S Parat

Publications (17)17.74 Total impact

• Article: [The role of neonatologist in perinatal care for congenital heart disease diagnosed in utero].

  S Parat, A Giuseppi
  Archives de Pédiatrie 06/2010; 17(6):746-7. · 0.30 Impact Factor
• Article: [Imagining a palliative care project for newborns. Part two of Palliative care in the neonatal period].

  P Bétrémieux, F Gold, S Parat, G Moriette, M-L Huillery, J-L Chabernaud, L Storme, P Narcy, P Deruelle, S Kracher
  Archives de Pédiatrie 04/2010; 17(4):413-9. · 0.30 Impact Factor
• Article: [Implementing palliative care for newborns in various care settings. Part 3 of "Palliative care in the neonatal period"].

  P Bétrémieux, F Gold, S Parat, C Farnoux, M Rajguru, C Boithias, D Mahieu-Caputo, J-M Jouannic, P Hubert, U Simeoni
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  ABSTRACT: Palliative care in newborns may take place in the delivery room and then continued either in maternity wards or in the neonatal unit. For babies developing a chronic condition, going home may be advantageous. The population concerned includes babies born with a severe intractable congenital malformation and certain extremely preterm newborn babies at the limits of viability. Care procedures as well as withholding and withdrawing treatments are reviewed.
  Archives de Pédiatrie 03/2010; 17(4):420-5. · 0.30 Impact Factor
• Article: [Palliative care in the neonatal period. Part one: general considerations].

  P Bétrémieux, F Gold, S Parat, L Caeymaex, C Danan, P De Dreuzy, D Vernier, M-L Viallard, P Kuhn
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  ABSTRACT: In France, the law dated 22 April 2005 required that all practitioners offer palliative care to patients as an alternative to unreasonable obstinacy. The practical development of palliative care during the neonatal period is not easy, even though obstetricians and neonatologists have always been aware of the ethical necessity of comfort in the dying newborn. The decision leading to palliative care begins with the recognition of patent or potential unreasonable obstinacy, followed by withdrawing treatment and technical support, and finally a palliative care plan is drawn up with the medical team and the parents.
  Archives de Pédiatrie 03/2010; 17(4):409-12. · 0.30 Impact Factor
• Article: [Retrospective diagnosis of congenital CMV infection in DBS from Guthrie cards: French experience].

  M Leruez-Ville, C Vauloup-Fellous, S Couderc, S Parat, S Ouchérif, C Castel, J-F Magny
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  ABSTRACT: Systematic screening for cytomegalovirus congenital infection is not performed in France. For children with hearing loss or other neurological CMV compatible symptoms, retrospective diagnosis is possible by PCR detection of CMV DNA in dried blood spot of neonatal Guthrie cards. We report here the results obtained with this technique in the French national reference laboratory for cytomegalovirus.
  Archives de Pédiatrie 10/2009; 16(11):1503-6. · 0.30 Impact Factor
• Article: [Preventing childhood overweight by prenatal education of overweight or obese pregnant women].

  S Parat, V Nègre, F Lorenzini, E Cosson, M Tauber, A-M Bertrand, A Rodrigues, P Valensi, M Uzan, A Lapillonne, J-J Altman, M Dabbas, C Elie
  Archives de Pédiatrie 07/2009; 16(6):568-9. · 0.30 Impact Factor
• Article: [Premedication before tracheal intubation in French neonatal intensive care units and delivery rooms].

  E Walter-Nicolet, C Flamant, M Négréa, S Parat, P Hubert, D Mitanchez
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  ABSTRACT: Tracheal intubation is a painful procedure commonly used in the neonatal intensive care units and in the delivery rooms. It can be complicated by changes in vital signs. To ascertain the use of sedatives and/or analgesics before tracheal intubation in French neonatal intensive care units and delivery rooms. A survey by questionnaire sent to 58 neonatal intensive care units and 58 maternities. We obtained 46 responses (79,3%) from the neonatal intensive care units and 38 (65,5%) from the delivery rooms. In neonatal intensive care units, 74% of the newborns received a sedative and/or an analgesic before being intubated, and 60% of the units had specific written guidelines. Opioïds and benzodiazepines were the main drugs used. In the delivery rooms, sedatives or analgesics were only used in 21% of the centres. The use of sedation-analgesia seems to improve in neonatology but is still insufficient in the delivery rooms. The development of specific guidelines and a best learning about the different drugs are necessary.
  Archives de Pédiatrie 03/2007; 14(2):144-9. · 0.30 Impact Factor
• Article: Delayed surgery in pericardial teratoma with neonatal hydrops.

  D Mitanchez, A G Grébille, S Parat, P Vouhé, D Sidi, M Dommergues, P Hubert
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  ABSTRACT: Timing of neonatal surgery in cases of pericardial teratoma with hydrops is not standardised. We report two cases of hydropic premature newborns with pericardial teratoma in which surgery was delayed until respiratory and haemodynamic stabilisation. Mature teratoma was removed on day 3. The newborns were weaned from the ventilator on postoperative day 5 and 10, respectively. Both infants were doing well at 18 months, suggesting delayed surgery may be feasible and effective.
  European Journal of Pediatric Surgery 01/2006; 15(6):431-3. · 0.81 Impact Factor
• Article: P171: Three‐dimensional prenatal diagnosis of en epignathus teratoma

  R. Ruano, A. Benachi, M. C. Aubry, S. Parat, Y. Dumez, Y. Mannach, M. Dommergues
  Ultrasound in Obstetrics and Gynecology 08/2003; 22(S1):116 - 116. · 3.01 Impact Factor
• Article: Low-dose doxapram for treatment of apnoea following early weaning in very low birthweight infants: a randomized, double-blind study.

  C Huon, E Rey, P Mussat, S Parat, G Moriette
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  ABSTRACT: The effects of low-dose doxapram (0.5 mg kg(-1)h(-1)) in combination with caffeine were evaluated on apnoea frequency following weaning from mechanical ventilation, and on blood pressure, in very low birthweight (BW) premature infants. Twenty-nine infants with BW < or=1250 g, gestational age at birth (GA) <34 weeks and postnatal age <5 d, who required minimal respiratory support, were included. Following randomization, they received a loading dose of caffeine citrate and a continuous infusion of doxapram (doxapram, n=14) or placebo (n=15) was started. They were extubated 8 h after starting the infusion, which was continued for 5 d. During this period, weaning was well tolerated in both groups, apnoeas occurred less frequently and there was a greater increase in systolic blood pressure in infants treated with doxapram than in controls. Plasma doxapram levels were also higher than expected. It is therefore suggested that doxapram, even at low doses, should not be used during the first few days of life. Careful monitoring of blood pressure is required if doxapram is used later.
  Acta Paediatrica 12/1998; 87(11):1180-4. · 2.07 Impact Factor
• Article: Long-term pulmonary functional outcome of bronchopulmonary dysplasia and premature birth.

  S Parat, G Moriette, M F Delaperche, P Escourrou, A Denjean, C Gaultier
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  ABSTRACT: Pulmonary function and exercise tolerance were evaluated in late childhood in two groups of prematurely born children: one group with bronchopulmonary dysplasia (BPD) [n = 15; gestational age at birth (GA): 29.6 +/- 2.8 weeks; birth weight (BW): 1,367 +/- 548 g; age at test: 7.9 +/- 0.6 years], and a second group without significant neonatal lung disease [pre-term (PT)] (n = 9; GA: 30.3 +/- 1.7 weeks; BW: 1,440 +/- 376 g; age at test: 7.8 +/- 0.22 years). The results were compared with a control group of children of similar ages and heights, born at term [term born (TB)]. We observed that total lung resistance (RL) was significantly higher in BPD (11 +/- 3 cmH2O/L/s), and in PT (9 +/- 2) than in TB [5 +/- 1; (P < 0.001 and P < 0.05, respectively)]. In BPD RL was higher than in PT (P < 0.05). Dynamic lung compliance (CLdyn) was decreased in BPD (43 +/- 11 mL/cmH2O) and in PT (56 +/- 17) compared with TB (76 +/- 20) (P < 0.001 and P < 0.05), and also in BPD compared with PT (P < 0.05). Forced expiratory volume in 1 second (FEV1) and FEV1/forced vital capacity (FVC) were lower in BPD (1.07 +/- 0.15 L and 72 +/- 7%) than in PT (1.29 +/- 0.23 L, and 80 +/- 7%) (P < 0.05). Exercise tests were performed in six boys with BPD. The ratio between minute ventilation at maximal workload (VEmax) and the predicted value of maximal voluntary ventilation (MVV) was elevated in the six BPD boys tested, compared with five boys of Group 2 and five TB boys (87 +/- 15% vs. 62 +/- 14% and 65 +/- 13%) (P < 0.05). We conclude that: 1) prematurity and BPD is followed by long-term airway obstruction and a mild degree of exercise intolerance and; 2) premature birth without BPD may be followed by a milder degree of airway obstruction in childhood than in infants who developed BPD during the neonatal period.
  Pediatric Pulmonology 11/1995; 20(5):289-96. · 2.53 Impact Factor
• Article: [Deafness in the neonatal period: basis for screening].

  P Bonfils, M François, D Aidan, P Avan, S Parat, C Boissinot, P Narcy
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  ABSTRACT: Deafness must be recognized in infancy in order to reduce auditory disability to a minimum. To achieve this, it is important to implement screening programmes as soon after birth as possible. In the United States, the Joint Committee on Infant Hearing recommended in 1982 that identification of hearing loss should be screened in the neonatal period. This early detection is now considered critical for optimal rehabilitative outcome. This paper presents the "state of art" neonatal screening principles and procedures. In France, neonatal screening programs for auditory dysfunction are not consistent with these principles. Evoked otoacoustic emissions represent an important advance in screening for hearing loss in normal neonates and babies from neonatal intensive care units. This method records very low intensity sound energy released by the cochlea in response to a brief sound stimulation. These otoacoustic emissions show promise as a rapid, cost-effective means of quickly discharging all babies with normal peripherical auditory systems.
  Archives de Pédiatrie 08/1995; 2(7):685-91. · 0.30 Impact Factor
• Article: Congenital chylothorax with hydrops: postnatal care and outcome following antenatal diagnosis.

  P Mussat, M Dommergues, S Parat, L Mandelbrot, E de Gamarra, Y Dumez, G Moriette
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  ABSTRACT: We consecutively managed 25 cases of fetal chylothorax with hydrops (pleuroamniotic shunting in 20/25 cases). Three of the 16 liveborn infants died before day 5 from malformations (n = 1) or complications of antenatal origin (n = 2). Eleven of the 13 survivors were treated in our unit. Four infants whose chylothorax had resolved before birth following antenatal shunting were delivered at term, and had no respiratory disease. Seven infants, whose chylothorax persisted, were delivered prematurely and required intensive respiratory care (with mechanical ventilation for a median duration of 34 days). The 11 infants were maintained on total parenteral nutrition for a median duration of 31 days. They were discharged home after complete clinical recovery at a median age of 64 days. Antenatal pleuroamniotic shunting may improve the prognosis of congenital chylothorax with hydrops. Chylothorax persisting at birth resolves progressively with medical management.
  Acta Paediatrica 08/1995; 84(7):749-55. · 2.07 Impact Factor
• Article: [Respiratory outcome in premature infants].

  G Moriette, S Parat, C Gaultier
  Archives de Pédiatrie 08/1994; 1(7):633-8. · 0.30 Impact Factor
• Article: Use of preestablished criteria for deciding on extubation in the very low birthweight newborn. Preliminary analysis of a randomized study.

  C Huon, G Moriette, P Mussat, S Parat, J P Relier
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  ABSTRACT: The duration of mechanical ventilation (MV) in very low birthweight infants can sometimes be very prolonged, even in the absence of any respiratory disease. To avoid this, we have developed a double-blind study protocol of the concomitant use of caffeine and doxapram or caffeine and placebo as an aid to early weaning from MV. This protocol necessitated the definition of very precise ventilatory criteria for extubation. Even before the double-blind code has been broken, we can note that the duration of ventilation was very significantly reduced (p < 0.001) from 27.5 days (median; range 1-99) in infants of the retrospective study group to 4 days (median: range 1-34) in the prospective study group (extubation according to strict criteria). This reduction in duration of MV cannot be explained by a difference in the severity of the initial pathology, or by the treatment of some of the infants with doxapram (the difference would not be so marked), but, probably, to the definition of strict criteria concerning extubation.
  Biology of the Neonate 01/1993; 63(2):75-9. · 1.90 Impact Factor
• Article: Use of Preestablished Criteria for Deciding on Extubation in the Very Low Birthweight Newborn

  C. Huon, G. Moriette, P. Mussat, S. Parat, J.P. Relier
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  ABSTRACT: The duration of mechanical ventilation (MV) in very low birthweight infants can sometimes be very prolonged, even in the absence of any respiratory disease. To avoid this, we have developed a double-blind study protocol of the concomitant use of caffeine and doxapram or caffeine and placebo as an aid to early weaning from MV. This protocol necessitated the definition of very precise ventilatory criteria for extubation. Even before the double-blind code has been broken, we can note that the duration of ventilation was very significantly reduced (p < 0.001) from 27.5 days (median; range 1–99) in infants of the retrospective study group to 4 days (median: range 1–34) in the prospective study group (extubation according to strict criteria). This reduction in duration of MV cannot be explained by a difference in the severity of the initial pathology, or by the treatment of some of the infants with doxapram (the difference would not be so marked), but, probably, to the definition of strict criteria concerning extubation.
  Neonatology 08/1970; 63(2):75-79. · 2.66 Impact Factor
• Article: Prématurité, hyperréactivité bronchique et asthme

  P.H. Jarreau, S. Parat, G. Moriette
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  ABSTRACT: Prematurity and mechanical ventilation during the neonatal period are sometimes held responsible for the subsequent onset of asthma. In actual fact, analysis of the literature devoted to the problem appears contradictory because of methodological problems leading to the creation of non-homogeneous groups of premature infants whose initial situations are not comparable. It nevertheless seems that prematurity in itself is a risk factor regarding subsequent bronchial hyper-reactivity in challenge tests. The role of mechanical ventilation concerning this hyperreactivity is discussed (excluding possible progression to bronchopulmonary dysplasia). This hyperreactivity is not synonymous with asthma, the risk of onset of which is scarcely greater than in the population as a whole. The possible role of a family history of asthma in the onset of neonatal respiratory disorders or in their course has been raised but remains very uncertain.
  Revue Française d'Allergologie et d'Immunologie Clinique. 34(2):131-134.