Christophe Tournigand

Hôpital Henri Mondor (Hôpitaux Universitaires Henri Mondor), Créteil, Île-de-France, France

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Publications (166)794.84 Total impact

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    ABSTRACT: The management of unresectable metastatic colorectal cancer (mCRC) is a comprehensive treatment strategy involving several lines of therapy, maintenance, salvage surgery, and treatment-free intervals. Besides chemotherapy (fluoropyrimidine, oxaliplatin, irinotecan), molecular-targeted agents such as anti-angiogenic agents (bevacizumab, aflibercept, regorafenib) and anti-epidermal growth factor receptor agents (cetuximab, panitumumab) have become available. Ultimately, given the increasing cost of new active compounds, new strategy trials are needed to define the optimal use and the best sequencing of these agents. Such new clinical trials require alternative endpoints that can capture the effect of several treatment lines and be measured earlier than overall survival to help shorten the duration and reduce the size and cost of trials. STRATEGIC-1 is an international, open-label, randomized, multicenter phase III trial designed to determine an optimally personalized treatment sequence of the available treatment modalities in patients with unresectable RAS wild-type mCRC. Two standard treatment strategies are compared: first-line FOLFIRI-cetuximab, followed by oxaliplatin-based second-line chemotherapy with bevacizumab (Arm A) vs. first-line OPTIMOX-bevacizumab, followed by irinotecan-based second-line chemotherapy with bevacizumab, and by an anti-epidermal growth factor receptor monoclonal antibody with or without irinotecan as third-line treatment (Arm B). The primary endpoint is duration of disease control. A total of 500 patients will be randomized in a 1:1 ratio to one of the two treatment strategies. The STRATEGIC-1 trial is designed to give global information on the therapeutic sequences in patients with unresectable RAS wild-type mCRC that in turn is likely to have a significant impact on the management of this patient population. The trial is open for inclusion since August 2013. STRATEGIC-1 is registered at NCT01910610 , 23 July, 2013. STRATEGIC-1 is registered at EudraCT-No.: 2013-001928-19, 25 April, 2013.
    BMC Cancer 12/2015; 15(1):496. DOI:10.1186/s12885-015-1503-7 · 3.32 Impact Factor
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    ABSTRACT: Colorectal cancer (CRC) is a growing cause of mortality in developing countries warranting investigation into its etiopathogenesis and earlier diagnosis. Here, we investigated the fecal metabolic phenotype of patients with advanced colorectal neoplasia and controls using 1H-nuclear magnetic resonance (NMR) spectroscopy and multivariate modeling. Wif-1 methylation levels in stools, serum and urine and seven fecal dominant and subdominant bacterial populations were quantified and correlated to metabolic profile of each patients. The predictivity of the model was 0.507 (Q2Y) and the explained variance was 0.755 (R2Y). Patients with advanced colorectal neoplasia demonstrated increased fecal concentrations of four short-chain fatty acids (valerate, acetate, propionate and butyrate) and decreased signals relating to β-glucose, glutamine and glutamate. The predictive accuracy of the multivariate 1H-NMR model was higher than guaiac-fecal occult blood test and Wif-1 methylation test for predicting advanced colorectal neoplasia. Correlation analysis between fecal metabolites and bacterial profiles revealed strong associations between Faecalibacterium prausnitzii and Clostridium leptum species with short-chain fatty acids concentration and inverse correlation between Faecalibacterium prausnitzii and glucose. These preliminary results suggest that fecal metabonomics may potentially have a future role in non-invasive colorectal screening program and may contribute to our understanding of the role of these dysregulated molecules in the cross-talk between the hosts and its bacterial microbiota.
    Journal of Proteome Research 07/2015; DOI:10.1021/acs.jproteome.5b00277 · 5.00 Impact Factor
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    ABSTRACT: We aim to assess the prevalence and associated factors of clinical depression in older patients with cancer. We studied a prospective cohort of cancer patients aged ≥70 years and referred to geriatric oncology clinics between 2007 and 2012. A multidimensional geriatric assessment was performed before choosing the cancer-treatment strategy. Clinical depression was diagnosed by senior geriatricians by a semi-structured interview. It encompassed criteria of the Diagnostic and Statistical Manual of Mental Disorders (fourth edition) and of the International Classification of Diseases (10th edition). Multivariate logistic regression was performed. Of 1121 consecutive patients, 1092 had available data (mean age, 80.4 years; women, 48.8%; metastases, 51.3%; cancer location: colorectal 21.1%, breast 16.8%, kidney, bladder or urinary tract 14.0%, and prostate 11.4%). The overall prevalence of clinical depression was 28.4% (95% confidence interval, 25.7-31.2). Factors independently associated with clinical depression by multivariate analysis adjusting for all following factors plus gender, and metastasis were impaired mobility (adjusted odds ratio [aOR], 2.35; 1.59-3.46), impaired functional status defined as Eastern Cooperative Oncology Group Performance Status ≥ 2 (aOR, 2.39; 1.66-3.43) or as activities of daily living < 6 (aOR, 2.43; 1.73-3.41), inpatient status (aOR, 1.68; 1.20-2.37), inadequate social support (aOR, 1.66; 1.16-2.37), cognitive impairment (aOR, 1.76; 1.24-2.49), polypharmacy defined as five or more non-antidepressant drugs (aOR, 1.65; 1.14-2.38), multimorbidity (aORadditional CIRS-G point , 1.08; 1.04-1.12), and cancer-related pain (aOR, 1.76; 1.26-2.46). In older patients with as-yet untreated cancer at various sites and stages, clinical depression was highly prevalent. Clinical depression was independently associated with several geriatric assessment findings (impaired mobility and function, inadequate social support, cognitive impairment, polypharmacy, and multimorbidity) independently from gender, tumor site, and metastatic status. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.
    Psycho-Oncology 06/2015; DOI:10.1002/pon.3886 · 4.04 Impact Factor
  • Annals of Oncology 06/2015; 26(suppl 4). DOI:10.1093/annonc/mdv234.09 · 6.58 Impact Factor
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    ABSTRACT: Systemic therapy is the standard care for patients with unresectable advanced colorectal cancer (CRC), but salvage surgery of metastatic disease should be considered in the case of adequate tumor shrinkage. Several drugs and combinations are now available for use in treating patients with advanced CRC, but the optimal sequence of therapy remains unknown. Moreover, the administration of antitumor therapy can be modulated by periods of maintenance or treatment breaks rather than delivered as full therapy until disease progression or unacceptable toxicity, followed by reintroduction of prior full therapy when required, before switching to other drugs. Consequently, randomized strategy trials are needed to define the optimal treatment sequences. Molecular testing for Kirsten rat sarcoma viral oncogene homolog (KRAS) and neuroblastoma RAS viral oncogene homolog (NRAS) is mandatory but not sufficient to select appropriate patients for epidermal growth factor receptor (EGFR) monoclonal antibody (MoAb) therapy.
    04/2015; 7(3). DOI:10.1177/1758834015572343
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    ABSTRACT: Mortality prediction is crucial to select the optimal treatment in elderly cancer patients. Our objective was to identify cancer-related factors and Comprehensive Geriatric Assessment (CGA) findings associated with 1-year mortality in elderly inpatients and outpatients with cancer. We prospectively included patients aged ≥70 years who had solid or hematologic malignancies and in whom the CGA was performed by geriatricians in two French teaching hospitals. We identified independent predictors of 1-year mortality after study inclusion, using multivariate Cox models stratified on inpatient/outpatient status. We built three multivariate Cox models, since strong correlations linked activities of daily living (ADL), Eastern Cooperative Oncology Group Performance Status (ECOG-PS), and timed get-up-and-go test (GUG) results; and since physicians' preferences for these three assessments vary. A sensitivity analysis was performed using multiple imputation. Of the 993 patients (mean age, 80.2 years; 51.2% men), 58.2% were outpatients and 46% had metastatic disease. Colorectal cancer was the most common malignancy (21.4%). Mortality rates after 6 and 12 months were 30.1% and 41.2%, respectively. In all models, tumor site and metastatic status (p < .001), age >80 years (p < .05), higher number of severe comorbidities (p < .05), and malnutrition (p < .001) were associated with death independently from impaired ECOG-PS (p < .001), ADL (p < .001), and GUG (p < .001). The adverse effect of metastatic status differed significantly across tumor sites, being greatest for breast and prostate cancer (p < .001). Multiple imputation produced similar results. The predictors of 1-year mortality identified in our study may help physicians select the optimal cancer-treatment strategy in elderly patients. © The Author 2015. Published by Oxford University Press on behalf of the Gerontological Society of America. All rights reserved. For permissions, please email:
    The Journals of Gerontology Series A Biological Sciences and Medical Sciences 04/2015; DOI:10.1093/gerona/glv025 · 4.98 Impact Factor
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    ABSTRACT: Trastuzumab with 5-fluorouracil (5-FU) and cisplatin offers prolonged survival in patients with HER2-overexpressing advanced gastric cancer (AGC) and advanced gastro-oesophageal junction cancer (AGOJ). Oxaliplatin in combination with intravenous 5-FU plus leucovorin (LV; modified [m]FOLFOX6) or capecitabine (XELOX) improves tolerability compared with 5-FU/cisplatin regimen. There are few data available on the efficacy and safety of trastuzumab-oxaliplatin-based chemotherapy in previously untreated HER2-positive AGC and AGOJ patients. Clinical data were retrospectively analysed in patients receiving trastuzumab plus mFOLFOX6 or XELOX as first-line therapy between July 2009 and December 2012. Eligible patients had histologically proven AGC or AGOJ, HER2 overexpression, and no prior chemotherapy for metastatic disease. Thirty-four patients met the eligibility criteria. Median age was 63 years, 79% of patients had ECOG PS score of 0-1, and all had metastatic disease. Median duration of treatment was 7.5 months. Overall response rate was 41% (95% CI: 25-56). Median progression-free survival and overall survival were 9.0 months (95% CI: 5.6-12) and 17.3 months (95% CI: 13.5-32.3), respectively. Tolerability was acceptable. The most frequent grade 3-4 toxicities were neutropenia (8.8%) and neuropathy (17.6%). mFOLFOX6-trastuzumab combination is an efficient regimen with an acceptable safety profile for AGC and AGOJ patients. These results warrant further prospective study. Copyright © 2015 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.
    Bulletin du cancer 03/2015; 102(4). DOI:10.1016/j.bulcan.2014.08.001 · 0.64 Impact Factor
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    ABSTRACT: Background: Four different antiangiogenic treatment are approved in first line advanced Renal Cell Carcinoma (RCC): sunitinib (Su), pazopanib (Pa), sorafenib (So) and bevacizumab (Be). Due to parallel development, most of them were not directly compared for efficacy and toxicities. The aim of the present study was to perform a network meta-analysis in order to compare each drug to the others for efficacy and safety outcome. Methods: As of the 31th of July 2014, two independent reviewers searched and collected data of randomized clinical trials (RCT) of first line assessing at least one approved antiangiogenic drug in advanced RCC (Su, Pa, So, Be). The study measured the following outcomes: response rate, progression-free survival (PFS), overall survival (OS), safety (CTCAE). We calculated a traditional weighted average meta-analysis and then conducted a network meta-analysis: we examined the network formed by treatments performing a linear mixed-effect model. Results: We screened 411 abstracts and selected 17 different articles corresponding to 9 RCT including 5,050 patients Treatment arms were: 3 Su, 2 Pa, 2 So, 1 Be, 3 Be+Interferon alpha (INF2A), 2 Placebo (Pl), 4 INF2A. Efficacy meta-analysis showed significantly improvement of PFS (HR = .6; IC95% .55-.65) and OS (HR = .87; IC95% .80-.95) compared to Pl or INF2A. Network meta-analysis showed: significantly better 6-month PFS for Su or Pa compared to So (OR = 1.6; IC95% 1.1-2.4 and 1.4; IC95% 1.0-2.1, respectively) or Be+IFN (OR = 1.4; IC95% 1.0-1.9 and 1.2; IC95% 0.9-1.8, respectively); no difference between antiangiogenics for drug-related toxicity discontinuation, all grade toxicity for hypertension, diarrhea, and weight loss (Su, Pa, So); significantly more treatment discontinuation with Be+IFN (vs Su, Pz, or So), less all grade fatigue for Pa vs (Su, So or Be+IFN), more all grade anemia for Su vs (Pa, So, or Be+IFN). Conclusions: This meta-analysis confirms benefits of first line antiangiogenic in advanced RCC both for PFS and OS. Network meta-analysis suggests better 6-month PFS for Su or Pa compared to Be+IFN or So, and different safety profiles that may help clinicians to better individualize treatment.
    Journal of Clinical Oncology 01/2015; 33((suppl; abstr e15586)). · 18.43 Impact Factor
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    ABSTRACT: Background: Because of weak solubility in water, many cytotoxics are dissolved in ethanol. FDA recently raised alert noticing that patients could be intoxicated after their treatments. The main alcohol-containing chemotherapy drugs are gemcitabine (Gem), paclitaxel (Pac) and docetaxel (Doc). We explored prospectively blood alcohol levels in pts treated with Gem, Pac or Doc. Methods: Alcohol concentration was determined by peripheral blood sample before chemotherapy infusion (T0), at the end (T1) and 30 min later (T2) in three different prospective cohorts (Gem, Pac, Doc) in a single institution. Bioelectrical impedance analysis was performed to estimate fluid volume in order to calculate theoretical alcohol level. Clinical impact was evaluated through psychometric tests (Zazzo attention test, Stroop test) before and at the end of chemotherapy infusion. Results: 60 consecutive patients were included in our study (M/F 29/31) (Gem n = 21, Pac n = 19, Doc n = 21). Median age was 63.8 yrs (35-88). Median Gem infusion duration (ID) was 100 minutes. Median alcohol administration was 20.5 g (11.6-26). T0 alcohol concentration was 0 g/l, T1 0.32 g/l (0.1-0.65), T2 0.17g/l (0.1-0.4).Median Pac ID was 96 minutes. Median alcohol administration was 9.5 g (6.9-10.5). T0 alcohol concentration was 0 g/l, T1 0.1 g/l, T2 0.1 g/l. Median Doc ID was 90 minutes. Median alcohol administration was 2.8 g (1.8-4). T0 alcohol concentration was 0 g/l, T1 0.1 g/l, T2 0.1 g/l. Concerning Zazzo test, a significant decrease in attention abilities were shown after gemcitabine infusion, compared with taxanes (p = .001). Conclusions: Patients should be clearly informed concerning alcohol infusion during chemotherapy, and that abilities may be impaired. They should be monitored during 1 hour after gemcitabine infusion before leaving care unit.
    Journal of Clinical Oncology 01/2015; 33((suppl; abstr e17664)). · 18.43 Impact Factor
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    ABSTRACT: Adjuvant chemotherapy’s role after radical prostatectomy (RP) remains controversial in localized high-risk prostate cancer (HRPC). This phase II trial assessed the combination of weekly paclitaxel (WP) with androgen deprivation therapy (ADT) in this population. Methods: All eligible patients (pts) had undergone a laparoscopic RP with pelvic lymph node dissection for a localized HRPC defined with ≥1 of the following criteria: T3b-T4 post-operated Gleason score (GS) ≥8, PSA≥ 20 ng/mL, pN+, in Henri Mondor Hospital. Pts were randomly assigned to either triptoreline 11.25mg every 3 months during 3 years and 8 cycles of WP 100 mg/ m2 (WP arm, n=21) or triptoreline alone (ADT arm, n=26). The primary endpoint is disease free survival (DFS); events=PSA relapse, clinical and radiographic relapse, death. The planned number of pts was 152. Toxicity results indicated a good tolerability with neutropenic fever in 4.3% (n=1), and no negative impact on QoL in the WP arm (Ploussard, Prostate Cancer Prostatic Dis. 2010). Here we report 8-year DFS and overall survival (OS) results. Results: Between February 2005 and October 2007, 47 pts were enrolled. This trial was terminated prematurely because of slow accrual. After a mean follow-up of 8.4 y, we identified a PSA relapse in 25 pts (53%) and castrate-resistant prostate cancer occurred in 6 pts. No statistically difference was found in terms of either biochemical or clinical DFS (bDFS, cDFS) and OS: 8-year bDFS rate: 50% [n=11/22] in the WP arm vs 46% [n=12/26] in the ADT arm (p=0.79); 8-year cDFS rate: 95.4% [n=21/22] in the WP arm vs 88.5% [n=23/26] in the ADT arm (p=0.38). The 8-year OS rate is 90.9% (n=20/22) and 84.6% (n=22/26) respectively with no difference between treatment arms (p=0.51). No clinical, histological or biological variable demonstrated a difference in either 8-year bDFS, cDFS or OS rate. Conclusions: Provided that this trial is probably underpowered to detect a DFS benefit, adjuvant weekly paclitaxel after RP was not associated with any significant reduction in the risk of biological relapse or death compared to ADT alone in patients with localized HRPC. Chemotherapy should be only proposed in dedicated clinical trial for localized HRPC.
    Journal of Clinical Oncology 01/2015; 33((suppl 7; abstr 37)). · 18.43 Impact Factor
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    ABSTRACT: Background: Association between objective response rate (ORR), disease control rate (DCR) and progression free survival (PFS) remains controversial in renal cell carcinoma treated with first line antiangiogenics for advance disease. Methods: Following PRISMA guidelines, as of July,1, 2014, two independent reviewers systematically searched in MEDLINE and collected data from all published trials evaluating at least one antiangiogenic drug for advanced RCC (1st line or after cytokine only). Trials were included if it contains data about ORR, DCR and median PFS (mPFS). The association between ORR, DCR and mPFS was investigated by linear regression analysis weighted by sample size. Results: After screening 1,608 reports, we identified 33 eligible trials (19 randomised trials): 9 phase III, 21 phase II, 2 phase I-II and 1 phase I, involving 8965 pts and 57 treatment arms (35 monotherapy, 22 combination treatment). The median ORR and DCR were 27% (range 0-59) and 77% (22-93), respectively. mPFS and median overall survival (mOS) were 8.9 mo (2.8-16.8) and 23.5 mo (15.2-36.5), respectively. ORR and DCR significantly correlated with mPFS (p<001 and 0.004 respectively) with a better explicative power for the model including ORR (Adjusted R²: 47% for ORR and 16% for DCR). The regression coefficient was 0.15 for ORR, meaning that for or each 10% increase in ORR, PFS improved by 1.5 months. Conclusions: Our model suggests that ORR and DCR correlate with PFS in 1stline antiangiogenic trials in advanced RCC. ORR could be an interesting surrogate marker of PFS in future trials with antiangiogenics in RCC. Study characteristics. Total Total nb of trials 33 Total nb of treatment arms 57 Total nb. of pts 8965 Median nb. of pts per trial (range) 91 (18-557) Total nb of randomly arms 40 Total nb of randomized trials 19 Phase (III/II/I-II/I) 9/21/2/1 Nb of monotherapy / combination regimen 35 / 22 Pts with good MSKC, median % (range) 34 (6-55) Pts with intermediate MSKC, median % (range) 56 (39-92) Pts with poor MSKC, median % (range) 7 (0-26) Male pts, median % (range) 71,5 (44-85) Median age (range) 61 (18-89) % no antiangiogenics pretreated pts 84 % prior nephrectomy 87
    Journal of Clinical Oncology 01/2015; 33((suppl; abstr e15581)). · 18.43 Impact Factor
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    ABSTRACT: Several bacterial species have been implicated in the development of colorectal carcinoma (CRC), but CRC-associated changes of fecal microbiota and their potential for cancer screening remain to be explored. Here, we used metagenomic sequencing of fecal samples to identify taxonomic markers that distinguished CRC patients from tumor-free controls in a study population of 156 participants. Accuracy of metagenomic CRC detection was similar to the standard fecal occult blood test (FOBT) and when both approaches were combined, sensitivity improved > 45% relative to the FOBT, while maintaining its specificity. Accuracy of metagenomic CRC detection did not differ significantly between early- and late-stage cancer and could be validated in independent patient and control populations (N = 335) from different countries. CRC-associated changes in the fecal microbiome at least partially reflected microbial community composition at the tumor itself, indicating that observed gene pool differences may reveal tumor-related host–microbe interactions. Indeed, we deduced a metabolic shift from fiber degradation in controls to utilization of host carbohydrates and amino acids in CRC patients, accompanied by an increase of lipopolysaccharide metabolism.
    Molecular Systems Biology 11/2014; 10(11). DOI:10.15252/msb.20145645 · 14.10 Impact Factor
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    ABSTRACT: Purpose: Progression-free survival (PFS) has previously been established as a surrogate for overall survival (OS) for first-line metastatic colorectal cancer (mCRC). Because mCRC treatment has advanced in the last decade with extended OS, this surrogacy requires re-examination. Methods: Individual patient data from 16,762 patients were available from 22 first-line mCRC studies conducted from 1997 to 2006; 12 of those studies tested antiangiogenic and/or anti-epidermal growth factor receptor agents. The relationship between PFS (first event of progression or death) and OS was evaluated by using R2 statistics (the closer the value is to 1, the stronger the correlation) from weighted least squares regression of trial-specific hazard ratios estimated by using Cox and Copula models. Results: Forty-four percent of patients received a regimen that included biologic agents. Median first-line PFS was 8.3 months, and median OS was 18.2 months. The correlation between PFS and OS was modest (R2, 0.45 to 0.69). Analyses limited to trials that tested treatments with biologic agents, nonstrategy trials, or superiority trials did not improve surrogacy. Conclusion: In modern mCRC trials, in which survival after the first progression exceeds time to first progression, a positive but modest correlation was observed between OS and PFS at both the patient and trial levels. This finding demonstrates the substantial variability in OS introduced by the number of lines of therapy and types of effective subsequent treatments and the associated challenge to the use of OS as an end point to assess the benefit attributable to a single line of therapy. PFS remains an appropriate primary end point for first-line mCRC trials to detect the direct treatment effect of new agents.
    Journal of Clinical Oncology 11/2014; 33(1). DOI:10.1200/JCO.2014.56.5887 · 18.43 Impact Factor
  • 2014 Palliative Care in Oncology Symposium, boston; 10/2014
  • Journal of Geriatric Oncology 10/2014; 5:S59. DOI:10.1016/j.jgo.2014.09.102 · 1.15 Impact Factor
  • Journal of Geriatric Oncology 10/2014; 5:S67. DOI:10.1016/j.jgo.2014.09.122 · 1.15 Impact Factor
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    Jean-Baptiste Rey · Vincent Launay-Vacher · Christophe Tournigand
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    ABSTRACT: Regorafenib (BAY 73-4506, Stivarga® Bayer HealthCare Pharmaceutical Inc) is an oral multikinase inhibitor with a distinct and wide-ranging profile of tyrosine kinase inhibition, resulting in antiangiogenic and antiproliferative properties in tumors. Single-agent regorafenib administered as a 160-mg daily dose for the first 21 days of a 28-day cycle is approved for use in patients with pretreated metastatic colorectal cancer (mCRC) and gastrointestinal stromal tumor (GIST) progressing on imatinib and sunitinib, following publication of data from the phase III CORRECT and GRID studies respectively. Regorafenib is currently under phase III investigation in patients with hepatocellular carcinoma and is in several phase II studies in patients with gastrointestinal (GI) tumors. This review describes the clinical development of regorafenib in patients with GI cancers, and highlights the key issues important for the modern day clinical pharmacist who forms part of the multidisciplinary team ensuring safe and effective delivery of the drug to the patient. This information is considered of particular importance to the clinical pharmacist for the future development of regorafenib in this treatment setting.
    Targeted Oncology 09/2014; 10(2). DOI:10.1007/s11523-014-0333-x · 3.46 Impact Factor
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    ABSTRACT: This two-arm, randomised, multicentre, open-label, phase IIIb study investigated the safety and efficacy of a 3-h catumaxomab infusion with/without prednisolone premedication to reduce catumaxomab-related adverse events. Patients with malignant ascites due to epithelial cancer received four 3-h intraperitoneal catumaxomab infusions with/without intravenous prednisolone (25 mg) premedication before each infusion. The primary safety endpoint was a composite safety score calculated from the incidence and intensity of the most frequent catumaxomab-related adverse events (pyrexia, nausea, vomiting and abdominal pain). Puncture-free survival (PuFS) was a co-primary endpoint. Time to next puncture (TTPu) and overall survival (OS) were secondary endpoints. Prednisolone premedication did not result in a significant reduction in the main catumaxomab-related adverse events. The mean composite safety score was comparable in both arms (catumaxomab plus prednisolone, 4.1; catumaxomab, 3.8; p = 0.383). Median PuFS (30 vs. 37 days) and TTPu (78 vs. 102 days) were shorter in the catumaxomab plus prednisolone arm than in the catumaxomab arm, but the differences were not statistically significant (p = 0.402 and 0.599, respectively). Median OS was longer in the catumaxomab plus prednisolone arm than in the catumaxomab arm (124 vs. 86 days), but the difference was not statistically significant (p = 0.186). The superiority of catumaxomab plus prednisolone versus catumaxomab alone could not be proven for the primary endpoint. Prednisolone did not result in a significant reduction in the main catumaxomab-related adverse events. The study confirms the safety and efficacy of catumaxomab administered as four 3-h intraperitoneal infusions for the treatment of malignant ascites.
    Medical Oncology 08/2014; 31(8):76. DOI:10.1007/s12032-014-0076-7 · 2.06 Impact Factor
  • Revue d Épidémiologie et de Santé Publique 08/2014; 62:S129. DOI:10.1016/j.respe.2014.05.038 · 0.66 Impact Factor

Publication Stats

4k Citations
794.84 Total Impact Points


  • 2012–2015
    • Hôpital Henri Mondor (Hôpitaux Universitaires Henri Mondor)
      Créteil, Île-de-France, France
  • 2014
    • Université Paris-Est Créteil Val de Marne - Université Paris 12
      Créteil, Île-de-France, France
    • Mayo Clinic - Rochester
      Рочестер, Minnesota, United States
  • 2013
    • University of Paris-Est
      La Haye-Descartes, Centre, France
  • 2011
    • Pierre and Marie Curie University - Paris 6
      Lutetia Parisorum, Île-de-France, France
  • 2009–2011
    • Assistance Publique – Hôpitaux de Paris
      Lutetia Parisorum, Île-de-France, France
  • 2006–2011
    • Hôpital Saint-Antoine (Hôpitaux Universitaires Est Parisien)
      • Service d’Oncologie Médicale
      Paris, Ile-de-France, France
    • Hospital Universitario Marques de Valdecilla
      Santander, Cantabria, Spain
  • 2010
    • French Institute of Health and Medical Research
      Lutetia Parisorum, Île-de-France, France
  • 2007
    • Hôpital Tenon (Hôpitaux Universitaires Est Parisien)
      Lutetia Parisorum, Île-de-France, France
    • Hasselt University
      Hasselt, Flemish, Belgium
  • 2000
    • Bristol-Myers Squibb
      New York, New York, United States