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ABSTRACT: The authors report a rare case of a large primary intraorbital hydatid cyst diagnosed in 3-year-old children who had presented with unilateral progressive nonpulsatile proptosis of the left eye, explored by computed tomography and magnetic resonance imaging.
Child s Nervous System 03/2011; 27(5):693-5. · 1.54 Impact Factor
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ABSTRACT: Connective tissue defects may play a significant role in the development of intracranial aneurysms (IAs). Multiorgan connective tissue disorders may, therefore, indicate a risk of IA development. We investigated biomarkers of connective tissue disease in patients with IAs. A series of 62 patients with IAs was studied by physical examination, echocardiography, ultrasound examination of the kidneys and abdomen, and microscopic examination of skin tissue (temporal area) and superficial temporal artery taken at operation. Patients with IAs had a higher incidence of biomarkers of systemic connective tissue disease than controls and identification of these markers may be important for screening for IAs. Microscopic investigation of biopsies of the skin and superficial temporal artery from patients and their relatives may become valuable for clinical diagnosis, identification of people at risk and basic studies of the pathogenesis of this vascular disease.
Journal of Clinical Neuroscience 05/2010; 17(9):1119-21. · 1.25 Impact Factor
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Clinical Medicine & Research 03/2010; 8(1):25-7.
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ABSTRACT: To investigate acute changes of systemic parameters following experimental subarachnoid hemorrhage (SAH) and cerebral vasospasm conditions created by intracisternal injection of fresh autologous blood in a rabbit model.
The study was carried out at the Neurosurgery Clinic, Izmir Training and Research Hospital, Izmir, Turkey between April 2002 and March 2005. Thirty-two male rabbits were divided into the following 4 groups: group one with mild hemorrhage received 0.5 cc of blood, group 2 with moderate hemorrhage received 0.7 cc of blood, group 3 with severe hemorrhage received 1 cc of blood, and the sham-operated group 4 with no blood. The clinical parameters of all animals were monitored 2 hours after the operation, and blood analysis was performed just after hemorrhage. A series of systemic parameters such as rectal temperature, systolic and diastolic blood pressure, and blood gas analysis were measured before and after administration of blood injection. Results were compared by analysis of variance and paired t-tests, and p-values less than 0.05 were considered significant.
The systolic blood pressures were significantly different in groups 1, 2, and 3 before and after the bleeding period. The diastolic blood pressures were also considerably different.
This study suggests that the presence of a blood clot and different amounts of blood in the subarachnoid space can evoke a series of changes in both local and systemic states in experimental models.
Neurosciences 01/2010; 15(1):15-20. · 0.12 Impact Factor
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ABSTRACT: There is a growing interest in cystic lesions of the brain. Examining the cyst content of brain tumors may contribute in determining the malignancy of the given tumor accompanied by a cyst.
In this work, samples of cyst fluid from 18 patients with brain tumor were collected and studied biochemically regarding their protein, lactate contents and pH values; magnetic resonance spectroscopic images of these patients were also compared. We investigated the relation between the grade of malignancy and the lactate concentration and the discrepancy between the high levels of lactate in cysts and their alkaline environment.
There appears to be a positive relation between the grade of malignancy and the concentration of lactate in the cysts' fluid. A significant two-fold increase in lactate concentration in malignant tumors cysts has been found as compared with the more benign tumor cysts (p<0.001). This increase in lactate level is probably because of aerobic glycolysis, which causes lactate production by the tumor.
High lactate levels found through magnetic resonance spectroscopy are positively related to the grade of tumor malignancy. The pH values in the cyst fluids were above normal, resulting to a discrepancy in high levels of lactate in the cyst and the alkaline environment. This suggests efflux of H+ ions by a Na/H exchange mechanism to compensate for the change of pH.
Neurological Research 05/2009; 32(2):194-7. · 1.52 Impact Factor
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ABSTRACT: Ependymomas are neuroectodermal tumours arising from ependymal cells of the ventricular system, choroid plexus, filum terminale, or central canal of the spinal cord. We report on a 160-mm-long cervicothoracic intramedullary spinal cord ependymoma. The tumour was totally removed; no radiotherapy was used as an adjunctive therapy. Postoperative magnetic resonance imaging confirmed that the tumour had been totally removed.
Case Reports 01/2009; 2009.
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ABSTRACT: This report describes a patient with a rare distal anterior choroidal artery (AChoA) aneurysm that developed a right intracerebral haematoma and intraventricular haemorrhage and was treated by surgical exploration and clipping via a transtemporal/ventricular approach. The patient was discharged neurologically intact. We review the literature related to these rare aneurysms within the temporal horn, and the surgical anatomy of the AChoA.
Journal of Clinical Neuroscience 12/2008; 16(1):132-4. · 1.25 Impact Factor
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ABSTRACT: To examine the clinical and radiologic findings of patients with developmental venous anomaly (DVA) associated with intracranial haemorrhage but unrelated to cavernoma.
Computed tomography (CT) was used to obtain intracranial images from seven patients ranging in age from 6 to 51 years. Magnetic resonance imaging (MRI) was then performed on six patients, and two patients were further examined via CT angiography. Finally, digital subtraction angiography (DSA) was performed to confirm the initial diagnosis.
CT showed intraparenchymal supratentorial haemorrhage in all patients. The combined imaging modalities eventually confirmed a diagnosis of arterialized DVA in four patients and arterialized DVA associated with arteriovenus malformation (AVM) in three. Two patients were managed symptomatically, two underwent radiosurgery, one underwent surgery, one underwent combined embolisation plus radiosurgery and the remaining patient underwent combined embolisation plus surgery. Two patients died, one as a result of re-bleeding, and the other due to radiation necrosis. The mean follow-up period was 33 months (6 months to 6 years) for the remaining five patients with favourable outcome.
DVA associated with intraparenchymal haemorrhage, but not related to cavernoma, was confirmed. Though very rare, DVA may present with non-cavernoma-related haemorrhage in the form of arterialized DVA or DVA with AVM.
Neuroradiology 10/2008; 51(1):25-32. · 2.82 Impact Factor
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ABSTRACT: A case of 19 years old female patient with 24 large primary cerebral hydatid cysts, in different localisations is presented. Cysts were removed unruptured by five separate operations in 6 months. The patient was observed to be in good health 1 year after the last operation. This case is the first case presented that contains such high number of cysts to our knowledge. The importance of MRI examination in localizing the cysts and designing the operative plan is emphasized. Interestingly, albendazole, which is an antiparasitic drug, was reported to be ineffective by infectious disease department of our hospital, because of large diameter of the cysts, in this case.
Clinical Neurology and Neurosurgery 12/2007; 109(9):821-6. · 1.58 Impact Factor
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ABSTRACT: Seventeen patients with depressed fractures over cranial venous sinus who had undergone operations between 1993 and 1998 were reviewed retrospectively. There were 15 male and two female patients. Their ages ranged from 7 to 48 years. The most frequent causes of trauma were motor vehicle accident (in eight cases) followed by assault (in six cases). In the majority of cases, depressed fractures were localized over the superior sagittal sinus, and half of them were over the medial third of the sinus. In 11 cases, massive blood loss occurred intraoperatively that could be controlled by digital pressure with gelfoam or with a free muscle flap. Postoperative infection developed in one case and was treated successfully with antibiotic medication alone. Two patients died due to associated intracerebral lesions. The remaining 15 patients returned to daily living activity in the follow-up period.
Journal of Emergency Medicine 09/2005; 29(2):137-9. · 1.31 Impact Factor
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ABSTRACT: In this case report, a thoracic extradural metastatic pheochromocytoma without bony invasion, is presented. The disease which has been identified with its symptoms, bio-chemical features, radiological appearance, histological diagnosis has been discussed in comparison with malignant pheochromocytoma metastases in the literature. The origin of this tumor is the adrenal glands. Our review of the literature shows that tumor has primary metastasis in bony structures of the spine and then demonstrates secondary intraspinal invasion. This is the first case report of an epidural metastasis from malignant pheochromocytoma without a bony invasion.
The Kobe journal of medical sciences 02/2005; 51(3-4):49-53.
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ABSTRACT: A 58-year-old man presented with a sudden onset gait disturbance and urinary incontinence. Magnetic resonance (MR) imaging and MR angiography showed a fusiform basilar artery aneurysm, 2 cm in diameter and 5 cm long. The aneurysm was thrombosed except the ectatic basilar artery flowing through it. Compression of the cerebrospinal fluid (CSF) pathways caused obstructive hydrocephalus with resultant transependymal CSF leakage. Conventional angiography missed the aneurysm. A one-sided ventriculoperitoneal shunt was placed to treat the patient's hydrocephalus. The patient's symptoms improved after surgery. MR imaging and MR angiography were useful noninvasive methods of detecting the aneurysm, defining its relationship with surrounding structures, and determining the cause of the hydrocephalus.
Skull Base Surgery 12/2002; 12(4):197-200. · 0.66 Impact Factor
