Kenichi Katsu

Publications (11)14.05 Total impact

• Article: [One case that accompanied accessory papilla carcinoid for von Recklinghausen's disease].

  Shin Kuwakado, Toshihiro Inoue, Gou Edagawa, Mototsugu Fujii, Daisuke Ohgitani, Toshimitsu Tanaka, Takayuki Kii, Akito Moriguchi, Nobuaki Kanemitsu, Takashi Yoshida, Hidehiro Kitae, Arata Kayano, Keiji Suga, Shinsyou Morita, Hiroshi Ueno, Yutarou Egashira, Kenichi Katsu, Hidekazu Higuchi
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  ABSTRACT: A 45-year-old man: pointed out von Recklinghausen disease (following vR disease) in 18 years old. He had a checkup in a close inspection purpose of a duodenum tumor at our hospital. We diagnosis that the accessory papilla carcinoid, and Pancreas Divisum was doubted. Rocal resection of the accessory papilla was performed and picked out carcinoid of 7 mm size. In literatures searches, as for accessory papilla carcinoid, merger frequency of a papilla tumor was high in the example, and merged, vR disease of lymph node metastasis.
  Nippon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology 02/2009; 106(1):77-84.
• Article: Hepatic computed tomography for simultaneous depiction of hepatocellular carcinoma, intrahepatic portal veins, and hepatic veins in real-time virtual sonography: initial experience.

  Fuminari Tatsugami, Mitsuru Matsuki, Go Nakai, Masato Tanikake, Shushi Yoshikawa, Isamu Narabayashi, Katsuhiko Miyaji, Akira Asai, Shinya Fujiwara, Yasushi Hongo, Kenichi Katsu
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  ABSTRACT: The aim of this study was to examine a double-step injection of contrast material in hepatic computed tomography (CT) for the simultaneous depiction of hepatocellular carcinoma (HCC), intrahepatic portal veins, and hepatic veins in real-time virtual sonography. This study consisted of 6 patients with solitary HCC nodules with early enhancement on dynamic contrast-enhanced CT. Computed tomographic scanning was performed in a combined late arterial/hepatic phase after 2 sequential contrast material injections. In all 6 patients, the solitary HCC nodule, intrahepatic portal veins, and hepatic veins were simultaneously visualized with enhancement, for which CT values were appreciably higher than that of the liver parenchyma. In virtual sonography, HCC nodules and intrahepatic vessels were simultaneously shown, and the HCC lesions were treated by radio frequency ablation without vascular injury. A double-step injection of contrast material in hepatic CT was helpful in the identification of the relationship between the HCC nodule and intrahepatic vessels under virtual sonography and contributed to the accurate and safe performance of radio frequency ablation for HCC.
  Journal of ultrasound in medicine: official journal of the American Institute of Ultrasound in Medicine 09/2007; 26(8):1065-9. · 1.25 Impact Factor
• Article: [Second-line chemotherapy in gastric cancer].

  Hiroya Takiuchi, Masahiro Goto, Shinichiro Kawabe, Syunsuke Ohta, Kenichi Katsu
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  ABSTRACT: Japan Clinical Oncology Group (JCOG) conducted a randomized phase III trial that compared 5-FU alone with 5-FU+cisplatin (JCOG 9205). The primary endpoint of this study was overall survival, and both regimens showed equivalence not only in median survival time (approximately 7 months) but also in one- and two-year survival rate (28% vs 29%, and 7% vs 7%, respectively). The toxicities were significantly lower with 5-FU alone than with 5-FU+cisplatin. Then the JCOG steering committee determined that 5-FU alone should be the reference arm and overall survival should still be the primary endpoint in the next study (JCOG 9912). According to the monitoring report of this study at the interim analysis, median survival time of all patients registered for the study exceeded 11 months. Surprisingly, there was an improvement in median survival time from 7 months in JCOG 9205 to 11 months in JCOG 9912. Many newer agents were used, such as TS-1, CPT-11, docetaxel, and paclitaxel, which were absent during the previous study (JCOG 9205). Using these agents as a second-line treatment may cause the improvement of survival. Two phase II studies of CPT-11- and paclitaxel-based regimens indicate that patients derive benefit from second-line treatment, and this warrants further investigation in a randomized trial.
  Gan to kagaku ryoho. Cancer & chemotherapy 02/2005; 32(1):19-23.
• Article: Vanishing gastric tumor caused by anisakiasis.

  Yoshihiko Nakanishi, Shujiro Yazumi, Daisuke Ikeuchi, Akio Matsumoto, Hiromi Yamamura, Shinsuke Yoshizaki, Shinichi Mise, Norio Fukuyama, Chikao Shimamoto, Kenichi Katsu
  Gastrointestinal Endoscopy 02/2005; 61(1):102. · 4.88 Impact Factor
• Article: [4 cases of pseudomembranous colitis due to antituberculous agents].

  Hiroshi Akutagawa, Kou Takada, Yutaro Egashira, Gakuji Adachi, Yoshitaka Kurisu, Gou Edagawa, Ichirou Hirata, Kenichi Katsu, Yuro Shibayama
  Nippon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology 09/2004; 101(8):890-4.
• Article: [A case of double cancer of squamous cell carcinoma and adenocarcinoma of the gallbladder].

  Noriaki Kanemitsu, Yoshifumi Arisaka, Chikao Shimamoto, Toshihiro Inoue, Yutaro Egashira, Hiroshi Kojima, Katsuhiko Miyaji, Motomi Kashiwagi, Tetsuya Momose, Yutaka Hiraike, Michiaki Shiozaki, Yasushi Hongo, Ichiro Hirata, Kenichi Katsu
  Nippon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology 05/2004; 101(4):403-8.
• Article: [Effectiveness of chemotherapy for outpatients with gastric or colorectal cancer].

  Masahiro Gotoh, Shinichiro Kawabe, Hiroya Takiuchi, Syunsuke Ohta, Kenichi Katsu
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  ABSTRACT: We retrospectively evaluated the efficacy of chemotherapy regarding symptom control, toxicity and discharge rate in 39 patients with gastric or colorectal cancer. Treatment consisted of TS-1 (n = 16), TS-1 + CPT-11 (n = 8), CDDP + CPT-11 (n = 5), paclitaxel (n = 8) and MTX + 5-FU (n = 4) for gastric cancer and 5-FU + l-leucovirin (n = 6), 5-FU + CPT-11 (n = 5), MMC + CPT-11 (n = 8) and 5-FU protracted continuous infusion (n = 5) for colorectal cancer. The rates of symptom improvement were the following: pain 60% (10/15), general fatigue 56% (5/9) and abdominal fullness 53% (8/15). 87% (34/39) of the patients were discharged from hospital and continued chemotherapy as outpatients grade 3 toxicities were the following: anemia 10.3%, nausea and/or vomiting 7.7%, diarrhea 5.1%. There was no treatment related death. The rates of outpatient based treatment duration improvement were the following: gastric cancer: 47.6%, colorectal cancer: 72%. These data suggest that these treatments for gastric and colorectal cancer are safe and improve the patients' QOL.
  Gan to kagaku ryoho. Cancer & chemotherapy 01/2003; 29 Suppl 3:470-4.
• Article: A simple method of detecting K-ras point mutations in stool samples for colorectal cancer screening using one-step polymerase chain reaction/restriction fragment length polymorphism analysis.

  Takashi Nishikawa, Kentaro Maemura, Ichiro Hirata, Ryouichi Matsuse, Hiroshi Morikawa, Ken Toshina, Mitsuyuki Murano, Keiichi Hashimoto, Yoshihito Nakagawa, Osamu Saitoh, Kazuo Uchida, Kenichi Katsu
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  ABSTRACT: We examined a technique for detecting point mutations of K-ras codon 12 in stool samples using one-step polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP) analysis, in order to determine whether it could be used to screen for colorectal cancer. DNA was extracted from 200-mg stool specimens of 5 healthy controls and 31 colorectal cancer patients. A 107-base-pair fragment of exon 1 of K-ras was amplified by PCR using mismatched primers. PCR products were digested with Bst NI and analyzed by gel electrophoresis followed by silver staining. Specificity of one-step PCR/RFLP was examined by using synthetic oligonucleotides. The detection limit of K-ras codon 12 mutations was determined by using SW480 and HT29 cells. The K-ras gene was successfully amplified from all healthy controls and colorectal cancer patients studied. Mutations of K-ras codon 12 were not detected in any of the healthy controls, but were identified in 13 (41.9%) of the 31 patients with colorectal cancer. Mutations were detectable in all six synthetic mutant DNAs, while none were detected among the wild type. The detection limit of this method was > or = 0.1%. PCR/RFLP analysis could be used in mass screening for colorectal cancer, because it is highly specific, has a low detection limit, and is simpler than conventional methods for detecting genetic abnormalities.
  Clinica Chimica Acta 05/2002; 318(1-2):107-12. · 2.54 Impact Factor
• Article: Arsenic trioxide-induced apoptosis through oxidative stress in cells of colon cancer cell lines.

  Yoshihito Nakagawa, Yukihiro Akao, Hiroshi Morikawa, Ichiro Hirata, Kenichi Katsu, Tomoki Naoe, Nobuko Ohishi, Kunio Yagi
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  ABSTRACT: Exposure of three colon cancer cell lines, SW480, DLD-1, and COLO201, to arsenic trioxide in the medium induced a marked concentration-dependent suppression of cell growth. The intracellular contents of reduced glutathione (GSH) in these cell lines tended to be inversely correlated with the sensitivity of the cells to arsenic trioxide. Among the cell lines, SW480 cells underwent apoptosis at the low arsenic trioxide concentration of 2 microM, which was prevented by pretreatment of the cells with N-acetylcysteine and was enhanced by buthionine sulfoximine. The production of reactive oxygen intermediates which were examined by 2',7'-dichlorodihydrofluorescein diacetate (H2DCF-DA), increased with time after treatment with arsenic trioxide. The apoptosis was executed by the activation of caspase 3, which was shown by Western blot, enzymatic activity, and apoptosis inhibition assay. The mitochondrial membrane potential of adherent apoptotic SW480 cells and the cells from intermediate layer separated by density gradient centrifugation, both of which showed the active form of caspase 3 by Western blot analysis, was not lost. The overexpression of Bcl-2 protein in SW480 cells could not prevent the apoptosis induced by the treatment with arsenic trioxide. All these findings indicate that arsenic trioxide-induced apoptosis in SW480 cells is executed by the activation of caspase 3 without mediating by mitochondria under the overproduction of reactive oxygen species.
  Life Sciences 04/2002; 70(19):2253-69. · 2.53 Impact Factor
• Article: Long‐term histological prognosis and serum fibrosis markers in chronic hepatitis C patients treated with interferon

  Hiroshi Kojima, Yasushi Hongo, Hideharu Harada, Toshihiro Inoue, Katsuhiko Miyaji, Motomi Kashiwagi, Tetsuya Momose, Yoshifumi Arisaka, Hideo Fukui, Seiyo Murai, Hajime Tokita, Hiroshi Kamitsukasa, Michiyasu Yagura, Kenichi Katsu
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  ABSTRACT: Background: Interferon (IFN) therapy is effective in 20–40% of patients with chronic hepatitis C, but the relationship between histological changes and the response to interferon is still unclear. We investigated the long-term histological prognosis and the changes of serum fibrosis markers after interferon therapy relation to the response.Methods and Results: One hundred and eighteen patients with chronic hepatitis C who received interferon therapy were divided into four groups based on the detection of viremia and the serum alanine aminotransferase (ALT) level after treatment. A histological examination was performed by using the histological activity index and the criteria of the METAVIR score. Serum fibrosis markers were used to measure the levels of hyaluronic acid and type IV collagen 7s. Responders, whose serum ALT levels became normal after treatment, demonstrated histological improvement. Histological improvement was more rapid in sustained virological responders with hepatitis C virus (HCV) RNA seronegativity than in biochemical responders with HCV-RNA seropositivity. Only sustained virological responders exhibited histological cure. In partial responders, whose serum ALT levels decreased to less than twice the upper of normal, and non-responders whose serum ALT levels were not reduced, liver fibrosis was unchanged or showed progression. Serum fibrosis markers increased with progression of the histological stage and varied depending on the response to interferon.Conclusion: Normalization of serum ALT levels after interferon therapy led to a histological improvement, and that with viral clearance achieved histological cure. Serum fibrosis markers were useful indicators for long-term according to the response of IFN therapy.
  Journal of Gastroenterology and Hepatology 08/2001; 16(9):1015 - 1021. · 2.87 Impact Factor
• Article: Co-overexpression of DEAD box protein rck/p54 and c-myc protein in human colorectal adenomas and the relevance of their expression in cultured cell lines

  Keisuke Hashimoto, Yoshihito Nakagawa, Hiroshi Morikawa, Masami Niki, Yutaro Egashira, Ichiro Hirata, Kenichi Katsu, Yukihiro Akao
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  ABSTRACT: The RCK gene was cloned through a study of the breakpoint of the t(11;14)(q23;q32) chromosomal translocation observed in a human B-cell lymphoma and overexpression of the protein (rck/p54) due to the translocation was shown to be associated with malignant transformation. The rck/p54 protein belongs to the DEAD box protein/RNA helicase family, which has a variety of functions such as translation initiation, pre-mRNA splicing and ribosome assembly. It is considered that rck/p54 protein may have significant effects on the mRNA structure of genes associated with cell proliferation, facilitating protein synthesis. Expression of rck/p54 in colorectal adenomas, which are a premalignant lesion of colorectal cancer, was examined by Western blot analysis and immunohistochemistry. The rck/p54 protein was found to be overexpressed in tumor tissues resected from 17 of 26 cases (65.4%) of colorectal adenomas and 13 of 14 c-myc-positive cases (92.8%) also co-overexpressed rck/p54 protein. Thus, a significant correlation between rck/p54 and c-myc co-overexpression was found (Spearman's rank correlation, P = 0.0018). We demonstrate that overexpression of rck/p54 in two different cell lines, COS 7 and human colorectal cancer cell line SW480, caused an increase in c-myc protein levels by enhancement of its translation efficiency and/or stabilization of its mRNA. These results suggest that rck/p54 of the DEAD box protein/RNA helicase family may contribute to cell proliferation and carcinogenesis in the development of human colorectal tumors at the translational level by increasing synthesis of c-myc protein.