" and "congenital malformations/birth defects". 72 neonatal tumours were identified (2.8% of all pediatric cancers diagnosed in our hospital) and in 15 cases (20.8%) there was some associated malformation, disease or syndrome. The association between congenital abnormalities and neonatal tumours were: a) angiomas in three patients: two patients with congenital heart disease with a choanal stenosis, laryngomalacia; b) neuroblastomas in two patients: horseshoe kidney with vertebral anomalies and other with congenital heart disease; c) teratomas in two patients: one with cleft palate with vertebral anomalies and other with metatarsal varus; d) one tumour of the central nervous system with Bochdaleck hernia; e) heart tumours in four patients with tuberous sclerosis; f) acute leukaemia in one patient with Down syndrome and congenital heart disease; g) kidney tumour in one case with triventricular hydrocephaly, and h) adrenocortical tumour: hemihypertrophy. The publications included the tumours diagnosed in different pediatric periods and without unified criteria to classify the congenital abnormalities. Little data exist on the neonatal period and the majority are from medical institutions registers. The prevalence varies from 15 to 31.6%. To explain this association, the hypotheses are based on prenatal exposures (preconceptional and transplacental exposure), to mutagenic and carcinogenic risk factors. Neonatal tumours are more often associated to congenital abnormalities than other pediatric cancers. The inclusion and classification criteria needs to be unified to better understand the association between the neonatal tumours and congenital abnormalities. The environmental history in all neonatal tumours associated to congenital abnormalities, including the constitutional and environmental risk factors, will help to improve our knowledge of the underlying prenatal mechanisms and to an advance in its prevention.
  Anales de Pediatría 07/2008; 68(6):589-95. · 0.77 Impact Factor
• Article: [Environment and pediatric cancer].

  J Ferrís Tortajada, J A Ortega García, A Marco Macián, J García Castell
  [show abstract] [hide abstract]
  ABSTRACT: Cancer is the final result of the variable combination of two determinants: endogenous or constitutional factors and exogenous or environmental factors. Between 85 % and 96 % of pediatric cancers (PC) are probably associated with environmental risk factors (RF), most of which have not been identified. The spectacular progress made in survival in PC contrasts with the lack of knowledge of the RF implicated in its etiopathogenesis. 1) To analyze up-to-date knowledge of the interaction among environmental RF in the etiopathogenesis of PC, and 2) to inform pediatricians of the "Environment and Pediatric Cancer" research project directed by the Pediatric Environmental Health Specialty Unit of the Hospital Infantil Universitari La Fe in Valencia (Spain). Current medical records focus almost exclusively on the diagnosis and treatment of cancer. The Pediatric Environmental Medical Record will contain the validated items required to document and presence or absence of endogenous and exogenous RF associated with PC described in the literature, as well as the main human cancerogenic agents identified by the International Agency for Research on Cancer and the US National Toxicology Program. The project aims to determine the frequency of endogenous and exogenous RF associated with PC in Spain. This project will enable hypotheses to be formulated for future epidemiologic case-control and cohort studies in Spain and other European countries, thus stimulating the introduction of educational and preventive policies in the Spanish population. The project requires the aid of all hospital and non-hospital pediatricians involved in pediatric cancer in informing parents and offering them the possibility of voluntarily collaborating in the "Environment and Pediatric Cancer" project by contacting the Pediatric Health Specialty Unit (Unidad de Salud Medioambiental del Hospital Infantil La Fe de Valencia [www.pehsu.org]). The collaboration of our colleagues will be essential in gaining greater insight into the RF associated with PC and in achieving prevention in the medium and long term.
  Anales de Pediatría 08/2004; 61(1):42-50. · 0.77 Impact Factor
• Article: [Risk factors for Hodgkin's lymphomas].

  J Ferrís Tortajada, J García Castell, J A López Andreu, S Clar Gimeno, O Berbel Tornero
  [show abstract] [hide abstract]
  ABSTRACT: To divulge the risk factors associated with Hodgkin's lymphoma (HL) in children and adults among pediatricians. We performed a literature review of the last 25 years through the Medline, IAR Cancer, and Cancerlit databases. The search profile was "HL risk factors". The most interesting papers, as well as those cited and published more than 25 years prior to the search, were selected. The following risk factors for HL were reported with greater or lesser evidence: a) genetic (variation in the HLA class II region); b) viral infections (Epstein-Barr virus); c) childhood environment and socio-economic status; d) congenital and acquired immunodeficiency; e) medical conditions and f) occupational exposure (the wood industry and its derivatives). The etiology of most HL is unknown. The most important risk factors are: 1) genetic; 2) Epstein-Barr virus (infectious mononucleosis); 3) congenital and acquired immunodeficiency; 4) occupational exposure (the wood industry).
  Anales espanoles de pediatria 10/2001; 55(3):239-43.
• Article: [Risk factors for non-Hodgkin's lymphomas].

  J Ferrís Tortajada, J García Castell, O Berbel Tornero, S Clar Gimeno
  [show abstract] [hide abstract]
  ABSTRACT: To divulge the risk factors for non-Hodgkin lymphomas (NHL) in children and adults among pediatricians. We performed a literature review of articles published in the last 25 years through the Medline, IAR Cancer and Cancerlit databases. The search profile was "NHL risk factors". The most interesting papers, as well as the most relevant articles cited and published more than 25 years prior to the search, were selected. The following risk factors for the development of NHL were reported with greater or lesser evidence: socioeconomic status, family factors, immunodeficiencies, bacterial and viral infections, vaccinations and drugs, radiation,occupational exposure, exposure to animals, diet, and lifestyle. The etiology of most NHLs is unknown. The most important risk factors are: a) congenital and acquired immunodeficiency; b) viral (human T-cell leukemia virus type-I, Epstein-Barr virus, AIDS virus), and bacterial (Helicobacter pylori) infections; c) therapy with diphenylhydantoin and antineoplastic drugs, and d) exposure to pesticides and organic solvents.
  Anales espanoles de pediatria 10/2001; 55(3):230-8.
• Article: A poroid neoplasia arising close to a seborrheic keratosis and a trichoepithelioma.

  E Nagore, F Díaz, J M Sánchez-Motilla, A Prats, J García-Castell, A Aliaga
  [show abstract] [hide abstract]
  ABSTRACT: A 69-year-old woman had a well-defined, slightly raised, brownish, keratotic plaque with an eccentric group of roughly circular, bluish, dome nodules on her right scapular area. Histological study revealed the presence of an eccrine poroma demonstrating features of eccrine poroma, hidroacanthoma simplex, and dermal duct tumor and arising in a lesion of seborrheic keratosis and a trichoepithelioma. In the eccrine poroma region, an area with malignant changes was evident. The findings in this case support the view of eccrine poroma as a spectrum of histological variants and the possibility of malignant transformation from a eccrine poroma towards porocarcinoma. The association with seborrheic keratosis is most probably coincidental, and the trichoepithelioma was probably due to induction of the tumoral stroma on adjacent follicular epithelia.
  The Journal of Dermatology 05/1999; 26(4):253-7. · 1.49 Impact Factor
• Article: [Pediatric diseases associated with passive smoking].

  J Ferrís Tortajada, J A Alonso López Andreu, J García Castell, S Pérez Tarazona, I Cortell Aznar
  Anales espanoles de pediatria 11/1998; 49(4):339-47.
• Article: [Papillary transitional cell carcinoma of the frontal sinus].

  R Carbonell Sanchis, J Marcote Icart, F López Catalá, P Canals Ruiz, J L Peris Beaufils, J García Castell
  [show abstract] [hide abstract]
  ABSTRACT: A case is reported of primary transitional-cell carcinoma in the frontal sinus of a 54-year-old woman, which was interesting because of the histological type, evolution, and difficulty of follow-up. A 54-year-old woman with no history of exposure to risk factors presented swelling of the frontal area of 3 months duration. Fine needle aspiration biopsy revealed an adenoma but TAC showed an intrasinusal tumor with destruction of the inner and outer walls. Surgical exeresis revealed the correct histological diagnosis. Local recurrence at 12 months, without cervical lymph nodes or distant metastases, was treated surgically and the patient remained asymptomatic and disease-free 24 months later. Malignant tumors of the frontal sinus are rare in the literature. We describe the histological features of transitional-cell tumor and emphasize its similarity with papilloma, benign behavior and management options, in which surgery is of choice. Prognostic and survival factors in the literature are reviewed.
  Acta Otorrinolaringológica Española 06/1998; 49(4):313-6.
• Article: [Erythroderma as presentation form of visceral leishmaniasis in a patient with human immunodeficiency virus infection].

  A Belda Mira, J M Pascual Izuel, A Prats Mañez, J García Castell
  Revista Clínica Española 12/1992; 191(8):454. · 2.01 Impact Factor
• Article: Tumores neonatales y malformaciones congénitas

  Octavio Berbel Tornero, J A Ortega García, Josep Ferrís-Tortajada, J García Castell, Joaquín Donat Colomer
  [show abstract] [hide abstract]
  ABSTRACT: La asociación entre tumores y malformaciones congénitas está bien establecida, pero no existen datos exclusivos en el período neonatal y se desconocen los mecanismos subyacentes que generan dicha relación. Objetivos Este trabajo tiene dos objetivos: primero, analizar la frecuencia de los tumores neonatales asociados a malformaciones congénitas, y segundo, comentar las posibles hipótesis etiopatogénicas de la relación entre ambas entidades. Materiales y método Estudio retrospectivo de las historias clínicas de los tumores neonatales, en el Hospital Universitario Materno-Infantil La Fe de Valencia, desde enero de 1990 hasta diciembre de 1999. Selección y descripción de las variedades histológicas asociadas a malformaciones congénitas. Éstas se han agrupado siguiendo los criterios de la Clasificación Internacional de Enfermedades CIE-9, códigos 740.0-759.9. Revisión sistemática bibliográfica de los últimos 25 años, obtenida del Medline, Cancerlit, Index Citation Science y Embase. El perfil de búsqueda utilizado fue la combinación de �neonatal/congenital-tumors/cancer/ neoplasms� y �congenital malformations/birth defects�. Resultados Se identificaron 72 tumores neonatales (2,8 % del total de tumores pediátricos diagnosticados en dichos años) y 15 de ellos (20,8 %) asociados a malformaciones congénitas, enfermedades o síndromes congénitos. Las asociaciones entre tumores neonatales y malformaciones congénitas fueron las siguientes: a) angioma en 3 pacientes: con dos cardiopatías congénitas y una atresia de coanas-laringomalacia; b) neuroblastoma en 2 pacientes: uno con riñón en herradura y anomalías vertebrales, y otro con cardiopatía congénita; c) teratoma en 2 pacientes: uno con fisura palatina y anomalías vertebrales, y otro con metatarso varo; d) tumor del sistema nervioso central en un paciente con hernia de Bochdaleck; e) tumor cardíaco en 4 pacientes con esclerosis tuberosa; f) leucemia aguda en un paciente con síndrome de Down y cardiopatía congénita; g) tumor renal en un caso con hidrocefalia triventricular, y h) tumor adrenal en un caso con hemihipertrofia. En la bibliografía específica, las publicaciones engloban tumores de diferentes épocas pediátricas y sin unanimidad de criterios para clasificar las malformaciones congénitas. Apenas existen datos en el período neonatal y la asociación entre ambas entidades se obtiene de registros de instituciones médicas. La prevalencia oscila entre el 15 y el 31,6 %. Las hipótesis etiopatogénicas que explican la asociación entre tumores neonatales y malformaciones congénitas están basadas en las exposiciones prenatales (preconcepcionales y transplacentarias) a factores de riesgo potencialmente mutagénicos y carcinogénicos. Conclusiones Probablemente, los tumores neonatales se asocian con mayor frecuencia a malformaciones congénitas que los tumores diagnosticados en épocas posteriores de la vida. Para conocer la prevalencia real de la asociación entre tumores neonatales y malformaciones congénitas, es necesario unificar los criterios de inclusión y definición de ambas entidades. La obtención de una minuciosa historia medioambiental en todos los tumores neonatales asociados a malformaciones congénitas, donde se detallen y registren todos los factores de riesgo constitucionales y ambientales, es fundamental para mejorar nuestros escasos conocimientos de los mecanismos prenatales subyacentes y avanzar en su prevención.
  Anales españoles de pediatría: Publicación oficial de la Asociación Española de Pediatría (AEP), ISSN 1695-4033, Vol. 68, Nº. 6, 2008, pags. 589-595.