Toru Muranaka

Publications (19)14.35 Total impact

• Article: Lung CT: Part 1, Mimickers of Lung Cancer--Spectrum of CT Findings With Pathologic Correlation.

  Kiyomi Furuya, Kotaro Yasumori, Sadanori Takeo, Ikuo Sakino, Noriko Uesugi, Seiya Momosaki, Toru Muranaka
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  ABSTRACT: OBJECTIVE: The purpose of this article is to describe CT findings of miscellaneous pulmonary conditions that mimic lung cancers, especially primary cancers, to improve diagnosis of pulmonary lesions. Brief descriptions of patient clinical information and pathologic findings will be included and correlated with imaging findings in actual cases. CONCLUSION: A wide variety of pulmonary conditions present imaging features that mimic those of primary lung cancers and are difficult to differentiate from cancer. Awareness of these conditions with an understanding of their pathologic background and careful attention to the clinical information will help achieve correct diagnoses.
  American Journal of Roentgenology 10/2012; 199(4):W454-63. · 2.78 Impact Factor
• Article: [Survival benefits of chemotherapy for unresectable biliary tract cancer--a multicenter retrospective analysis].

  Akihiro Funakoshi, Hikoyuki Horiuchi, Terufumi Sakai, Toshihiko Miyahara, Toru Muranaka, Masashi Nakamura, Kazuhiro Mizumoto, Toshiharu Ueki, Akinobu Taketomi, Hiroya Yamaguchi, Toshihiko Sumii, Tetsuhide Ito
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  ABSTRACT: There is no agreement on the standard chemotherapeutic regimen for biliary tract cancer(BTC), although multi-drug regimens such as gemcitabine and/or S-1 have been tested in clinical trials. This study retrospectively reviewed data from patients with BTC who were seen at hospitals in the Kitakyushu and Fukuoka areas between 2005 and 2006, and examined the effect of systemic chemotherapy regimen on survival benefits in patients with unresectable BTC. Chemotherapy may benefit patients with BTC any age group, regardless of the primary site.
  Gan to kagaku ryoho. Cancer & chemotherapy 12/2010; 37(13):2875-9.
• Source

  Available from: PubMed Central

  Article: Apparent Diffusion Coefficient in Invasive Ductal Breast Carcinoma: Correlation with Detailed Histologic Features and the Enhancement Ratio on Dynamic Contrast-Enhanced MR Images.

  Roka Namoto Matsubayashi, Teruhiko Fujii, Kotaro Yasumori, Toru Muranaka, Seiya Momosaki
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  ABSTRACT: Purpose. To investigate the correlation of Apperent Diffusion Coefficient (ADC) values in invasive ductal breast carcinomas with detailed histologic features and enhancement ratios on dynamic contrast-enhanced MRI. Methods and Materials. Dynamic MR images and diffusion-weighted images (DWIs) of invasive ductal breast carcinomas were reviewed in 25 (26 lesions) women. In each patient, DWI, T2WI, T1WI, and dynamic images were obtained. The ADC values of the 26 carcinomas were calculated with b-factors of 0 and 1000 s/mm(2) using echoplanar DWI. Correlations of the ADC values were examined on dynamic MRI with enhancement ratios (early to delayed phase: E/D ratio) and detailed histologic findings for each lesion, including cellular density, the size of cancer nests, and architectural features of the stroma (broad, narrow, and delicate) between cancer nests. Results. The mean ADC was 0.915 ± 0.151 × 10(-3) mm(2)/sec. Cellular density was significantly correlated with ADC values (P = .0184) and E/D ratios (P = .0315). The ADC values were also significantly correlated to features of the stroma (broad to narrow, P = .0366). Conclusion. The findings suggest that DWIs reflect the growth patterns of carcinomas, including cellular density and architectural features of the stroma, and E/D ratios may also be closely correlated to cellular density.
  Journal of Oncology 01/2010; 2010.
• Article: [Phase I/II study of combination chemotherapy with gemcitabine and UFT for advanced pancreatic cancer in a multi-center trial].

  Toshihiko Sumii, Akihiro Funakoshi, Kazuhiro Mizumoto, Masao Tanaka, Yoshiyuki Arita, Tetsuhide Ito, Hiroya Yamaguchi, Toshiharu Ueki, Terufumi Sakai, Toshihiko Miyahara, Toru Muranaka, Hisato Igarashi, Hirotsugu Shinozaki, Naofumi Eriguchi
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  ABSTRACT: The aim of this phase I/II study was to evaluate the tolerability and efficacy of combination chemotherapy with gemcitabine (GEM) and UFT for advanced pancreatic cancer. In phase I study UFT was given orally every day for 14 days and GEM was infused on day 1 and 8 at three dose levels (800, 900, 1,000 mg/m(2)/week) every 21 days. GEM 1,000 mg/m(2) and UFT 400 mg/m(2) did not reach the maximum tolerated dose. We decided that the recommended dose (RD) was GEM 1,000 mg/m(2)and UFT 400 mg/m(2). In phase II study 27 patients were enrolled and received GEM and UFT at RD. The tumor response rate was 17.6%, and the median survival was 221 days, which was very similar to that of GEM monotherapy. Due to adverse events, especially liver dysfunction, protocol therapy was discontinued in 12 patients. This study could not revealed the superiority of the GEM monotherapy.
  Gan to kagaku ryoho. Cancer & chemotherapy 05/2008; 35(4):603-6.
• Article: Hypogenetic lung syndrome with anomalous venous return to the left inferior pulmonary vein: multidetector row CT findings.

  Kiyomi Furuya, Kinji Kaku, Kotaro Yasumori, Takuro Kometani, Sadanori Takeo, Ippei Watanabe, Toru Muranaka
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  ABSTRACT: A unique case of hypogenetic lung syndrome is demonstrated with contrast-enhanced multidetector row computed tomography images. This is the first report of hypogenetic lung syndrome with anomalous venous return to the left inferior pulmonary vein.
  Journal of Thoracic Imaging 12/2007; 22(4):351-4. · 0.98 Impact Factor
• Article: SPECT evaluation of cerebral blood flow during arm exercise in patients with subclavian steal.

  Koichiro Kaneko, Shigeru Fujimoto, Yasushi Okada, Takashi Yoshiura, Kotaro Yasumori, Toru Muranaka, Masayuki Sasaki, Hirofumi Koga, Koichiro Abe, Hirofumi Sawamoto, Hiroshi Honda
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  ABSTRACT: To explore the cerebral hemodynamics in subclavian steal syndrome, we examined the cerebral perfusion of seven patients with subclavian steal (one symptomatic and six asymptomatic) using single-photon emission computed tomography (SPECT) during resting, arm exercise, and acetazolamide-activated conditions. The regional CBF (rCBF) was measured with SPECT under all conditions, and region of interest (ROI) analysis was performed using a three-dimensional stereotaxic ROI template (3DSRT). We evaluated the relationship between arm exercise-induced rCBF change and (1) presence of subclavian artery stenosis, (2) vertebral reverse flow severity, (3) presence of vertebro-basilar insufficiency (VBI) symptoms, and (4) cerebrovascular reactivity (CVR) to acetazolamide. Overall, no arm exercise-induced rCBF reduction was observed on either the affected or the unaffected side, even in patients with severe vertebral reverse flow. One patient with VBI symptoms showed an arm exercise-induced global rCBF reduction in the cerebrum and cerebellum, whereas the other asymptomatic patients did not. The %rCBF changes in segments with severely impaired CVR (-8.6%+/-10.7%, mean+/-SD) were significantly lower than those in other segments with less impaired CVR (P<0.01). Our results suggest that subclavian steal is a benign condition in asymptomatic patients. On the other hand, arm exercise-induced rCBF reduction can occur in the cerebrum and cerebellum in patients with VBI symptoms possibly related to low CVR.
  Annals of Nuclear Medicine 10/2007; 21(8):463-70. · 1.50 Impact Factor
• Article: Atypical manifestations of pancreatitis with autoimmune phenomenon in an adolescent female.

  Kazuta Fukumori, Satoshi Shakado, Toshihiko Miyahara, Kunitaka Fukuizumi, Ryosuke Takemoto, Hidehiro Nishi, Hironori Sakai, Toru Muranaka, Michio Sata
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  ABSTRACT: We report a case of an adolescent girl with atypical manifestations of pancreatitis with autoimmune phenomenon presenting with epigastralgia and back pain. While no abnormalities were detected on computed tomography and magnetic resonance imaging, apart from the absence of peripancreatic spread, laboratory and serological findings, such as hypergammaglobulinemia, a high titer of immunoglobulin G, a high titer of immunoglobulin G4, slight positivity for antinuclear antibodies, and positivity for autoantibodies to lactoferrin, were suggestive of autoimmune pancreatitis (AIP). Magnetic resonance cholangiopancreatography imaging (MRCP) visualized only the main pancreatic duct (MPD) in the pancreas head region. Proteoclastic enzyme inhibitor treatment was ineffective but the patient responded well to oral prednisolone. The patient and her family did not consent to endoscopic retrograde pancreatography or biopsy/histopathological examination. The case could not be diagnosed as AIP due to lack of typical diagnostic criteria, and thus the final diagnosis was considered pancreatitis with autoimmune phenomenon. We considered that the MRCP finding of partly visible MPD was due to diffuse irregular narrowing of the MPD. This case suggests that while MRCP imaging of the MPD may be helpful in the diagnosis of pancreatitis with autoimmune phenomenon, a negative result does not preclude such diagnosis.
  Internal Medicine 09/2005; 44(8):886-91. · 0.94 Impact Factor
• Article: [A case of hepatocellular carcinoma with bone metastasis treated by TS-1 and CDDP].

  Naoki Yamashita, Satoshi Shakado, Ryosuke Takemoto, Hidehiro Nishi, Kazuta Fukumori, Kunitaka Fukuizumi, Toshihiko Miyahara, Hironori Sakai, Kotaro Yasumori, Toru Muranaka, Yuko Takami, Hideki Saitsu, Jiro Watanabe
  Nippon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology 03/2005; 102(2):196-201.
• Article: [ROC analysis of detection of interval changes in interstitial lung diseases on digital chest radiographs using the temporal subtraction technique].

  Yoshiharu Higashida, Tadamitsu Ideguchi, Toru Muranaka, Nobuyuki Tabata, Ryuichi Miyajima, Fumio Akazawa, Hirotaka Ikeda, Ken Morimoto, Masafumi Ohki, Fukai Toyofuku, Kunio Doi
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  ABSTRACT: To demonstrate the clinical usefulness of a temporal subtraction technique for the detection of interval changes in various interstitial lung diseases on digital chest radiographs. One hundred pairs of chest radiographs in 34 patients (63 with and 37 without interval changes) with various interstitial lung diseases were selected. All cases were confirmed by serial chest computed tomography (CT) and ascertained by radiologists. All chest radiographs were obtained with a computed radiography (CR) system, and temporal subtraction images were produced with an iterative image-warping technique. Four radiologists and two thoracic physicians provided confidence levels for interval changes in interstitial lung diseases with and without temporal subtraction. Their performances with and without temporal subtraction were evaluated by means of receiver operating characteristic (ROC) analysis using a sequential test. The area under the ROC curve (Az) values of six observers obtained with and without temporal subtraction were 0.90 and 0.78, respectively. Results showed that the detection of interval changes in interstitial lung diseases was significantly improved by the use of temporal subtraction images compared with CR images alone(P = 0.002). Furthermore, the high detection rate was achieved with temporal subtraction images regardless of the subtlety and location of interval changes. Temporal subtraction improved the diagnostic accuracy of radiologists in detecting interval changes in interstitial lung diseases on chest radiographs. It was also useful for cases of multiple interval changes.
  Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica 02/2004; 64(1):35-40.
• Article: Radiologic features of Castleman's disease occupying the renal sinus.

  Akihiro Nishie, Kengo Yoshimitsu, Hiroyuki Irie, Hitoshi Aibe, Tsuyoshi Tajima, Kenji Shinozaki, Tomohiro Nakayama, Daisuke Kakihara, Seiji Naito, Minoru Ono, Toru Muranaka, Hiroshi Honda
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  ABSTRACT: OBJECTIVE: Our purpose was to describe the radiologic findings in five abnormalities in three patients with Castleman's disease occupying the renal sinus. CONCLUSION: Common findings such as mild homogeneous enhancement passing through the mass of the collecting system with mild hydronephrosis on contrast-enhanced CT and hypointense signal on T2-weighted images were obtained. Castleman's disease may be considered in a differential diagnosis of a mass occupying the renal sinus, although it is difficult to differentiate from malignant lymphoma.
  American Journal of Roentgenology 11/2003; 181(4):1037-40. · 2.78 Impact Factor
• Article: [A case of hepatocellular carcinoma treated with TS-1].

  Ryosuke Takemoto, Satoshi Shakado, Naoki Yamashita, Hidehiro Nishi, Kazuta Fukumori, Kunitaka Fukuizumi, Toshihiko Miyahara, Hironori Sakai, Koutaro Yasumori, Toru Muranaka, Yuko Takami, Hideki Saitsu, Jiro Watanabe, Michio Sata
  Nippon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology 10/2003; 100(9):1123-8.
• Article: [Multi-center trial of gemcitabine for 49 patients with advanced pancreatic cancer].

  Toshihiko Sumii, Akihiro Funakoshi, Tetsuhide Ito, Kazuhiro Mizumoto, Masao Tanaka, Yoshikatsu Migita, Terufumi Sakai, Hirotsugu Shinozaki, Hiroya Yamaguchi, Toshihiko Niyahara, Toru Muranaka, Naofumi Eriguchi, Toshiharu Ueki
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  ABSTRACT: Forty-nine patients with unresectable pancreatic cancer (stage IV disease) received gemcitabine in a multi-center trial in the Fukuoka pancreatic cancer chemotherapy group, Japan. No complete remissions, 5 partial remissions (10%) and 25 no changes (51%) were obtained. Gemcitabine could maintain QOL. Main toxicities were hematologic, especially neutropenia. Neutropenia tended to appear in early administration. Non-hematologic toxicities were anorexia, nausea/vomiting, and skin rash. The mean overall survival period was 7.5 months. Carcinomatous ascites and/or pleural effusion resulted in a poor prognosis (average survival 3.1 months). Gemcitabine could be given without severe toxicities in outpatient clinics. These results suggested that gemcitabine is currently a first-line therapeutic agent for advanced pancreatic cancer.
  Gan to kagaku ryoho. Cancer & chemotherapy 08/2003; 30(7):971-6.
• Article: [A case of chronic renal failure caused hyperkalemia following percutaneous radiofrequency ablation therapy for hepatocellular carcinoma].

  Kazuta Fukumori, Satoshi Shakado, Tetsuji Makihata, Ryosuke Takemoto, Kunitaka Fukuizumi, Toshihiko Miyahara, Kotaro Yasumori, Toru Muranaka, Jiro Watanabe, Hideki Saitsu, Hironori Sakai, Michio Sata
  Nippon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology 07/2003; 100(6):702-6.
• Article: [A case of intrahepatic dissemination of hepatocellular carcinoma after radiofrequency ablation therapy with expandable needle electrode].

  Satoshi Shakado, Hideki Saitsu, Jiro Watanabe, Ryosuke Takemoto, Kazuta Fukumori, Ikutaro Akasu, Kunitaka Fukuizumi, Tetsuji Makihata, Jiro Oouchi, Toshihiko Miyahara, Hironori Sakai, Koutaro Yasumori, Toru Muranaka
  Nippon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology 01/2003; 99(12):1493-7.
• Article: Pancreatic enlargement in obstructive jaundice

  Toru Muranaka, Tokugen Ro, Yuichi Masuda, Toshihiko Sumii, Motonori Saku, Yoshihiko Oshiumi
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  ABSTRACT: To verify the influence of obstructive jaundice on pancreatic growth, the anteroposterior width of the pancreas was measured by computed tomography in 30 cholangiocarcinoma patients excluded patients with distal bile duct tumor (jaundice group) and 74 control subjects. Follow-up examinations were performed on 12 patients with and without internal biliary drainage to elucidate the temporal relationship between pancreatic enlargement and the diversion of the obstructed biliary stream. Histologic analysis on autopsy samples from 13 control and 10 jaundice cases also was performed. Mean pancreatic head and body widths in the jaundice group were 2.930.3 cm and 2.010.3 cm, respectively. These values were significantly greater than those of the controls (2.130.3 cm and 1.490.3 cm,P<0.01). The glandular widths returned to their normal sizes following internal biliary drainage. No changes were seen in patients who underwent external drainage alone. Histologic examination revealed that enlargement of the acinar cells or of the islet of Langerhans was often seen in the jaundiced patients. Therefore obstructive jaundice is thought to cause pancreatic growth through a trophic effect by interrupting biliary circulation.
  Digestive Diseases and Sciences 06/1995; 40(7):1554-1560. · 2.12 Impact Factor
• Article: Well-differentiated fetal adenocarcinoma of the lung: early-phase sequential high-resolution computed tomographic findings.

  Kiyomi Furuya, Kotaro Yasumori, Sadanori Takeo, Noriko Uesugi, Yasuhiro Otsu, Masao Ichiki, Toru Muranaka
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  ABSTRACT: Well-differentiated fetal adenocarcinoma is a rare primary adenocarcinoma originating in the lung. We present an early phase case that was followed up for 2 years with chest roentgens and high-resolution computed tomography. Multicentric origin was suspected in the sequential high-resolution computed tomography study findings.
  Journal of computer assisted tomography 32(5):806-9. · 1.38 Impact Factor
• Article: Adenoma of the nipple: correlation of magnetic resonance imaging findings with histologic features.

  Roka Namoto Matsubayashi, Akiko Adachi, Kotaro Yasumori, Toru Muranaka, Koji Ikejiri, Toshiro Yahara, Morishige Takeshita
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  ABSTRACT: Adenoma of the nipple (nipple adenoma) is a rare breast tumor that can show various histologic features. We present magnetic resonance (MR) and other imaging findings of a case of nipple adenoma and correlate them with detailed histologic features of the tumor. The lesion showed early strong enhancement with rim enhancement on dynamic contrast-enhanced MR images, and internal portions of the lesion showed washout on delayed MR images. Histologically, the tumor showed expansive growth with surrounding dense collagenous tissue and large vessels. Internal portions of the lesion showed a relatively low degree of fibrosis compared with that of the surrounding area, and tiny vessels were observed. These features were clearly reflected in the MR findings.
  Journal of Computer Assisted Tomography 30(1):148-50. · 1.22 Impact Factor
• Article: Distribution of synchronous and metachronous multiple colorectal cancers.

  Yoichi Ikeda, Motonori Saku, Hirofumi Kawanaka, Toru Muranaka, Morishige Takeshita, Jiro Watanabe, Kohji Yoshida, Keizo Sugimachi
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  ABSTRACT: Synchronous and metachronous multiple colorectal cancers are not rare occurrences. Since features of colorectal cancer depend on tumor location, we focused attention on the tumor distribution of synchronous and meta-chronous lesions in colorectal cancer. The records of 1812 patients with colorectal malignancies (either invasive colorectal cancer or high grade dysplasia) were clinicopathologically analyzed. In one hundred and twenty patients with colorectal malignancies there were synchronous or metachronous lesions. The distribution of synchronous malignancies showed a significant shift from the proximal to the distal site, while in metachronous malignancies, the distribution of second tumors showed a significant shift from the distal to the proximal site. Our findings suggest that different types of cancer lesions do exist, hence careful and meticulous examinations are important.
  Hepato-gastroenterology 51(56):443-6. · 0.66 Impact Factor
• Article: New CR system with pixel size of 50 microm for digital mammography: physical imaging properties and detection of subtle microcalcifications.

  Tadamitsu Ideguchi, Yoshiharu Higashida, Yasuyuki Kawaji, Mitsuo Sasaki, Makoto Zaizen, Rei Shibayama, Yumiko Nakamura, Kimihiko Koyanagi, Hirotaka Ikeda, Masafumi Ohki, Fukai Toyofuku, Toru Muranaka
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  ABSTRACT: To investigate the physical imaging properties and detection of simulated microcalcifications of a new computed radiography (CR) system with a pixel size of 50 microm for digital mammography. New and conventional CR were employed in this study. The new CR system included a high-resolution imaging plate coupled with the FCR5000MA (50 microm pixel pitch) including transparent support and a dual-sided reader. The conventional CR system was coupled with the FCR9000 (100 microm pixel pitch). Modulation transfer functions (MTFs) and Wiener spectra (WS) of the new and conventional CR systems were measured. Observer performance tests were conducted to compare the effects of pixel size (50 microm vs. 100 microm) on the diagnostic accuracy of CR systems in the detection of simulated microcalcifications. The presampling MTF of the new CR system was higher at high frequencies than the conventional CR system. The WS of the new CR system was comparable to that of the conventional CR system at all frequencies. The area under the receiver operating characteristic (ROC) curve (Az) obtained with the new CR and the conventional CR systems were 0.84 and 0.79, respectively. Results showed that the detection of simulated clustered microcalcifications was significantly improved by use of the new CR system compared with the conventional CR system (p<0.05). The new CR mammography system improved physical imaging properties and detection of simulated microcalcifications over conventional CR mammography.
  Radiation Medicine 22(4):218-24.