Turgay Akgül

Publications (16)38.93 Total impact

• Article: Ginkgo biloba (EGB 761) affects apoptosis and nitric-oxide synthases in testicular torsion: an experimental study

  Turgay Akgül, Ersagun Karagüzel, Hatice Sürer, Hatice Yağmurdur, Ali Ayyıldız, Hüseyin Üstün, Cankon Germiyanoğlu
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  ABSTRACT: IntroductionWe investigated the effect of ginkgo biloba on germ cell apoptosis and also on expressions of endothelial (eNOS) and inducible (iNOS) nitric oxide synthases after testicular torsion. Materials and methodsThirty-two Wistar albino rats were randomly assigned into four groups. Torsion/detorsion (T/D) was performed on the rats in group 1, group 2 received ginkgo biloba for a month before T/D, group 3 received only gingko biloba for a month, and group 4 was the sham group. Left testicular torsion was created in group 1 and group 2, and the testes were untwisted and replaced in the scrotum for reperfusion. No procedure was applied to group 3, and after 1 month, testes were removed in all groups. ResultsMean apoptotic cell, eNOS, and iNOS were increased in group 1. Group 2 showed significantly decreased apoptotic cells, eNOS, and iNOS in testes compared to group 1 (P<0.05). The rats in group 3 had significantly decreased apoptotic cell, eNOS, and iNOS values, like the sham group (P<0.05), and this group provided basal values. ConclusionsGinkgo biloba, as a free radical scavenger, seems to have a protective role against apoptosis in testicular ischemia reperfusion injury.
  International Urology and Nephrology 04/2012; 41(3):531-536. · 1.47 Impact Factor
• Article: Do hydronephrosis and extracorporeal shock wave lithotripsy affect carbohydrate antigens?

  Turgay Akgül, Barış Nuhoğlu, Ali Ayyıldız, Uğur Balcı, Sema Nur Ayyıldız, Cankon Germiyanoğlu
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  ABSTRACT: ObjectivesTo investigate carbohydrate antigen (CA 19-9, CA 15-3, and CA 125) levels in the patients who had hydronephrosis with renal stones and in whom Extracorporeal shock wave lithotripsy (ESWL) was performed. Materials and MethodsThis prospective study included 20 people with no known disease for control group and 30 patients who had hydronephrosis with renal stones and in whom ESWL was performed between January 2005 and January 2006. None of patients had urinary infection and malignancy. The blood for carbohydrate antigens was taken pre-ESWL and 30min after ESWL in both groups. CA 19-9, CA 15-3, and CA 125 in the serum were tested with the electro-immunoassay method on the Roche® E-170 apparatus with the original Roche® kit. ResultsThe CA 19-9 and CA 125 values in the patients group were found to be statistically significant when compared with the control group but the CA 15-3 was not found to be significant. However, CA 19-9, CA 15-3, and CA 125 values of post-ESWL were not statistically significant when compared with pre-ESWL group (P>0.05). ConclusionsThe average serum values of CA 125 and CA 19-9 in patients were found to be significantly high. However, serum values of CA 19-9, CA 15-3, and CA 125 were not affected by ESWL.
  International Urology and Nephrology 04/2012; 39(4):1001-1004. · 1.47 Impact Factor
• Article: A very unusual anatomical variation and complication of common iliac artery and ureter in retroperitonoscopic ureterolithotomy.

  Emre Huri, Turgay Akgül, Tolga Karakan, Mustafa Sargon, Cankon Germiyanoğlu
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  ABSTRACT: Anatomical localization of theureter comes along psoas major muscle and crosses over common iliac artery bifurcation. Common iliac artery aneurysm and impacted atherosclerosis are a rare condition that should be differed from the impacted ureter stone to avoid from undesirable complication. In this case, we present a very unusual anatomical variation and complication of common iliac artery and ureter in retroperitonoscopic ureterolithotomy.
  Journal of Minimal Access Surgery 04/2011; 7(2):145-6.
• Article: Phosphodiesterase 5 inhibitors attenuate renal tubular apoptosis after partial unilateral ureteral obstruction: an experimental study.

  Turgay Akgül, Emre Huri, Hatice Yagmurdur, Ali Ayyıldız, Hüseyin Ustün, Cankon Germiyanoğlu
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  ABSTRACT: The aim of the present study was to evaluate the effects of phosphodiesterase 5 inhibitors on renal tubular apoptosis and also on expressions of endothelial and inducible nitric oxide synthases (eNOS and iNOS) in the ipsilateral kidney after partial unilateral ureteral obstruction (PUUO) in a rat model. Forty Wistar albino rats were divided into five groups. In Groups 1-4, left experimental PUUO was created. Sildenafil, vardenafil, and tadalafil were administrated to the rats of Groups 2-4, respectively. The pills were orally given to the rats for 30 days. Group 5 was defined as sham. After 30 days, all rats were sacrificed, and nephrectomy was performed. The renal specimens were examined histopathologically. Left hydroureteronephrosis was observed in Groups 1-4. Mean apoptotic cell count and eNOS and iNOS levels were significantly increased in Group 1 when compared with the other groups. The rats in Groups 2-4 showed significantly decreased apoptotic cell count and eNOS and iNOS values in the renal tubular tissue in accordance with Group 1 (p<0.05). There were significant differences in apoptotic cell counts between sildenafil group and the other two study groups. The sildenafil group demonstrated lesser apoptotic cell count than the vardenafil (p=0.021) and tadalafil (p=0.009) groups. PUUO increases the renal tubular apoptosis and elevates NOS concentrations in renal tubular tissue after PUUO. Phosphodiesterase 5 inhibitors have a protective effect against the tubular apoptosis.
  The Kaohsiung journal of medical sciences 01/2011; 27(1):15-9. · 0.61 Impact Factor
• Article: First clinical experience of Ankaferd BloodStopper as a hemostatic agent in partial nephrectomy.

  Emre Huri, Turgay Akgül, Ali Ayyildiz, Murat Bağcioğlu, Cankon Germiyanoğlu
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  ABSTRACT: Open partial nephrectomy is an effective and safe alternative treatment modality to radical nephrectomy for small renal tumors. Many techniques that use hemostatic agents have been described to provide hemostasis during this procedure. Ankaferd BloodStopper® (ABS) is a unique folkloric medicinal plant extract that has been used historically in Turkish traditional medicine as a hemostatic agent. ABS has therapeutic potential to manage hemorrhage and this agent should be investigated in clinical trials. In the present case, we evaluated the effectiveness of ABS in partial nephrectomy and reviewed the literature.
  The Kaohsiung journal of medical sciences 09/2010; 26(9):493-5. · 0.61 Impact Factor
• Article: Re: Effect of Suturing Technique and Urethral Plate Characteristics on Complication Rate Following Hypospadias Repair: A Prospective Randomized Study.

  Emre Huri, Turgay Akgül, Cankon Germiyanoğlu
  The Journal of urology 03/2010; · 4.02 Impact Factor
• Article: Experiences in laparoscopic removal of upper ureteral stones: multicenter analysis of cases, based on the TurkUroLap Group.

  Emre Huri, Erem Kaan Basok, Ozgür Uğurlu, Cenk Gurbuz, Turgay Akgül, Yaşar Ozgök, Selahattin Bedir
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  ABSTRACT: Laparoscopic surgery for ureteral stones was restricted to special cases-those with large or impacted ureteral stones. We present special cases of patients who underwent laparoscopic ureterolithotomy at various clinics in Turkey. Forty-one patients were included in the study from five urology clinics in which laparoscopic surgery was being performed. After a disease-specific history and physical examination, age and sex were recorded. The mean patient age was 41.8 years (30 men and 11 women). Urinalysis, determination of creatinine level, intravenous urography, and ultrasonography were performed. The parameters of stone size, presence of hydronephrosis, previous shockwave lithotripsy, previous ureteroscopic stone therapy, type of laparoscopic approach, operative time, ureteral incision, insertion of a Double-J stent, amount of drainage, hospitalization period, and perioperative complications were evaluated. Mean ureteral stone size was 22 mm. The retroperitoneoscopic approach was preferred in 35 (85.3%) patients, while the transperitoneal approach was used in 6 (14.7%) patients. Grade I hydronephrosis was detected in 4 patients, grade 2 in 22 patients, and grade 3 in 12 patients. In six patients, a history of shockwave lithotripsy was confirmed. The ureteral wall was incised with a cold knife in 5, scissors in 16, J-hook in 3, and a monopolar or bipolar dissector in 17 patients. In six patients, a Double-J stent was inserted, while in one patient, the operation was converted to an open procedure. The mean operative time was 124 minutes. The mean amount of drainage was 220 ml. Mean hospitalization time was 4.8 days. In five (12.5%) of seven patients, persistent drainage was a major complication that was managed by insertion of a Double-J stent. All patients were discharged stone free. Increased hospitalization and operative time can be related to the large stone sizes and prolonged urine leakage. In our opinion, however, the overall success of laparoscopic ureterolithotomy makes it a feasible and effective procedure, especially for stones that could not be managed easily with ureteroscopic stone therapy.
  Journal of endourology / Endourological Society 03/2010; 24(8):1279-82. · 1.75 Impact Factor
• Article: Hemostatic role of a folkloric medicinal plant extract in a rat partial nephrectomy model: controlled experimental trial.

  Emre Huri, Turgay Akgül, Ali Ayyildiz, Hüseyin Ustün, Cankon Germiyanoğlu
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  ABSTRACT: Ankaferd BloodStopper is a mixture of 5 plants used in traditional Turkish medicine as hemostatic agent for external traumatic, postoperative and dental bleeding. We investigated the hemostatic efficacy of Ankaferd BloodStopper for partial nephrectomy. A total of 24 Wistar rats were divided into 4 groups of 6 each. Group 1 underwent partial nephrectomy with hilar control as the conventional technique. Group 2 underwent the conventional technique with hemostatic agent application. Group 3 underwent hemostatic agent application to the renal parenchyma. In Group 4 partial nephrectomy was performed and the hemostatic agent was used without hilar control. Warm ischemia and partial nephrectomy times, and the number of hemostatic agent applications were recorded. Histopathological evaluations were completed. The Fisher, Kruskal-Wallis and Mann-Whitney U tests were used for statistical analysis. Mean kidney size was 2 x 2.5 x 0.05 cm. Mean partial nephrectomy time was 3.7, 2.7, 1.8 and 3.2 minutes in groups 1 to 4, respectively, which was significantly different between groups 1 and 3 (p = 0.007). Warm ischemia time in group 3 was less than in group 1 (p = 0.011). The number of hemostatic agent applications was higher in groups 3 and 4 compared to those in group 2 (p = 0.003). Glomerular necrosis was detected at a higher rate in group 1 compared to that in groups 3 and 4 (p = 0.015). Calcification formed significantly more in group 1 than in groups 2 to 4 (p <0.05). Erythrocyte aggregation was greater in groups 2 to 4 than in group 1 (p = 0.015). Giant cell reaction, fibrosis, inflammation and microvascular proliferation were not statistically different among the groups (p >0.05). Ankaferd BloodStopper decreases partial nephrectomy and warm ischemia times, and provides hemostasis. Erythrocyte aggregation confirmed the hemostatic action of the agent, while the absence of glomerular necrosis and calcification may have positive relevance.
  The Journal of urology 03/2009; 181(5):2349-54. · 4.02 Impact Factor
• Article: Effect of cyanoacrylic glue on penile fracture: an experimental study.

  Turgay Akgül, Ali Ayyildiz, Ozden Cebeci, Bariş Nuhoğlu, Elif Ozer, Cankon Germiyanoğlu, Hüseyin Ustün
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  ABSTRACT: We investigated the effect of Glubran(R)2 cyanoacrylic glue on rat cavernous tissue after forming penile fractures experimentally as well as the histopathological effect. We also investigated its clinical use. Experimental penile fracture was formed by incising from the proximal dorsal side of the penis in 32 Wistar Albino rats. The rats were randomly assigned to 4 main groups of 8 each. In the control group the incision was not repaired and it was left to secondary healing. In the glue group cyanoacrylic glue was only applied to the incision region. In the primary repair group the incision was primarily repaired and in the final group cyanoacrylic glue was applied to the incision region following primary repair. Three weeks later penectomy materials were examined histopathologically. When the control group was compared with the other groups, the differences in cavernous tissue healing with fibrosis and hyperemia-bleeding were statistically significant (p = 0.043 and 0.003, respectively). In the glue group fibrosis was observed in 2 rats. This group was the best according to cavernous healing. Although there was no significant difference between the control group and the other groups according to inflammation (p = 0.057), the glue group was better than the primary repair group (p = 0.026). No significant inflammation or hyperemia-bleeding was observed in the glue group. When the experimental groups were evaluated for histopathological parameters, it was observed that the best results were obtained in the glue group. Cyanoacrylic glue can be used in cavernous surgery due to its hemostatic, adhesive and anti-inflammatory properties.
  The Journal of urology 09/2008; 180(2):749-52. · 4.02 Impact Factor
• Article: Ginkgo biloba (EGb 761) usage attenuates testicular injury induced by testicular ischemia/reperfusion in rats

  Turgay Akgül, Ali Ayyıldız, Barış Nuhoğlu, Ersagun Karagüzel, Elmas Öğüş, Hatice Yağmurdur, Hüseyin Üstün, Cankon Germiyanoğlu
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  ABSTRACT: IntroductionWe investigated the effect of ginkgo biloba on testicular ischemia-reperfusion (IR) injury. Materials and methodsThirty-two Wistar Albino rats were randomly assigned into four groups. Torsion/detorsion (T/D) performed to the rats in group 1, group 2 received ginkgo biloba (50mg/day) for a month before T/D, group 3 received only gingko biloba (50mg/day) for a month and group 4 was defined as sham group. After 1month the testes were removed. ResultsMean testicular malondialdehyde, nitrate and nitrite levels were significantly increased in group 1 compared to groups 2, 3 and 4 (P<0.05). The rats in group 3 provided basal histological appearance. In group 1, edema, congestion and hemorrhage between seminiferous tubules were predominant. In group 2, histopathologic features were markedly less than group 1. ConclusionsMalondialdehyde, nitrate and nitrite levels were increased after unilateral testicular torsion. EGb 761 has a protective effect on testicular injury induced by IR.
  International Urology and Nephrology 08/2008; 40(3):685-690. · 1.47 Impact Factor
• Source

  Available from: urologyjournal.org

  Article: Comparison of sertraline and citalopram for treatment of premature ejaculation.

  Turgay Akgül, Tolga Karakan, Ali Ayyildiz, Cankon Germiyanoğlu
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  ABSTRACT: We evaluated the efficacy of citalopram and sertraline in the treatment of premature ejaculation (PE). Of 101 married men with PE, 80 were eligible and consented to participate in this randomized controlled trial. Erectile dysfunction and administration of drugs for the treatment of PE were the exclusion criteria. The patients were evaluated using index of premature ejaculation (IPE) questionnaire and were randomly assigned into groups 1 (sertraline) and 2 (citalopram). They received one of these drugs for 8 weeks and then were re-evaluated by the IPE. Pretreatment and posttreatment results were compared within and between the study groups. A total of 80 patients entered and completed the study. The mean age of the patients was 38.4 +/- 7.7 in group 1 and 37.5 +/- 6.9 in group 2 (P = .60). The mean pretreatment IPE scores were 21.4 +/- 1.8 and 20.9 +/- 1.3 in the patients of groups 1 and 2, respectively (P = .23). After 8 weeks, significant improvement was seen in both groups in terms of the IPE questionnaire results (39.8 +/- 1.4; P < .001 and 39.5 +/- 2.9; P < .001, respectively). However, the treatment response was not different between the 2 groups (P = .50). No serious adverse effects were detected in any of the patients and both drugs were tolerated well. Citalopram and sertraline are safe and effective in patients with PE. Additionally, we failed to find any difference between the effects of these two drugs in the treatment of this condition.
  Urology journal 01/2008; 5(1):41-5. · 0.58 Impact Factor
• Article: Ginkgo biloba (EGb 761) usage attenuates testicular injury induced by testicular ischemia/reperfusion in rats.

  Turgay Akgül, Ali Ayyildiz, Bariş Nuhoğlu, Ersagun Karagüzel, Elmas Oğüş, Hatice Yağmurdur, Hüseyin Ustün, Cankon Germiyanoğlu
  [show abstract] [hide abstract]
  ABSTRACT: We investigated the effect of ginkgo biloba on testicular ischemia-reperfusion (IR) injury. Thirty-two Wistar Albino rats were randomly assigned into four groups. Torsion/detorsion (T/D) performed to the rats in group 1, group 2 received ginkgo biloba (50 mg/day) for a month before T/D, group 3 received only gingko biloba (50 mg/day) for a month and group 4 was defined as sham group. After 1 month the testes were removed. Mean testicular malondialdehyde, nitrate and nitrite levels were significantly increased in group 1 compared to groups 2, 3 and 4 (P<0.05). The rats in group 3 provided basal histological appearance. In group 1, edema, congestion and hemorrhage between seminiferous tubules were predominant. In group 2, histopathologic features were markedly less than group 1. Malondialdehyde, nitrate and nitrite levels were increased after unilateral testicular torsion. EGb 761 has a protective effect on testicular injury induced by IR.
  International Urology and Nephrology 11/2007; 40(3):685-90. · 1.47 Impact Factor
• Article: Re: Hamid Mazdak, Iraj Meshki and Fatemeh Ghassami. Effect of mitomycin C on anterior urethral stricture recurrence after internal urethrotomy. Eur Urol 2007;51:1089-92.

  Ali Ayyildiz, Turgay Akgül, Bariş Nuhoğlu
  European Urology 10/2007; 52(3):929. · 8.49 Impact Factor
• Article: Re: A prospective, randomized trial comparing conventional transurethral prostate resection with PlasmaKinetic vaporization of the prostate: physiological changes, early complications and long-term followup: N. H. Hon, D. Brathwaite, Z. Hussain, S. Ghiblawi, H. Brace, D. Hayne and S. W. Coppinger. J Urol 2006; 176: 205-209.

  Turgay Akgül, Bariş Nuhoğlu, Ali Ayyildiz
  The Journal of Urology 05/2007; 177(4):1587. · 3.75 Impact Factor
• Article: Re: Transcutaneous electrical nerve stimulation: an effective treatment for pain caused by renal colic in emergency care. B. Mora, E. Giorni, M. Dobrovits, R. Barker, T. Lang, C. Gore and A. Kober, J Urol 2006; 175: 1737.

  Ali Ayyildiz, Turgay Akgül, Bariş Nuhoğlu
  The Journal of Urology 02/2007; 177(1):405. · 3.75 Impact Factor
• Article: Do hydronephrosis and extracorporeal shock wave lithotripsy affect carbohydrate antigens?

  Turgay Akgül, Bariş Nuhoğlu, Ali Ayyildiz, Uğur Balci, Sema Nur Ayyildiz, Cankon Germiyanoğlu
  [show abstract] [hide abstract]
  ABSTRACT: To investigate carbohydrate antigen (CA 19-9, CA 15-3, and CA 125) levels in the patients who had hydronephrosis with renal stones and in whom Extracorporeal shock wave lithotripsy (ESWL) was performed. This prospective study included 20 people with no known disease for control group and 30 patients who had hydronephrosis with renal stones and in whom ESWL was performed between January 2005 and January 2006. None of patients had urinary infection and malignancy. The blood for carbohydrate antigens was taken pre-ESWL and 30 min after ESWL in both groups. CA 19-9, CA 15-3, and CA 125 in the serum were tested with the electro-immunoassay method on the Roche E-170 apparatus with the original Roche kit. The CA 19-9 and CA 125 values in the patients group were found to be statistically significant when compared with the control group but the CA 15-3 was not found to be significant. However, CA 19-9, CA 15-3, and CA 125 values of post-ESWL were not statistically significant when compared with pre-ESWL group (P > 0.05). The average serum values of CA 125 and CA 19-9 in patients were found to be significantly high. However, serum values of CA 19-9, CA 15-3, and CA 125 were not affected by ESWL.
  International Urology and Nephrology 01/2007; 39(4):1001-4. · 1.47 Impact Factor