Jun Young Lee

Chosun University, Gwangju, Gwangju, South Korea

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Publications (258)467.01 Total impact

  • Organic Electronics 12/2014; 15(12):3439–3444. · 3.84 Impact Factor
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    ABSTRACT: Although silver bromide has recently drawn considerable attention due to its high photocatalytic activity, it tends to form agglomerated metallic silver under the irradiation of visible light. Therefore, photocatalytic activity decreases with time and cannot be applied for repeated uses. To overcome this limitation, in the present work, we complexed AgBr with nitrogen doped (N-doped) and amine functionalized reduced graphene oxide (GN). N-doped and/or amine functionalized graphene shows intrinsically good catalytic activity. Besides, amine groups can undergo complexation with silver ions to suppress its reduction to metallic Ag. As a result, this complexed catalysts show excellent photocatalytic activity for the degradation of methylene blue (MB) dye under the irradiation of visible light. Photocatalytic degradation of MB shows that the catalytic activity is optimized at a condition of 0.5 wt% GN, under which ~ 99 % of MB was degraded only after 50 min of visible light irradiation. Notably, the complexed catalyst is quiet stable and retained almost full of its catalytic activity even after greater than ten repeated cycles. Moreover, the catalyst can also efficiently decompose 2-chlorophenol, a colorless organic contaminant, under visible light exposure. Detailed experimental investigation reveals that hydroxyl (·OH) radicals play an important role for dye degradation reactions. A relevant mechanism for dye degradation has also been proposed.
    ACS Applied Materials & Interfaces 11/2014; · 5.90 Impact Factor
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    ABSTRACT: Bioreducible nanoparticles, composed of hydrophilic carboxymethyl dextran and hydrophobic bile acid, are developed by J. H. Park and co-workers on page 1829 for the site-specific delivery of poorly water-soluble anticancer drugs at the tumor microenvironment.
    Advanced Healthcare Materials 11/2014; 3(11).
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    ABSTRACT: Objective To investigate the natural course of depressive symptoms among community-dwelling elderly over 5 years. Rates and correlates of the incidence and the persistence of late-life depression were examined.MethodsA total of 701 elderly people 65 years of age or older without dementia at baseline were included in this study. The association between categorically defined late-life depression (score of ≥8 on the Korean version of the Geriatric Depression Scale-Short Form) and possible lifestyle and clinical risk factors, including physical activity assessed with a modified Korean version of the International Physical Activity Questionnaire (IPAQ) and transformed into weekly Metabolic Equivalent Task (MET) values, was longitudinally investigated using multiple logistic regression analyses. Adjustment was done with sociodemographic variables, chronic medical illnesses, and cognitive dysfunction.ResultsDuring the 5-year follow-up, 74 (26.5%) of the non-depressed elderly developed depression, whereas 30 (49.2%) of the depressed elderly experienced persistent depression. Above-moderate baseline physical activity was independently associated with decreased incidence and persistence rates of late-life depression (adjusted odds ratio (AOR) = 0.44, 95% confidence interval (CI) = 0.22–0.85; AOR = 0.17, 95% CI = 0.03–0.92, respectively), whereas mild physical activity was not. Conversely, poorer executive function also predicted 5-year incident depression (AOR = 0.93, 95% CI = 0.89–0.98) but not persistent depression.Conclusion This study suggests that a minimum of moderate physical activity is related to both emergent and persistent depression in elderly individuals. Research with an extended follow-up period and a shorter inter-assessment interval is needed to confirm this result. Copyright © 2014 John Wiley & Sons, Ltd.
    International Journal of Geriatric Psychiatry 11/2014; · 3.09 Impact Factor
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    Annals of Dermatology 10/2014; 26(5):669-70. · 0.61 Impact Factor
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    ABSTRACT: The present study assessed the changes in the length of the first metatarsal bone after performing proximal chevron metatarsal osteotomy (PCMO) or distal Chevron metatarsal osteotomy (DCMO) for patients with hallux valgus deformity. A total of 60 patients with moderate-to-severe hallux valgus deformity from July 2009 to July 2011 were randomly divided into the PCMO and DCMO groups, with 30 patients in each group. The distal soft tissue procedure was performed in the same method for both groups. Measurements were performed preoperatively, postoperatively, and at the last follow-up visit at 6.1 ± 0.8 months. The postoperative length change with respect to the preoperative length was 0.7 ± 2.5 mm and -0.7 ± 5.1 mm for the PCMO and DCMO groups, respectively, with a slight lengthening of the first metatarsal bone in the PCMO group and a shortening in the DCMO group (p < .01). The follow-up length change with respect to the preoperative length was -2.1 ± 3.0 mm and -4.4 ± 2.2 mm for the PCMO and DCMO groups, respectively, demonstrating a clear shortening of the first metatarsal length at the last follow-up point in the DCMO group (p < .01).When DCMO and the distal soft tissue procedure were performed, significant shortening was found at 6 months of follow-up.
    The Journal of foot and ankle surgery: official publication of the American College of Foot and Ankle Surgeons 09/2014;
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    ABSTRACT: Background: Eyelashes of Asians differ from those of Caucasians in morphology and growth characteristics. Ethnic differences also exist for the tolerability profile of prostaglandin analogues. Objective: To evaluate the long-term utility and durability of bimatoprost 0.03% in eyelash augmentation in Asian females. Methods: One cohort received bimatoprost 0.03% for 36 weeks and another for 20 weeks, with the latter cohort followed for 16 weeks after treatment cessation. The primary endpoint was the percent change in eyelash length at week 20. Secondary measures included percent change in eyelash thickness and darkness, physician's Global Eyelash Assessment and patient satisfaction. Results: At week 20, eyelash length was enhanced in a time-dependent manner, with maximum improvement achieved (19.3%; p < 0.0001). Significant improvements in thickness and darkness were also achieved (22.9%, 6.0%; p < 0.0001). 77.8% of subjects improved by ≥1 grade on Global Eyelash Assessment, with 83.1% satisfied/very satisfied. Improvements were maintained with ongoing treatment to 36 weeks, while these effects were progressively lost with discontinuation. Conclusion: Bimatoprost 0.03% safely enhanced eyelashes in Asian females, maintained with ongoing treatment. Cessation of treatment was associated with progressive loss of effects. © 2014 S. Karger AG, Basel.
    Dermatology 09/2014; · 2.02 Impact Factor
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    Annals of Dermatology 08/2014; 26(4):528-31. · 0.61 Impact Factor
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    ABSTRACT: We fabricated dye-sensitized MoS2 photodetectors that utilized a single-layer MoS2 treated with rhodamine 6G (R6G) organic dye molecules (with an optical band gap of 2.38 eV or 521 nm). The proposed photodetector showed an enhanced performance with a broad spectral photoresponse and a high photoresponsivity compared with the properties of the pristine MoS2 photodetectors. The R6G dye molecules deposited onto the MoS2 layer increased the photocurrent by an order of magnitude due to charge transfer of the photoexcited electrons from the R6G molecules to the MoS2 layer. Importantly, the photodetection response extended to the infrared (λ < 980 nm, which corresponded to about half the energy band gap of MoS2), thereby distinguishing the device performance from that of a pristine MoS2 device, in which detection was only possible at wavelengths shorter than the band gap of MoS2, i.e., λ < 681 nm. The resulting device exhibited a maximum photoresponsivity of 1.17 AW-1, a photodetectivity of 1.5 x 107 Jones, and a total effective quantum efficiency (EQE) of 280% at 520 nm. The device design described here presents a significant step toward high-performance 2D nanomaterial-based photodetector.
    ACS Nano 07/2014; · 12.03 Impact Factor
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    ABSTRACT: Background The pathogenesis of cholinergic urticaria (ChU) has been unclear except for the involvement of acetylcholine. Attempts to classify ChU according to etiology have rarely been performed.Objective To evaluate the significance of responsiveness to autologous sweat and serum in ChU in relation to their clinical characteristics.Methods This study involved 18 patients diagnosed with ChU between January 2010 and April 2011 in the Catholic Medical Center-St. Paul's Hospital. History taking included symptom duration, association with atopy, decreased sweat secretions, seasonal variation, and response to treatment. Intradermal autologous serum skin test (ASST) and autologous sweat skin test (ASwST) and basophil histamine release test with sweat were done.ResultsSweat hypersensitivity was proven by a positive ASwST and basophil histamine release test in only 37.5% of patients with ChU, and in none of the healthy controls. The weal size of ASwST correlated with percentage basophil histamine release. A positive response to autologous serum was displayed by 38.9% of patients, whereas 10% of healthy controls showed a positive ASST response. Intriguingly, patients with a positive ASwST had a negative ASST, and vice versa. Despite this, there was no difference in the clinical characteristics between positive ASST and positive ASwST groups.Conclusions The frequency of hypersensitivity to autologous sweat and serum was significantly higher in patients with ChU, compared with healthy controls. This suggests that autoimmunity to an unknown serum factor as well as sweat hypersensitivity may be involved in the pathogenesis of ChU.
    International journal of dermatology 07/2014; · 1.18 Impact Factor
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    ABSTRACT: To minimize the premature drug release of nanocarriers, we have developed chemically cross-linked bioreducible polymersomes (CLPMs) that can specifically release the drug inside cancer cells. Polymersomes were prepared using poly(ethylene glycol)-b-poly(lysine)-b-poly(caprolactone), a biocompatible triblock copolymer. To chemically cross-link the polymersomes, the primary amine of the triblock copolymer was reacted with a disulfide-containing cross-linker. Doxorubicin (DOX) was chosen as a model anti-cancer drug, and was effectively encapsulated into the CLPMs. The drug-loaded polymersomes greatly retarded the release of DOX under physiological conditions (pH 7.4), whereas the release rate of DOX increased remarkably in the presence of 10 mM glutathione, mimicking an intracellular environment. Microscopic observation showed that DOX-loaded CLPMs could effectively deliver the drug into an intracellular level of SCC7 cancer cells, leading to high cytotoxicity. These observations suggest that CLPMs are promising nanocarriers for intracellular DOX delivery.
    Polym. Chem. 06/2014;
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    ABSTRACT: Anticancer agents can induce sarcoidosis. Interferon-alpha, which is used for the treatment of malignant melanoma and renal cell cancer, is one causative agent of sarcoidosis. However, there are few reports of interferon-alpha-induced sarcoidosis in patients with malignant melanoma. Clinically, it is important to consider the possibility of sarcoidosis in such patients because it could be easily regarded as a metastatic lesion due to underlying malignancy and given unnecessary treatment. Here, we report on the first case of interferon-alpha-induced sarcoidosis in an Asian melanoma patient.
    Asia-Pacific Journal of Clinical Oncology 06/2014; · 0.91 Impact Factor
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    ABSTRACT: Pterygium inversum unguis (PIU) is a rare nail abnormality in which the distal nail bed adheres to the ventral surface of the nail plate, with obliteration of the distal groove. Because of the rarity of this condition, its exact origin is unknown. This disorder can be either congenital or acquired, with or without a family history. The acquired forms may be idiopathic or secondary to systemic connective tissue diseases or other causes such as stroke, neurofibromatosis, leprosy, or the use of nail fortifiers. We present an unusual case of acquired idiopathic PIU of the 10 fingernails in a 22-year-old man.
    Annals of Dermatology 06/2014; 26(3):374-6. · 0.61 Impact Factor
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    ABSTRACT: Aims: Urinary cystatin C has been suggested as a useful biomarker for diagnosis of acute kidney injury (AKI). Multiple myeloma is often complicated by AKI. Therefore, we investigated whether the urinary cystatin C was available for diagnosis of AKI in multiple myeloma. Materials and methods: This study included 39 patients with monoclonal gammopathy of undetermined significance (MGUS) or multiple myeloma. We reviewed the medical records retrospectively and investigated whether urinary γ-globulin and myeloma progression had effects on urinary cystatin C excretion. Results: Spearman's correlation analysis showed that serum β2-microglobulin and serum cystatin C had a significant positive correlation with the urinary cystatin C excretion (r = 0.513, p = 0.001, r = 0.659, p < 0.001) and FEcystatinC (r = 0.585, p = 0.002, r = 0.711, p < 0.001). The GFRcr also had a significant negative correlation with the urinary cystatin C excretion (r = -0.582, p < 0.001) and FEcystatinC (r = -0.474, p = 0.002). In addition, the urinary γ-globulin had a significant positive correlation with the urinary cystatin C excretion (r = 0.678, p < 0.001) and FEcystatinC (r = 0.731, p < 0.001). Urinary γ-globulin was the most significant factor to influence urinary cystatin C excretion in multiple regression test. Conclusion: These results indicate that urinary γ-globulin and myeloma progression can increase the fractional and total excretion of urinary cystatin C. Therefore, it is believed that the urinary cystatin C can be affected by urinary γ-globulin and myeloma progression in the diagnosis of AKI in multiple myeloma. In addition, urinary γ-globulin is believed to be the most significant factor to influence on urinary cystatin C.
    Clinical nephrology 05/2014; 81(5):345-349. · 1.29 Impact Factor
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    Annals of Dermatology 04/2014; 26(2):254-5. · 0.61 Impact Factor
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    ABSTRACT: Balneotherapy, although not a well-established dermatological treatment, is thought to have therapeutic properties for psoriasis and is used as an alternative treatment modality throughout the world.
    Annals of Dermatology 04/2014; 26(2):221-30. · 0.61 Impact Factor
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    ABSTRACT: Bioreducible carboxymethyl dextran (CMD) derivatives are synthesized by the chemical modification of CMD with lithocholic acid (LCA) through a disulfide linkage. The hydrophobic nature of LCA allows the conjugates (CMD-SS-LCAs) to form self-assembled nanoparticles in aqueous conditions. Depending on the degree of LCA substitution, the particle diameters range from 163 to 242 nm. Doxorubicin (DOX), chosen as a model anticancer drug, is effectively encapsulated into the nanoparticles with high loading efficiency (>70%). In vitro optical imaging tests reveal that the fluorescence signal of DOX quenched in the bioreducible nanoparticles is highly recovered in the presence of glutathione (GSH), a tripeptide capable of reducing disulfide bonds in the intracellular compartments. Bioreducible nanoparticles rapidly release DOX when they are incubated with 10 mm GSH, whereas the drug release is greatly retarded in physiological buffer (pH 7.4). DOX-loaded bioreducible nanoparticles exhibit higher toxicity to SCC7 cancer cells than DOX-loaded nanoparticles without the disulfide bond. Confocal laser scanning microscopy observation demonstrate that bioreducible nanoparticles can effectively deliver DOX into the nuclei of SCC7 cells. In vivo biodistribution study indicates that Cy5.5-labeled CMD-SS-LCAs selectively accumulate at tumor sites after systemic administration into tumor-bearing mice. Notably, DOX-loaded bioreducible nanoparticles exhibit higher antitumor efficacy than reduction-insensitive control nanoparticles. Overall, it is evident that bioreducible CMD-SS-LCA nanoparticles are useful as a drug carrier for cancer therapy.
    Advanced Healthcare Materials 04/2014;
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    ABSTRACT: Cholinergic urticaria is a type of physical urticaria characterized by heat-associated wheals. Several reports are available about cholinergic urticaria; however, the clinical manifestations and pathogenesis are incompletely understood.
    Annals of Dermatology 04/2014; 26(2):189-94. · 0.61 Impact Factor
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    ABSTRACT: Purpose: Estimation of body fluid volume in hyponatremia is useful for diagnosis and therapeutic decision-making. Physical examination has been generally used to estimate body fluid volume, but it depends on the physician's abilities. Bioimpedance spectroscopy has been suggested to be a reliable method for the estimation of body fluid volume. Therefore, this study investigated whether bioimpedance spectroscopy could replace physical examination in hyponatremia. Materials and Methods: The study included 30 patients with hyponatremia. At the time of the initial visit, body fluid volume was estimated simultaneously by both physical examination and bioimpedance spectroscopy. Estimation of body fluid status by clinical diagnosis was performed as well, which determined body fluid status corresponds with the most likely cause of hyponatremia (clinical body fluid estimation). Results: The results of body fluid volume estimated by physical examination, bioimpedance spectroscopy, and clinical body fluid estimation showed that 9, 10, and 9 patients, respectively, were hypervolemic; 13, 15 and 16 patients, respectively, were euvolemic; and 8, 5, and 5 patients, respectively, were hypovolemic. Cohen's kappa analysis showed a significant agreement between physical examination and bioimpedance spectroscopy (kappa coefficient, 0.632, p<0.001). In addition, bioimpedance spectroscopy showed a higher level of agreement with clinical body fluid estimation than physical examination (kappa coefficient, 0.602 vs. 0.524). Conclusion: This study suggests that bioimpedance spectroscopy could replace physical examination for estimating body fluid status in hyponatremia. In addition, bioimpedance spectroscopy might correspond better with clinical diagnosis than physical examination in the estimation of body fluid status in hyponatremia.
    Yonsei medical journal 03/2014; 55(2):482-6. · 0.77 Impact Factor
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    ABSTRACT: The hallmark of atherosclerosis in its early pathogenic process is the overexpression of class A scavenger receptors (SR-A) by activated macrophages. In this study, dextran sulfate-coated superparamagnetic iron oxide nanoparticles (DS-SPIONs), as a magnetic resonance (MR) imaging contrast agent of atherosclerosis, was prepared via the facile co-precipitation method using a versatile double-hydrophilic block copolymer comprising of a DS segment (ligand for SR-A) and a poly(glyclerol methacrylate) segment (SPIONs surface-anchoring unit). The physicochemical properties of the DS-SPIONs were investigated using various instruments. DS-SPIONs exhibited high aqueous stability compared to dextran-coated SPIONs (Dex-SPIONs), which were used as controls. The cellular uptake behaviors of DS-SPIONs and Dex-SPIONs were evaluated using Prussian blue assay. Interestingly, the DS-SPIONs were effectively taken up by activated macrophages compared to Dex-SPIONs. However, the cellular uptake of DS-SPIONs by activated macrophages was remarkably reduced in the presence of free DS. These results suggest that activated macrophages internalize DS-SPIONs via receptor (SR-A)-mediated endocytosis. T2-weighted MR imaging of the cells demonstrated that activated macrophages treated with DS-SPIONs showed a significantly lower signal intensity compared to those treated with Dex-SPIONs. Overall, these results suggest that DS-SPIONs may be utilized as a potential contrast agent for atherosclerosis MR imaging.
    Carbohydrate polymers. 01/2014; 101:1225-33.

Publication Stats

927 Citations
467.01 Total Impact Points

Institutions

  • 2004–2014
    • Chosun University
      • College of Medicine
      Gwangju, Gwangju, South Korea
  • 2001–2014
    • Catholic University of Korea
      • Department of Dermatology
      Sŏul, Seoul, South Korea
  • 2000–2014
    • Sungkyunkwan University
      • • Department of Polymer Science and Engineering
      • • Department of Chemical Engineering
      Sŏul, Seoul, South Korea
  • 2013
    • Seoul National University Hospital
      • Department of Neuropsychiatry
      Sŏul, Seoul, South Korea
  • 2012–2013
    • Yonsei University Hospital
      • Department of Internal Medicine
      Seoul, Seoul, South Korea
    • Dongguk University
      • College of Science and Technology
      Sŏul, Seoul, South Korea
  • 2010–2013
    • International St. Mary's Hospitals
      Chemulpo, Incheon, South Korea
    • Yeungnam University
      • Division of Internal Medicine
      Onyang, South Chungcheong, South Korea
  • 2011–2012
    • Chonbuk National University Hospital
      Sŏul, Seoul, South Korea
    • University of Seoul
      Sŏul, Seoul, South Korea
  • 2009–2012
    • Wonkwang University School of Medicine and Hospital
      Riri, North Jeolla, South Korea
    • Korea Institute of Industrial Technology
      Anzan, Gyeonggi Province, South Korea
  • 2000–2012
    • Yonsei University
      • Department of Chemical and Biomolecular Engineering
      Sŏul, Seoul, South Korea
  • 2001–2011
    • Korea Advanced Institute of Science and Technology
      • • Department of Chemical and Biomolecular Engineering
      • • Department of Chemistry
      Seoul, Seoul, South Korea
  • 2008–2010
    • Seoul National University
      • • College of Medicine
      • • Department of Neuropsychiatry
      Seoul, Seoul, South Korea
    • Chung-Ang University
      • College of Medicine
      Seoul, Seoul, South Korea
  • 2007
    • Soonchunhyang University
      Onyang, South Chungcheong, South Korea
  • 2006
    • Keimyung University
      • Department of Chemical System Engineering
      Seoul, Seoul, South Korea
  • 1997–2004
    • Korea Institute of Science and Technology
      • Electronic Materials Research Center
      Sŏul, Seoul, South Korea
  • 1999–2003
    • University of Suwon
      Suigen, Gyeonggi Province, South Korea
  • 2002
    • University of Ulsan
      • College of Medicine
      Urusan, Ulsan, South Korea
    • Catholic University of Daegu
      • Department of Food Science and Nutrition
      Hayang, North Gyeongsang, South Korea