Hong-Duo Chen

ShenJing Hospital of China Medical University, Feng-t’ien, Liaoning, China

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Publications (124)335.53 Total impact

  • Journal of Investigative Dermatology Symposium Proceedings 07/2015; 17(1):37-39. DOI:10.1038/jidsymp.2015.14 · 3.73 Impact Factor
  • 06/2015; DOI:10.1684/ejd.2015.2585
  • Hao Guo, Xing-Hua Gao, Hong-Duo Chen, Jiu-Hong Li
    Indian journal of dermatology, venereology and leprology 05/2015; DOI:10.4103/0378-6323.157463 · 1.33 Impact Factor
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    ABSTRACT: Traditional Chinese medicine (TCM) is increasingly being used in the Western world particularly in specialty areas such as gynecology, pediatrics, nutrition, and dermatology. TCM is an alternative method of therapy that proposes to treat symptoms that Western medicine is unable to manage by treating the underlying causes of disease. The authors provide a general overview of TCM remedies used in the treatment of various dermatologic disorders (acne, psoriasis, atopic dermatitis) for dermatologists interested in this unconventional therapeutic approach.
    SKINmed 01/2015; 13(1):32-8; quiz 39.
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    ABSTRACT: Abstract Background: Vitiligo is an acquired cutaneous hypopigmentary disorder which characterized by solitary or multiple depigmented maculae or patches. The 308-nm excimer laser has been used as phototherapy on vitiligo. Objective: To evaluate the efficacy and safety of 308-nm excimer laser on vitiligo. Methods: Randomized Controlled Trials (RCTs) were searched to conduct a systematic review. The keywords were identified as laser/ excimer laser/ quasimolecule/ XeCl" and "vitiligo". Results: Seven studies with 390 vitiligo patients were included. No significant differences were seen between 308-nm excimer laser and 308-nm excimer lamp on either ≥75% or ≥50% re-pigmentation rate, or between 308-nm excimer laser and narrow band-ultraviolet B (NB-UVB) on either 100% or ≥75% re-pigmentation rate. More patients or lesions achieved ≥50% re-pigmentation rate by 308-nm excimer laser treatment than by NB-UVB treatment. The side effects of 308-nm excimer laser were slight and tolerable. Conclusions: The 308-nm excimer laser showed equivalent efficacies to 308-nm excimer lamp control and NB-UVB control concerning of ≥75% re-pigmentation rate of vitiligo patches. More studies with high methodological quality, low risk of bias and more sample size are needed to confirm the conclusion.
    Journal of Dermatological Treatment 11/2014; DOI:10.3109/09546634.2014.991268 · 1.76 Impact Factor
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    ABSTRACT: Background: The relationship between serum hormone levels and adolescent acne is not fully clarified. Objective: To determine the relationship between levels of androstenedione, dehydroepiandrosterone sulfate (DHEA-S), testosterone, estradiol and 17α-hydroxyprogesterone (17-OHP) with adolescent acne in Northeast China. Methods: A transversal study included 242 acne cases and 188 controls. All data were analyzed using SPSS version 17.0. Results: Androstenedione and testosterone levels were significantly higher (p < 0.0001) in the cases than in the control group. In males, the difference in 17-OHP levels was statistically significant (p < 0.0001), as well as between mild and severe acne cases (p = 0.002). The estradiol level was significantly different (p < 0.0001) between cases and controls in females. Conclusion: Higher androstenedione and testosterone levels are significant risk factors in the occurrence of adolescent acne. A higher 17-OHP level aggravates the severity of male adolescent acne, while a higher estradiol level protects females against the onset of adolescent acne. © 2014 S. Karger AG, Basel.
    Dermatology 11/2014; DOI:10.1159/000365656 · 1.69 Impact Factor
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    Acta Dermato Venereologica 11/2014; 95(5). DOI:10.2340/00015555-1999 · 4.24 Impact Factor
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    ABSTRACT: This study aims to assess the impact of childhood vitiligo on the psychological status and quality of life of their parents, and to determine how this varies according to their children's disease condition. The study included 50 families of children with vitiligo (a total of 75 participants) and 50 families of normal children (a total of 79 participants). The psychosocial impact of the disease on parents was measured using the Self-rated Health Measurement Scale (SRHMS) and the Dermatitis Family Impact Questionnaire (DFI). SRHMS scores for parents of children with vitiligo were significantly lower than for parents with normal children. In addition, women had lower scores than men in the study group. The mean DFI score in affected families was higher than in unaffected families. Parents of children with vitiligo have significant psychological problems, and their quality of life is poorer than for parents of normal children. In conclusion, parents of children with vitiligo need as much care and attention as their affected children.
    Acta Dermato Venereologica 08/2014; 95(3). DOI:10.2340/00015555-1940 · 4.24 Impact Factor
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    ABSTRACT: Abstract Objective: To assess the effect and safety of NB-UVB for vitiligo using an evidence-based approach. Methods: Randomized controlled trials (RCTs) on the treatment of vitiligo with NB-UVB were identified by searching PubMed and the Cochrane Library. The primary outcome was re-pigmentation degree. Results: A total of 7 RCTs involving 232 participants with vitiligo were included in this systematic review. The methodological qualities of included studies were generally moderate. Two trials compared narrow-band ultraviolet B (NB-UVB) with UVA control, showing no significant differences between two methods on the number of patients who achieved >60% re-pigmentation (RR=2.50, 95%CI: 0.11-56.97, P>0.05). Two trials compared NB-UVB with psoralens plus UVA (PUVA) control, and no difference was seen between the two treatments on the number of patients who achieved >50 re-pigmentation (RR=1.16, 95%CI: 0.64-2.11, P>0.05) or >75% re-pigmentation (RR=2.00, 95%CI: 0.89-4.48, P>0.05). Three trials compared NB-UVB with 308-nm excimer light/laser (EL) control, and again no significant difference was found between the two methods (P>0.05). The adverse events of NB-UVB in the included studies were slight and tolerated. Conclusion: NB-UVB showed equivalent efficacies to UVA, PUVA, or 308-nm EL control in the treatment of vitiligo. Side effects of NB-UVB were acceptable. More RCTs were needed to validate the results.
    Journal of Dermatological Treatment 08/2014; DOI:10.3109/09546634.2014.952610 · 1.76 Impact Factor
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    ABSTRACT: Background Photodynamic therapy (PDT) has been used for acne, however, the efficacy and safety need to be determined. Objective To assess the effects and safety of PDT for acne using an evidence-based approach. Methods Randomized controlled trials (RCTs) on the treatment of acne with PDT were identified by searching PubMed, CNKI and the Cochrane Library. Results A total of 14 RCTs involving 492 patients were included. Photosensitizers included aminolevulinic acid (ALA), methylaminolevulinate (MAL), and indole-3-acetic acid (IAA). Light sources included red light, pulsed dye laser (PDL), intense pulsed light (IPL), long-pulsed dye laser (LPDL) and green light. The PDT protocols, including ALA + red light, ALA + PDL, ALA + IPL, MAL + red light, and MAL + LPDL, all showed great efficacy on inflammatory lesions. ALA + red light also had effects on non-inflammatory lesions and sebum secretion. ALA + IPL and IAA + green light significantly decreased sebum secretion. Triple treatment protocols showed great improvement on inflammatory and non-inflammatory lesions. Increasing ALA concentration, ALA incubation time, PDT sessions, dose of light source or using occlusion for photosensitizers, or a combination of other treatments with PDT may achieve greater efficacy. The common side effects of PDT were tolerable and transient. Conclusion Limited evidence indicates that PDT shows good efficacy in the treatment of acne with acceptable side effects. ALA + red light was shown to be the optimal choice. However, more RCTs are needed to determine the types and concentrations of photosensitizers and light sources, and the duration of light activation and incubation.
    European journal of dermatology: EJD 06/2014; 24(4). DOI:10.1684/ejd.2014.2347 · 1.95 Impact Factor
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    ABSTRACT: Adult colloid milium is a rare cutaneous deposition disorder that frequently involves areas of chronic sun exposure. The most common clinical presentation exhibits multiple, firm, and amber-colored papules that cluster to form large plaques. Histologically, there are masses of amorphous, eosinophilic material expanding the papillary dermis, and at times extending into the mid-dermis, with adjacent solar elastosis. When this disorder affects the face, disfiguring is of great concern and treatment is often sought. Attempts to safely remove colloid milium are generally unsuccessful. Dermabrasion has been reported to be effective. The present authors present a case with extensive facial colloid milium successfully ablated by the fractionated CO2 laser.
    Dermatologic Therapy 03/2014; 27(2):68-70. DOI:10.1111/dth.12056 · 1.48 Impact Factor
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    Acta Dermato-Venereologica 01/2014; 94(5). DOI:10.2340/00015555-1786 · 4.24 Impact Factor
  • Dermatologic Therapy 01/2014; 27(1):52-4. DOI:10.1111/dth.12045 · 1.48 Impact Factor
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    ABSTRACT: Syphilis, the "great imitator," with regard to skin diseases, is a chronic systemic infectious disease with a clinical course that waxes and wanes. The incidence of tertiary syphilis had decreased drastically these decades. We report a case of tertiary neurosyphilis presenting with moth-eaten bone lesions of the lower extremities. To the best of our knowledge, we have not seen such reports.
    Dermatologic Therapy 11/2013; 26(6):486-488. DOI:10.1111/dth.12020 · 1.48 Impact Factor
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    06/2013; 23(3). DOI:10.1684/ejd.2013.2061
  • 06/2013; 149(8):1-2. DOI:10.1001/jamadermatol.2013.4399
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    ABSTRACT: Primary cutaneous amyloidosis (PCA), either familial or sporadic, poses a therapeutic challenge. We conducted an open trial using thalidomide to treat three cases of familial and three cases of sporadic PCA, at initial dose of 100 mg/day. Dosage adjustment was made according to improvement of symptoms or patient's own choice. All except one sporadic case experienced moderate to significant relief on the symptoms of itching, over an observational period of 8 weeks by visual analog score (from 8.08 ± 0.88 to 1.60 ± 0.68, on average) as well as clinical amelioration of symptoms. Side effects included fatigue, drowsiness, numbness, and facial and leg edema in some of the patients. From the present observation, it seems that thalidomide is a promising drug to treat PCA.
    Dermatologic Therapy 05/2013; 26(3):263-6. DOI:10.1111/j.1529-8019.2013.01548.x · 1.48 Impact Factor
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    Yan Wu, Yuan-Hong Li, Xing-Hua Gao, Hong-Duo Chen
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    ABSTRACT: Abstract Nanotechnology has been introduced into dermatology for years. Nanoemulsions (NEs) are promising drug delivery systems with practical applications for pharmaceutical, cosmetic and chemical industry applications. Herein, we provide an overview of the application of NEs in dermatology during the latest 5 years. We reviewed the antioxidants in NEs form, non-steroidal anti-inflammatory drug loaded by NE, NEs in photodynamic therapy, NEs in decontamination of radionuclides, antimicrobial NEs, NEs carrying lipids, NEs containing Octyl Methoxycinnamate, et al. NEs demonstrate good stability, stable physical and chemical properties. NEs are able to enhance the functionality and efficacy of active chemicals and natural ingredients. NEs exhibit great application potential in the field of dermatology.
    Journal of Drug Targeting 04/2013; DOI:10.3109/1061186X.2013.765442 · 2.72 Impact Factor
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    ABSTRACT: The sensitization and elicitation phases are involved in the immunopathogenesis of contact hypersensitivity (CHS). Langerhans cells (LCs) are believed to play pivotal roles in the sensitization stage of CHS. Local hyperthermia on skin induces the migration as well as maturation of epidermal LCs. Although fever-range whole body hyperthermia and local hyperthermia at 43°C prior to sensitization were reported to suppress CHS, the effects of different temperatures and the timing sequence of local hyperthermia on CHS have not been tackled. Local hyperthermia was applied to murine dorsal skin 3 days prior to, concurrent with, or 2 days post sensitization with fluorescein isothiocyanate (FITC) in BALB/c mice. Local hyperthermia temperatures at 37°C, 39°C, 41°C and 43°C were applied to mouse dorsal skin and the severity of CHS was calculated by measuring the swelling response of the challenged ears. Local hyperthermia at 39°C, 41°C and 43°C prior to sensitization reduced the severity of CHS, as compared with that at 37°C. The suppression of CHS was temperature dependant in that higher temperature had a stronger effect. On the contrary, the hyperthermia treatments, either concurrent with or post-sensitization, resulted in an enhanced temperature-dependant ear swelling response. The severity of murine CHS could be influenced by local hyperthermia at the sensitization stage in a temperature dependant manner. The temporal effect of local hyperthermia suggested a novel factor in interpreting the severity of allergic contact dermatitis.
    Chinese medical journal 04/2013; 126(8):1555-9. · 1.02 Impact Factor

Publication Stats

674 Citations
335.53 Total Impact Points


  • 2008–2015
    • ShenJing Hospital of China Medical University
      Feng-t’ien, Liaoning, China
    • China Medical University (ROC)
      臺中市, Taiwan, Taiwan
  • 2004–2014
    • China Medical University (PRC)
      • Department of Dermatology
      Feng-t’ien, Liaoning, China
    • Southern Medical University
      Shengcheng, Guangdong, China
  • 2012–2013
    • Northeastern University (Shenyang, China)
      Feng-t’ien, Liaoning, China
  • 2011
    • General Hospital of the Air Force, PLA
      Peping, Beijing, China
  • 2009
    • Mount Sinai Medical Center
      • Department of Dermatology
      New York City, New York, United States