Publications (19)38.09 Total impact
-
Article: Microchromosomal deletions involving SCN1A and adjacent genes in severe myoclonic epilepsy in infancy.
[show abstract] [hide abstract]
ABSTRACT: Genetic abnormalities of the gene encoding alpha1 subunit of the sodium channel (SCN1A), which can be detected by direct sequencing, are present in more than 60% of patients with severe myoclonic epilepsy in infancy (SMEI) or its borderline phenotype (SMEB). Microchromosomal deletions have been recently reported as additional causes of SMEI. This study examines whether such microdeletions are associated with SMEI as well as with SMEB. We recruited patients with SMEI (n = 35) and SMEB (n = 34), who were confirmed previously to have no mutations of SCN1A by direct sequencing. Microdeletions were sought by multiplex ligation-dependent probe amplification (MLPA), and then confirmed and characterized by fluorescence in situ hybridization (FISH) and array-based comparative genomic hybridization (aCGH), respectively. Heterozygous multiple exonic deletions were identified in 7/35 SMEI patients (20%) and 0/34 SMEB patients (0%), with a net frequency of 10.1% (7/69 patients). Deletions were confirmed by FISH and aCGH analysis. The concomitant deletions of adjacent genes were revealed by aCGH. None of the parents who agreed to undergo the analysis had such deletions suggesting that the deletions were de novo. The phenotypes of patients with the deletions were indistinguishable from those of SMEI resulting from point mutations. Our findings indicate that microchromosomal deletion, often involving not only SCN1A but also several adjacent genes, is associated with core SMEI. As microchromosomal deletion cannot be anticipated by the phenotypes or detected by conventional methods, genetic abnormalities in SMEI should be carefully sought by techniques that can detect microdeletions.Epilepsia 06/2008; 49(9):1528-34. · 3.96 Impact Factor -
Article: High molecular weight adiponectin as a predictor of long-term clinical outcome in patients with coronary artery disease.
[show abstract] [hide abstract]
ABSTRACT: Adiponectin is an adipocyte-specific secretory protein that is highly and specifically expressed in adipose tissue, and low plasma levels of adiponectin are associated with coronary artery disease (CAD). It has been suggested that high molecular weight (HMW) adiponectin is more important for vascular protection than total amount of adiponectin. To establish the clinical relevance of HMW adiponectin, we measured its serum levels in 149 patients with CAD. The levels were lower in vasospastic angina pectoris (3.4 +/- 2.4 microg/ml, p <0.01), stable angina pectoris (3.3 +/- 2.6 microg/ml, p <0.001), and healed myocardial infarction (3.8 +/- 2.9 microg/ml, p <0.01) than chest pain syndrome (controls) (6.6 +/- 5.4 microg/ml). The levels were also lower in multivessel CAD (3.4 +/- 2.4 microg/dl) compared with single vessel CAD (4.2 +/- 2.7 microg/ml, p <0.05) or no organic stenosis (5.1 +/- 3.5 microg/ml, p <0.01). In univariate analysis, diabetes mellitus (p = 0.03), insulin resistance (p = 0.06), high-sensitivity C-reactive protein levels (p = 0.0012), and low HMW adiponectin levels (p = 0.0001) predicted cardiovascular events during 7 years of follow-up. However, multivariate analysis showed that only HMW adiponectin levels were an independent predictor of cardiovascular events (relative risk 2.79, 95% confidence interval 1.49 to 5.24, p = 0.0014). In conclusion, serum HMW adiponectin levels may serve as a predictor of future cardiovascular events in patients with CAD as well as a marker for severity of CAD.The American Journal of Cardiology 08/2007; 100(4):569-74. · 3.37 Impact Factor -
Article: Comparison of serum high-molecular weight (HMW) adiponectin with total adiponectin concentrations in type 2 diabetic patients with coronary artery disease using a novel enzyme-linked immunosorbent assay to detect HMW adiponectin.
[show abstract] [hide abstract]
ABSTRACT: Adiponectin (Acrp30), an adipocyte-derived protein, exists in serum as a trimer, a hexamer, and a high-molecular weight (HMW) form, including 12-18 subunits. Because HMW adiponectin may be biologically active, we measured it in serum using a novel enzyme-linked immunosorbent assay (ELISA) confirmed by gel filtration chromatography that the ELISA detected mainly adiponectin with 12-18 subunits, and we compared HMW with total adiponectin concentration in patients with type 2 diabetes. We next investigated the relationship between serum HMW and coronary artery disease (CAD) in 280 consecutive type 2 diabetic patients, including 59 patients with angiographically confirmed CAD. Total adiponectin was measured in serum by a commercially available ELISA. Like serum total adiponectin, HMW adiponectin correlated positively with HDL cholesterol and negatively with triglyceride, insulin sensitivity, creatinine clearance, and circulating inflammatory markers. Total and HMW adiponectin were significantly higher in women than in men, as was the HMW-to-total adiponectin ratio. Serum HMW and the HMW-to-total adiponectin ratio were significantly lower in men with than without CAD (P < 0.05, respectively). In women, the ratio, but neither total nor HMW adiponectin, tended to be lower when CAD was present. In conclusion, determination of HMW adiponectin, especially relative to total serum adiponectin, is useful for evaluating CAD in type 2 diabetic patients.Diabetes 08/2006; 55(7):1954-60. · 8.29 Impact Factor -
Article: Serum Copper and Zinc Levels in Epileptic Children with Valproate Treatment
[show abstract] [hide abstract]
ABSTRACT: Valproate (VPA) induces zinc (Zn) deficiency in experimental animals, but whether VPA treatment induces deterioration of serum trace metal homeostasis in humans is uncertain. We measured serum copper (Cu) and Zn levels in epileptic children treated with VPA and/or other antiepileptic drugs (AEDs). Patients treated with VPA monotherapy had significantly lower levels of serum Cu (82.2 ± 16.6 μg/dl) than normal controls (97.3 ± 23.0 μg/dl). Patients treated with VPA in addition to some other AED also had significantly lower levels of serum Cu (84.8 ± 20.0 μg/dl). Serum Cu concentrations in patients treated with AEDs except for VPA (87.7 ± 19.1 pg/dl) were not statistically different from those of control subjects. In contrast to the reported results of animal experiments, serum Zn levels were not altered in patients with VPA treatment. Although none of our patients showed any symptoms of Cu deficiency, we should pay attention to potential Cu deficiency in patients with VPA treatment.Epilepsia 08/2005; 33(3):555 - 557. · 3.96 Impact Factor -
Article: Multi-institutional study on the correlation between chromosomal abnormalities and epilepsy.
[show abstract] [hide abstract]
ABSTRACT: While there is an abundance of literature describing the association of chromosome aberrations with epilepsy, only a few refer to the detailed features of epilepsy. It is important to investigate the associations between specific chromosome abnormalities and features of epilepsy to identify genes involved in epilepsy and treat them more effectively. We investigated the correlation between specific chromosome aberrations and epilepsy by sending questionnaires to the members of Kyoto Multi-institutional Study Group of Pediatric Neurology. Seventy-six patients were collected from 10 institutions. Chromosome abnormalities included: Down syndrome (n = 19); Angelman syndrome (n = 8); Prader-Willi syndrome (n = 4); 4p- syndrome (n = 3); 1q- syndrome (n = 2); 5p- syndrome (n = 2); Miller-Dieker syndrome (n = 2); 18q- syndrome; (n = 2); Klinefelter syndrome; (n = 2); and 32 other individual chromosomal aberrations. Overall, the severity of mental retardation correlated with the severity of epilepsy. We could abstract characteristic features of epilepsy in some syndromes. In Angelman and Prader-Willi syndromes, febrile seizures occurred frequently, the onset of epilepsy was in early childhood and seizure phenotype was multiple. Paroxysmal discharge of the occipital region and diffuse high voltage slow wave on electroencephalography were characteristic in Angelman syndrome. In Down syndrome, West syndrome and focal epilepsy were common and the prognosis of epilepsy in West syndrome with Down syndrome was good. In 4p- syndrome, febrile seizures were often seen, and unilateral or generalized clonic or tonic-clonic status epilepticus were characteristic. For the other chromosomal aberrations investigated here, the patient numbers were too small to abstract common features of epilepsy.Brain and Development 04/2005; 27(2):127-34. · 2.12 Impact Factor -
Article: Cloxazolam treatment for patients with intractable epilepsy.
[show abstract] [hide abstract]
ABSTRACT: We examined the antiepileptic effect of cloxazolam on seizures in 23 patients with intractable epilepsy. Most of the patients had central nervous system complications, as well as frequent seizures, and were being treated with polypharmacy. Cloxazolam was administered 1 to 5 mg/day (0.05 to 0.14 mg/kg) at initiation, in two divided doses daily, and gradually increased (1 to 4 mg/day; 0.05 to 0.15 mg/kg) every month at the outpatient clinic. Plasma levels of the main active metabolite, chloro-N-desmethyldiazepam, were measured in 13 patients. Four of 23 patients (17%) became seizure-free, and nine patients (39%) manifested a good response. Both patients with generalized and partial epilepsy manifested a good response. The spectrum of cloxazolam as an antiepileptic was wide. Effective doses were 0.07 to 0.56 mg/kg, and plasma effective levels of chloro-N-desmethyldiazepam were 12.3-115.1 ng/mL. Cloxazolam may be an effective and safe antiepileptic for intractable epilepsy, and should be used as an adjunct to other antiepileptic drugs or administered after other agents.Pediatric Neurology 03/2004; 30(2):111-4. · 1.52 Impact Factor -
Article: [Intractable epilepsy (apneic seizure) in an infant with 18q deletion syndrome].
[show abstract] [hide abstract]
ABSTRACT: We report here an infant with 18q deletion syndrome, and intractable apneic seizures. He had intrauterine growth retardation and dysmorphic features. Chromosomal analysis demonstrated mosaicism of 18q interstitial deletion (q12.3-q22.3). From the age of 3 months, apneic attacks occurred from once a week to over 10 times a day despite many oral antiepileptic agents, and were diagnosed as complex partial seizures. Ictal electroencephalogram and 18F-fluorodeoxyglucose-positron emission tomography at the age of 10 months identified the epileptic focus in the right parieto-temporal region. He also had severe psychomotor retardation. Head MRI examination revealed diffuse cerebral atrophy and severe white matter dysmyelination, which was caused by the deletion of myelin basic protein gene at the locus of 18q22.3. This locus may be responsible for the clinical manifestations of 18q deletion syndrome. Detailed description of the onset, seizure types, and prognosis of epilepsy associated with 18q deletion syndrome is rare. It was suggested that the locus of 18q21.3-q22.3 was responsible for autonomic seizures in 18q deletion syndrome.No to hattatsu. Brain and development 12/2003; 35(6):521-6. -
Article: A novel missense mutation in the DKC1 gene in a Japanese family with X-linked dyskeratosis congenita.
[show abstract] [hide abstract]
ABSTRACT: The authors report 2 male patients with dyskeratosis congenita (DC) in a Japanese kindred. Sequencing of the complementary DNA of the dyskerin gene (DKC1) revealed a T-to-C transition at nucleotide 1285 in exon 12 that resulted in a novel missense mutation L398P. Despite harboring the same mutation in the DKC1 gene, one patient had significantly milder hematological symptoms than the other, indicating that there may be other factors that determine the severity of DC.Pediatric Hematology and Oncology 10/2002; 19(6):413-9. · 0.89 Impact Factor -
Article: Dichloroacetate therapy in Leigh syndrome with a mitochondrial T8993C mutation.
[show abstract] [hide abstract]
ABSTRACT: A 6-year-old female with Leigh syndrome associated with a T-to-C mutation at nucleotide 8993 of mitochondrial deoxyribonucleic acid (T8993C) was treated with dichloroacetate, once during the first acute deterioration after a febrile illness and another time when she demonstrated subacute regression without precipitating events. Dichloroacetate reversed the clinical course on both occasions, and diffuse lesions in the midbrain revealed on magnetic resonance imaging during the second episode disappeared completely. However, dichloroacetate could not prevent the second acute deterioration associated with a febrile illness that occurred during the second treatment. Thus dichloroacetate treatment, although limited, was effective for T8993C-associated Leigh syndrome.Pediatric Neurology 08/2002; 27(1):58-61. · 1.52 Impact Factor -
Article: Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke‐like Episodes
[show abstract] [hide abstract]
ABSTRACT: We present an autopsy report on a 14-year-old girl with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), placing emphasis on the mitochondrial enzymatic histochemistry of the 3 types skeletal muscle and cardiomyocytes. Generalized muscular atrophy, cardiac hypertrophy, cerebral cortical laminar necrosis, basal ganglia calcification and liver steatosis were observed. In the skeletal muscles, modified Gomori's trichrome staining demonstrated scattered ragged red fibers, and histochemical staining for mitochondrial enzymes showed intense positivity in the subsarcolemmai zones of some muscle fibers. Some of the hypertrophic cardiomyocytes also showed a ragged red appearance with the modified Gomori's trichrome stain. Histochemical staining for mitochondrial enzymes showed patchy loss of enzymatic activity in the myocardium. Electron microscopically, extreme accumulation of enlarged mitochondria and severe loss of myofibrils was observed in both skeletal muscle fibers and cardiomyocytes. The arteriolar smooth muscle cells also showed a mild increase in mitochondria. Acta Pathol Jpn 39: 599 606, 1989.Pathology International 08/1989; 39(9):599 - 606. · 1.62 Impact Factor -
Article: Carbamazepine Therapy and LongTerm Prognosis in Epilepsy of Childhood
[show abstract] [hide abstract]
ABSTRACT: Sixty-seven of 90 patients (74% who had been treated with carbamazepine (CBZ) alone were seizure-free for > 3 years. The EEG of the patients given CBZ monotherapy was more often normal in those without neurologic abnormalities other than mental retardation or a genetic predisposition. The prognosis of patients with partial seizures secondarily generalized was poorer than that of the other patients. Patients without mental retardation more often had monotherapy CBZ. The lowest blood level of CBZ for maintenance was considered to be 4 μg/ml, although the therapeutic blood level was between 6 and 12 μ.g/ml. Most of the side effects were mild.RÉSUMÉ67 patients parmi 90 enfants (soit 74%) qui avaient été traités par carbamazépine (CBZ) en monothérapie n'ont plus présenté de crises pendant au moins 3 ans. L'EEG de patients traités par CBZ en monothérapie était souvent normal chez ceux qui ne présentaient pas d'anomalies neurologiques en dehors d'un retard mental ou d'une predisposition genetique. Le pronostic était plus mauvais chez les patients présentant des crises partielles secondairement généralisées que chez les autres. Les patients sans retard mental avaient plus souvent que les autres une monotherapie par CBZ. Le seuil inferieur efficace du taux sanguin de CBZ a été estiméà 4 mg/1, bien que le taux thérapeutique se soit situé entre 6 et 12 mg/1. La plupart des effets secondares ont été peu importants.RESUMENSesenta y siété de 90 pacientes (74%) que habian sido tratados con carbamazepina (CBZ) como medicación única, permanecieron libres de ataques durante más de 3 años. El EEG de los pacientes que recibfan monoterapia con CBZ fue mis frecuent-emente normal que el de los enfermos sin anomalfas neurológicas, aparte de retraso mental o predisposición genética. El pronóstico de los pacientes con ataques parciales con generalización secundaria fue peor que en otros pacientes. Los enfermos sin retraso mental recibieron monoterapia con CBZ más frecuente-mente. Se consideró que los niveles en sangre de CBZ más bajos de mantenimiento fueron de 4 μg/ml a pesar de que el nivel terapéutico se consideraba entre 6 y 12 μ.g/ml. Los síntomas colaterales fueron, en su mayor parte, de poca importancia.Epilepsia 01/1989; 30(1):57 - 61. · 3.96 Impact Factor -
Article: Immunoreactive Leucine‐Enkephalin Content in Brains of Epileptic E1 Mice
[show abstract] [hide abstract]
ABSTRACT: The immunoreactive leucine-enkephalin (IR Leu-E) content in the brains of epileptic E1 mice was determined. E1 mice are mutants from the dd strain of mice and are susceptible to convulsions. Seizures were elicited in E1 mice by repeated postural stimulations. As controls, ddY strain (nonconvulsive) mice and nonstimulated E1 mice (which had not developed convulsions) were used. IR Leu-E content was measured by radioimmunoassay. Before the convulsion, the IR Leu-E content in the striatum of E1 mice was 60% of the content in the controls. In the hypothalamus, IR Leu-E levels were increased by 85% 45 min after a convulsion. IR Leu-E was also increased in the striatum (176% of preconvulsive state), cortex (121%), medulla oblongata + pons (132%), hypothalamus (180%), and midbrain (159%) 48 h after a convulsion.RÉSUMÉNous avons measuré les taux de leucine-enképhaline immunoréactive (IR Leu-E) dans le cerveau de souris épileptiques El. Les souris E1 sont des mutantes de la souche dd et sont prédisposées aux convulsions. Les crises ont été provoquées par des stimulations posturales répétées. Nous avons utilisé comme témoins des souris de souche ddY (non-épileptiques) et des souris E1 non stimulus (qui ne présentaient pas de convulsions). Les taux de IR Leu-E ont été mésurés par radio-immunologie. Avant la convulsion, les taux de IR Leu-E mesurés au niveau du striatum chez les souris E1 était à environ 60% des taux observés chez les témoins. Au niveau de l'hypothalamus, les taux de IR Leu-E ont augmenté de 85% 45 minutes aprés une convulsion. Les taux de IR Leu-E ont aussi été trouvés augmentés dans le striatum (176%), dans le cortex (121%). dans le bulbe et la pro-tuvérance (132%), dans l'hypothalamus (180%) et dans le mésencéphale (159%) 48 heures aprés une convulsion.ZUSAMMENFASSUNGDer immunreaktive Leukin-Enkephalin (IR Leu-E)-Gehalt im Gehirn von epileptischen El-Mausen wurde bestimmt. El-Mäuse sind anfallsempfindliche Mutanten eines dd-Mäuse-stammes. Die Anfälle wurden durch wiederholte Körperste-lungs-Stimulation ausgelöst. Als Kontrolltiere diente ein ddY-Mäusestamm (nicht konvulsiv) sowie nicht stimulierte El-Mäuse, die bislang keine Anfälle entwickelt hatten. Der IR Leu-E-Gehalt wurde durch einen Radioimmunoassay bestimmt. Vor den Anfällen betrug der IR Leu-E-Gehalt des Striatums bei El-Mäusen ungefähr 60% des Gehaltes der Kontrolltiere. Im Hypothalamus war der IR Leu-E-Gehalt 45 Minuten nach den Anfällen urn 85% erhoht. IR Leu-E war 48 Stunden nach den Anfällen auch im Striatum urn 176%, im Kortex urn 121%, in der Medulla oblongata und Ponsbereich urn 132%. im Hypothalamus urn 180% und im Mittelhirnbereich um 159% erhöht gefunden worden.Epilepsia 01/1988; 29(1):91 - 96. · 3.96 Impact Factor -
Article: SEQUENTIAL CT STUDIES OF 24 CHILDREN WITH INFANTILE SPASMS ON ACTH THERAPY
[show abstract] [hide abstract]
ABSTRACT: Sequential CT studies were performed in 24 patients with infantile spasms, before, during and after ACTH therapy, in order to analyze the relationship between the dose of ACTH and changes in CT scan findings. In six cases CT scans did not return to their original state after ACTH therapy. Two illustrative cases are reported. There was a good correlation between the total dose of ACTH and the percentage decrease of brain parenchyma. It is concluded that ‘cerebral atrophy’ on CT scans may represent an accumulative effect of ACTH and that ACTH should be given with the utmost discretion, and in as low a dose as possible.RÉSUMÉEtudes séquentielles tomodensitométriques (CT) chez 24 enfants sous traitement ACTH pour spasmes infantiles Des études séquentielles CT ont été réalisées chez 24 sujets présentant des spasmes infantiles, durant et après un traitement d'ACTH dans le but d'analyser les relations entre la dose d'ACTH et les modifications des données CT. Dans six cas, les données CT ne sont pas retournées à leur état original aprés traitement d'ACTH. Deux cas évocateurs sont rapportés. II y a eu une forte corrélation entre la dose totale d'ACTH et le pourcentage de perte de parenchyme cérébral. Les auteurs concluent que l'atrophie cérébrale’ au CT peut traduire un effet accumulatif de l'ACTH. De ce fait, l'ACTH ne devrait être donné qu'avec la plus grande prudence et à doses aussi faibles que possible.ZUSAMMENFASSUNGCT Untersuchungen hei 24 Kindern mit BNS Krmpfen unter ACTH TherapieCT Untersuchungen wurden bei 24 Kindern mit BNS Krmpfen whrend und nach Beendigung der ACTH Therapie durchgeführt, um die Beziehung zwischen ACTH Dosis und Vernderungen der CT Befunde zu analysieren. Bei sechs Fllen normalisierten sich die CT Befunde nach Beendigung der ACTH Therapie nicht. Zwei anschauliche Flle werden dargestellt. Es fand sich eine gute Korrelation zwischen der Gesamtdosis ACTH und dem Verlust an Hirnparenchym. Man schließt daraus, daß‘Hirnatrophie’ im CT vielleicht einen akkumulativen Effekt des ACTH darstellt. Daher sollte ACTH mit ßerster Zurückhaltung und in möglichst niedriger Dosierung gegeben werden.RESUMENEstudios secuenciales con TAC en 24 niños con espasmos infantiles con tratamiento con ACTHSe realizaron estudios secuenciales con TAC en 24 pacientes con espasmos infantiles, durante y después de una terapia con ACTH con el objeto de analizar las relaciones entre la dosis de ACTH y los cambios hallados en la TAC. En seis casos los hallazgos en la TAC no regresaron a su estado original después de la terapia con ACTH. Se aportan dos casos ilustrativos. Habia una buena correlacion entre la dosis total de ACTH y la disminución porcentual del parénquima cerebral. Se concluyó que la atrofia cerebral en la TAC puede representar un efecto acumulativo del ACTH. Por lo tanto el ACTH debe administrarse con gran discretión y a la menor dosis posible.Developmental Medicine & Child Neurology 07/1983; 25(4):475 - 480. · 2.92 Impact Factor -
Article: 123I-IMP SPECT findings in mitochondrial encephalomyopathies
[show abstract] [hide abstract]
ABSTRACT: We performed N-isopropyl-[123I] p-iodoamphetamine (IMP) single photon emission computed tomography (SPECT) in three patients with Leigh syndrome, two patients with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS), and two siblings with progressive external ophthalmoplegia (PEO). The SPECT images were compared with the findings on magnetic resonance imaging (MRI) and computed tomography (CT). All Leigh syndrome patients showed low accumulation areas (LAA) bilaterally in the frontal lobes and the basal ganglia. The frontal lobe LAA was seen even in an area without abnormalities on CT/MRI. Each MELAS patient showed a focal LAA. SPECT could also detect an old stroke-like lesion that was no longer shown by CT/MRI. However, SPECT did not show LAA in the basal ganglia, which showed calcification on CT or abnormal signal intensity on MRI. MRI in the 2 PEO patients showed lesions bilaterally in the basal ganglia in one, and in the internal capsules in the other. SPECT showed LAA not only in corresponding areas, but also in the occipital lobes, where no lesions were revealed by MRI. Thus,123I-IMP SPECT was more sensitive than CT/MRI for detecting stroke-like lesions in MELAS patients, although it did not detect small lesions in the basal ganglia. LAA in the frontal lobes and occipital lobes may be SPECT findings characteristic of Leigh syndrome and PEO, respectively.Brain and Development. -
Article: Regional cerebral blood flow in diagnosis of childhood onset partial epilepsy
[show abstract] [hide abstract]
ABSTRACT: We compared regional cerebral blood flow assessed by[123I]N-isopropyl-p-iodoamphetamine (IMP) single-photon emission tomography (SPECT) with magnetic resonance imaging (MRI), computed tomography (CT) and interictal surface electroencephalography (EEG) to evaluate its diagnostic potential in 24 patients with partial seizures with onset in childhood. Focal low uptake areas were observed on SPECT scans of 18 patients and were presumed to represent epileptogenic areas in 17. MRI revealed an abnormality in 12 and CT in 6 patients, and all organic lesions showed SPECT abnormalities, too. Six patients without focal structural abnormalities showed regional perfusion deficit on SPECT. Routine scalp EEG revealed an epileptic focus in 17 patients and three of them showed discordant results between SPECT and EEG, which suggested more serious brain disorders. In two patients without EEG localization only SPECT showed focal abnormalities in the probable epileptic area. [123I]IMP-SPECT was useful in locating the epileptic focus, particularly during the early period after the onset of partial seizures when the EEG gave inconclusive results.Brain and Development. -
Article: Contrast enhanced hypodense areas in a case of acute disseminated encephalitis following influenza a virus
[show abstract] [hide abstract]
ABSTRACT: A case of a 5-yr-old girl with acute disseminated encephalomyelitis (ADE) following influenza A virus infection improved after corticosteroid treatment. CT showed reversible hypodense areas in the midbrain, basal ganglia and cerebral white matter. Contrast enhancement was noted in the basal ganglia and had not been reported in the literature of ADE.Computerized Radiology. -
Article: Lipoma of the corpus callosum: A case report with a review
[show abstract] [hide abstract]
ABSTRACT: A case of lipoma of the corpus callosum with developmental delay is reported. No other symptoms of the intracranial mass were noticed. Electroencephalography and plain skull radiography were normal. CT revealed a very low density area with a Hounsfield number of between −40 and −60 in the corpus callosum consistent with fat. The literature was reviewed. Among the collected 87 cases, epileptic seizures are reported in 49, developmental delay and/or mental retardation in 18, and no symptoms in 17.Computerized Radiology. -
Article: Symmetrical low density areas in bilateral thalami in an infant with measles encephalitis
[show abstract] [hide abstract]
ABSTRACT: Symmetrical low density areas in the bilateral thalami were observed on CT scan in an 11-month-old boy with measles encephalitis.Computerized Radiology. -
Article: Cerebellum and brain stem atrophy in a child with Huntington's chorea
[show abstract] [hide abstract]
ABSTRACT: An 11-yr-old girl with Huntington's chorea since the age of 4 had mental deterioration, chorea, rigidity, generalized convulsions and cerebellar ataxia. Computerized tomography (CT) showed atrophy of the cerebellum and brain stem in addition to atrophy of the caudate nucleus and cerebral cortex.Computerized Radiology
Top co-authors
Top Journals
Institutions
-
1989
-
Kyoto University
- Department of Pediatrics
Kyoto, Kyoto-fu, Japan
-
