A Sungur

Publications (44)162.88 Total impact

• Article: Unresponsiveness to human recombinant erythropoietin in an epileptic dialysis patient secondary to valproic acid toxicity.

  C Sungur, A Sungur, T Akpolat, U Yasavul, C Turgan, S Caglar
  Annals of Pharmacotherapy 10/1992; 26(9):1156. · 2.13 Impact Factor
• Article: Loss of heterozygosity in the VNTR region of intron 1 of P53 in two retinoblastoma cases.

  S Emre, A Sungur, S Bilgiç, M Büyükpamukçu, I Günalp, M Ozgüç
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  ABSTRACT: Loss of heterozygosity (LOH) was studied in 10 primary retinoblastoma tumors in the VNTR region of intron 1 in p53 gene by the polymerase chain reaction. To our knowledge mutations have not been reported in the p53 gene in retinoblastoma primary tumors. Heterozygosity was found at this region in 5 of 10 cases. Two pathology paraffin block samples showed loss of heterozygosity.
  Pediatric Hematology and Oncology 13(3):253-6. · 0.89 Impact Factor
• Article: A linkage analysis in two families with bilateral retinoblastoma.

  S Emre, A Sungur, V Hazar, S Bilgiç, M Büyükpamukçu, I Günalp
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  ABSTRACT: Using polymerase chain reaction (PCR) amplification from blood samples, Xbal and BamHI polymorphisms were analyzed in two families with bilateral retinoblastoma. In one of the families it was predicted using the BamHI polymorphism that the 200 bp allele co-segregates with the disease. This family was uninformative for Xbal polymorphism. The second family was uninformative for both Xbal and BamHI polymorphism.
  The Turkish journal of pediatrics 38(4):413-7. · 0.44 Impact Factor
• Article: Bcl-2 and LMP1 expression in nasopharyngeal carcinomas.

  S Sarac, M U Akyol, B Kanbur, A Poyraz, G Akyol, T Yilmaz, A Sungur
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  ABSTRACT: In vitro studies of B-cells immortalized by Epstein-Barr Virus (EBV) have shown that B-cell leukemia/lymphoma-2 (bcl-2) protein expression is upregulated by the EBV-latency-associated antigen, latent membrane protein 1 (LMP1). The same phenomenon has also been observed in epithelial cells in vitro. However, such correlation between these 2 markers has not been shown in nasopharyngeal carcinoma (NPC), in which EBV infection is a well-known etiologic factor. This retrospective study examined 35 cases of undifferentiated NPC to answer the question of whether LMP1 and/or bcl-2 presence can be used as biomarkers at treatment response, as well as to see the relationship between bcl-2 and LMP in NPC. Of the 35 patients, 26 (74.3%) were bcl-2, and 10 (28.6%) were LMP1-positive. Although a significant correlation was observed between bcl-2 and LMP1 staining (P =.003), it appeared that bcl-2 expression could be independent of LMP1. Statistical analysis showed that cervical lymph node metastasis (P =.04) and cranial nerve involvement (P =.03) are the only variables that significantly affect patient survival. At this time, bcl-2 and LMP1 presence are not significant indicators of outcome; however, although they are not directly related to survival, expression of both bcl-2 and LMP1 was strongly correlated with cervical lymph node metastasis, which is a potent predictor of patient survival.
  American Journal of Otolaryngology 22(6):377-82. · 0.87 Impact Factor