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ABSTRACT: Congenital heart block (CHB) associated with maternal anti-SSA/SSB antibodies: a report of four cases. CHB detected in utero is strongly associated with maternal antibodies to SSA (Ro) and SSB (La). Their pathogenic role in the development of CHB has been established in several studies. The mothers of affected infants frequently had autoimmune disease (systemic lupus erythematosus, Sjögren's syndrome) or were entirely asymptomatic. It is very difficult to identify pregnant asymptomatic mothers carrying anti-SSA/SSB antibodies. We report four cases of infants born to asymptomatic mothers with anti-SSA/SSB antibodies, three of them developed isolated congenital cardiac heart block and one with no evidence of CHB. All three CHB are detected during pregnancy between 16 and 24 weeks of gestation. All maternal sera contained antibodies to SSA alone or the both SSA and SSB. Three of four subsequent pregnancies were complicated by heart block. One child affected died in utero. While the two other newborns with CHB required pacemaker insertion during the first 3 months of life. Although the association of anti-SSA/SSB with CHB is widely accepted, the precise mechanism by which these antibodies cause cardiac conduction abnormalities remains to be defined. Antibodies to SSA/SSB have been proposed to be a serologic marker for neonatal lupus syndrome and CHB. Fetal and neonatal diseases are presumed to be due to the transplacental passage of these IgG autoantibodies from the mother into the fetal circulation. Since these antibodies may have a pathogenic role in CHB, screening of infants with isolated CHB or neonatal lupus and their mothers for the presence of anti-SSA and anti-SSB is strongly recommended.
Pathologie Biologie 05/2004; 52(3):138-47. · 1.53 Impact Factor
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ABSTRACT: The quasi-constantly benign nature of fibrithecomas of the ovary has been known for many years. However, there have been very few studies of their incidence and clinical characteristics. The aim of this study, based upon 19 cases of fibrothecal tumours of the ovary operated upon at the Rabta maternity unit during a 12 year period, is to give an idea as to epidemiological factors, diagnostic conditions and treatment methods used among the women studied.
Revue française de gynécologie et d'obstétrique 07/1994; 89(6):315-21.
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Contraception, fertilité, sexualité 05/1994; 22(4):225-7.
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ABSTRACT: The association of pelvic hydatid cyst with pregnancy is rare. We collected 4 cases between 1981-1990. Our incidence is of 1/30000 deliveries. The diagnosis was suggested in 3 cases by the patient's country of origin and previous history of extra-pelvic hydatid disease. It is confirmed by ultrasonography, which is still the first choice examination. During the 3 pregnancies managed to term, we did not find any modification in the cyst. One patient had vaginal delivery twice; however complications, sometimes fatal, are reported in the literature. The time for surgery and the mode of delivery are discussed because of the rarity of this association.
Journal de Gynécologie Obstétrique et Biologie de la Reproduction 02/1992; 21(7):803-5. · 0.42 Impact Factor
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ABSTRACT: We analyzed the relationship between the evolution of pregnancy and the amplitude of the lipid disorders in order to evaluate their chronologic transformations. This research concerned 83 pregnancies aged between 19-40 years during the 3 periods of gestation and 31 healthy control women in the same range of age. Our results showed an increased triglyceride in the 2nd period and an earlier decrease of both, cholesterol, phospholipid and apolipoproteins. These parameters showed a progressive increase of their blood concentrations during the 2nd and the 3rd period of pregnancy, in an other hand we evidenced a good correlation between gestational aged and these variations i.e.: triglyceride and mother's weight; this phenomenon could suggest an eventual role of the nutrition and the hygienic habitude in the lipid metabolism. The correlation between our observed lipid disorders and the mother's age or the parity were not significant.
Journal de Gynécologie Obstétrique et Biologie de la Reproduction 02/1992; 21(5):544-8. · 0.42 Impact Factor
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La Tunisie médicale 03/1988; 66(2):99-101.
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La Tunisie médicale 03/1987; 65(2):143-7.
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La Tunisie médicale 04/1986; 64(3):217-20.
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Journal de Gynécologie Obstétrique et Biologie de la Reproduction 02/1972; 1(5 Suppl 2):449-50. · 0.42 Impact Factor
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La Tunisie médicale 58(3):510-2.
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La Tunisie médicale 64(8-9):721-5.
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La Tunisie médicale 64(8-9):715-20.
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La Tunisie médicale 57(6):380-2.
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Le Pharmacien biologiste 25(194):197-202.
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La Tunisie médicale 63(8-9):475-7.
