Se Hyun Kim

Yeungnam University, Gyeongsan, Gyeongsangbuk-do, South Korea

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Publications (143)625.12 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Platinum-based doublet chemotherapy is the treatment of choice for patients with non-small cell lung cancer (NSCLC), however, the role of a platinum-based doublet as second-line therapy after failure of an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) for NSCLC patients has not yet been elucidated. The purpose of this study was to compare the clinical efficacy of pemetrexed versus a platinum-based doublet as second-line therapy after failure of EGFR TKI used as first-line therapy for NSCLC patients with EGFR mutations. We designed a multicenter retrospective cohort study of 314 NSCLC patients with EGFR mutations who received an EGFR TKI as first-line palliative chemotherapy. Our analysis included 83 patients who failed EGFR TKI therapy and received second-line cytotoxic chemotherapy. Forty-six patients were treated using a platinum-based doublet and 37 patients were treated using singlet pemetrexed. The overall response rates (RRs) of patients receiving a platinum-based doublet and patients receiving pemetrexed were17.4% and 32.4%, respectively (P=0.111). The median progression-free survival (PFS) of patients receiving pemetrexed was significantly longer than that of patients receiving a platinum-based doublet (4.2 months vs. 2.7 months, respectively; P=0.008). The hazard ratio (HR) was 0.54 (95% confidence interval [CI], 0.34-0.86;P=0.009). s Our retrospective analysis found that second-line pemetrexed singlet therapy provided significantly prolonged PFS compared to second-line platinum-based doublet chemotherapy for NSCLC patients with EGFR mutations who failed first-line EGFR TKI. Conduct of prospective studies for confirmation of our results is warranted.
    Cancer research and treatment : official journal of Korean Cancer Association. 02/2015;
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    ABSTRACT: Solution-processed organic field effect transistors (OFETs), which are amenable to facile large-area processing methods, have generated significant interest as key elements for use in all-organic electronic applications aimed at realizing low-cost, lightweight, and flexible devices. The low performance levels of n-type solution-processed bottom-contact OFETs unfortunately continue to pose a barrier to their commercialization. In this study, we introduced a combination of CVD-grown graphene source/drain (S/D) electrodes and fullerene (C60) in a solution-processable n-type semiconductor toward the fabrication of n-type bottom-contact OFETs. The C60 coating in the channel region was achieved by modifying the surface of the oxide gate dielectric layer with a phenyl group-terminated self-assembled monolayer (SAM). The graphene and phenyl group in the SAMs induced π-π interactions with C60, which facilitated the formation of a C60 coating. We also investigated the effects of thermal annealing on the reorganization properties and field-effect performances of the overlaying solution-processed C60 semiconductors. We found that thermal annealing of the C60 layer on the graphene surface improved the crystallinity of the face-centered cubic (fcc) phase structure, which improved the OFET performance and yielded mobilities of 0.055 cm(2) V(-1) s(-1). This approach enables the realization of solution-processed C60-based FETs using CVD-grown graphene S/D electrodes via inexpensive and solution-process techniques.
    Physical chemistry chemical physics : PCCP. 02/2015;
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    ABSTRACT: Nanocomposite gate insulators consisting of (Ba, Sr)TiO3 (barium strontium titanate; BST) nanoparticles and crosslinked poly(4-vinyl phenol) (PVP) polymers were fabricated. Well-dispersed nanocomposite films were prepared by optimizing the BST nanoparticle size sorting process (ultrasound crushing and centrifuge method). The size-sorted BST nanoparticles (∼30 nm in size) were homogeneously mixed in the PVP host polymer in various BST contents, from 0 to 70 wt%, to tune the dielectric constant (κ) of the resulting nanocomposite films. The composite films exhibit three-fold increase in the κ value from 3.9 to 11.3. The physical properties including leakage current and surface roughness of the composites were also measured as a function of the BST loading content and particle dispersion. The relationship between these properties and the electrical performance of the corresponding organic thin film transistor were explored.
    Organic Electronics 02/2015; 17:144-150. · 3.68 Impact Factor
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    ABSTRACT: The electrical performance of triethylsilylethynyl anthradithiophene (TES-ADT) organic field-effect transistors (OFETs) was significantly affected by dielectric surface polarity controlled by grafting hexamethyldisilazane and dimethyl chlorosilane-terminated polystyrene (PS-Si(CH3)2Cl) to 300-nm-thick SiO2 dielectrics. On the untreated and treated SiO2 dielectrics, solvent-vapor annealed TES-ADT films contained millimeter-sized crystals with low grain boundaries (GBs). The operation and bias stability of OFETs containing similar crystalline structures of TES-ADT could be significantly increased with a decrease in dielectric surface polarity. Among dielectrics with similar capacitances (10.5-11 nF cm−2) and surface roughnesses (0.40-0.44 nm), the TES-ADT/PS-grafted dielectric interface contained the fewest trap sites and therefore the OFET produced using it had low-voltage operation and a charge-carrier mobility ∼1.32 cm2 V−1 s−1, on-off current ratio >106, threshold voltage ∼0 V, and long-term operation stability under negative bias stress.
    Organic Electronics 02/2015; 17:87-93. · 3.68 Impact Factor
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    ABSTRACT: We investigated differential patterns of hallucinatory experiences between nonclinical and clinical samples. A total of 223 nonclinical individuals (108 females) and 111 subjects with schizophrenia (54 females) completed the Launay-Slade Hallucination Scale-Revised (LSHS-R) and Perceptual Aberration Scale (PAS). The Minnesota Multiphasic Personality Inventory-2 (MMPI-2) was used for the nonclinical group, and the Positive and Negative Syndrome Scale (PANSS) hallucination item was used for the clinical group. Cronbach׳s alpha values showed good internal consistency for the LSHS-R. In the two groups, significant associations were found between LSHS-R and PAS scores. Two factors were extracted through a principal component analysis (PCA) in the nonclinical group, and three factors were identified in the clinical group. The results of a hierarchical cluster analysis (HCA) revealed that a perception-cognition dimension was clear cluster discriminating element for the nonclinical group, whereas alterations in perception-cognition dimension were characteristic in cluster structure of the clinical group. Our findings suggest that the nature of hallucinatory experiences may differ qualitatively between a nonclinical population and subjects with schizophrenia. Perceptual or cognitive aberrations may add a psychopathologic dimension to hallucinatory experiences. Exploring the internal structure of hallucinatory experiences may provide explanatory insight into these experiences in the general population. Copyright © 2015. Published by Elsevier Ireland Ltd.
    Psychiatry research. 01/2015;
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    ABSTRACT: Background: Patients with bipolar disorder are at a high risk for becoming obese. Adipokines are associated with depression and obesity via the inflammatory process. However, few studies have investigated the associations between depression and leptin, adiponectin and resistin levels in patients with bipolar disorder. We explored the associations between serum levels of leptin, adiponectin and resistin and mood and metabolic status in patients with bipolar disorder. Methods: Body mass index (BMI) and serum leptin, adiponectin and resistin levels were assessed in 94 Korean patients with bipolar disorder. The Hamilton Rating Scale for Depression-17 and the Young Mania Rating Scale were used to assess mood state. Results: Leptin (17.19 ± 13.08 vs. 10.47 ± 10.05 ng/ml; p = 0.008) and adiponectin (10.51 ± 8.37 vs. 5.91 ± 2.82 μg/ml; p = 0.001) levels were higher in female than in male patients. After adjusting for mood state, age, smoking, alcohol habit, and BMI in a multivariate analysis of covariance (MANCOVA), leptin (17.86 ± 1.22 vs. 10.05 ± 1.48 ng/ml; p < 0.001) and adiponectin (10.18 ± 0.98 vs. 6.40 ± 1.19 μg/ml; p = 0.027) levels were still higher in female than in male patients. Compared to euthymic patients, depressed patients had higher levels of leptin (17.37 ± 14.69 vs. 11.65 ± 9.04 ng/ml; p = 0.024), but there was no significant difference in adiponectin and resistin levels between the two groups. After adjusting for age, gender and BMI in the MANCOVA, leptin levels were also significantly higher in depressed (16.78 ± 1.34 ng/ml) than in euthymic patients (10.73 ± 1.22 ng/ml; p = 0.001). Conclusion: Leptin is closely associated with the regulation of mood and metabolic homeostasis in patients with bipolar disorder. © 2014 S. Karger AG, Basel.
    Neuropsychobiology 11/2014; 70(4):203-209. · 2.30 Impact Factor
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    ABSTRACT: There are few data on the clinical implications of immunosuppressive protein expression in tumors and immune cell infiltration within the tumor microenvironment in patients with gastric cancer (GC). In this study, 243 patients with curatively resected GC were included. The levels of immunosuppressive protein expression [programmed cell death 1 ligand 1 (PD-L1), cytotoxic T-lymphocyte antigen 4 (CTLA-4), and indoleamine 2,3-dioxygenase (IDO)] in tumors and the densities of immune cells [CD3(+), CD4(+), CD8(+), or PD-1(+) cells] within the tumor microenvironment were measured using immunohistochemical analysis. Positive PD-L1, CTLA-4, and IDO expression was observed in 43.6, 65.8, and 47.7 % of the patients, respectively. Expression of PD-L1, CTLA-4, and IDO was related to less advanced stage, intestinal type, and well/moderately differentiated adenocarcinoma (P < 0.05). PD-L1 expression was related to better disease-free survival (DFS) and overall survival (OS) in GC [PD-L1(+) vs. PD-L1(-) tumors: 5-year DFS rate, 82.6 vs. 66.9 %; 5-year OS rate, 83.0 vs. 69.1 % (P values <0.05)]. Survival outcomes were also better in patients with a higher density of CD3(+) cells within the tumor microenvironment than in those with a lower density of CD3(+) cells [5-year DFS rate, 80.9 vs. 67.0 %; 5-year OS rate, 82.5 vs. 68.0 % (P values <0.05)]. In multivariate analysis, these two immune markers had a prognostic impact on survival, independent of other clinical variables. GC patients with immunosuppressive protein expression (PD-L1, CTLA-4, or IDO) had distinct clinicopathological characteristics. PD-L1(+) expression and a high-CD3 tumor microenvironment are favorable prognostic markers in GC.
    Gastric Cancer 11/2014; · 4.83 Impact Factor
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    ABSTRACT: Although about one-fourth of patients dying of lung cancer are aged 80 years or older in Korea, the current treatment status and outcome in octogenarians are largely unknown. We aimed to evaluate the proportion of octogenarians with advanced non-small cell lung cancer (NSCLC) who receive systemic chemotherapy and analyze the clinical outcome in these patients. The medical records of 281 octogenarians who were diagnosed with stage IIIB/IV or recurrent NSCLC were retrospectively reviewed. In total, 127 out of 281 patients (45 %) received chemotherapy. Among the patients with ECOG PS 0-2, 119 patients (57 %) received chemotherapy. The first-line treatments were platinum doublets in 61 patients (48 %), single-agent chemotherapy in 34 (27 %), and epidermal growth factor receptor tyrosine kinase inhibitors in 32 (25 %). In patients with ECOG PS 0-2, patients who received chemotherapy lived longer compared with patients who only received best supportive care (16.1 vs. 4.0 months, P < 0.001). Among the 127 patients who received chemotherapy, patients who received EGFR TKIs showed longer survival than patients who only received cytotoxic agents (21.4 vs. 9.8 months, P < 0.001). In a multivariate analysis, ECOG PS 3-4 and smoking history were unfavorable prognostic factors, while recurrent disease and systemic chemotherapy were favorable prognostic factors. Nearly half of octogenarians with advanced NSCLC received systemic chemotherapy. The patients showed prolonged survival compared with the best supportive care group. Further studies are warranted to provide an optimal tailored treatment for octogenarians.
    Journal of Cancer Research and Clinical Oncology 11/2014; · 3.01 Impact Factor
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    ABSTRACT: Printing electrically functional liquid inks is a promising approach for achieving low-cost, large-area, additive manufacturing of flexible electronic circuits. In order to print thin film transistors, a basic building block of thin film electronics, it is important to have several options for printable electrode materials that exhibit high conductivity, high stability, and low-cost. Here we report completely aerosol-jet printed (AJP) p- and n-type electrolyte gated transistors (EGTs) using a variety of different electrode materials including highly conductive metal nanoparticles (Ag), conducting polymers (polystyrenesulfonate doped poly(3,4-ethylendedioxythiophene, PEDOT:PSS), transparent conducting oxides (indium tin oxide), and carbon based materials (reduced graphene oxide). Using these source-drain electrode materials and a PEDOT:PSS/ion gel gate stack, we demonstrated high performance all-printed p- and n-type EGTs in combination with poly (3-hexythiophene) and ZnO semiconductors. All transistor components (including electrodes, semiconductors, and gate insulators) were printed by AJP. Both kinds of devices showed typical p- and n-type transistor characteristics, and exhibited both low threshold voltages (< 2 V) and high hole and electron mobilities. Our assessment suggests Ag electrodes may be the best option in terms of overall performance for both types of EGTs.
    ACS Applied Materials & Interfaces 10/2014; · 5.90 Impact Factor
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    ABSTRACT: In the arginylation branch of the N-end rule pathway, unacetylated N-terminal destabilizing residues function as essential determinants of protein degradation signals (N-degron). Here, we show that a neurostimulant, para-chloroamphetamine (PCA), specifically inhibits the Arg/N-end rule pathway, delaying the degradation of its artificial and physiological substrates, including regulators of G protein signaling 4 (RGS4), in vitro and in cultured cells. In silico computational analysis indicated that PCA strongly interacts with both UBR box and ClpS box, which bind to type 1 and type 2 N-degrons, respectively. Moreover, intraperitoneal injection of PCA significantly stabilized endogenous RGS4 proteins in the whole mouse brain and, particularly, in the frontal cortex and hippocampus. Consistent with the role of RGS4 in G protein signaling, treatment with PCA impaired the activations of GPCR downstream effectors in N2A cells, phenocopying ATE1-null mutants. In addition, levels of pathological C-terminal fragments of TDP43 bearing N-degrons (Arg208-TDP25) were significantly elevated in the presence of PCA. Thus, our study identifies PCA as a potential tool to understand and modulate various pathological processes regulated by the Arg/N-end rule pathway, including neurodegenerative processes in FTLD-U and ALS.
    Scientific Reports 09/2014; 4:6344. · 5.08 Impact Factor
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    ABSTRACT: Bone metastasis (BM) is reported as a poor prognostic factor in gastric cancer. However, the clinicopathologic characteristics and clinical outcomes of patients with BM compared with patients without BM have not been well described.
    European journal of cancer (Oxford, England: 1990) 09/2014; · 4.12 Impact Factor
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    ABSTRACT: Tuning of the energetic barriers to charge transfer at the semiconductor/dielectric interface in organic field-effect transistors (OLEDs) is achieved by varying dielectric functionalities. Based on this, we demonstrate the correlation between the magnitude of the energy barrier and the gate-bias stress stability of the OFETs, and reveal the origin of the excellent device stability of OFETs employing fluorinated dielectrics.
    Advanced Materials 09/2014; · 15.41 Impact Factor
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    ABSTRACT: Organic field-effect transistors (OFETs) that operated with good electrical stability were prepared by synthesizing fluorinated polyimide (PI) gate dielectrics based on 6FDA-PDA-PDA PI and 6FDA-CF3Bz-PDA PI. 6FDA-PDA-PDA PI and 6FDA-CF3Bz-PDA PI contain 6 and 18 fluorine atoms per repeat unit, respectively. These fluorinated polymers provided smooth surface topographies and surface energies that decreased as the number of fluorine atoms in the polymer backbone increased. These properties led to a better crystalline morphology in the semiconductor film grown over their surfaces. The number of fluorine atoms in the PI backbone increased, the field-effect mobility improved, and the threshold voltage shifted toward positive values (from -0.38 to +2.21 V) in the OFETs with pentacene and triethylsilylethynyl anthradithiophene. In addition, the highly fluorinated polyimide dielectric showed negligible hysteresis and a notable gate bias stability under both a N2 environment and ambient air.
    ACS Applied Materials & Interfaces 08/2014; · 5.90 Impact Factor
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    ABSTRACT: We report herein that a mixed layer of the electron-donating copper phthalocyanine (CuPc) and electron-accepting N,N-ditridecyl perylene diimide (PTCDI-C13) can be an efficient hole injection layer (HIL) for highperformance organic light-emitting diodes (OLEDs). From photophysical, morphological, and structural studies combined with electrical analysis based on the Mott–Schottky model, we conclude that the excellent miscibility between CuPc and PTCDI-C13 enables highly efficient charge transfer, and thus effective p-doping of CuPc, leading to increased hole conductivity of the HIL. As a result, turn-on voltages as low as 2.45 V and greatly improved thermal stabilities as compared to those of OLEDs with conventional CuPc HILs are observed.
    Science of Advanced Materials 08/2014; 6(8). · 2.91 Impact Factor
  • Organic Electronics 07/2014; · 3.68 Impact Factor
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    ABSTRACT: The evidence of the association between depression and metabolic syndrome is increasing, but the existence of sex differences in this association remains controversial. The aim of this study was to investigate the association between subjective depressive symptoms and metabolic syndrome and each of its components by sex in the Korean population.
    Progress in Neuro-Psychopharmacology and Biological Psychiatry 06/2014; · 4.03 Impact Factor
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    ABSTRACT: Printed low-voltage complementary inverters based on electrolyte gated transistors are demonstrated. The printed complementary inverters showed gain of 18 and power dissipation below 10 nW. 5-stage ring oscillators operate at 2 V with an oscillation frequency of 2.2 kHz, corresponding to stage delays of less than 50 μs. The printed circuits exhibit good stability under continuous dynamic operation.
    Advanced Materials 06/2014; 26(41). · 15.41 Impact Factor
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    ABSTRACT: Increased levels of alanine aminotransferase (ALT) are a biomarker for metabolic syndrome (MetS), but this relationship remains unproven in patients with schizophrenia. We assessed the relationship between aminotransferase levels and MetS in patients with schizophrenia. This pooled analysis from two open-label prospective studies included 342 patients with schizophrenia who did not meet criteria for MetS at baseline. The development of MetS was assessed at weeks 12 and 24. MetS developed in 19.1 % of patients during the 24-week follow-up period. ALT levels were significantly associated with incident MetS: for each sex-specific standard deviation increase in log ALT, the odds ratio (OR) of MetS was 1.357 (p = .006) after adjusting for age, sex, duration of illness, smoking, and previous use of antipsychotics. This result remained significant after adjusting for interim weight changes. Compared with patients in the lowest quartile, the OR of MetS in those in the highest quartile within the normal range of ALT levels was 4.276 (p = .024). However, this association was significant only in male patients. Using a cutoff value of 23.0 U/L, sensitivity and specificity were 70.6 and 68.3 %, respectively, in male patients whose ALT levels were in the normal range. A prospective association between ALT levels and MetS highlights the value of ALT levels, even mild ALT elevations within the normal range, as a predictor of the MetS risk in male patients. Baseline liver function tests and monitoring should be obtained during antipsychotic treatment to identify the risk for MetS.
    Psychopharmacology 05/2014; · 3.99 Impact Factor
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    ABSTRACT: Organic electronic devices require a passivation layer that protects the active layers from moisture and oxygen because most organic materials are very sensitive to such gases. Passivation films for the encapsulation of organic electronic devices need excellent stability and mechanical properties. Although Al2O3 films obtained with plasma enhanced atomic layer deposition (PEALD) have been tested as passivation layers because of their excellent gas barrier properties, amorphous Al2O3 films are significantly corroded by water. In this study, we examined the deformation of PEALD Al2O3 films when immersed in water, and attempted to fabricate a corrosion-resistant passivation film by using a PEALD-based Al2O3/TiO2 nano-lamination (NL) technique. Our Al2O3/TiO2 NL films were found to exhibit excellent water anti-corrosion and low gas permeation and require only low-temperature processing (< 100°C). Organic thin film transistors with excellent air-stability (52 days under high humidity (a relative humidity of 90% and a temperature of 38°C)) air were fabricated.
    ACS Applied Materials & Interfaces 04/2014; · 5.90 Impact Factor
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    ABSTRACT: ObjectiveWe investigated possible association between depressive disorders and BDNF Val66Met and 5-HTTLPR. Brain derived neurotrophic factor (BDNF) gene and serotonin transporter (SLC6A4) gene are promising candidate genes for depressive disorders. It has been suggested that BDNF promotes the survival and differentiation of serotonergic neurons and that serotonergic transmission exerts powerful control over BDNF gene expression.MethodsFinal analyses were performed on 186 patients with depressive disorders and 1032 controls. Val66Met polymorphism of BDNF gene and 5-HTTLPR polymorphism of serotonin transporter gene were genotyped and allele and genotypic associations on the diagnosis of depression and age at onset of depression were analyzed.ResultsThe 5-HTTLPR was positively associated with depressive affected status in the total sample and in females (p=0.038 for allelewise, p=0.015 for genotype-wise associations), but, not in males. The BDNF Val66Met showed no association with depression. BDNF Val66Met and 5-HTTLPR alone were not associated with age at onset of depression. Additional analysis on the interaction between BDNF Val66Met and 5-HTTLPR found a significant association with age at onset of depression in the entire patient group. This association was also found in the female but not in the male patient group. None of the positive results survived Bonferroni correction for multiple testing.ConclusionThis result suggested that BDNF Val66Met and 5-HTTLPR may contribute to depressive disorders in a complex way and that the genetic effect could differ by gender. Further studies with large number of patients will be necessary.
    Psychiatry investigation 04/2014; 11(2):192-9. · 1.15 Impact Factor
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Publication Stats

1k Citations
625.12 Total Impact Points

Institutions

  • 2013–2015
    • Yeungnam University
      • Department of Nano, Medical and Polymer Materials
      Gyeongsan, Gyeongsangbuk-do, South Korea
  • 2014
    • Dongguk University
      Sŏul, Seoul, South Korea
    • Seoul National University Bundang Hospital
      Sŏul, Seoul, South Korea
  • 2010–2014
    • Seoul National University
      • • Medical Research Center
      • • Department of Biomedical Sciences
      Sŏul, Seoul, South Korea
    • Inha University
      Chemulpo, Incheon, South Korea
  • 2012–2013
    • University of Minnesota Duluth
      • Department of Chemistry and Biochemistry
      Duluth, Minnesota, United States
    • Yonsei University
      • Division of Medical Oncology
      Seoul, Seoul, South Korea
  • 2009–2013
    • Eulji University
      • Department of Psychiatry
      Sŏul, Seoul, South Korea
  • 2007–2013
    • Yonsei University Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2006–2013
    • Seoul National University Hospital
      • Department of Neuropsychiatry
      Sŏul, Seoul, South Korea
    • Pohang University of Science and Technology
      • Department of Chemical Engineering
      Antō, North Gyeongsang, South Korea
  • 2011–2012
    • Konkuk University
      • Research Center for Transcription Control
      Sŏul, Seoul, South Korea
    • Hoseo University
      Onyang, South Chungcheong, South Korea
  • 2009–2012
    • Kyung Hee University
      • Graduate School of East-West Medical Science
      Sŏul, Seoul, South Korea
  • 2008
    • Sungkyunkwan University
      • Department of Psychiatry
      Sŏul, Seoul, South Korea
  • 2003
    • CHA University
      • College of Medicine
      Sŏul, Seoul, South Korea