J P Kühn

Publications (8)21.05 Total impact

• Article: Population imaging as valuable tool for personalized medicine.

  H Völzke, C O Schmidt, K Hegenscheid, J-P Kühn, F Bamberg, W Lieb, H K Kroemer, N Hosten, R Puls
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  ABSTRACT: Personalized medicine is commonly regarded as an extension of genomic medicine. However, a personalized treatment should be based solely on the presence or absence of genetic factors. Complex imaging methods supplement the diagnostic picture of an individual patient. Comprehensive imaging in population-based settings provides information on reference intervals, the predictive value of subclinical findings, and the complex interrelationships among risk factors, subclinical imaging phenotypes, and diseases.
  Clinical Pharmacology &#38 Therapeutics 08/2012; 92(4):422-4. · 6.04 Impact Factor
• Article: Seltene Differenzialdiagnostik des akuten Abdomens im Erwachsenenalter

  J.-P. Kühn, R. Puls, S. Maier, N. Hosten
  Der Radiologe 05/2012; 48(10):969-971. · 0.61 Impact Factor
• Article: [Thoracic aortic interventions].

  R Puls, C Rosenberg, J P Kühn, T Traeger, B Mensel, A Hoene
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  ABSTRACT: The treatment of thoracic aortic diseases has undergone a paradigm shift due to the introduction and further development of interventional techniques in recent years. Thoracic endovascular aortic repair (TEVAR) of the descending aorta has significantly lower mortality and complication rates compared to open repair. Meanwhile this endovascular approach is the first option for the treatment of the majority of thoracic aortic diseases.
  RöFo - Fortschritte auf dem Gebiet der R 01/2012; 184(1):15-23. · 2.76 Impact Factor
• Article: Whole-body magnetic resonance imaging of healthy volunteers: pilot study results from the population-based SHIP study.

  K Hegenscheid, J P Kühn, H Völzke, R Biffar, N Hosten, R Puls
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  ABSTRACT: Approximately 4000 volunteers will undergo whole-body magnetic resonance imaging (WB-MRI) within the next 3 years in the population-based Study of Health in Pomerania (SHIP). Here we present a pilot study conducted (a) to determine the feasibility of adding a WB-MRI protocol to a large-scale population-based study, (b) to evaluate the reliability of standardized MRI interpretation, and (c) to establish an approach for handling pathological findings. The institutional review board approved the study, and oral and written informed consent was obtained from each participant. Two hundred healthy volunteers (99 women, 101 men; mean age 48.3 years) underwent a standardized WB-MRI protocol. The protocol was supplemented by contrast-enhanced cardiac MRI and magnetic resonance (MR) angiography in 61 men (60.4%) and cardiac MRI and MR mammography in 44 women (44.4%). MR scans were evaluated independently by two readers. Abnormalities were discussed by an advisory board and classified according to the need for further clinical work-up. One hundred ninety-four (97.0%) WB-MRI examinations were successfully completed in a mean scan time per subject of 90 minutes. There were 431 pathological findings in 176 (88%) of the participants. Of those 45 (10.4%) required further clinical work-up and 386 (89.6%) characterized as benign lesions did not. The interobserver agreement for the detection of pathological findings was excellent (kappa = 0.799). The preliminary results presented here indicate that a large prospective, population-based study using WB-MRI is feasible and that the results of image analysis are reproducible. A variety of positive findings provide valuable information regarding disease prevalence in a general adult population.
  RöFo - Fortschritte auf dem Gebiet der R 09/2009; 181(8):748-59. · 2.76 Impact Factor
• Article: [Ruptured visceral artery aneurysm as the initial symptomatic manifestation of panarteritis nodosa].

  J P Kühn, K Hegenscheid, R Puls
  RöFo - Fortschritte auf dem Gebiet der R 11/2008; 180(10):922-4. · 2.76 Impact Factor
• Article: [Characteristics of necrosis after laser-induced thermotherapy in contrast-enhanced MRI and implications for treatment success].

  J P Kühn, R Puls, H Wallaschowski, C D Heidecke, C Rosenberg, N Hosten
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  ABSTRACT: This article reports on the use of magnetic resonance imaging to access the post-interventional necrosis volume of liver metastases immediately after and 48 hours after LITT. In this prospective study, 56 liver metastases from 39 patients (16 females, 23 males, mean age 60.4 years) underwent LITT. The 56 metastases were divided into 4 groups according to the ablation strategy (dependent on multi-applicator technique and laser duration). Groups I and II were treated with an applicator and a time of ablation greater than 15 minutes and 20 minutes, respectively. In groups III and IV the multi-applicator technology with 3 or 4 applicators and a constant ablation time of 20 minutes were used. With the help of heightened contrast MRI of the liver, the portrayal of the post-interventional necrosis was conducted immediately after LITT and 48 hours after LITT. The post-interventional controls after 48 hours were performed during the inpatient stay. The protocol was complemented by an outpatient long-term control after more than 3 months. The local tumor control rate was initially 96.4%. After 3 months it decreased to 92.1%. The mean necrosis volume directly after LITT was: Group I (n = 11; 1 applicator, 30 watt, 10-15 minutes) 6.69 cm(3); Group II (n = 13; 1 applicator, 30 watt, 20 minutes) 10.95 cm(3); Group III (n = 28; 2 applicator, 30 watt, 10-15 minutes) 21.47 cm(3); Group IV (n = 4; 3 applicator, 30 watt, 20 minutes) 40.20 cm(3). In comparison, the necrosis volume after 48 hours increased: Group I 10.56 cm(3); Group II 15.11 cm(3); Group III 31.33 cm(3), Group IV 55.73 cm(3)). After 48 hours a progressive increase of post-interventional necrosis volumes compared to volumes directly after LITT was able to be observed. An MRI control after 48 hours, as opposed to an MRI control directly after intervention, is a better indicator for post-interventional success after LITT.
  RöFo - Fortschritte auf dem Gebiet der R 10/2008; 180(9):816-20. · 2.76 Impact Factor
• Article: [Rare differential diagnosis of the acute abdomen in the adult age].

  J-P Kühn, R Puls, S Maier, N Hosten
  Der Radiologe 02/2008; 48(10):969-71. · 0.61 Impact Factor
• Article: [PTCD with with a transhepatic approach over the gallbladder--relieving a secondary duodenal stump insufficiency after gastrectomy ].

  J P Kühn, R Puls, S Maier, N Hosten
  RöFo - Fortschritte auf dem Gebiet der R 09/2007; 179(8):860-2. · 2.76 Impact Factor